diuretics

A EFFACER - Amiloride - Furosemide - Hydrochlorothiazide - Indapamide - Rolofylline - Thiazid diuretic - Tonapofylline - Various diuretics      

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Trial Studied trt Control trt patientstagsNCTROB Result

acute heart failure

rolofylline
PROTECT, 2010rolofyllineplaceboNCT00328692Low risk of bias negative
REACH UP ongoing rolofyllineplaceboNCT00443690 ongoing
PROTECT-2 ongoing rolofyllineplaceboNCT00354458 ongoing
PROTECT-1 ongoing rolofyllineplaceboNCT00328692 ongoing
7418-503 ongoing rolofyllineplaceboNCT00729222 ongoing
2007_806 ongoing rolofyllineplaceboNCT00652782 ongoing
tonapofylline
TRIDENT-1 ongoing tonapofyllineplaceboNCT00709865 ongoing
POSEIDON ongoing tonapofyllineplaceboNCT00745316 ongoing

heart failure

amiloride
Cheitlin, 1991amilorideplaceboExploratory -
eplerenone
EMPHASIS-HF, 2010eplerenoneplaceboNCT00232180Low risk of bias suggesting
EPHESUS, 2003eplerenoneplaceboLow risk of bias suggesting
REMODEL ongoing eplerenoneplaceboNCT00082589 ongoing
Weir ongoing eplerenoneplaceboNCT00132093Exploratory ongoing
furosemide
Boccanelli, 1986furosemidecaptoprilExploratory negative
Cowley, 1986furosemidecaptoprilExploratory -
hydrochlorothiazide
Nordrehaug, 1992hydrochlorothiazidebenazeprilExploratory suggesting
Sievert, 1989hydrochlorothiazide+triamterenedigoxinExploratory -
rolofylline
PROTECT-1rolofyllineplaceboNCT00328692 -
spironolactone
Cicoira, 2004spironolactonecontrol -
Cicoira, 2002spironolactonecontrolExploratory -
Ramires, 2000spironolactonecontrolExploratory -
RALES, 1998spironolactoneplaceboRisk of bias suggesting
Agostoni, 2005spironolactoneplaceboExploratory -
Mottram, 2004spironolactoneplaceboExploratory -
Macdonald, 2004spironolactoneplaceboExploratory -
Yee, 2001spironolactoneplacebo -
Tsutamoto, 2001spironolactoneplaceboExploratory -
Farquharson, 2000spironolactoneplaceboExploratory -
MacFadyen, 1997spironolactoneplaceboExploratory -
Barr, 1995spironolactoneplaceboExploratory -
PIE II ongoing spironolactoneplaceboNCT00123955 ongoing
Han, 1994spironolactone+captoprilcaptoprilExploratory -
Bednarz, 2000aldactonefurosemideExploratory -
Dalhstrom, 1986furosemide + spironolactoneprenalterolExploratory negative
Mauersberger, 1985spironolactone+furosemidespironolactone+butizideExploratory -