prevention

     

Select            
Trial Studied trt Control trt patientstagsROB Trial resultDiabetes cardiovascular events

atrial fibrillation

atorvastatin
Ozaydin, 2006     atorvastatincontrolExploratory suggesting
Almroth, 2009     atorvastatin placeboLow risk of bias suggesting
MIRACL (sub-group) (Schwartz), 2004   atorvastatinplaceboLow risk of bias suggesting
Dernellis, 2006     atorvastatinplaceboExploratory suggesting
ARMYDA-3 (AF ancillary study), 2006     atorvastatinplacebosuggesting
Chello, 2006     atorvastatinplaceboLow risk of bias negative
MIRACL (AF ancillary study), 2001     atorvastatinplaceboLow risk of bias negative
candesartan
CAPRAF (Tveit), 2007      NCTcandesartanplaceboLow risk of bias -
CHARM (AF ancillary study), 2005     candesartanplacebosuggesting
enalapril
Ueng, 2003     enalaprilcontrolsuggesting
SOLVD (AF ancillary study), 2003     enalaprilplacebosuggesting
gemfibrozil
VA HIT (AF ancillary study), 1999       gemfibrozilplaceboLow risk of bias negative
irbesartan
Madrid, 2002     irbesartancontrolsuggesting
ACTIVE I, 2009    NCTirbesartanplaceboLow risk of bias suggesting
lisinopril
Van den Burg, 1995   lisinoprilplaceboLow risk of bias negative
GISSI-3 (AF ancillary study), 2003     lisinoprilplacebonegative
losartan
LIFE (AF ancillary study), 2005     losartanatenololsuggesting
pravastatin
Tveit, 2004     pravastatincontrolExploratory negative
rosuvastatin
GISSI HF (subgroup and ancillary study), 2009    NCTrosuvastatin placeboLow risk of bias negative
valsartan
GISSI-AF (Disertori), 2009      NCTvalsartanplaceboLow risk of bias negative
Val-HeFT (AF ancillary study), 2003   valsartanplacebosuggesting

diabetes type 2

diet
Liao, 2002     AHA 2 dietAHA 1 dietExploratory negative-48%
glargine
GRACE - ORIGIN (glargine), 2012   insulin glargineplaceboRisk of bias -
glipizide
Eriksson, 2006     glipizideplaceboLow risk of bias negative-82%
metformin
IDDP (Ramachandran), 2006     lifestyle modification + metformincontrolRisk of bias negative-35%
Jarret, 1979   lifestyle modification + metformincontrolExploratory negative-16%
James, 2005     metformincontrol -
US-DPP (metformin) (Knowler), 2002     metforminplaceboLow risk of bias negative-31%
EDIT (Holman), 2003   metforminplacebo -
Li, 1999     metforminplaceboLow risk of bias negative-51%
Baillargeon, 2004     metforminplacebo -
Bridger, 2006     metforminplacebo -
Charles, 1998     metforminplacebonegative-100%
Charles, 2000     metforminplacebo -
Choux, 2003     metforminplacebo -
Crave, 1995     metforminplacebo -
Fleming, 2002     metforminplacebo -
Freemark, 2001     metforminplacebo -
Gambineri, 2004   metforminplacebo -
Giugliano, 1993   metforminplacebo -
Hoeger, 2004     metforminplacebo -
Kay, 2001     metforminplacebo -
Kelly, 2002     metforminplacebo -
Kocak, 2002     metforminplacebo -
Lehtovirta, 2001     metforminplacebonegative
Moghetti, 2000     metforminplacebo -
Morel, 1999     metforminplacebo -
Ng, 2001     metforminplacebo -
Orchard, 2005   metforminplacebosuggesting-29%
Pasquali, 2000     metforminplacebo -
Rodriguez, 2004     metforminplacebo -
Rodriguez-Moctezuma, 2004     metforminplacebonegative-100%
Sirtori, 1984   metforminplacebo -
Srinivasan, 2006     metforminplacebo -
Stakos, 2005     metforminplacebo -
Sturrock, 2002     metforminplacebo -
Tang, 2006     metforminplacebo -
Vitale, 2005     metforminplacebo -
CANOE, 2010      NCTrosiglitazone and metforminplaceboLow risk of bias suggesting-75%
nateglinide
NAVIGATOR nateglinide, 2010    NCTnateglinideplaceboLow risk of bias negative 6%-5%
orlistat
Heymsfield, 2000     orlistatplaceboLow risk of bias negative-61%
XENDOS (Chiasson), 2002       orlistatplaceboLow risk of bias negative-52%
ramipril
DREAM ramipril, 2006        NCTramiprilplaceboLow risk of bias negative -7%7%
rosiglitazone
DREAM rosiglitazone, 2006      NCTrosiglitazoneplaceboLow risk of bias suggesting -53%52%
troglitazone
TRIPOD (Buchanan), 2002     troglitazoneplaceboLow risk of bias -
US DDP troglitazone (Knowler), 2005     troglitazoneplaceboLow risk of bias -
valsartan
NAVIGATOR valsartan, 2010        NCTvalsartanplaceboLow risk of bias suggesting-10%-2%
voglibose
Voglibose Ph-3, 2009       vogliboseplaceboLow risk of bias suggesting-54%

impaired fasting glucose

glargine
GRACE - ORIGIN (glargine), 2012   insulin glargineplaceboRisk of bias -
metformin
US-DPP (metformin) (Knowler), 2002     metforminplaceboLow risk of bias negative-31%
CANOE, 2010      NCTrosiglitazone and metforminplaceboLow risk of bias suggesting-75%
nateglinide
NAVIGATOR nateglinide, 2010    NCTnateglinideplaceboLow risk of bias negative 6%-5%
ramipril
DREAM ramipril, 2006        NCTramiprilplaceboLow risk of bias negative -7%7%
rosiglitazone
DREAM rosiglitazone, 2006      NCTrosiglitazoneplaceboLow risk of bias suggesting -53%52%
valsartan
NAVIGATOR valsartan, 2010        NCTvalsartanplaceboLow risk of bias suggesting-10%-2%
voglibose
Voglibose Ph-3, 2009       vogliboseplaceboLow risk of bias suggesting-54%

post stroke

folic acid
VITATOPS, 2010    NCTfolic acid, vit B12 and vit B6placeboLow risk of bias suggesting-9%
VISP (Toole), 2004   high dose - folic acid, vit B12 and vit B6low dose - folic acid, vit B12 and vit B6Low risk of bias negative-3%