myocardial revascularization  

Coronary Artery Bypass - Coronary Artery Bypass Surgery      

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Trial Studied trt Control trt patientstagsNCTROB Result

acute coronary syndrome

anistreplase
UNASEM, 1992anistreplaseplaceboLow risk of bias -
t-pa
Nicklas, 1989t-PAplaceboLow risk of bias negative
Gold, 1987t-PAplaceboExploratory -
Williams, 1990t-PAplaceboLow risk of bias negative
Freeman, 1992t-PAplaceboLow risk of bias negative
van der Brand, 1991t-PAplaceboLow risk of bias negative
charbonnier, 1992t-PAplaceboLow risk of bias -
Ardissino, 1990t-PAplaceboLow risk of bias negative
TIMI 3B, 1995t-PAplaceboLow risk of bias -
Topol, 1988t-PAplaceboExploratory negative
TIMI 3A, 1993t-PAplaceboLow risk of bias -

acute myocardial infarction

abciximab
BRAVE (Kastrati), 2004Abciximab + reteplaseprimary intervention -
ERAMI (Mesquita Gabriel), 2003Abciximabprimary interventionnegative
REOMOBILE (Arntz), 2003Abciximabprimary interventionnegative
Zorman, 2002Abciximabprimary interventionnegative
ReoPro-BRIDGING (Gyongyosi), 2004Abciximabprimary interventionnegative
Bellandi, 2006Abciximabprimary interventionnegative
FINESSE (abciximab-facilitated PCI), 2008Abciximabprimary interventionNCT00046228negative
FINESSE (combination-facilitated PCI), 2008Abciximab + reteplaseprimary interventionNCT00046228negative
alteplase
LIMI (Vermeer), 1999alteplaseprimary interventionnegative
PACT (Ross,), 1999alteplaseprimary interventionnegative
anistreplase
TEAM 2, 1991anistreplasestreptokinaseLow risk of bias -
APSAC
APSIM, 1989APSACcontrolnegative
AIMS, 1988APSACplaceboLow risk of bias suggesting
German Multicenter Trial, 1988APSACplacebosuggesting
ISIS III (SK/APSAC), 1992APSACstreptokinaseLow risk of bias negative
TEAM 3, 1992APSACt-PALow risk of bias -
drug-eluting stents
DEDICATION, 2008drug-eluting stentsbare-metal stentNCT00192868Risk of bias suggesting
PASEO, 2009drug-eluting stentsbare-metal stent -
eptifibatide
INTAMI (Zeymer), 2005Eptifibatideprimary interventionnegative
lanoteplase
InTIME-II, 2000lanoteplaseaccelerated t-PALow risk of bias negative
paclitaxel
PASSION, 2006paclitaxel eluting stentbare-metal stentISRCTN65027270Risk of bias negative
HAAMU-STENT, 2006paclitaxel eluting stentbare-metal stentExploratory negative
HORIZONS-AMI Stent, 2008paclitaxel eluting stentbare-metal stentsuggesting
PCI
WEST, 2006systematic PCI (+stent)no systematic PCInegative
CAPITAL AMI, 2005systematic PCI (+stent)no systematic PCInegative
GRACIA-1, 2004systematic PCI (+stent)no systematic PCIRisk of bias negative
SIAM III, 2002systematic PCI (+stent)no systematic PCInegative
PRAGUE, 2000systematic PCI (+stent)no systematic PCInegative
C-PORT, 2002primary PCIaccelerated t-PA -
STAT, 2001primary stentingaccelerated t-PA -
Jaksch, 1998primary stentingballoon angioplastysuggesting
GRAMI (Rodriguez), 1998primary stentingballoon angioplastynegative
Zwolle 5 (Suryapranata), 1998primary stentingballoon angioplastysuggesting
stent-PAMI (Grines), 1999primary stentingballoon angioplastysuggesting
PASTA (Saito), 1999primary stentingballoon angioplastysuggesting
PRISAM (Kawashima), 1999primary stentingballoon angioplastynegative
STENTIM-2 (Maillard), 2000primary stentingballoon angioplastynegative
PSSAAMI (Scheller), 2001primary stentingballoon angioplastysuggesting
FRESCO, 1998primary stentingballoon angioplasty -
CADILLAC abciximab., 2002primary stentingballoon angioplasty -
CADILLAC (no abciximab), 2002primary stentingballoon angioplasty -
ZWOLLE 6, 2005primary stentingballoon angioplasty -
STOPAMI 3, 2004primary stentingballoon angioplasty -
STOPAMI 2, 2002primary stentingimmediate thrombolysis -
senior PAMI, 2005primary PCIThrombolysisNCT00136929Risk of bias suggesting
primary angioplasty
Ribichini, 1996primary ballon angioplastyaccelerated t-PA -
Garcia, 1997primary ballon angioplastyaccelerated t-PA -
GUSTO 2B, 1997primary ballon angioplastyaccelerated t-PA -
DANAMI-2, 1997primary ballon angioplastyaccelerated t-PA -
DeWood, 1989primary ballon angioplastyduteplase -
Gibbons, 1993primary ballon angioplastyduteplase -
O'Neill, 1986primary ballon angioplastyintracoronary streptokinase -
Zwolle, 1994primary ballon angioplastystreptokinasenegative
Ribeiro, 1993primary ballon angioplastystreptokinase -
Grinfeld, 1996primary ballon angioplastystreptokinase -
Zijlstra, 1997primary ballon angioplastystreptokinase -
Zijlstra , 1993primary ballon angioplastystreptokinase -
Akhras, 1997primary ballon angioplastystreptokinase -
PAMI, 1993primary ballon angioplastyt-PA -
TRIANA, 2009primary ballon angioplastytenecteplaseNCT00257309Risk of bias negative
PTCA
MAASTRICHT (Vermeer), 1999primary angioplastyimmediate thrombolysisnegative
PRAGUE-1, 2000primary angioplastyimmediate thrombolysissuggesting
AIR-PAMI, 2002primary angioplastyimmediate thrombolysisnegative
CAPTIM, 2002primary angioplastyimmediate thrombolysisnegative
DANAMI-2, 2003primary angioplastyimmediate thrombolysissuggesting
PRAGUE-2, 2003primary angioplastyimmediate thrombolysissuggesting
TAMI 1 pilot, 1987immediate systematic ballon angioplastyteno immediate angioplastyExploratory suggesting
ECSG, 1988immediate systematic ballon angioplastyteno immediate angioplastyExploratory negative
TAMI-5 (Califf), 1991immediate systematic ballon angioplastyteno immediate angioplasty -
SHOCK (Hochman), 1999immediate systematic ballon angioplastyteno immediate angioplastyNCT00000552Risk of bias suggesting
Ellis, 1994immediate systematic ballon angioplastyteno immediate angioplasty -
Erbel, 1989immediate systematic ballon angioplastyteno immediate angioplasty -
MERLIN (Sutton), 2004immediate systematic ballon angioplastyteno immediate angioplasty -
SWISS-SMASH, 1999immediate systematic ballon angioplastyteno immediate angioplastyExploratory negative
TIMI 2A, 1988immediate systematic ballon angioplastyteno immediate angioplastyExploratory -
Belenkie, 1991immediate systematic ballon angioplastyteno immediate angioplastyExploratory -
Topol, 1987immediate systematic ballon angioplastyteno immediate angioplastyExploratory -
TOMIIS, 1994late PTCAno PTCAnegative
Horie et al, 1998late PTCAno PTCAsuggesting
TOAT, 2002late PTCAno PTCAnegative
DECOPI, 2004late PTCAno PTCAnegative
Silva et al, 2005late PTCAno PTCAnegative
OAT, 2006late PTCAno PTCAnegative
TOSCA-2, 2006late PTCAno PTCANCT00025766 -
REACT (rescue PCI), 2005rescue PTCAno rescue PTCAsuggesting
MERLIN, 2004rescue PTCAno rescue PTCAnegative
RESCUE II, 2000rescue PTCAno rescue PTCAnegative
RESCUE, 1994rescue PTCAno rescue PTCAnegative
Belenkie, 1992rescue PTCAno rescue PTCARisk of bias negative
SWIFT, 1991systematic ballon angioplastyno systematic angioplastyRisk of bias negative
SIAM, 1992systematic ballon angioplastyno systematic angioplastyExploratory negative
TIMI 2, 1989systematic ballon angioplastyno systematic angioplastyRisk of bias negative
Guerci, 1987systematic ballon angioplastyno systematic angioplastyExploratory negative
Van den Brand, 1991systematic ballon angioplastyno systematic angioplastyExploratory negative
TOPS, 1992systematic ballon angioplastyno systematic angioplastyExploratory negative
TIMI II-A (defered)systematic ballon angioplastyno systematic angioplasty -
Vermeer, 1999systematic ballon angioplastyno systematic angioplasty -
TAMI 6, 1992systematic ballon angioplastyno systematic angioplasty -
Barbash, 1990systematic ballon angioplastyno systematic angioplasty -
reteplase
GUSTO III, 1997reteplaseaccelerated t-PAnegative
RAPID-2, 1996reteplaseaccelerated t-PAExploratory suggesting
INJECT, 1995reteplasestreptokinaseLow risk of bias negative
saruplase
COMPASS, 1998saruplasestreptokinaseLow risk of bias negative
PRIMI (vs SK), 1989saruplasestreptokinaseLow risk of bias -
SESAM, 1997saruplaset-PAExploratory negative
PRIMI (vs UK), 1989saruplaseurokinaseLow risk of bias -
sirolimus eluting stent
TYPHOON, 2006sirolimus eluting stentbare-metal stentNCT00232830suggesting
SESAMI, 2007sirolimus eluting stentbare-metal stentNCT00288210Risk of bias suggesting
MISSION, 2008sirolimus eluting stentbare-metal stentISRCTN62825862Risk of bias suggesting
Díaz de la Llera, 2007sirolimus eluting stentbare-metal stent -
PROSIT, 2006sirolimus eluting stentpaclitaxel eluting stentnegative
Di Lorenzo et al., 2005sirolimus eluting stentpaclitaxel eluting stentnegative
Juwana, 2009sirolimus eluting stentpaclitaxel eluting stentISRCTN90526229negative
streptokinase
ISAM, 1986streptokinaseplaceboLow risk of bias negative
ISIS-2 (SK), 1988streptokinaseplaceboLow risk of bias suggesting
Western Washington Intravenous Trial, 1988streptokinaseplaceboNCT00000507negative
GISSI I, 1986streptokinaseplacebosuggesting
EMERAS (all delay), 1993streptokinaseplaceboLow risk of bias negative
ISIS 2 pilot, 1987streptokinaseplaceboLow risk of bias -
EMERAS (7-12h), 1993streptokinaseplaceboLow risk of bias -
SAMI (O’Neill), 1992streptokinaseprimary interventionnegative
PRAGUE (Widimisky), 2000streptokinaseprimary interventionnegative
GUSTO tPA-SK Hiv, 1993t-PA + streptokinasestreptokinasenegative
t-pa
ASSET, 1988t-PAplaceboLow risk of bias suggesting
LATE, 1993t-PAplaceboLow risk of bias negative
TAMI 6, 1992t-PAplaceboLow risk of bias negative
COBALT, 1997bolus t-PAaccelerated t-PALow risk of bias negative
TAPS, 1992accelerated t-PAAPSACnegative
TIMI 4, 1994accelerated t-PAAPSACLow risk of bias -
GUSTO tPA Hiv, 1993accelerated t-PAstreptokinasesuggesting
GISSI II, 1990t-PAstreptokinasesuggesting
International Study Group, 1990t-PAstreptokinaseLow risk of bias suggesting
ISIS III (SK/tPA), 1992t-PAstreptokinaseLow risk of bias suggesting
Centre Illinois, 1993t-PAstreptokinase -
Cherng, 1992t-PAstreptokinasenegative
ECSG, 1985t-PAstreptokinasenegative
PAIMS, 1989t-PAstreptokinase -
TIMI-1, 1987t-PAstreptokinaseNCT00000505Low risk of bias -
White, 1989t-PAstreptokinaseLow risk of bias -
RAAMI, 1992accelerated t-PAt-PA -
KAMIT, 1991t-PA half doset-PAExploratory negative
TAMI 5 (t-PA vs uroK), 1991t-PAurokinase -
tenecteplase
ADVANCE-MI, 2005Eptifibatide + tenecteplaseprimary intervention -
ASSENT-2, 1999tenecteplaseaccelerated t-PALow risk of bias suggesting
ASSENT-4 PCI (Van de Werf), 2006primary interventionNCT00168792negative
GRACIA (Fernandez-Aviles,), 2004tenecteplaseprimary interventionnegative
tirofiban
On-Time (van’t Hof), 2004Tirofibanprimary interventionnegative
TIGER-PA (Lee), 2003Tirofibanprimary interventionnegative
Cutlip, 2003Tirofibanprimary interventionnegative
urokinase
USIM, 1991urokinasecontrol -
zotarolimus eluting stent
ZEST AMI (vs PES), 2009zotarolimus eluting stentpaclitaxel eluting stentNCT00422565Risk of bias negative
ZEST AMI (vs SES), 2009zotarolimus eluting stentsirolimus eluting stentNCT00422565negative

coronary artery disease

abciximab
Kim, 2010abciximab-coated stentbare-metal stentExploratory -
angioplasty
AMIST (Reeves), 2004angioplastyMIDCABRisk of bias -
biolimus eluting stent
LEADERS, 2008biolimus eluting stentsirolimus eluting stentNCT00389220negative
Coronary Artery Bypass Surgery
Allen, 2000TMR+CABGCABG -
STICH (ventricular reconstruction), 2009CABG+surgical ventricular reconstructionCABGNCT00023595negative
Loubani, 2003TMR+CABGCABGExploratory -
Zhao, 2006TMR+CABGCABGExploratory -
MASS II, 2007CABGmedical treatmentnegative
VA, 1984CABGmedical treatmentsuggesting
ECSS (European), 1988CABGmedical treatmentsuggesting
CASS, 1983CABGmedical treatmentNCT00000489negative
Texas, 1977CABGmedical treatmentnegative
Oregon, 1979CABGmedical treatmentnegative
New zealand 1, 1981CABGmedical treatmentnegative
BARI 2D, 2009CABG or PCImedical treatmentNCT00006305Risk of bias negative
dactinomycin eluting stent
ACTION, 2004dactinomycin eluting stentbare-metal stentsuggesting
drug-eluting stents
ISAR-CABG ongoing drug-eluting stentsbare-metal stentNCT00611910 ongoing
Boudriot, 2008DESCABGExploratory negative
Leipzig ongoing drug-eluting stentsCABGNCT00176397 ongoing
FREEDOM, 2012PCI with drug-eluting stentsCABGNCT00086450Risk of bias negative
Hong, 2005PCI withdrug-eluting stentsCABGRisk of bias -
VA CARDS ongoing PCI withdrug-eluting stentsCABGNCT00326196Risk of bias ongoing
everolimus eluting stent
FUTURE I, 2004everolimus eluting stentbare-metal stentnegative
FUTURE II, 2006everolimus eluting stentbare-metal stentLow risk of bias -
SPIRIT I, 2005everolimus eluting stentbare-metal stentNCT00180453Exploratory negative
RESET, 2011everolimus eluting stentsirolimus eluting stentNCT01035450 -
PLATINUM, 2011everolimus eluting stenteverolimus eluting stentNCT00823212 -
SPIRIT II, 2006everolimus eluting stentpaclitaxel eluting stentNCT00180310Risk of bias negative
SPIRIT IV, 2010everolimus eluting stentpaclitaxel eluting stentNCT00307047Risk of bias suggesting
SPIRIT III, 2008everolimus eluting stentpaclitaxel eluting stentNCT00180479Exploratory suggesting
SORT OUT IV, 2012everolimus eluting stentsirolimus eluting stentNCT00552877Risk of bias -
ISAR-TEST 4 (EES vs SES)everolimus eluting stentsirolimus eluting stentsuggesting
ESSENCE diabeteseverolimus eluting stentsirolimus ESNCT00997763 -
LEFT-MAIN-2 ongoing everolimus eluting stentzotarolimus eluting stentNCT00598637 ongoing
paclitaxel
ISAR-DESIRE (PES vs PTCA), 2005paclitaxel eluting stentballoon angioplastysuggesting
TAXUS I, 2003paclitaxel eluting stentbare-metal stentLow risk of bias negative
TAXUS II, 2003paclitaxel eluting stentbare-metal stentNCT00299026Low risk of bias suggesting
TAXUS IV, 2004paclitaxel eluting stentbare-metal stentNCT00292474Low risk of bias suggesting
SCORE, 2004paclitaxel eluting stentbare-metal stentsuggesting
TAXUS V (all patients), 2005paclitaxel eluting stentbare-metal stentNCT00301522Low risk of bias suggesting
TAXUS VI, 2005paclitaxel eluting stentbare-metal stentNCT00297804Low risk of bias suggesting
PASSION, 2006paclitaxel eluting stentbare-metal stentISRCTN65027270Risk of bias negative
HAAMU-STENT, 2006paclitaxel eluting stentbare-metal stentExploratory negative
TAXUS II (diabetics), 2003paclitaxel eluting stentbare-metal stentLow risk of bias suggesting
TAXUS IV (diabetics), 2005paclitaxel eluting stentbare-metal stentNCT00292474Low risk of bias suggesting
TAXUS V (diabetics), 2005paclitaxel eluting stentbare-metal stentLow risk of bias suggesting
TAXUS VI (diabetics), 2005paclitaxel eluting stentbare-metal stentNCT00297804Low risk of bias suggesting
BASKET-SAVAGE ongoing paclitaxel eluting stentbare-metal stentNCT00595647 ongoing
ASPECT, 2003paclitaxel, non-polymeric eluting stentbare-metal stentNCT00196079Low risk of bias suggesting