aldosterone blockade  

Eplerenone - Spironolactone      

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Trial Studied trt Control trt patientstagsNCTROB Result

heart failure

eplerenone
EPHESUS, 2003eplerenoneplaceboLow risk of bias suggesting
EMPHASIS-HF, 2010eplerenoneplaceboNCT00232180Low risk of bias suggesting
REMODEL ongoing eplerenoneplaceboNCT00082589Low risk of bias ongoing
Weir ongoing eplerenoneplaceboNCT00132093Low risk of bias ongoing
spironolactone
Cicoira, 2004spironolactonecontrol -
Cicoira, 2002spironolactonecontrolExploratory -
Ramires, 2000spironolactonecontrolExploratory -
RALES, 1998spironolactoneplaceboRisk of bias suggesting
Agostoni, 2005spironolactoneplaceboExploratory -
Mottram, 2004spironolactoneplaceboLow risk of bias -
Macdonald, 2004spironolactoneplaceboLow risk of bias -
Yee, 2001spironolactoneplaceboLow risk of bias -
Tsutamoto, 2001spironolactoneplaceboLow risk of bias -
Farquharson, 2000spironolactoneplaceboLow risk of bias -
MacFadyen, 1997spironolactoneplaceboLow risk of bias -
PIE II ongoing spironolactoneplaceboNCT00123955Low risk of bias ongoing
Han, 1994spironolactone+captoprilcaptoprilExploratory -
Bednarz, 2000aldactonefurosemideExploratory -
Nouvel essai ongoing spironolactonespironolactoneNCT00125437Exploratory ongoing
Mauersberger, 1985spironolactone+furosemidespironolactone+butizideExploratory -