insulin secretagogues - DPP-4 inhibitors

     

Select
Display
Trial Studied trt Control trt patientstagsNCTROB Result

diabetes type 2

alogliptin
Seino, 2011alogliptinNCT01263509 -
Seino, 2011alogliptin -
Bosi , 2011alogliptinNCT00432276 -
Kaku, 2011alogliptin -
Rosenstock, 2010alogliptinNCT00395512 -
Rosenstock, 2009alogliptinNCT00286429 -
Pratley, 2009alogliptinNCT00286494 -
Pratley, 2009alogliptinNCT00286468 -
DeFronzo , 2008alogliptinNCT00286455 -
EXAMINE, 2011alogliptinplaceboNCT00968708negative
Nauck, 2009alogliptinplacebo (add on MET)NCT00286442Exploratory negative
glyburide
CV181-040saxagliptin + glyburideglyburide uptitrationNCT00313313 -
linagliptin
Forst, 2010linagliptinNCT00309608 -
CAROLINA, 2012linagliptinglimepirideNCT01243424Exploratory suggesting
Gallwitz, 2012linagliptinglimepiride (add on MET)NCT00622284 -
linagliptin 1218.62 ongoing linagliptin low doselinagliptinNCT01012037 ongoing
OwenslinagliptinMetformin + sulfonylureaNCT00602472 -
Del PratolinagliptinplaceboNCT00621140 -
linagliptine 1218.50 ongoing linagliptinplaceboNCT00740051 ongoing
linagliptin1218.5 ongoing linagliptinplaceboNCT00328172 ongoing
linagliptin 1218.46 ongoing linagliptinplaceboNCT00798161 ongoing
Taskinenlinagliptinplacebo (add on MET)NCT00601250 -
linagliptin 1218.65 ongoing linagliptinplacebo (add on MET)NCT01215097 ongoing
linagliptin 1218.61 ongoing linagliptinplacebo (add on MET+TZD)NCT00996658 ongoing
Gomis, 2011linagliptinplacebo (add on pioglitazone)NCT00641043 -
Lewin, 2010linagliptinplacebo (add on SU)NCT00819091 -
linagliptin 1264.3 ongoing linagliptin + pioglitazonepioglitazoneNCT01183013 ongoing
saxagliptin
Kawamori, 2012saxagliptinNCT00654381 -
Forst, 2011Saxagliptin -
Fonseca, 2012saxagliptinNCT00960076 -
Nowicki, 2011saxagliptinNCT00614939 -
Yang, 2011saxagliptinNCT00661362 -
Nowicki, 2011saxagliptinNCT00614939 -
Göke, 2010saxagliptin -
Scheen , 2010saxagliptin -
Stenlöf , 2010Saxagliptin -
CV181-085saxagliptin plus metformin XR 1500mgmetformin up to 2000mgNCT00918138 -
SAVOR-TIMI 53, 2013saxagliptinplaceboNCT01107886negative
saxgliptin, renal studysaxagliptinplacebo (add on current treatment) -
CV181-057saxagliptinplacebo (add on insulin)NCT00757588 -
DeFronzo, 2009saxagliptinplacebo (add on MET)NCT00121667negative
Jadzinsky, 2009saxagliptinplacebo (add on MET)NCT00327015 -
CV181-066saxagliptinplacebo (add on MET)NCT00683657 -
CV181-080saxagliptinplacebo (add on MET)NCT00885378 -
Hollandersaxagliptinplacebo (add on TZD)NCT00295633 -
Rosenstock, 2008saxagliptinplacebo (monotherapy)NCT00950599 -
CV181-011saxagliptinplacebo (monotherapy)NCT00121641 -
CV181-038saxagliptinplacebo (monotherapy)NCT00316082 -
CV181-041saxagliptinplacebo (monotherapy)NCT00374907 -
saxagliptin vs sitagliptinsaxagliptinsitagliptin (add on MET) -
saxagliptinsaxagliptinglipizide -
sitagliptin
Stafford , 2011sitagliptinNCT00451113 -
Reasner, 2011sitagliptincontrol (add on MET)NCT00482729) -
Arechavaleta, 2011sitagliptinglimepiride (add on MET)NCT00701090 -
Aschner, 2010sitagliptin monotherapymetforminNCT00449930 -
Derosa , 2010sitagliptin+piometformin+pio -
Goldstein, 2007sitagliptinplaceboNCT00103857negative
Hanefeld, 2007sitagliptinplacebonegative
Scott* (sit vs pbo), 2007sitagliptin 50mg bid monotherapyplacebonegative
Aschner, 2006sitagliptin monotherapyplaceboNCT00087516negative
Nonaka, 2008sitagliptin monotherapyplaceboNCT00371007negative
Raz, 2006sitagliptin monotherapyplacebonegative
Barzilai, 2011sitagliptin monotherapyplaceboNCT00305604 -
Mohan , 2009sitagliptin monotherapyplacebo -
Chan, 2008sitagliptin monotherapyplacebo -
Vilsbøll, 2010sitagliptinplacebo (add on insulin+/-MET)NCT00395343 -
Charbonnel, 2006sitagliptinplacebo (add on MET)NCT0086515negative
Nauck, 2007sitagliptinplacebo (add on MET)NCT00094770negative
Scott** (sit vs pbo on top met), 2007sitagliptinplacebo (add on MET)negative
raz, 2008sitagliptinplacebo (add on MET)NCT00337610 -
Rosenstock , 2006sitagliptinplacebo (add on PIO)NCT00086502 -
Rosenstock (sit on top pio vs pbo), 2006sitagliptinplacebo (on top PIO)NCT00086502suggesting
Hermansen, 2007sitagliptinplacebo (on-top glimepiride+/- metformine)negative
Rigby , 2010sitagliptinrosiglitazone (add on MET) -
Al Sifri, 2011sitagliptinSulphonylurea (on top MET) -
Iwamoto , 2010sitagliptin monotherapyvoglibose -
Scott* (sit vs glipi), 2007sitagliptin 50mg bid monotherapyglipizide -
Goldstein (sit vs met), 2007sitagliptinmetformin -
Goldstein (sit+met vs met), 2007sitagliptinmetformin -
Pérez-Monteverde, 2011sitagliptinpioglitazoneNCT00541450 -
vildagliptin
NCT00101673vildagliptinNCT00101673 -
Pan, 2008vildagliptin monotherapyacarboseNCT00110240 -
Foley, 2009vildagliptin monotherapygliclazideNCT00102388 -
Filozof, 2009vildagliptingliclazide (add on MET)NCT00102466 -
Matthews , 2010vildagliptinglimepiride (add on MET) -
CLAF237A 23104vildagliptin + METMETNCT00396357 -
Schweizer, 2009vildagliptinmetforminNCT00246619 -
Mimori, 2006vildagliptinplacebo -
Scherbaum [2], 2008vildagliptinplaceboNCT00101712negative
Rosenstock, 2008vildagliptinplaceboNCT00237250 -
NCT00351832vildagliptinplaceboNCT00351832 -
Dejager [1], 2007vildagliptin monotherapyplaceboNCT00099905negative
Pi-Sunyer, 2007vildagliptin monotherapyplaceboNCT00120536suggesting
Pratley, 2006vildagliptin monotherapyplacebonegative
Ristic, 2005vildagliptin monotherapyplacebonegative
Foley, 2011vildagliptin monotherapyplaceboNCT00260156 -
Kikuchi, 2009vildagliptin monotherapyplacebo -
Ahren, 2009vildagliptin monotherapyplaceboNCT00390520 -
Lukashevich , 2011vildagliptinplacebo (add on current therapy)NA -
Kikuchi, 2010vildagliptinplacebo (add on glimepiride)NCT00325117 -
Fonseca, 2007vildagliptinplacebo (add on insulin)NCT00099931suggesting
Fonseca , 2008vildagliptinplacebo (add on insulin) -
Ahren, 2004vildagliptinplacebo (add on MET)negative
Bosi, 2007vildagliptinplacebo (add on MET)NCT00099892negative
Goodman, 2009vildagliptinplacebo (add on MET)Exploratory negative
Bosi, 2009vildagliptinplacebo (add on MET)NCT00382096 -
NCT00728351vildagliptinplacebo (add on MET)NCT00728351 -
NCT00822211vildagliptinplacebo (add on MET)NCT00822211 -
NCT00494884 (Wollmer)vildagliptinplacebo (add on MET)NCT00494884 -
NCT00396071vildagliptinplacebo (add on MET)NCT00396071 -
Garber, 2008vildagliptinplacebo (add on SU)NCT00099944 -
Garber, 2007vildagliptinplacebo (on top pioglitazone)NCT00099853negative
Rosenstock, 2009vildagliptinrosiglitazoneNCT00138619 -
Ferrannini, 2009vildagliptinSulfonylurea (add on to MET)NCT00106340Exploratory suggesting
GALIANT (Blonde), 2009vildagliptinTZD (add on MET)NCT00396227 -
NCT00368134vildagliptinvogliboseNCT00368134 -
Iwamoto, 2010vildagliptinvogliboseNA -
Schweizer, 2007vildagliptinmetforminNCT00099866negative
Goke, 2008vildagliptinmetformin -
Rosenstock** (vilda vs pio), 2007vildagliptin monotherapypioglitazoneNCT00101803 -
Bolli, 2008vildagliptinpioglitazone (add on MET)NCT00237237negative
Rosenstock** (vilda + pio vs pio), 2007vildagliptinplacebo (add on TZD)NCT00101803negative
Rosenstock* (vilda vs rosi), 2007vildagliptinrosiglitazoneNCT00099918 -