angiotensin renin system blockade

     

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Trial Studied trt Control trt patientstagsNCTROB Result

diabetes type 2

captopril
UKPDS 38, 1998captopril or atenololcontrolExploratory suggesting
UKPDS 39, 1998captoprilatenololExploratory negative
CAPP (diabetic subgroup), 1999captoprildiuretic and/or beta-blockersExploratory suggesting
irbesartan
IPDM (150mg), 2001irbesartanplaceboExploratory suggesting
IDNT (irbesartan vs pbo), 2001irbesartanplaceboLow risk of bias suggesting
IDNT (irbesartan vs amlodipine), 2001irbesartanamlodipineLow risk of bias suggesting
lisinopril
ALLHAT (lisi vs chlor, diabetic subgroup), 2002lisinoprilchlorthalidoneExploratory negative
losartan
RENAAL, 2001losartanplaceboLow risk of bias suggesting
olmesartan
ROADMAP, 2010olmesartanplaceboNCT00185159Low risk of bias suggesting
ORIENTolmesartanplaceboNCT00141453negative