phosphodiesterase III inhibitors

Amrinone - Vesnarinone

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Trial	Studied trt	Control trt	patients	tags	NCT	ROB	Result
heart failure
amrinone
AMTG, 1985	Amrinone	placebo				Low risk of bias	negative
Enoximone
WESG, 1991	Enoximone	placebo				Low risk of bias	negative
EMTG, 1990	Enoximone	placebo				Low risk of bias	negative
ESG, 2000	Enoximone	placebo				Low risk of bias	negative
Lardoux, 1987	Enoximone	placebo				Low risk of bias	negative
ESSENTIAL (I and II), 2009	enoximone	placebo			NCT00051285	Low risk of bias	negative
Cowley, 1994	Enoximone	placebo				Low risk of bias	negative
EMOTE, 2007	enoximone	placebo				Low risk of bias	-
EMPOWER ongoing	enoximone	placebo (on top metoprolol)			NCT00077948	Low risk of bias	ongoing
Flosequinan
Cowley, 1993	Flosequinan	placebo				Low risk of bias	negative
FACET, 1993	Flosequinan	placebo				Low risk of bias	negative
REFLECT, 1993	Flosequinan	placebo				Low risk of bias	negative
REFLECT II, 1991	Flosequinan	placebo				Low risk of bias	negative
ibopamine
PRIME II, 1997	ibopamine	placebo				Low risk of bias	negative
Milrinone
PROMISE, 1991	Milrinone	placebo				Low risk of bias	negative
MMTG, 1989	Milrinone	placebo				Low risk of bias	negative
vesnarinone
OPC-8212 MRG, 1990	Vesnarinone	placebo				Low risk of bias	negative
VEST, 1998	Vesnarinone	placebo				Low risk of bias	negative
VSG, 1993	Vesnarinone	placebo				Low risk of bias	suggesting