diuretics  

A EFFACER - Amiloride - Furosemide - Hydrochlorothiazide - Indapamide - Rolofylline - Thiazid diuretic - Tonapofylline - Various diuretics      

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Trial Studied trt Control trt patientstagsNCTROB Result

acute heart failure

rolofylline
PROTECT, 2010rolofyllineplaceboNCT00328692Low risk of bias negative
REACH UP ongoing rolofyllineplaceboNCT00443690 ongoing
PROTECT-2 ongoing rolofyllineplaceboNCT00354458 ongoing
PROTECT-1 ongoing rolofyllineplaceboNCT00328692 ongoing
7418-503 ongoing rolofyllineplaceboNCT00729222 ongoing
2007_806 ongoing rolofyllineplaceboNCT00652782 ongoing
tonapofylline
TRIDENT-1 ongoing tonapofyllineplaceboNCT00709865 ongoing
POSEIDON ongoing tonapofyllineplaceboNCT00745316 ongoing

heart failure

amiloride
Cheitlin, 1991amilorideplaceboLow risk of bias -
eplerenone
EMPHASIS-HF, 2010eplerenoneplaceboNCT00232180Low risk of bias suggesting
EPHESUS, 2003eplerenoneplaceboLow risk of bias suggesting
REMODEL ongoing eplerenoneplaceboNCT00082589Low risk of bias ongoing
Weir ongoing eplerenoneplaceboNCT00132093Low risk of bias ongoing
furosemide
Boccanelli, 1986furosemidecaptoprilLow risk of bias negative
Cowley, 1986furosemidecaptoprilLow risk of bias -
hydrochlorothiazide
Nordrehaug, 1992hydrochlorothiazidebenazeprilLow risk of bias suggesting
Sievert, 1989hydrochlorothiazide+triamterenedigoxinLow risk of bias -
rolofylline
PROTECT-1rolofyllineplaceboNCT00328692 -
spironolactone
Cicoira, 2004spironolactonecontrol -
Cicoira, 2002spironolactonecontrolExploratory -
Ramires, 2000spironolactonecontrolExploratory -
RALES, 1998spironolactoneplaceboRisk of bias suggesting
Agostoni, 2005spironolactoneplaceboExploratory -
Mottram, 2004spironolactoneplaceboLow risk of bias -
Macdonald, 2004spironolactoneplaceboLow risk of bias -
Yee, 2001spironolactoneplaceboLow risk of bias -
Tsutamoto, 2001spironolactoneplaceboLow risk of bias -
Farquharson, 2000spironolactoneplaceboLow risk of bias -
MacFadyen, 1997spironolactoneplaceboLow risk of bias -
Barr, 1995spironolactoneplaceboLow risk of bias -
PIE II ongoing spironolactoneplaceboNCT00123955Low risk of bias ongoing
Han, 1994spironolactone+captoprilcaptoprilExploratory -
Bednarz, 2000aldactonefurosemideExploratory -
Dalhstrom, 1986furosemide + spironolactoneprenalterolLow risk of bias negative
Mauersberger, 1985spironolactone+furosemidespironolactone+butizideExploratory -