aldosterone blockade

Eplerenone - Spironolactone      

Select            
Trial Studied trt Control trt patientstagsROB Trial resultAll cause deathserious hyperkalemia

heart failure

eplerenone
EPHESUS, 2003       eplerenoneplaceboLow risk of bias suggesting -14%43%
EMPHASIS-HF, 2010        NCTeplerenoneplaceboLow risk of bias suggesting -19%119%
spironolactone
Cicoira, 2004     spironolactonecontrol -
Cicoira, 2002     spironolactonecontrolExploratory -
Ramires, 2000     spironolactonecontrolExploratory -
RALES, 1998         spironolactoneplaceboRisk of bias suggesting -25%105%
Agostoni, 2005     spironolactoneplaceboExploratory -
Mottram, 2004     spironolactoneplaceboLow risk of bias -
Macdonald, 2004     spironolactoneplaceboLow risk of bias -
Yee, 2001     spironolactoneplaceboLow risk of bias -
Tsutamoto, 2001     spironolactoneplaceboLow risk of bias -
Farquharson, 2000     spironolactoneplaceboLow risk of bias -
MacFadyen, 1997     spironolactoneplaceboLow risk of bias -
Han, 1994     spironolactone+captoprilcaptoprilExploratory -
Bednarz, 2000     aldactonefurosemideExploratory -
Mauersberger, 1985     spironolactone+furosemidespironolactone+butizideExploratory -