Miscellaneous

     

Select            
Trial Studied trt Control trt patientstagsROB Trial result

melanoma

Interferon alpha
EORTC18991 (Eggermont), 2008   PEG IFN alpha-2b (I M)observationadjuvantsuggesting
EORTC18871/DKG 80-1 stage III   rIFN alpha-2bobservation -
ipilimumab
EORTC 18071 (Eggermont), 2015        NCTipilimumabplaceboadjuvant adjuvant Low risk of bias conclusive
nivolumab
CheckMate 238 subgroup IIIB-C   nivolumabipilimumabsuggesting
pembrolizumab
KEYNOTE-054, 2018      NCTpembrolizumabplaceboadjuvant adjuvant Low risk of bias conclusive
trametinib + dabrafenib
COMBI-AD, 2017      NCTtrametinib and dabrafenibplaceboadjuvantLow risk of bias suggesting
vemurafenib
BRIM 8 (cohort IIIC)   vemurafenibplacebonegative

sarcoma

pazopanib
PALETTE (van der Graaf), 2012      NCTpazopanib placebosuggesting