angiotensin renin system blockade

     

Select            
Trial Studied trt Control trt patientstagsROB Trial resultAll cause deathcardiovascular events

diabetes type 2

captopril
UKPDS 38, 1998     captopril or atenololcontrolExploratory suggesting -17%
UKPDS 39, 1998     captoprilatenololExploratory negative 14%
CAPP (diabetic subgroup), 1999       captoprildiuretic and/or beta-blockersExploratory suggesting -46%-41%
irbesartan
IPDM (150mg), 2001     irbesartanplaceboLow risk of bias suggesting
IDNT (irbesartan vs pbo), 2001     irbesartanplaceboLow risk of bias suggesting-8%-9%
IDNT (irbesartan vs amlodipine), 2001     irbesartanamlodipineLow risk of bias suggesting4%3%
lisinopril
ALLHAT (lisi vs chlor, diabetic subgroup), 2002       lisinoprilchlorthalidoneLow risk of bias negative-1%7%
losartan
RENAAL, 2001     losartanplaceboLow risk of bias suggesting2%
olmesartan
ROADMAP, 2010        NCTolmesartanplaceboLow risk of bias suggesting 72%
ORIENT    NCTolmesartanplaceboLow risk of bias negative-4%