calcium channel blockers  

Amlodipine - Diltiazem - Diltiazem - Felodipine - Nicardipine - Nidrendipine - Nifedipine - Nisoldipine - Verapamil      

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Trial Studied trt Control trt patientstagsNCTROB Result

acute coronary syndrome

diltiazem
Göbel (Dutch study), 1995diltiazemplaceboLow risk of bias -
DRS, 1986diltiazemplaceboLow risk of bias -
nifedipine
HINT (nifedipine vs metoprolol), 1988nifedipinemetoprolol -

acute myocardial infarction

diltiazem
Machecourt, 1986diltiazemnegative
Gibson, 1986diltiazemplaceboLow risk of bias negative
MDPIT, 1988diltiazemplaceboLow risk of bias negative
Zannad, 1988diltiazemplaceboLow risk of bias negative
nifedipine
Muller, 1984nifedipineLow risk of bias negative
Gordon, 1984nifedipinenegative
MI study group, 1979nifedipine -
Eisenberg, 1985nifedipineplaceboLow risk of bias negative
Bradagan, 1986nifedipineplaceboLow risk of bias negative
Jaffe, 1987nifedipineplacebonegative
Gottlieb, 1988nifedipineplaceboLow risk of bias negative
Erbel, 1988nifedipineplaceboLow risk of bias negative
SPRINT I, 1988nifedipineplaceboLow risk of bias negative
SPRINT II, 1993nifedipineplaceboLow risk of bias negative
Loogna, 1985nifedipineplaceboLow risk of bias negative
TRENT (Wilcox), 1986nifedipineplaceboLow risk of bias negative
Walker, 1988nifedipineplaceboLow risk of bias negative
Sirnes, 1984nifedipineplaceboLow risk of bias negative
verapamil
Bussman, 1984verapamilcontrolnegative
DAVIT I, 1984verapamilplaceboLow risk of bias -
Crea, 1985verapamilplacebonegative
DAVIT II, 1990verapamilplaceboLow risk of bias negative
CRIS, 1996verapamilplaceboLow risk of bias negative
Danish study, 1984verapamilplaceboLow risk of bias negative

heart failure

amlodipine
Packer, 1991amlodipinecontrolLow risk of bias -
Smith, 1994amlodipinecontrolLow risk of bias -
Udelson, 1996amlodipinecontrolLow risk of bias -
Binkley, 1996amlodipinecontrolLow risk of bias -
Ghali, 1997amlodipinecontrolLow risk of bias -
PRAISE, 1996amlodipineplaceboLow risk of bias negative
PRAISE II , 2000AmlodipineplaceboLow risk of bias negative
diltiazem
Liao , 1998DiltiazemplaceboExploratory suggesting
DiDi, 1996diltiazemplaceboLow risk of bias negative
felodipine
VHeFT III, 1997felodipineplaceboLow risk of bias negative
Kassis, 1987felodipineplaceboLow risk of bias -
Littler, 1995FelodipineplaceboLow risk of bias negative
Kassis, 1990felodipineplaceboLow risk of bias -
Dunselman, 1990felodipineenalaprilLow risk of bias -
De Vries, 1995felodipineenalaprilLow risk of bias -
isradipine
Van den Toren, 1996isradipineplaceboLow risk of bias -
mibefradil
MACH 1, 2000mibefradilplaceboLow risk of bias suggesting
nicardipine
Gheorghiade, 1991nicardipinecontrolLow risk of bias -
Abrams, 1993nicardipinecontrolLow risk of bias -
nisoldipine
Gaudron, 1996NisoldipineplaceboExploratory -
Rousseau, 1994nisoldipineplaceboLow risk of bias -
Schofer, 1990nisoldipinecaptoprilLow risk of bias -

post myocardial infarction

diltiazem
MDPIT, 1988diltiazemplaceboLow risk of bias negative
nifedipine
MI study group, 1979nifedipine -
SPRINT I, 1988nifedipineplaceboLow risk of bias negative
SPRINT II, 1993nifedipineplaceboLow risk of bias negative
verapamil
DAVIT I, 1984verapamilplaceboLow risk of bias -
DAVIT II, 1990verapamilplaceboLow risk of bias negative
CRIS, 1996verapamilplaceboLow risk of bias negative
Danish study, 1984verapamilplaceboLow risk of bias negative