angiotensin-receptor blockers

Candesartan - Irbesartan - Losartan - Telmisartan - Valsartan      

Select            
Trial Studied trt Control trt patientstagsROB Trial result

acute myocardial infarction

losartan
OPTIMAAL, 2002     LosartanCaptoprilLow risk of bias suggesting
valsartan
VALIANT (valsartan+capropril), 2003     Valsartan+ACE inhibitor ACE inhibitor onlyLow risk of bias negative
VALIANT (valsartan alone), 2003     ValsartanCaptoprilLow risk of bias negative

diabetes type 2

irbesartan
IPDM (150mg), 2001     irbesartanplaceboLow risk of bias suggesting
IDNT (irbesartan vs amlodipine), 2001     irbesartanamlodipineLow risk of bias suggesting
losartan
RENAAL, 2001     losartanplaceboLow risk of bias suggesting
olmesartan
ROADMAP, 2010        NCTolmesartanplaceboLow risk of bias suggesting
ORIENT    NCTolmesartanplaceboLow risk of bias negative

heart failure

candesartan
ARCH-J, 2003     candesartanplaceboLow risk of bias -
CHARM-Alternative, 2003     candesartanplaceboLow risk of bias suggesting
Mitrovic et al., 2003     candesartanplaceboLow risk of bias suggesting
SPICE, 2000     candesartanplaceboLow risk of bias negative
STRETCH, 1999     candesartanplaceboLow risk of bias -
CHARM preserved, 2003   candesartanplaceboLow risk of bias -
CHARM-Added, 2003       candesartan+ACE inhibitorACE inhibitor onlyLow risk of bias negative
RESOLVD association, 1999     candesartan+ACE inhibitorACE inhibitor onlyExploratory negative
RESOLVD (candesartan alone), 1999     candesartanenalaprilLow risk of bias negative
irbesartan
I-PRESERVE (McMurray), 2008      NCTibesartanplaceboLow risk of bias negative
Tonkon et al., 2000   irbesartan+ACE inhibitorACE inhibitor onlyLow risk of bias -
losartan
HEAAL, 2009        NCTlosartan 150mglosartan 50mgLow risk of bias suggesting
Losartan Phase III International, 1996       losartanplaceboLow risk of bias suggesting
Losartan Phase III U.S., 1995     losartanplaceboLow risk of bias negative
Hamroff et al., 1999     losartan+ACE inhibitorACE inhibitor onlyLow risk of bias -
ELITE, 1997       losartancaptoprilLow risk of bias negative
ELITE II, 2000     losartancaptoprilLow risk of bias -
Dickstein et al., 1995     losartanenalaprilLow risk of bias -
Lang et al., 1997     losartanenalaprilLow risk of bias -
Losartan phase II S, 1996     losartanenalaprilLow risk of bias -
losartan phase II US, 1996     losartanenalaprilLow risk of bias -
telmisartan
REPLACE, 2001     telmisartanenalaprilLow risk of bias -
valsartan
VALIDD, 2007    NCTvalsartanno valsartanLow risk of bias negative
Mazayev et al. (vs placebo), 1998     valsartanplaceboLow risk of bias -
V-HeFT, 1999     valsartan+ACE inhibitorACE inhibitor onlyLow risk of bias negative
Val-HeFT, 2001     valsartan+ACE inhibitorACE inhibitor onlyLow risk of bias suggesting
HEAVEN, 2002     valsartanenalaprilLow risk of bias -
Mazayev et al. (vs lisinopril, 1998     valsartanLisinoprilExploratory -

hypertension

candesartan
Takahashi, 2006     candesartancontrolExploratory negative
E-COST, 2005     candesartanconventional treatmentRisk of bias suggesting
E-COST-R, 2005     candesartanconventional treatmentRisk of bias negative
HIJ-CREATE, 2009     candesartanconventional treatmentRisk of bias suggesting
SCOPE, 2003   candesartanplaceboLow risk of bias negative
HIJ-CREATE, 2009     Candesartanusual careRisk of bias -
CASE-J, 2008     candesartanamlodipineRisk of bias suggesting
ALPINE, 2003   candesartanhydrochlorothiazideLow risk of bias suggesting
captopril
VALIANT/Val+Cap, 2003       Valsartan + captoprilCaptoprilLow risk of bias negative
irbesartan
IDNT (irbesartan vs pbo), 2001       irbesartanplaceboLow risk of bias negative
IRMA 2, 2001     irbesartanplaceboLow risk of bias negative
losartan
RENAAL, 2001     losartanplaceboLow risk of bias -
LIFE, 2002     losartanatenololLow risk of bias suggesting
ELITE, 1997     LosartanCaptoprilLow risk of bias suggesting
ELITE-II, 2000     LosartanCaptoprilLow risk of bias negative
OPTIMAAL, 2001     LosartanCaptoprilRisk of bias negative
ramipril
ONTARGET/Tel+Ram, 2008     Telmisartan + ramiprilRamiprilLow risk of bias negative
telmisartan
PROPHESS, 2008      NCTtelmisartanplaceboLow risk of bias negative
DETAIL, 2004     TelmisartanEnalaprilLow risk of bias negative
ONTARGET/Tel, 2008     TelmisartanRamiprilLow risk of bias negative
valsartan
VALIANT/Val, 2003       ValsartanCaptoprilLow risk of bias negative

miscellaneous

candesartan
Takahashi, 2006     candesartancontrolExploratory negative
E-COST, 2005     candesartanconventional treatmentRisk of bias suggesting
E-COST-R, 2005     candesartanconventional treatmentRisk of bias negative
HIJ-CREATE, 2009     candesartanconventional treatmentRisk of bias suggesting
SCOPE, 2003   candesartanplaceboLow risk of bias negative
TROPHY, 2006      NCTcandesartanplaceboLow risk of bias suggesting
CASE-J, 2008     candesartanamlodipineRisk of bias suggesting
ALPINE, 2003   candesartanhydrochlorothiazideLow risk of bias suggesting
irbesartan
IDNT (irbesartan vs pbo), 2001       irbesartanplaceboLow risk of bias negative
IRMA 2, 2001     irbesartanplaceboLow risk of bias negative
losartan
RENAAL, 2001     losartanplaceboLow risk of bias -
LIFE, 2002     losartanatenololLow risk of bias suggesting
olmesartan
ROADMAP, 2010        NCTolmesartanplaceboLow risk of bias suggesting
ORIENT    NCTolmesartanplaceboLow risk of bias negative
ramipril
ONTARGET (association vs ramipril), 2008    NCTtelmisartan + ramiprilramiprilLow risk of bias negative
ONTARGET (association vs telmisartan), 2008    NCTtelmisartan + ramipriltelmisartanLow risk of bias suggesting
telmisartan
TRANSCEND, 2008    NCTtelmisartanplaceboLow risk of bias suggesting
PROPHESS, 2008      NCTtelmisartanplaceboLow risk of bias negative
ONTARGET (telmisartan alone), 2008      NCTtelmisartanramiprilLow risk of bias suggesting

patients at high risk for cardiovascular events

candesartan
SCOPE, 2003   candesartanplaceboLow risk of bias negative
losartan
RENAAL, 2001     losartanplaceboLow risk of bias -
LIFE, 2002     losartanatenololLow risk of bias suggesting
ramipril
ONTARGET (association vs ramipril), 2008    NCTtelmisartan + ramiprilramiprilLow risk of bias negative
ONTARGET (association vs telmisartan), 2008    NCTtelmisartan + ramipriltelmisartanLow risk of bias suggesting
telmisartan
TRANSCEND, 2008    NCTtelmisartanplaceboLow risk of bias suggesting
PROPHESS, 2008      NCTtelmisartanplaceboLow risk of bias negative
ONTARGET (telmisartan alone), 2008      NCTtelmisartanramiprilLow risk of bias suggesting