prevention

     

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Trial Studied trt Control trt patientstagsNCTROB Result

atrial fibrillation

atorvastatin
Ozaydin, 2006atorvastatincontrolExploratory suggesting
Almroth, 2009atorvastatin placeboRisk of bias suggesting
MIRACL (sub-group) (Schwartz), 2004atorvastatinplaceboExploratory suggesting
Dernellis, 2006atorvastatinplaceboExploratory suggesting
ARMYDA-3 (AF ancillary study), 2006atorvastatinplacebosuggesting
Chello, 2006atorvastatinplaceboExploratory negative
MIRACL (AF ancillary study), 2001atorvastatinplaceboExploratory negative
STOP-AF ongoing atorvastatinplaceboNCT00252967 ongoing
candesartan
CAPRAF (Tveit), 2007candesartanplaceboNCT00130975Risk of bias -
CHARM (AF ancillary study), 2005candesartanplacebosuggesting
enalapril
Ueng, 2003enalaprilcontrolsuggesting
SOLVD (AF ancillary study), 2003enalaprilplacebosuggesting
gemfibrozil
VA HIT (AF ancillary study), 1999gemfibrozilplaceboExploratory negative
irbesartan
Madrid, 2002irbesartancontrolsuggesting
ACTIVE I, 2009irbesartanplaceboNCT00249795Low risk of bias suggesting
lisinopril
Van den Burg, 1995lisinoprilplacebonegative
GISSI-3 (AF ancillary study), 2003lisinoprilplacebonegative
losartan
LIFE (AF ancillary study), 2005losartanatenololsuggesting
olmesartan
ANTIPAF ongoing olmesartanplaceboNCT00098137Low risk of bias ongoing
pravastatin
Tveit, 2004pravastatincontrolExploratory negative
ramipril
Brown ongoing ramiprilplaceboNCT00141778 ongoing
rosuvastatin
GISSI HF (subgroup and ancillary study), 2009rosuvastatin placeboNCT00336336Exploratory negative
valsartan
GISSI-AF (Disertori), 2009valsartanplaceboNCT00376272Low risk of bias negative
Val-HeFT (AF ancillary study), 2003valsartanplacebosuggesting

diabetes type 2

diet
Liao, 2002AHA 2 dietAHA 1 dietExploratory negative
glipizide
Eriksson, 2006glipizideplaceboExploratory negative
metformin
IDDP (Ramachandran), 2006lifestyle modification + metformincontrolRisk of bias negative
Jarret, 1979lifestyle modification + metformincontrolExploratory negative
James, 2005metformincontrol -
US-DPP (metformin) (Knowler), 2002metforminplaceboLow risk of bias negative
EDIT (Holman), 2003metforminplacebo -
Li, 1999metforminplaceboExploratory negative
Baillargeon, 2004metforminplacebo -
Bridger, 2006metforminplacebo -
Charles, 1998metforminplacebonegative
Charles, 2000metforminplacebo -
Choux, 2003metforminplacebo -
Crave, 1995metforminplacebo -
Fleming, 2002metforminplacebo -
Freemark, 2001metforminplacebo -
Gambineri, 2004metforminplacebo -
Giugliano, 1993metforminplacebo -
Hoeger, 2004metforminplacebo -
Kay, 2001metforminplacebo -
Kelly, 2002metforminplacebo -
Kocak, 2002metforminplacebo -
Lehtovirta, 2001metforminplacebonegative
Moghetti, 2000metforminplacebo -
Morel, 1999metforminplacebo -
Ng, 2001metforminplacebo -
Orchard, 2005metforminplacebosuggesting
Pasquali, 2000metforminplacebo -
Rodriguez, 2004metforminplacebo -
Rodriguez-Moctezuma, 2004metforminplacebonegative
Sirtori, 1984metforminplacebo -
Srinivasan, 2006metforminplacebo -
Stakos, 2005metforminplacebo -
Sturrock, 2002metforminplacebo -
Tang, 2006metforminplacebo -
Vitale, 2005metforminplacebo -
CANOE, 2010rosiglitazone and metforminplaceboNCT00116932Low risk of bias suggesting
nateglinide
NAVIGATOR nateglinide, 2010nateglinideplaceboNCT00097786Low risk of bias negative
orlistat
Heymsfield, 2000orlistatplaceboLow risk of bias negative
XENDOS (Chiasson), 2002orlistatplaceboRisk of bias negative
ramipril
DREAM ramipril, 2006ramiprilplaceboNCT00095654Low risk of bias negative
rosiglitazone
DREAM rosiglitazone, 2006rosiglitazoneplaceboNCT00095654Low risk of bias suggesting
troglitazone
TRIPOD (Buchanan), 2002troglitazoneplaceboExploratory -
US DDP troglitazone (Knowler), 2005troglitazoneplaceboLow risk of bias -
valsartan
NAVIGATOR valsartan, 2010valsartanplaceboNCT00097786Low risk of bias suggesting
voglibose
Voglibose Ph-3, 2009vogliboseplaceboUMIN 000001109-Low risk of bias suggesting

impaired fasting glucose

metformin
US-DPP (metformin) (Knowler), 2002metforminplaceboLow risk of bias negative
CANOE, 2010rosiglitazone and metforminplaceboNCT00116932Low risk of bias suggesting
nateglinide
NAVIGATOR nateglinide, 2010nateglinideplaceboNCT00097786Low risk of bias negative
ramipril
DREAM ramipril, 2006ramiprilplaceboNCT00095654Low risk of bias negative
rosiglitazone
DREAM rosiglitazone, 2006rosiglitazoneplaceboNCT00095654Low risk of bias suggesting
valsartan
NAVIGATOR valsartan, 2010valsartanplaceboNCT00097786Low risk of bias suggesting
voglibose
Voglibose Ph-3, 2009vogliboseplaceboUMIN 000001109-Low risk of bias suggesting

post stroke

folic acid
VITATOPS, 2010folic acid, vit B12 and vit B6placeboNCT00097669ÐX&Low risk of bias suggesting
VISP (Toole), 2004high dose - folic acid, vit B12 and vit B6low dose - folic acid, vit B12 and vit B6Low risk of bias negative