plasma homocysteine lowering intervention

     

Select            
Trial Studied trt Control trt patientstagsROB Trial resultNon fatal MIstroke (fatal and non fatal)

cardiovascular prevention

folic acid
FOLARDA (Liem), 2004   folic acidcontrolExploratory negative+Infini%
GOES (Liem), 2003   folic acidcontrolRisk of bias negative-27%30%
NORVIT (folic acid + B12) (Bonaa), 2006    NCTfolic acid, B12controlLow risk of bias negative13%0%
NORVIT (folic acid, B12 and vit B6) (Bonaa), 2006    NCTfolic acid, vit B12 and vit B6controlLow risk of bias negative 28%-22%
CHAOS-2, 2002   folic acidplaceboLow risk of bias negative
CSPPT, 2015      NCTfolic acidplaceboLow risk of bias suggesting-21%
SEARCH, 2007      NCTfolic acid, B12placeboLow risk of bias negative0%2%
WENBIT (folic ac,B12), 2008    NCTfolic acid, B12placeboLow risk of bias negative -10%
WAFACS, 2008    NCTfolic acid, vit B12 and vit B6placeboLow risk of bias negative14%
HOPE-2 (Lonn), 2006        NCTfolic acid, vit B12 and vit B6placeboLow risk of bias suggesting-24%
VITATOPS, 2010    NCTfolic acid, vit B12 and vit B6placeboLow risk of bias suggesting
SU.FOL.OM3   folic acid, vit B12 and vit B6placeboLow risk of bias negative -11%-41%
VISP (Toole), 2004   high dose - folic acid, vit B12 and vit B6low dose - folic acid, vit B12 and vit B6Low risk of bias negative4%