vasodilators therapy

Buflomedil - Epoprostenol      

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Trial Studied trt Control trt patientstagsNCTROB Result

heart failure

epoprostenol
FIRST, 1997epoprostenolstandard careExploratory -
hydralazine
Chatterjee, 1980hydralazinecontrolExploratory -
Franciosa, 1982hydralazineplaceboExploratory -
Conradson , 1984hydralazineplaceboExploratory -
Magorien , 1984hydralazineplaceboExploratory -
hydralazine-ISDN
VHeFT I (hydralazine ISDN), 1986hydralazine-ISDNplaceboLow risk of bias negative
isosorbide dinitrate
NICE (Lewis), 1999isosorbide dinitrateplacebo -
Franciosa , 1978isosorbide dinitrateplaceboExploratory -
nesiritide
NSGET (comparative trial), 2000nesiritidecontrolLow risk of bias -
FUSION 2, 2008nesiritideplaceboNCT00091520Low risk of bias -
NSGET (efficacy trial), 2000nesiritideplaceboLow risk of bias negative
PROACTION, 2003nesiritideplaceboLow risk of bias negative
BNP-CARDS, 2007nesiritideplaceboNCT00186329Exploratory -
ASCEND-HF, 2011nesiritideplaceboNCT00475852Low risk of bias negative
VMAC (intravenous neseritide), 2002nesiritideplaceboNCT00083772Low risk of bias -
PRECEDENT, 2002nesiritidedobutamineNCT00270400Exploratory -
VMAC (24h), 2002nesiritidenitroglycerinNCT00083772Risk of bias negative
FUSION 1, 2004nesiritidestandard careNCT00270361Low risk of bias -

peripheral vascular diseases

buflomedil
LIMB, 2008buflomedilplaceboLow risk of bias suggesting
Diamantopoulos, 2001buflomédilplacebo -
cilostazol
Beebe, 1999cilostazolplacebo -
Dawson, 1998cilostazolplacebo -
Money, 1998cilostazolplacebo -
Strandness, 2002cilostazolplacebo -
Dawson (cilostazol), 2000cilostazolplacebo -
Elam, 1998cilostazolplacebo -
Otsuka 21-95-201cilostazolplacebo -
ginko biloba
Bauer, 1984ginko bilobaplacebo -
Peters, 1998ginko bilobaplacebo -
naftidrofuryl
Meehan, 1982naftidrofuryl IVcontrol -
NIQOL germany, 1999Naftidrofurylplacebo -
Clyne, 1980naftidrofurylplacebo -
NIQOL belgium, 2001naftidrofurylplacebo -
NCIS, 2001naftidrofurylplacebo -
Testart, 1994naftidrofuryl IVplacebo -
D'Hooge D, 2001naftidrofuryl IVplacebo -
Negus, 1987naftidrofuryl IVprostacyclin -
pentoxifylline
Dawson (pentoxifylline), 2000pentoxifyllineplacebo -
APIC, 1989pentoxifyllineplacebo -
Donaldson, 1984pentoxifyllineplacebo -
Porter, 1982pentoxifyllineplacebo -
Belcaro, 2002pentoxifyllineplacebo -