renin inhibitor  

Aliskiren      

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Trial Studied trt Control trt patientstagsNCTROB Result

heart failure

aliskiren
ATMOSPHERE ongoing aliskirenEnalaprilNCT00853658Low risk of bias ongoing
ASTRONAUT, 2013AliskirenplaceboNCT00894387Low risk of bias -

hypertension

aliskiren
AVOID, 2008aliskirenplaceboNCT00097955Low risk of bias negative
Schmieder (vs HCTZ), 2009aliskirenhydrochlorothiazideLow risk of bias negative
ALLAY, 2009aliskirenlosartanNCT00219141Exploratory negative
Andersen, 2008aliskirenramiprilLow risk of bias -