diuretics

A EFFACER - Amiloride - Furosemide - Hydrochlorothiazide - Indapamide - Rolofylline - Thiazid diuretic - Tonapofylline - Various diuretics      

Select            
Trial Studied trt Control trt patientstagsROB Trial resultexacerbation of heart failure All cause death

acute heart failure

rolofylline
PROTECT, 2010    NCTrolofyllineplaceboLow risk of bias negative

heart failure

amiloride
Cheitlin, 1991   amilorideplaceboLow risk of bias -
eplerenone
EMPHASIS-HF, 2010        NCTeplerenoneplaceboLow risk of bias suggesting -19%
EPHESUS, 2003       eplerenoneplaceboLow risk of bias suggesting -14%
furosemide
Boccanelli, 1986   furosemidecaptoprilLow risk of bias negative+Infini%
Cowley, 1986     furosemidecaptoprilLow risk of bias -
hydrochlorothiazide
Nordrehaug, 1992   hydrochlorothiazidebenazeprilLow risk of bias suggesting
Sievert, 1989   hydrochlorothiazide+triamterenedigoxinLow risk of bias -
rolofylline
PROTECT-1    NCTrolofyllineplacebo -
spironolactone
Cicoira, 2004     spironolactonecontrol -
Cicoira, 2002     spironolactonecontrolExploratory -
Ramires, 2000     spironolactonecontrolExploratory -
RALES, 1998         spironolactoneplaceboRisk of bias suggesting -21%-25%
Agostoni, 2005     spironolactoneplaceboExploratory -
Mottram, 2004     spironolactoneplaceboLow risk of bias -
Macdonald, 2004     spironolactoneplaceboLow risk of bias -
Yee, 2001     spironolactoneplaceboLow risk of bias -
Tsutamoto, 2001     spironolactoneplaceboLow risk of bias -
Farquharson, 2000     spironolactoneplaceboLow risk of bias -
MacFadyen, 1997     spironolactoneplaceboLow risk of bias -
Barr, 1995     spironolactoneplaceboLow risk of bias -
Han, 1994     spironolactone+captoprilcaptoprilExploratory -
Bednarz, 2000     aldactonefurosemideExploratory -
Dalhstrom, 1986   furosemide + spironolactoneprenalterolLow risk of bias negative
Mauersberger, 1985     spironolactone+furosemidespironolactone+butizideExploratory -