angiotensin renin system blockade

     

Select            
Trial Studied trt Control trt patientstagsROB Trial result

diabetes type 2

captopril
UKPDS 38, 1998     captopril or atenololcontrolExploratory suggesting
UKPDS 39, 1998     captoprilatenololExploratory negative
CAPP (diabetic subgroup), 1999       captoprildiuretic and/or beta-blockersExploratory suggesting
irbesartan
IPDM (150mg), 2001     irbesartanplaceboLow risk of bias suggesting
IDNT (irbesartan vs pbo), 2001     irbesartanplaceboLow risk of bias suggesting
IDNT (irbesartan vs amlodipine), 2001     irbesartanamlodipineLow risk of bias suggesting
lisinopril
ALLHAT (lisi vs chlor, diabetic subgroup), 2002       lisinoprilchlorthalidoneLow risk of bias negative
losartan
RENAAL, 2001     losartanplaceboLow risk of bias suggesting
olmesartan
ROADMAP, 2010        NCTolmesartanplaceboLow risk of bias suggesting
ORIENT    NCTolmesartanplaceboLow risk of bias negative