myocardial revascularization

Coronary Artery Bypass - Coronary Artery Bypass Surgery      

Select            
Trial Studied trt Control trt patientstagsROB Trial resultAll cause deathmyocardial infarction (fatal and non fatal)

acute coronary syndrome

anistreplase
UNASEM, 1992   anistreplaseplaceboLow risk of bias -
t-pa
Nicklas, 1989   t-PAplaceboLow risk of bias negative
Gold, 1987   t-PAplaceboExploratory -
Williams, 1990   t-PAplaceboLow risk of bias negative 47%
Freeman, 1992   t-PAplaceboLow risk of bias negative100%
van der Brand, 1991     t-PAplaceboLow risk of bias negative19%
charbonnier, 1992   t-PAplaceboLow risk of bias -
Ardissino, 1990     t-PAplaceboLow risk of bias negative-50%
TIMI 3B, 1995     t-PAplaceboLow risk of bias -
Topol, 1988   t-PAplaceboExploratory negative
TIMI 3A, 1993   t-PAplaceboLow risk of bias -

acute myocardial infarction

abciximab
BRAVE (Kastrati), 2004     Abciximab + reteplaseprimary intervention -
ERAMI (Mesquita Gabriel), 2003   Abciximabprimary interventionnegative-16%
REOMOBILE (Arntz), 2003   Abciximabprimary interventionnegative-100%
Zorman, 2002     Abciximabprimary interventionnegative -100%
ReoPro-BRIDGING (Gyongyosi), 2004     Abciximabprimary interventionnegative
Bellandi, 2006     Abciximabprimary interventionnegative 4%
FINESSE (abciximab-facilitated PCI), 2008    NCTAbciximabprimary interventionnegative23%
FINESSE (combination-facilitated PCI), 2008    NCTAbciximab + reteplaseprimary interventionnegative 16%
alteplase
LIMI (Vermeer), 1999     alteplaseprimary interventionnegative 22%
PACT (Ross,), 1999     alteplaseprimary interventionnegative 11%
anistreplase
TEAM 2, 1991   anistreplasestreptokinaseLow risk of bias -
APSAC
APSIM, 1989   APSACcontrolnegative
AIMS, 1988   APSACplaceboLow risk of bias suggesting
German Multicenter Trial, 1988   APSACplacebosuggesting
ISIS III (SK/APSAC), 1992   APSACstreptokinaseLow risk of bias negative
TEAM 3, 1992   APSACt-PALow risk of bias -
drug-eluting stents
DEDICATION, 2008      NCTdrug-eluting stentsbare-metal stentRisk of bias suggesting100%
PASEO, 2009   drug-eluting stentsbare-metal stent -
eptifibatide
INTAMI (Zeymer), 2005     Eptifibatideprimary interventionnegative -8%
lanoteplase
InTIME-II, 2000   lanoteplaseaccelerated t-PALow risk of bias negative
paclitaxel
PASSION, 2006     paclitaxel eluting stentbare-metal stentRisk of bias negative-30%-16%
HAAMU-STENT, 2006   paclitaxel eluting stentbare-metal stentExploratory negative114%
HORIZONS-AMI Stent, 2008     paclitaxel eluting stentbare-metal stentsuggesting1%-18%
PCI
WEST, 2006     systematic PCI (+stent)no systematic PCInegative
CAPITAL AMI, 2005     systematic PCI (+stent)no systematic PCInegative
GRACIA-1, 2004     systematic PCI (+stent)no systematic PCIRisk of bias negative
SIAM III, 2002     systematic PCI (+stent)no systematic PCInegative
PRAGUE, 2000     systematic PCI (+stent)no systematic PCInegative
C-PORT, 2002     primary PCIaccelerated t-PA -
STAT, 2001     primary stentingaccelerated t-PA -
Jaksch, 1998   primary stentingballoon angioplastysuggesting-40%
GRAMI (Rodriguez), 1998     primary stentingballoon angioplastynegative-50%
Zwolle 5 (Suryapranata), 1998     primary stentingballoon angioplastysuggesting-32%
stent-PAMI (Grines), 1999     primary stentingballoon angioplastysuggesting96%
PASTA (Saito), 1999     primary stentingballoon angioplastysuggesting-58%
PRISAM (Kawashima), 1999   primary stentingballoon angioplastynegative-100%
STENTIM-2 (Maillard), 2000     primary stentingballoon angioplastynegative+Infini%
PSSAAMI (Scheller), 2001     primary stentingballoon angioplastysuggesting100%
FRESCO, 1998     primary stentingballoon angioplasty -
CADILLAC abciximab., 2002     primary stentingballoon angioplasty -
CADILLAC (no abciximab), 2002     primary stentingballoon angioplasty -
ZWOLLE 6, 2005     primary stentingballoon angioplasty -
STOPAMI 3, 2004     primary stentingballoon angioplasty -
STOPAMI 2, 2002     primary stentingimmediate thrombolysis -
senior PAMI, 2005    NCTprimary PCIThrombolysisRisk of bias suggesting
primary angioplasty
Ribichini, 1996   primary ballon angioplastyaccelerated t-PA -
Garcia, 1997     primary ballon angioplastyaccelerated t-PA -
GUSTO 2B, 1997     primary ballon angioplastyaccelerated t-PA -
DANAMI-2, 1997         primary ballon angioplastyaccelerated t-PA -
DeWood, 1989   primary ballon angioplastyduteplase -
Gibbons, 1993     primary ballon angioplastyduteplase -
O'Neill, 1986   primary ballon angioplastyintracoronary streptokinase -
Zwolle, 1994   primary ballon angioplastystreptokinasenegative
Ribeiro, 1993   primary ballon angioplastystreptokinase -
Grinfeld, 1996   primary ballon angioplastystreptokinase -
Zijlstra, 1997     primary ballon angioplastystreptokinase -
Zijlstra , 1993     primary ballon angioplastystreptokinase -
Akhras, 1997   primary ballon angioplastystreptokinase -
PAMI, 1993     primary ballon angioplastyt-PA -
TRIANA, 2009    NCTprimary ballon angioplastytenecteplaseRisk of bias negative
PTCA
MAASTRICHT (Vermeer), 1999     primary angioplastyimmediate thrombolysisnegative
PRAGUE-1, 2000     primary angioplastyimmediate thrombolysissuggesting
AIR-PAMI, 2002     primary angioplastyimmediate thrombolysisnegative
CAPTIM, 2002     primary angioplastyimmediate thrombolysisnegative
DANAMI-2, 2003   primary angioplastyimmediate thrombolysissuggesting-24%
PRAGUE-2, 2003     primary angioplastyimmediate thrombolysissuggesting
TAMI 1 pilot, 1987   immediate systematic ballon angioplastyteno immediate angioplastyExploratory suggesting
ECSG, 1988   immediate systematic ballon angioplastyteno immediate angioplastyExploratory negative
TAMI-5 (Califf), 1991   immediate systematic ballon angioplastyteno immediate angioplasty -
SHOCK (Hochman), 1999      NCTimmediate systematic ballon angioplastyteno immediate angioplastyRisk of bias suggesting
Ellis, 1994   immediate systematic ballon angioplastyteno immediate angioplasty -
Erbel, 1989     immediate systematic ballon angioplastyteno immediate angioplasty -
MERLIN (Sutton), 2004     immediate systematic ballon angioplastyteno immediate angioplasty -
SWISS-SMASH, 1999   immediate systematic ballon angioplastyteno immediate angioplastyExploratory negative
TIMI 2A, 1988   immediate systematic ballon angioplastyteno immediate angioplastyExploratory -
Belenkie, 1991   immediate systematic ballon angioplastyteno immediate angioplastyExploratory -
Topol, 1987   immediate systematic ballon angioplastyteno immediate angioplastyExploratory -
TOMIIS, 1994   late PTCAno PTCAnegative-24%+Infini%
Horie et al, 1998     late PTCAno PTCAsuggesting-78%-62%
TOAT, 2002     late PTCAno PTCAnegative113%219%
DECOPI, 2004     late PTCAno PTCAnegative-16%26%
Silva et al, 2005     late PTCAno PTCAnegative-100%
OAT, 2006       late PTCAno PTCAnegative4%34%
TOSCA-2, 2006      NCTlate PTCAno PTCA -
REACT (rescue PCI), 2005       rescue PTCAno rescue PTCAsuggesting -51%
MERLIN, 2004       rescue PTCAno rescue PTCAnegative -11%
RESCUE II, 2000     rescue PTCAno rescue PTCAnegative+Infini%
RESCUE, 1994   rescue PTCAno rescue PTCAnegative-47%
Belenkie, 1992   rescue PTCAno rescue PTCARisk of bias negative-81%
SWIFT, 1991   systematic ballon angioplastyno systematic angioplastyRisk of bias negative
SIAM, 1992   systematic ballon angioplastyno systematic angioplastyExploratory negative
TIMI 2, 1989   systematic ballon angioplastyno systematic angioplastyRisk of bias negative
Guerci, 1987   systematic ballon angioplastyno systematic angioplastyExploratory negative
Van den Brand, 1991   systematic ballon angioplastyno systematic angioplastyExploratory negative
TOPS, 1992   systematic ballon angioplastyno systematic angioplastyExploratory negative
TIMI II-A (defered)   systematic ballon angioplastyno systematic angioplasty -
Vermeer, 1999     systematic ballon angioplastyno systematic angioplasty -
TAMI 6, 1992   systematic ballon angioplastyno systematic angioplasty -
Barbash, 1990   systematic ballon angioplastyno systematic angioplasty -
reteplase
GUSTO III, 1997       reteplaseaccelerated t-PAnegative
RAPID-2, 1996     reteplaseaccelerated t-PAExploratory suggesting
INJECT, 1995   reteplasestreptokinaseLow risk of bias negative
saruplase
COMPASS, 1998   saruplasestreptokinaseLow risk of bias negative
PRIMI (vs SK), 1989   saruplasestreptokinaseLow risk of bias -
SESAM, 1997     saruplaset-PAExploratory negative
PRIMI (vs UK), 1989   saruplaseurokinaseLow risk of bias -
sirolimus eluting stent
TYPHOON, 2006      NCTsirolimus eluting stentbare-metal stentsuggesting1%
SESAMI, 2007        NCTsirolimus eluting stentbare-metal stentRisk of bias suggesting-57%-1%
MISSION, 2008   sirolimus eluting stentbare-metal stentRisk of bias suggesting-52%-38%
Díaz de la Llera, 2007     sirolimus eluting stentbare-metal stent -
PROSIT, 2006   sirolimus eluting stentpaclitaxel eluting stentnegative-18%-2%
Di Lorenzo et al., 2005     sirolimus eluting stentpaclitaxel eluting stentnegative-25%33%
Juwana, 2009     sirolimus eluting stentpaclitaxel eluting stentnegative44%3%
streptokinase
ISAM, 1986   streptokinaseplaceboLow risk of bias negative
ISIS-2 (SK), 1988   streptokinaseplaceboLow risk of bias suggesting
Western Washington Intravenous Trial, 1988    NCTstreptokinaseplacebonegative
GISSI I, 1986   streptokinaseplacebosuggesting
EMERAS (all delay), 1993   streptokinaseplaceboLow risk of bias negative
ISIS 2 pilot, 1987   streptokinaseplaceboLow risk of bias -
EMERAS (7-12h), 1993   streptokinaseplaceboLow risk of bias -
SAMI (O’Neill), 1992   streptokinaseprimary interventionnegative
PRAGUE (Widimisky), 2000     streptokinaseprimary interventionnegative 73%
GUSTO tPA-SK Hiv, 1993   t-PA + streptokinasestreptokinasenegative
t-pa
ASSET, 1988   t-PAplaceboLow risk of bias suggesting
LATE, 1993   t-PAplaceboLow risk of bias negative
TAMI 6, 1992   t-PAplaceboLow risk of bias negative
COBALT, 1997     bolus t-PAaccelerated t-PALow risk of bias negative
TAPS, 1992   accelerated t-PAAPSACnegative
TIMI 4, 1994   accelerated t-PAAPSACLow risk of bias -
GUSTO tPA Hiv, 1993   accelerated t-PAstreptokinasesuggesting
GISSI II, 1990   t-PAstreptokinasesuggesting
International Study Group, 1990   t-PAstreptokinaseLow risk of bias suggesting
ISIS III (SK/tPA), 1992   t-PAstreptokinaseLow risk of bias suggesting
Centre Illinois, 1993   t-PAstreptokinase -
Cherng, 1992   t-PAstreptokinasenegative
ECSG, 1985   t-PAstreptokinasenegative
PAIMS, 1989   t-PAstreptokinase -
TIMI-1, 1987    NCTt-PAstreptokinaseLow risk of bias -
White, 1989   t-PAstreptokinaseLow risk of bias -
RAAMI, 1992   accelerated t-PAt-PA -
KAMIT, 1991   t-PA half doset-PAExploratory negative
TAMI 5 (t-PA vs uroK), 1991   t-PAurokinase -
tenecteplase
ADVANCE-MI, 2005     Eptifibatide + tenecteplaseprimary intervention -
ASSENT-2, 1999     tenecteplaseaccelerated t-PALow risk of bias suggesting
ASSENT-4 PCI (Van de Werf), 2006      NCTprimary interventionnegative 58%
GRACIA (Fernandez-Aviles,), 2004   tenecteplaseprimary interventionnegative