plasma homocysteine lowering intervention

     

Select            
Trial Studied trt Control trt patientstagsROB Trial result

cardiovascular prevention

folic acid
FOLARDA (Liem), 2004   folic acidcontrolExploratory negative
GOES (Liem), 2003   folic acidcontrolRisk of bias negative
NORVIT (folic acid + B12) (Bonaa), 2006    NCTfolic acid, B12controlLow risk of bias negative
NORVIT (folic acid, B12 and vit B6) (Bonaa), 2006    NCTfolic acid, vit B12 and vit B6controlLow risk of bias negative
CHAOS-2, 2002   folic acidplaceboLow risk of bias negative
CSPPT, 2015      NCTfolic acidplaceboLow risk of bias suggesting
SEARCH, 2007      NCTfolic acid, B12placeboLow risk of bias negative
WENBIT (folic ac,B12), 2008    NCTfolic acid, B12placeboLow risk of bias negative
WAFACS, 2008    NCTfolic acid, vit B12 and vit B6placeboLow risk of bias negative
HOPE-2 (Lonn), 2006        NCTfolic acid, vit B12 and vit B6placeboLow risk of bias suggesting
VITATOPS, 2010    NCTfolic acid, vit B12 and vit B6placeboLow risk of bias suggesting
SU.FOL.OM3   folic acid, vit B12 and vit B6placeboLow risk of bias negative
VISP (Toole), 2004   high dose - folic acid, vit B12 and vit B6low dose - folic acid, vit B12 and vit B6Low risk of bias negative