insulin sensitizer

     

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Display
Trial Studied trt Control trt patientstagsNCTROB Result

diabetes type 2

metformin
Teupe, 1991metforminplacebonegative
Kooy (HOME), 2009metforminplaceboLow risk of bias suggesting
Campbell, 1994metforminGlipizidenegative
UKPDS (vs SU or INS)metforminSU/Insulinsuggesting
pioglitazone
EC404pioglitazonemetforminExploratory negative
EC409pioglitazone + sulfonylureametformin + sulfonylureaExploratory negative
PROactive, 2005pioglitazoneplaceboNCT00174993Low risk of bias suggesting
PNFP-026pioglitazoneplaceboExploratory negative
PNFP-012pioglitazoneplaceboExploratory negative
PNFP-001pioglitazoneplaceboExploratory negative
TIDE ongoing rosiglitazone pioglitazoneplaceboNCT00879970Low risk of bias ongoing
PNFP-014pioglitazone + insulinplacebo (add on insulin)Exploratory negative
OPI-502pioglitazone + insulinplacebo (add on insulin)Exploratory negative
PNFP-027pioglitazone + metforminplacebo (add on MET)Exploratory negative
GLAIpioglitazonerosiglitazoneNCT00331487Exploratory negative
PPAR ongoing pioglitazonestandard glucose-lowering drugsNCT00212004 ongoing
OPI-504pioglitazonesulfonylureaNCT00521820Exploratory negative
EC405pioglitazonesulfonylureaExploratory negative
OPI-501pioglitazonesulfonylureaExploratory negative
OPI-520pioglitazonesulfonylureaNCT00521742Exploratory negative
OPI-506pioglitazonesulfonylureaNCT00494312Exploratory negative
PNFP-010pioglitazone + sulfonylureasulfonylureaExploratory negative
EC410pioglitazone + metforminsulfonylurea + metforminExploratory negative
PERISCOPE, 2008pioglitazoneglimepirideNCT00225277Exploratory negative
rosiglitazone
AVM100264 rosiglitazoneNCT00359112Exploratory -
BRL 49653C/185 rosiglitazoneExploratory -
SB-712753/007 rosiglitazoneExploratory -
SB-712753/009 rosiglitazoneExploratory -
Wang, 2005rosiglitazonecontrolExploratory -
49653/020 rosiglitazoneglyburideExploratory -
49653/143 rosiglitazoneglyburideNCT00333723Exploratory -
49653/079 rosiglitazoneglyburideExploratory -
49653/080 rosiglitazoneglyburideExploratory -
49653/097 rosiglitazoneglyburideExploratory -
49653/137 rosiglitazoneglyburide (add on MET)NCT00500955Exploratory -
49653/093 rosiglitazonemetforminExploratory -
49653/094 rosiglitazonemetforminExploratory -
49653/011 rosiglitazoneplaceboExploratory -
BRL 49653/334 rosiglitazoneplaceboNCT00306644Exploratory -
49653/128 rosiglitazoneplaceboExploratory -
49653/134 rosiglitazoneplaceboExploratory -
49653/136 rosiglitazoneplaceboExploratory -
49653/330 rosiglitazoneplaceboExploratory -
49653/331 rosiglitazoneplaceboExploratory -
AVA100193 rosiglitazoneplaceboExploratory -
49653/145 rosiglitazoneplacebo (add on glicazide)Exploratory -
49653/234 rosiglitazoneplacebo (add on glimepiride)Exploratory -
49653/135 rosiglitazoneplacebo (add on glipizide)Exploratory -
100684 rosiglitazoneplacebo (add on glyburide)NCT01045590Exploratory -
49653/127 rosiglitazoneplacebo (add on glyburide)Exploratory -
49653/162 rosiglitazoneplacebo (add on glyburide)Exploratory -
BRL 49653/347 rosiglitazoneplacebo (add on insulin)NCT00054782Exploratory -
49653/085 rosiglitazoneplacebo (add on insulin)Exploratory -
49653/095 rosiglitazoneplacebo (add on insulin)Exploratory -
49653/284 rosiglitazoneplacebo (add on MET)NCT00501020Exploratory -
712753/008 rosiglitazoneplacebo (add on MET)NCT00241605Exploratory -
SB-712753/002 rosiglitazoneplacebo (add on MET)Exploratory -
SB-712753/003 rosiglitazoneplacebo (add on MET)Exploratory -
49653/015 rosiglitazoneplacebo (add on SU)Exploratory -
49653/125 rosiglitazoneplacebo (add on SU)NCT00422955Exploratory -
49653/147 rosiglitazoneplacebo (add on SU)Exploratory -
49653/132 rosiglitazoneplacebo (add on SU)Exploratory -
49653/211 rosiglitazoneusual careExploratory -
APPROACH, 2008rosiglitazoneglipizideNCT00116831Exploratory -
ADOPT, 2006rosiglitazonestandard glucose-lowering drugsNCT00279045Exploratory negative
RECORD, 2009rosiglitazonestandard glucose-lowering drugsNCT00379769Risk of bias negative