insulin sensitizers - glitazones

     

Select            
Trial Studied trt Control trt patientstagsROB Trial result

diabetes type 2

pioglitazone
EC404   pioglitazonemetforminExploratory negative
EC409   pioglitazone + sulfonylureametformin + sulfonylureaExploratory negative
PROactive, 2005      NCTpioglitazoneplaceboLow risk of bias suggesting
PNFP-026   pioglitazoneplaceboExploratory negative
PNFP-012   pioglitazoneplaceboExploratory negative
PNFP-001   pioglitazoneplaceboExploratory negative
PNFP-014   pioglitazone + insulinplacebo (add on insulin)Exploratory negative
OPI-502   pioglitazone + insulinplacebo (add on insulin)Exploratory negative
PNFP-027   pioglitazone + metforminplacebo (add on MET)Exploratory negative
GLAI    NCTpioglitazonerosiglitazoneExploratory negative
OPI-504    NCTpioglitazonesulfonylureaExploratory negative
EC405   pioglitazonesulfonylureaExploratory negative
OPI-501   pioglitazonesulfonylureaExploratory negative
OPI-520    NCTpioglitazonesulfonylureaExploratory negative
OPI-506    NCTpioglitazonesulfonylureaExploratory negative
PNFP-010   pioglitazone + sulfonylureasulfonylureaExploratory negative
EC410   pioglitazone + metforminsulfonylurea + metforminExploratory negative
Bolli, 2008       pioglitazonevildagliptinnegative
PERISCOPE, 2008      NCTpioglitazoneglimepirideLow risk of bias negative
rosiglitazone
AVM100264    NCTrosiglitazoneExploratory -
BRL 49653C/185   rosiglitazoneExploratory -
SB-712753/007   rosiglitazoneExploratory -
SB-712753/009   rosiglitazoneExploratory -
Wang, 2005     rosiglitazonecontrolExploratory -
49653/020   rosiglitazoneglyburideExploratory -
49653/143    NCTrosiglitazoneglyburideExploratory -
49653/079   rosiglitazoneglyburideExploratory -
49653/080   rosiglitazoneglyburideExploratory -
49653/097   rosiglitazoneglyburideExploratory -
49653/137    NCTrosiglitazoneglyburide (add on MET)Exploratory -
49653/093   rosiglitazonemetforminExploratory -
49653/094   rosiglitazonemetforminExploratory -
49653/011   rosiglitazoneplaceboExploratory -
BRL 49653/334    NCTrosiglitazoneplaceboExploratory -
49653/128   rosiglitazoneplaceboExploratory -
49653/134   rosiglitazoneplaceboExploratory -
49653/136   rosiglitazoneplaceboExploratory -
49653/330   rosiglitazoneplaceboExploratory -
49653/331   rosiglitazoneplaceboExploratory -
AVA100193   rosiglitazoneplaceboExploratory -
49653/145   rosiglitazoneplacebo (add on glicazide)Exploratory -
49653/234   rosiglitazoneplacebo (add on glimepiride)Exploratory -
49653/135   rosiglitazoneplacebo (add on glipizide)Exploratory -
100684    NCTrosiglitazoneplacebo (add on glyburide)Exploratory -
49653/127   rosiglitazoneplacebo (add on glyburide)Exploratory -
49653/162   rosiglitazoneplacebo (add on glyburide)Exploratory -
BRL 49653/347    NCTrosiglitazoneplacebo (add on insulin)Exploratory -
49653/085   rosiglitazoneplacebo (add on insulin)Exploratory -
49653/095   rosiglitazoneplacebo (add on insulin)Exploratory -
49653/284    NCTrosiglitazoneplacebo (add on MET)Exploratory -
712753/008    NCTrosiglitazoneplacebo (add on MET)Exploratory -
SB-712753/002   rosiglitazoneplacebo (add on MET)Exploratory -
SB-712753/003   rosiglitazoneplacebo (add on MET)Exploratory -
49653/015   rosiglitazoneplacebo (add on SU)Exploratory -
49653/125    NCTrosiglitazoneplacebo (add on SU)Exploratory -
49653/147   rosiglitazoneplacebo (add on SU)Exploratory -
49653/132   rosiglitazoneplacebo (add on SU)Exploratory -
49653/211   rosiglitazoneusual careExploratory -
APPROACH, 2008        NCTrosiglitazoneglipizideLow risk of bias -
ADOPT, 2006        NCTrosiglitazonestandard glucose-lowering drugsLow risk of bias negative
RECORD, 2009          NCTrosiglitazonestandard glucose-lowering drugsRisk of bias negative