plasma homocysteine lowering intervention

     

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Trial Studied trt Control trt patientstagsNCTROB Result

cardiovascular prevention

folic acid
FOLARDA (Liem), 2004folic acidcontrolExploratory negative
GOES (Liem), 2003folic acidcontrolRisk of bias negative
NORVIT (folic acid + B12) (Bonaa), 2006folic acid, B12controlNCT00266487Low risk of bias negative
NORVIT (folic acid, B12 and vit B6) (Bonaa), 2006folic acid, vit B12 and vit B6controlNCT00266487Low risk of bias negative
CHAOS-2, 2002folic acidplacebonegative
CSPPT, 2015folic acidplaceboNCT00794885Low risk of bias suggesting
SEARCH, 2007folic acid, B12placeboNCT00124072Low risk of bias negative
WENBIT (folic ac,B12), 2008folic acid, B12placeboNCT00354081Low risk of bias negative
WAFACS, 2008folic acid, vit B12 and vit B6placeboNCT00000541Low risk of bias negative
HOPE-2 (Lonn), 2006folic acid, vit B12 and vit B6placeboNCT00106886Low risk of bias suggesting
VITATOPS, 2010folic acid, vit B12 and vit B6placeboNCT00097669ÐX&Low risk of bias suggesting
SU.FOL.OM3folic acid, vit B12 and vit B6placeboISRCTN41926726negative
VISP (Toole), 2004high dose - folic acid, vit B12 and vit B6low dose - folic acid, vit B12 and vit B6Low risk of bias negative