insulin sensitizer - biguanides

     

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Trial Studied trt Control trt patientstagsROB Trial resultAll cause deathmyocardial infarction (fatal and non fatal)

diabetes type 2

metformin
Teupe, 1991   metforminplacebonegative+Infini%
Kooy (HOME), 2009     metforminplaceboLow risk of bias suggesting48%11%
Campbell, 1994   metforminGlipizidenegative
UKPDS (vs SU or INS)     metforminSU/Insulinsuggesting -27%-22%