insulin secretagogues - sulfonylureas

     

Select            
Trial Studied trt Control trt patientstagsROB Trial resultAll cause deathmyocardial infarction (fatal and non fatal)

diabetes type 2

gliclazide
Ristic, 2006       gliclazidenateglinide (add on MET)Low risk of bias -
Matthews, 2005     gliclazidepioglitazone (add on MET)Low risk of bias -
Khanolkar, 2008     gliclaziderosiglitazone (add on MET) -
glimepiride
Charpentier, 2001     glimepiride monotherapymetforminLow risk of bias -
glimeripide
Study 201 (Goldberg), 1996   glimepirideplaceboLow risk of bias -
Schade, 1998   glimepirideplaceboLow risk of bias -
Rosenstock, 1996   glimepirideplaceboLow risk of bias -
Luis Bautista, 2003   glimepirideplaceboLow risk of bias -
Kaneko, 1993   glimepirideplacebo -
Study 202   glimepirideplacebo -
Riddle, 1994   glimepirideplacebo (add on insulin) -
LEAD-2 (Nauck) Sulf vs pbo, 2009      NCTglimepirideplacebo (add on MET)Low risk of bias -
Charpentier, 2001     glimepirideplacebo (add on MET)Low risk of bias negative
Draeger, 1996     glimepirideglibenclamideLow risk of bias -
Protocol 311   glimepirideglibenclamide -
Charpentier (301F)   glimepiridegliclazide -
Inukai, 2005     glimepiridegliclazide or glibenclamide -
Sonnenberg, 1997   glimepiride odglimepiride bid -
Clark (301), 1997   glimepirideglipizide -
Dills, 1996   glimepirideglyburideLow risk of bias -
glipizide
Goldstein   glipizidecontrol (add on MET) -
Rosenstock, 1993   glipizideglyburide -
Birkeland, 1994   glipizideglyburide -
Birkeland, 1994   glipizideglyburideLow risk of bias -
Simonson, 1997   glipizideplaceboLow risk of bias -
Testa, 1998   glipizideplacebo -
Feinglos, 2005     glipizide GITSplacebo (add on MET)Low risk of bias -
Nauck, 2007     glipizidesitagliptin (add on MET) -
glyburide
Hermann, 1991   glibenclamidec (add on MET) -
DeFronzo, 1995   glyburidec (add on MET)Low risk of bias -
Erle, 1999   glyburidec (add on MET) -
Marre (ass), 2002   glibenclamidecontrol (add on MET)Low risk of bias -
Tosi, 2003   glibenclamidecontrol (add on MET)Low risk of bias -
Blonde, 2002   glyburidecontrol (add on MET)Low risk of bias -
Garber, 2003   glyburidecontrol (add on MET) -
Garber, 2002   glyburideplaceboLow risk of bias -
Vray, 1995   glyburideplaceboLow risk of bias -
Garber, 2006     glibenclamiderosiglitazone (add on MET)Low risk of bias -