phosphodiesterase III inhibitors

Amrinone - Vesnarinone      

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Trial Studied trt Control trt patientstagsNCTROB Result

heart failure

amrinone
AMTG, 1985Amrinoneplacebonegative
Enoximone
WESG, 1991Enoximoneplacebonegative
EMTG, 1990Enoximoneplacebonegative
ESG, 2000Enoximoneplacebonegative
Lardoux, 1987Enoximoneplacebonegative
ESSENTIAL (I and II), 2009enoximoneplaceboNCT00051285Low risk of bias negative
Cowley, 1994Enoximoneplacebonegative
EMOTE, 2007enoximoneplacebo -
EMPOWER ongoing enoximoneplacebo (on top metoprolol)NCT00077948 ongoing
Flosequinan
Cowley, 1993Flosequinanplacebonegative
FACET, 1993Flosequinanplacebonegative
REFLECT, 1993Flosequinanplacebonegative
REFLECT II, 1991Flosequinanplacebonegative
ibopamine
PRIME II, 1997ibopamineplacebonegative
Milrinone
PROMISE, 1991Milrinoneplacebonegative
MMTG, 1989Milrinoneplacebonegative
vesnarinone
OPC-8212 MRG, 1990Vesnarinoneplacebonegative
VEST, 1998Vesnarinoneplacebonegative
VSG, 1993Vesnarinoneplacebosuggesting