B-Raf enzyme inhibitors

Trametinib + dabrafenib - Vemurafenib      

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Trial Studied trt Control trt patientstagsROB Trial result

melanoma

encorafenib plus binimetinib
COLUMBUS, 2018      NCTencorafenib plus binimetinibvemurafenib1LRisk of bias suggesting
trametinib + dabrafenib
Flaherty, 2012      NCTtrametinib and dabrafenibdabrafenibsuggesting
COMBI-D (Long), 2014        NCTtrametinib and dabrafenibdabrafenib1L unresectablesuggesting
COMBI-AD, 2017      NCTtrametinib and dabrafenibplaceboadjuvantLow risk of bias suggesting
COMBI neo, 2018      NCTtrametinib and dabrafenib SOCadjuvant -
COMBI-V (Robert), 2015      NCTtrametinib and dabrafenibvemurafenib1Lsuggesting
vemurafenib
BRIM 8, 2018      NCTvemurafenibplaceboadjuvantsuggesting
vemurafenib and cobimetinib
Larkin, 2014      NCTvemurafenib and cobimetinibvemurafenibsuggesting