vasodilators therapy

Buflomedil - Epoprostenol      

Select            
Trial Studied trt Control trt patientstagsROB Trial resultAll cause deathTreatment related complication

heart failure

epoprostenol
FIRST, 1997     epoprostenolstandard careExploratory - 29%
hydralazine
Chatterjee, 1980   hydralazinecontrolExploratory -
Franciosa, 1982     hydralazineplaceboLow risk of bias -
Conradson , 1984   hydralazineplaceboExploratory -
Magorien , 1984     hydralazineplaceboLow risk of bias -
hydralazine-ISDN
VHeFT I (hydralazine ISDN), 1986   hydralazine-ISDNplaceboLow risk of bias negative-12%
isosorbide dinitrate
NICE (Lewis), 1999     isosorbide dinitrateplacebo -
Franciosa , 1978   isosorbide dinitrateplaceboLow risk of bias -
nesiritide
NSGET (comparative trial), 2000     nesiritidecontrolLow risk of bias remark
FUSION 2, 2008        NCTnesiritideplaceboLow risk of bias remark
NSGET (efficacy trial), 2000     nesiritideplaceboLow risk of bias negative48%
PROACTION, 2003     nesiritideplaceboLow risk of bias negative388%
BNP-CARDS, 2007          NCTnesiritideplaceboLow risk of bias remark
ASCEND-HF, 2011        NCTnesiritideplaceboLow risk of bias negative -10%
VMAC (intravenous neseritide), 2002      NCTnesiritideplaceboLow risk of bias remark
PRECEDENT, 2002      NCTnesiritidedobutamineExploratory remark
VMAC (24h), 2002      NCTnesiritidenitroglycerinRisk of bias negative56%
FUSION 1, 2004    NCTnesiritidestandard careLow risk of bias remark

peripheral vascular diseases

buflomedil
LIMB, 2008   buflomedilplaceboLow risk of bias suggesting-12%-7%
Diamantopoulos, 2001   buflomédilplacebo -
cilostazol
Beebe, 1999   cilostazolplacebo -
Dawson, 1998   cilostazolplacebo -
Money, 1998   cilostazolplacebo -
Strandness, 2002   cilostazolplacebo -
Dawson (cilostazol), 2000   cilostazolplacebo -
Elam, 1998     cilostazolplaceboLow risk of bias -
Otsuka 21-95-201   cilostazolplaceboLow risk of bias -
ginko biloba
Bauer, 1984   ginko bilobaplacebo -
Peters, 1998   ginko bilobaplacebo -
naftidrofuryl
Meehan, 1982   naftidrofuryl IVcontrol -
NIQOL germany, 1999   Naftidrofurylplacebo -
Clyne, 1980   naftidrofurylplacebo -
NIQOL belgium, 2001   naftidrofurylplacebo -
NCIS, 2001   naftidrofurylplacebo -
Testart, 1994   naftidrofuryl IVplacebo -
D'Hooge D, 2001   naftidrofuryl IVplacebo -
Negus, 1987   naftidrofuryl IVprostacyclin -
pentoxifylline
Dawson (pentoxifylline), 2000   pentoxifyllineplacebo -
APIC, 1989   pentoxifyllineplacebo -
Donaldson, 1984   pentoxifyllineplacebo -
Porter, 1982   pentoxifyllineplacebo -
Belcaro, 2002   pentoxifyllineplacebo -