calcium channel blockers

Amlodipine - Diltiazem - Diltiazem - Felodipine - Nicardipine - Nidrendipine - Nifedipine - Nisoldipine - Verapamil      

Select            
Trial Studied trt Control trt patientstagsROB Trial resultAll cause deathconfirmed myocardial infarction

acute coronary syndrome

diltiazem
Göbel (Dutch study), 1995   diltiazemplaceboLow risk of bias -
DRS, 1986   diltiazemplaceboLow risk of bias -
nifedipine
HINT (nifedipine vs metoprolol), 1988   nifedipinemetoprolol -

acute myocardial infarction

diltiazem
Machecourt, 1986   diltiazemnegative-51%-3%
Gibson, 1986   diltiazemplaceboLow risk of bias negative23%
MDPIT, 1988   diltiazemplaceboLow risk of bias negative0%
Zannad, 1988   diltiazemplaceboLow risk of bias negative6%
nifedipine
Muller, 1984   nifedipineLow risk of bias negative231%-1%
Gordon, 1984   nifedipinenegative
MI study group, 1979   nifedipine -
Eisenberg, 1985     nifedipineplaceboLow risk of bias negative22%
Bradagan, 1986     nifedipineplaceboLow risk of bias negative59%24%
Jaffe, 1987   nifedipineplacebonegative+Infini%
Gottlieb, 1988   nifedipineplaceboLow risk of bias negative6%12%
Erbel, 1988   nifedipineplaceboLow risk of bias negative69%
SPRINT I, 1988   nifedipineplaceboLow risk of bias negative1%
SPRINT II, 1993   nifedipineplaceboLow risk of bias negative16%-4%
Loogna, 1985     nifedipineplaceboLow risk of bias negative
TRENT (Wilcox), 1986   nifedipineplaceboLow risk of bias negative0%
Walker, 1988     nifedipineplaceboLow risk of bias negative-2%
Sirnes, 1984   nifedipineplaceboLow risk of bias negative-8%
verapamil
Bussman, 1984   verapamilcontrolnegative
DAVIT I, 1984   verapamilplaceboLow risk of bias -
Crea, 1985   verapamilplacebonegative-100%
DAVIT II, 1990   verapamilplaceboLow risk of bias negative-18%
CRIS, 1996     verapamilplaceboLow risk of bias negative6%
Danish study, 1984     verapamilplaceboLow risk of bias negative-1%

heart failure

amlodipine
Packer, 1991   amlodipinecontrolLow risk of bias -
Smith, 1994     amlodipinecontrolLow risk of bias -
Udelson, 1996   amlodipinecontrolLow risk of bias -
Binkley, 1996   amlodipinecontrolLow risk of bias -
Ghali, 1997   amlodipinecontrolLow risk of bias -
PRAISE, 1996     amlodipineplaceboLow risk of bias negative-13%
PRAISE II , 2000     AmlodipineplaceboLow risk of bias negative6%
diltiazem
Liao , 1998     DiltiazemplaceboExploratory suggesting-69%
DiDi, 1996     diltiazemplaceboLow risk of bias negative2%
felodipine
VHeFT III, 1997     felodipineplaceboLow risk of bias negative8%
Kassis, 1987   felodipineplaceboLow risk of bias -
Littler, 1995   FelodipineplaceboLow risk of bias negative35%
Kassis, 1990   felodipineplaceboLow risk of bias -
Dunselman, 1990   felodipineenalaprilLow risk of bias -
De Vries, 1995     felodipineenalaprilLow risk of bias -
isradipine
Van den Toren, 1996     isradipineplaceboLow risk of bias -
mibefradil
MACH 1, 2000     mibefradilplaceboLow risk of bias suggesting10%
nicardipine
Gheorghiade, 1991   nicardipinecontrolLow risk of bias -
Abrams, 1993   nicardipinecontrolLow risk of bias -
nisoldipine
Gaudron, 1996   NisoldipineplaceboExploratory -
Rousseau, 1994   nisoldipineplaceboLow risk of bias -
Schofer, 1990   nisoldipinecaptoprilLow risk of bias -

post myocardial infarction

diltiazem
MDPIT, 1988   diltiazemplaceboLow risk of bias negative0%
nifedipine
MI study group, 1979   nifedipine -
SPRINT I, 1988   nifedipineplaceboLow risk of bias negative1%
SPRINT II, 1993   nifedipineplaceboLow risk of bias negative16%-4%
verapamil
DAVIT I, 1984   verapamilplaceboLow risk of bias -
DAVIT II, 1990   verapamilplaceboLow risk of bias negative-18%
CRIS, 1996     verapamilplaceboLow risk of bias negative6%
Danish study, 1984     verapamilplaceboLow risk of bias negative-1%