hormonal replacement therapy

     

Select            
Trial Studied trt Control trt patientstagsROB Trial resultAll cause deathcardiovascular events

cardiovascular prevention

estrogen
WAVE, 2002      NCTcombined estrogen and progestogenplaceboLow risk of bias negative78%-8%
EAGAR, 2006      NCTcombined estrogen and progestogenplaceboLow risk of bias negative -46%55%
HERS, 1998          NCTcombined estrogen and progestogenplaceboLow risk of bias negative 6%-1%
EVTET, 2000     combined estrogen and progestogenplaceboLow risk of bias negative
Hall, 1998     combined estrogen and progestogenplaceboLow risk of bias negative-100%-25%
WHI, 2002       combined estrogen and progestogenplaceboLow risk of bias negative 1%19%
WHISP, 2006     combined estrogen and progestogenplaceboLow risk of bias negative-100%-100%
WISDOM, 2007     combined estrogen and progestogenplaceboLow risk of bias negative 59%+Infini%
ERA (estrogen plus medroxyprogesterone), 2000      NCTcombined estrogen and progestogenplaceboLow risk of bias negative-50%68%
WELL-HART (estrogen-progestin), 2003      NCTcombined estrogen and progestogenplaceboLow risk of bias negative-23%16%
Schulman (NHLBI) (estrogen-progestogen), 2002      NCTcombined estrogen and progestogenplaceboLow risk of bias -
ERA (estrogen alone ), 2000        NCTestrogenplaceboLow risk of bias negative40%-2%
WELL-HART (estrogen alone), 2003      NCTestrogenplaceboLow risk of bias negative-50%
Schulman (NHLBI) (estrogen alone), 2002      NCTestrogenplaceboLow risk of bias -
EPAT, 2001     estrogenplaceboLow risk of bias negative-100%50%
ESPRIT, 2002     estrogenplaceboLow risk of bias negative-19%
WEST, 2001     estrogenplaceboLow risk of bias negative14%-21%