myocardial revascularization

Coronary Artery Bypass - Coronary Artery Bypass Surgery      

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Trial Studied trt Control trt patientstagsNCTROB Result

acute coronary syndrome

anistreplase
UNASEM, 1992anistreplaseplaceboExploratory -
t-pa
Nicklas, 1989t-PAplaceboExploratory negative
Gold, 1987t-PAplaceboExploratory -
Williams, 1990t-PAplaceboExploratory negative
Freeman, 1992t-PAplaceboLow risk of bias negative
van der Brand, 1991t-PAplaceboExploratory negative
charbonnier, 1992t-PAplaceboExploratory -
Ardissino, 1990t-PAplaceboExploratory negative
TIMI 3B, 1995t-PAplaceboLow risk of bias -
Topol, 1988t-PAplaceboExploratory negative
TIMI 3A, 1993t-PAplaceboExploratory -

acute myocardial infarction

abciximab
BRAVE (Kastrati), 2004Abciximab + reteplaseprimary intervention -
ERAMI (Mesquita Gabriel), 2003Abciximabprimary interventionnegative
REOMOBILE (Arntz), 2003Abciximabprimary interventionnegative
Zorman, 2002Abciximabprimary interventionnegative
ReoPro-BRIDGING (Gyongyosi), 2004Abciximabprimary interventionnegative
Bellandi, 2006Abciximabprimary interventionnegative
FINESSE (abciximab-facilitated PCI), 2008Abciximabprimary interventionNCT00046228negative
FINESSE (combination-facilitated PCI), 2008Abciximab + reteplaseprimary interventionNCT00046228negative
alteplase
LIMI (Vermeer), 1999alteplaseprimary interventionnegative
PACT (Ross,), 1999alteplaseprimary interventionnegative
anistreplase
TEAM 2, 1991anistreplasestreptokinase -
APSAC
APSIM, 1989APSACcontrolnegative
AIMS, 1988APSACplacebosuggesting
German Multicenter Trial, 1988APSACplacebosuggesting
ISIS III (SK/APSAC), 1992APSACstreptokinasenegative
TEAM 3, 1992APSACt-PA -
drug-eluting stents
DEDICATION, 2008drug-eluting stentsbare-metal stentNCT00192868Risk of bias suggesting
PASEO, 2009drug-eluting stentsbare-metal stent -
eptifibatide
INTAMI (Zeymer), 2005Eptifibatideprimary interventionnegative
lanoteplase
InTIME-II, 2000lanoteplaseaccelerated t-PAnegative
paclitaxel
PASSION, 2006paclitaxel eluting stentbare-metal stentISRCTN65027270Risk of bias negative
HAAMU-STENT, 2006paclitaxel eluting stentbare-metal stentExploratory negative
HORIZONS-AMI Stent, 2008paclitaxel eluting stentbare-metal stentsuggesting
PCI
WEST, 2006systematic PCI (+stent)no systematic PCInegative
CAPITAL AMI, 2005systematic PCI (+stent)no systematic PCInegative
GRACIA-1, 2004systematic PCI (+stent)no systematic PCIRisk of bias negative
SIAM III, 2002systematic PCI (+stent)no systematic PCInegative
PRAGUE, 2000systematic PCI (+stent)no systematic PCInegative
C-PORT, 2002primary PCIaccelerated t-PA -
STAT, 2001primary stentingaccelerated t-PA -
Jaksch, 1998primary stentingballoon angioplastysuggesting
GRAMI (Rodriguez), 1998primary stentingballoon angioplastynegative
Zwolle 5 (Suryapranata), 1998primary stentingballoon angioplastysuggesting
stent-PAMI (Grines), 1999primary stentingballoon angioplastysuggesting
PASTA (Saito), 1999primary stentingballoon angioplastysuggesting
PRISAM (Kawashima), 1999primary stentingballoon angioplastynegative
STENTIM-2 (Maillard), 2000primary stentingballoon angioplastynegative
PSSAAMI (Scheller), 2001primary stentingballoon angioplastysuggesting
FRESCO, 1998primary stentingballoon angioplasty -
CADILLAC abciximab., 2002primary stentingballoon angioplasty -
CADILLAC (no abciximab), 2002primary stentingballoon angioplasty -
ZWOLLE 6, 2005primary stentingballoon angioplasty -
STOPAMI 3, 2004primary stentingballoon angioplasty -
STOPAMI 2, 2002primary stentingimmediate thrombolysis -
senior PAMI, 2005primary PCIThrombolysisNCT00136929Risk of bias suggesting
primary angioplasty
Ribichini, 1996primary ballon angioplastyaccelerated t-PA -
Garcia, 1997primary ballon angioplastyaccelerated t-PA -
GUSTO 2B, 1997primary ballon angioplastyaccelerated t-PA -
DANAMI-2, 1997primary ballon angioplastyaccelerated t-PA -
DeWood, 1989primary ballon angioplastyduteplase -
Gibbons, 1993primary ballon angioplastyduteplase -
O'Neill, 1986primary ballon angioplastyintracoronary streptokinase -
Zwolle, 1994primary ballon angioplastystreptokinasenegative
Ribeiro, 1993primary ballon angioplastystreptokinase -
Grinfeld, 1996primary ballon angioplastystreptokinase -
Zijlstra, 1997primary ballon angioplastystreptokinase -
Zijlstra , 1993primary ballon angioplastystreptokinase -
Akhras, 1997primary ballon angioplastystreptokinase -
PAMI, 1993primary ballon angioplastyt-PA -
TRIANA, 2009primary ballon angioplastytenecteplaseNCT00257309Risk of bias negative
PTCA
MAASTRICHT (Vermeer), 1999primary angioplastyimmediate thrombolysisnegative
PRAGUE-1, 2000primary angioplastyimmediate thrombolysissuggesting
AIR-PAMI, 2002primary angioplastyimmediate thrombolysisnegative
CAPTIM, 2002primary angioplastyimmediate thrombolysisnegative
DANAMI-2, 2003primary angioplastyimmediate thrombolysissuggesting
PRAGUE-2, 2003primary angioplastyimmediate thrombolysissuggesting
TAMI 1 pilot, 1987immediate systematic ballon angioplastyteno immediate angioplastyExploratory suggesting
ECSG, 1988immediate systematic ballon angioplastyteno immediate angioplastyExploratory negative
TAMI-5 (Califf), 1991immediate systematic ballon angioplastyteno immediate angioplasty -
SHOCK (Hochman), 1999immediate systematic ballon angioplastyteno immediate angioplastyNCT00000552Risk of bias suggesting
Ellis, 1994immediate systematic ballon angioplastyteno immediate angioplasty -
Erbel, 1989immediate systematic ballon angioplastyteno immediate angioplasty -
MERLIN (Sutton), 2004immediate systematic ballon angioplastyteno immediate angioplasty -
SWISS-SMASH, 1999immediate systematic ballon angioplastyteno immediate angioplastyExploratory negative
TIMI 2A, 1988immediate systematic ballon angioplastyteno immediate angioplastyExploratory -
Belenkie, 1991immediate systematic ballon angioplastyteno immediate angioplastyExploratory -
Topol, 1987immediate systematic ballon angioplastyteno immediate angioplastyExploratory -
TOMIIS, 1994late PTCAno PTCAnegative
Horie et al, 1998late PTCAno PTCAsuggesting
TOAT, 2002late PTCAno PTCAnegative
DECOPI, 2004late PTCAno PTCAnegative
Silva et al, 2005late PTCAno PTCAnegative
OAT, 2006late PTCAno PTCAnegative
TOSCA-2, 2006late PTCAno PTCANCT00025766 -
REACT (rescue PCI), 2005rescue PTCAno rescue PTCAsuggesting
MERLIN, 2004rescue PTCAno rescue PTCAnegative
RESCUE II, 2000rescue PTCAno rescue PTCAnegative
RESCUE, 1994rescue PTCAno rescue PTCAnegative
Belenkie, 1992rescue PTCAno rescue PTCARisk of bias negative
SWIFT, 1991systematic ballon angioplastyno systematic angioplastyRisk of bias negative
SIAM, 1992systematic ballon angioplastyno systematic angioplastyExploratory negative
TIMI 2, 1989systematic ballon angioplastyno systematic angioplastyRisk of bias negative
Guerci, 1987systematic ballon angioplastyno systematic angioplastyExploratory negative
Van den Brand, 1991systematic ballon angioplastyno systematic angioplastyExploratory negative
TOPS, 1992systematic ballon angioplastyno systematic angioplastyExploratory negative
TIMI II-A (defered)systematic ballon angioplastyno systematic angioplasty -
Vermeer, 1999systematic ballon angioplastyno systematic angioplasty -
TAMI 6, 1992systematic ballon angioplastyno systematic angioplasty -
Barbash, 1990systematic ballon angioplastyno systematic angioplasty -
reteplase
GUSTO III, 1997reteplaseaccelerated t-PAnegative
RAPID-2, 1996reteplaseaccelerated t-PAExploratory suggesting
INJECT, 1995reteplasestreptokinasenegative
saruplase
COMPASS, 1998saruplasestreptokinasenegative
PRIMI (vs SK), 1989saruplasestreptokinase -
SESAM, 1997saruplaset-PAExploratory negative
PRIMI (vs UK), 1989saruplaseurokinase -
sirolimus eluting stent
TYPHOON, 2006sirolimus eluting stentbare-metal stentNCT00232830suggesting
SESAMI, 2007sirolimus eluting stentbare-metal stentNCT00288210Risk of bias suggesting
MISSION, 2008sirolimus eluting stentbare-metal stentISRCTN62825862Risk of bias suggesting
Díaz de la Llera, 2007sirolimus eluting stentbare-metal stent -
PROSIT, 2006sirolimus eluting stentpaclitaxel eluting stentnegative
Di Lorenzo et al., 2005sirolimus eluting stentpaclitaxel eluting stentnegative
Juwana, 2009sirolimus eluting stentpaclitaxel eluting stentISRCTN90526229negative
streptokinase
ISAM, 1986streptokinaseplacebonegative
ISIS-2 (SK), 1988streptokinaseplacebosuggesting
Western Washington Intravenous Trial, 1988streptokinaseplaceboNCT00000507negative
GISSI I, 1986streptokinaseplacebosuggesting
EMERAS (all delay), 1993streptokinaseplacebonegative
ISIS 2 pilot, 1987streptokinaseplacebo -
EMERAS (7-12h), 1993streptokinaseplacebo -
SAMI (O’Neill), 1992streptokinaseprimary interventionnegative
PRAGUE (Widimisky), 2000streptokinaseprimary interventionnegative
GUSTO tPA-SK Hiv, 1993t-PA + streptokinasestreptokinasenegative
t-pa
ASSET, 1988t-PAplacebosuggesting
LATE, 1993t-PAplaceboLow risk of bias negative
TAMI 6, 1992t-PAplacebonegative
COBALT, 1997bolus t-PAaccelerated t-PAnegative
TAPS, 1992accelerated t-PAAPSACnegative
TIMI 4, 1994accelerated t-PAAPSAC -
GUSTO tPA Hiv, 1993accelerated t-PAstreptokinasesuggesting
GISSI II, 1990t-PAstreptokinasesuggesting
International Study Group, 1990t-PAstreptokinasesuggesting
ISIS III (SK/tPA), 1992t-PAstreptokinasesuggesting
Centre Illinois, 1993t-PAstreptokinase -
Cherng, 1992t-PAstreptokinasenegative
ECSG, 1985t-PAstreptokinasenegative
PAIMS, 1989t-PAstreptokinase -
TIMI-1, 1987t-PAstreptokinaseNCT00000505 -
White, 1989t-PAstreptokinase -
RAAMI, 1992accelerated t-PAt-PA -
KAMIT, 1991t-PA half doset-PAExploratory negative
TAMI 5 (t-PA vs uroK), 1991t-PAurokinase -
tenecteplase
ADVANCE-MI, 2005Eptifibatide + tenecteplaseprimary intervention -
ASSENT-2, 1999tenecteplaseaccelerated t-PAsuggesting
ASSENT-4 PCI (Van de Werf), 2006primary interventionNCT00168792negative
GRACIA (Fernandez-Aviles,), 2004tenecteplaseprimary interventionnegative
tirofiban
On-Time (van’t Hof), 2004Tirofibanprimary interventionnegative
TIGER-PA (Lee), 2003Tirofibanprimary interventionnegative
Cutlip, 2003Tirofibanprimary interventionnegative
urokinase
USIM, 1991urokinasecontrol -
zotarolimus eluting stent
ZEST AMI (vs PES), 2009zotarolimus eluting stentpaclitaxel eluting stentNCT00422565Risk of bias negative
ZEST AMI (vs SES), 2009zotarolimus eluting stentsirolimus eluting stentNCT00422565negative

coronary artery disease

abciximab
Kim, 2010abciximab-coated stentbare-metal stentExploratory -
angioplasty
AMIST (Reeves), 2004angioplastyMIDCABRisk of bias -
biolimus eluting stent
LEADERS, 2008biolimus eluting stentsirolimus eluting stentNCT00389220negative
Coronary Artery Bypass Surgery
Allen, 2000TMR+CABGCABG -
STICH (ventricular reconstruction), 2009CABG+surgical ventricular reconstructionCABGNCT00023595negative
Loubani, 2003TMR+CABGCABGExploratory -
Zhao, 2006TMR+CABGCABGExploratory -
MASS II, 2007CABGmedical treatmentnegative
VA, 1984CABGmedical treatmentsuggesting
ECSS (European), 1988CABGmedical treatmentsuggesting
CASS, 1983CABGmedical treatmentNCT00000489negative
Texas, 1977CABGmedical treatmentnegative
Oregon, 1979CABGmedical treatmentnegative
New zealand 1, 1981CABGmedical treatmentnegative
BARI 2D, 2009CABG or PCImedical treatmentNCT00006305Risk of bias negative
dactinomycin eluting stent
ACTION, 2004dactinomycin eluting stentbare-metal stentsuggesting
drug-eluting stents
ISAR-CABG ongoing drug-eluting stentsbare-metal stentNCT00611910 ongoing
Boudriot, 2008DESCABGExploratory negative
Leipzig ongoing drug-eluting stentsCABGNCT00176397 ongoing
FREEDOM, 2012PCI with drug-eluting stentsCABGNCT00086450Risk of bias negative
Hong, 2005PCI withdrug-eluting stentsCABGRisk of bias -
VA CARDS ongoing PCI withdrug-eluting stentsCABGNCT00326196Risk of bias ongoing
everolimus eluting stent
FUTURE I, 2004everolimus eluting stentbare-metal stentnegative
FUTURE II, 2006everolimus eluting stentbare-metal stent -
SPIRIT I, 2005everolimus eluting stentbare-metal stentNCT00180453Exploratory negative
RESET, 2011everolimus eluting stentsirolimus eluting stentNCT01035450 -
PLATINUM, 2011everolimus eluting stenteverolimus eluting stentNCT00823212 -
SPIRIT II, 2006everolimus eluting stentpaclitaxel eluting stentNCT00180310Risk of bias negative
SPIRIT IV, 2010everolimus eluting stentpaclitaxel eluting stentNCT00307047Risk of bias suggesting
SPIRIT III, 2008everolimus eluting stentpaclitaxel eluting stentNCT00180479Exploratory suggesting
SORT OUT IV, 2012everolimus eluting stentsirolimus eluting stentNCT00552877Risk of bias -
ISAR-TEST 4 (EES vs SES)everolimus eluting stentsirolimus eluting stentsuggesting
ESSENCE diabeteseverolimus eluting stentsirolimus ESNCT00997763 -
LEFT-MAIN-2 ongoing everolimus eluting stentzotarolimus eluting stentNCT00598637 ongoing
paclitaxel
ISAR-DESIRE (PES vs PTCA), 2005paclitaxel eluting stentballoon angioplastysuggesting
TAXUS I, 2003paclitaxel eluting stentbare-metal stentnegative
TAXUS II, 2003paclitaxel eluting stentbare-metal stentNCT00299026suggesting
TAXUS IV, 2004paclitaxel eluting stentbare-metal stentNCT00292474Low risk of bias suggesting
SCORE, 2004paclitaxel eluting stentbare-metal stentsuggesting
TAXUS V (all patients), 2005paclitaxel eluting stentbare-metal stentNCT00301522suggesting
TAXUS VI, 2005paclitaxel eluting stentbare-metal stentNCT00297804suggesting
PASSION, 2006paclitaxel eluting stentbare-metal stentISRCTN65027270Risk of bias negative
HAAMU-STENT, 2006paclitaxel eluting stentbare-metal stentExploratory negative
TAXUS II (diabetics), 2003paclitaxel eluting stentbare-metal stentsuggesting
TAXUS IV (diabetics), 2005paclitaxel eluting stentbare-metal stentNCT00292474suggesting
TAXUS V (diabetics), 2005paclitaxel eluting stentbare-metal stentsuggesting
TAXUS VI (diabetics), 2005paclitaxel eluting stentbare-metal stentNCT00297804suggesting
BASKET-SAVAGE ongoing paclitaxel eluting stentbare-metal stentNCT00595647 ongoing
ASPECT, 2003paclitaxel, non-polymeric eluting stentbare-metal stentNCT00196079suggesting
ELUTES, 2004paclitaxel, non-polymeric eluting stentbare-metal stentnegative
DELIVER, 2004paclitaxel, non-polymeric eluting stentbare-metal stentRisk of bias negative
PATENCY, 2002paclitaxel, non-polymeric eluting stentbare-metal stentnegative
SYNTAX, 2009paclitaxel eluting stentCABGNCT00114972Risk of bias suggesting
VELETI ongoing paclitaxel eluting stentmedical treatmentNCT00289835 ongoing
PEPCAD IV ongoing paclitaxel eluting balloonpaclitaxel eluting stentNCT00462631 ongoing
PERSEUS Workhorse, 2010 ongoing paclitaxel eluting stentpaclitaxel eluting stentNCT00484315 ongoing
ISAR-test (diabetics), 2006paclitaxel eluting stentsirolimus eluting stentRisk of bias -
FRE-RACE ongoing paclitaxel eluting stentsirolimus eluting stentNCT00130546 ongoing
PCI
AVERT, 1995PCI with or without stentmedical treatmentRisk of bias negative
COURAGE, 2007PCI with or without stentmedical treatmentNCT00007657Risk of bias suggesting
MASS II, 2007PCI with or without stentmedical treatmentRisk of bias negative
Dakik, 1998PCI with or without stentmedical treatmentRisk of bias negative
ALKK, 2003PCI with or without stentmedical treatmentRisk of bias suggesting
Hambrecht, 2004PCI with or without stentmedical treatmentRisk of bias negative
Bech, 2001PCI with or without stentmedical treatmentRisk of bias negative
TIME, 2001PCI with or without stentmedical treatmentRisk of bias -
FAME, 2008FFR-guided PCIno PCINCT00267774suggesting
DEFER, 2001FFR-guided PCIno PCInegative
AWESOME, 2001PCICABGRisk of bias -
COMBAT ongoing PCICABG ongoing
Korean Randomized Study ongoing PCICABG ongoing
REVASCULARIZE ongoing PCICABG ongoing
PTCA
RITA 2, 1997balloon angioplastymedical treatmentRisk of bias suggesting
ACME, 1992balloon angioplastymedical treatmentRisk of bias suggesting
Sievers, 1993balloon angioplastymedical treatmentRisk of bias negative
MASS, 1995balloon angioplastymedical treatmentRisk of bias suggesting
ACME 2 (Folland), 1997balloon angioplastymedical treatmentRisk of bias negative
ACIP, 1997balloon angioplastymedical treatmentExploratory negative
INSPIRE, 2006balloon angioplastymedical treatmentRisk of bias negative
SWISSI II, 2007balloon angioplastymedical treatmentNCT00387231Exploratory suggesting
BARI, 1996balloon angioplastyCABGNCT00000462negative
MASS, 1995balloon angioplastyCABGnegative
CABRI, 1995balloon angioplastyCABGnegative
EAST, 1994balloon angioplastyCABGNCT00000465negative
GABI, 1994balloon angioplastyCABGnegative
Lausanne, 1994balloon angioplastyCABGnegative
RITA, 1993balloon angioplastyCABGnegative
ERACI, 1992balloon angioplastyCABGnegative
Toulouse, 1992balloon angioplastyCABGnegative
sirolimus eluting stent
ISAR-DESIRE (SES vs PTCA), 2005sirolimus eluting stentballoon angioplastysuggesting
Kochiadakis, 2007sirolimus eluting stentbare-metal stentExploratory -
RAVEL, 2002sirolimus eluting stentbare-metal stentNCT00233805suggesting
SIRIUS, 2003sirolimus eluting stentbare-metal stentNCT00232765Low risk of bias suggesting
C-SIRIUS, 2004sirolimus eluting stentbare-metal stentNCT00381420suggesting
E-SIRIUS, 2003sirolimus eluting stentbare-metal stentNCT00235144suggesting
SES-SMART, 2004sirolimus eluting stentbare-metal stentsuggesting
DIABETES, 2005sirolimus eluting stentbare-metal stentsuggesting
Pache et al, 2005sirolimus eluting stentbare-metal stentsuggesting
PRISON II, 2006sirolimus eluting stentbare-metal stentNCT00258596Risk of bias suggesting
SCANDSTENT, 2006sirolimus eluting stentbare-metal stentNCT00151658suggesting
TYPHOON, 2006sirolimus eluting stentbare-metal stentNCT00232830suggesting
SESAMI, 2007sirolimus eluting stentbare-metal stentNCT00288210Risk of bias suggesting
DECODE, 2005sirolimus eluting stentbare-metal stentNCT00489164suggesting
SCORPIUS, 2007sirolimus eluting stentbare-metal stentNCT00495898suggesting
MISSION, 2008sirolimus eluting stentbare-metal stentISRCTN62825862Risk of bias suggesting
Ortolani et al, 2007sirolimus eluting stentbare-metal stent -
Pasceri, 2003sirolimus eluting stentbare-metal stent -
GISSOC II, 2010sirolimus eluting stentbare-metal stentNCT00220558Exploratory suggesting