angiotensin-receptor blockers

Candesartan - Irbesartan - Losartan - Telmisartan - Valsartan      

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Trial Studied trt Control trt patientstagsNCTROB Result

acute myocardial infarction

losartan
OPTIMAAL, 2002LosartanCaptoprilsuggesting
valsartan
VALIANT (valsartan+capropril), 2003Valsartan+ACE inhibitor ACE inhibitor onlynegative
VALIANT (valsartan alone), 2003ValsartanCaptoprilnegative

diabetes type 2

irbesartan
IPDM (150mg), 2001irbesartanplaceboExploratory suggesting
IDNT (irbesartan vs amlodipine), 2001irbesartanamlodipineLow risk of bias suggesting
losartan
RENAAL, 2001losartanplaceboLow risk of bias suggesting
olmesartan
ROADMAP, 2010olmesartanplaceboNCT00185159Low risk of bias suggesting
ORIENTolmesartanplaceboNCT00141453negative

heart failure

candesartan
ARCH-J, 2003candesartanplaceboLow risk of bias -
CHARM-Alternative, 2003candesartanplaceboLow risk of bias suggesting
Mitrovic et al., 2003candesartanplaceboExploratory suggesting
SPICE, 2000candesartanplaceboExploratory negative
STRETCH, 1999candesartanplaceboExploratory -
CHARM preserved, 2003candesartanplaceboLow risk of bias -
CHARM-Added, 2003candesartan+ACE inhibitorACE inhibitor onlyLow risk of bias negative
RESOLVD association, 1999candesartan+ACE inhibitorACE inhibitor onlyExploratory negative
RESOLVD (candesartan alone), 1999candesartanenalaprilExploratory negative
irbesartan
I-PRESERVE (McMurray), 2008ibesartanplaceboNCT00095238Low risk of bias negative
Tonkon et al., 2000irbesartan+ACE inhibitorACE inhibitor onlyExploratory -
losartan
NCT00090259 ongoing losartanlosartanNCT00090259 ongoing
HEAAL, 2009losartan 150mglosartan 50mgNCT00090259Low risk of bias suggesting
Losartan Phase III International, 1996losartanplaceboExploratory suggesting
Losartan Phase III U.S., 1995losartanplaceboExploratory negative
Hamroff et al., 1999losartan+ACE inhibitorACE inhibitor onlyExploratory -
ELITE, 1997losartancaptoprilExploratory negative
ELITE II, 2000losartancaptoprilLow risk of bias -
Dickstein et al., 1995losartanenalaprilExploratory -
Lang et al., 1997losartanenalaprilExploratory -
Losartan phase II S, 1996losartanenalaprilExploratory -
losartan phase II US, 1996losartanenalaprilExploratory -
telmisartan
REPLACE, 2001telmisartanenalaprilExploratory -
valsartan
VALIDD, 2007valsartanno valsartanNCT00170924Exploratory negative
Mazayev et al. (vs placebo), 1998valsartanplaceboExploratory -
V-HeFT, 1999valsartan+ACE inhibitorACE inhibitor onlyExploratory negative
Val-HeFT, 2001valsartan+ACE inhibitorACE inhibitor onlyLow risk of bias suggesting
HEAVEN, 2002valsartanenalaprilExploratory -
Mazayev et al. (vs lisinopril, 1998valsartanLisinoprilExploratory -

hypertension

candesartan
Takahashi, 2006candesartancontrolExploratory negative
E-COST, 2005candesartanconventional treatmentRisk of bias suggesting
E-COST-R, 2005candesartanconventional treatmentRisk of bias negative
HIJ-CREATE, 2009candesartanconventional treatmentRisk of bias suggesting
SCOPE, 2003candesartanplaceboLow risk of bias negative
HIJ-CREATE, 2009Candesartanusual careRisk of bias -
CASE-J, 2008candesartanamlodipineRisk of bias suggesting
ALPINE, 2003candesartanhydrochlorothiazideLow risk of bias suggesting
captopril
VALIANT/Val+Cap, 2003Valsartan + captoprilCaptoprilLow risk of bias negative
irbesartan
IDNT (irbesartan vs pbo), 2001irbesartanplaceboLow risk of bias negative
IRMA 2, 2001irbesartanplaceboLow risk of bias negative
losartan
RENAAL, 2001losartanplaceboLow risk of bias -
LIFE, 2002losartanatenololLow risk of bias suggesting
ELITE, 1997LosartanCaptoprilExploratory suggesting
ELITE-II, 2000LosartanCaptoprilLow risk of bias negative
OPTIMAAL, 2001LosartanCaptoprilRisk of bias negative
ramipril
ONTARGET/Tel+Ram, 2008Telmisartan + ramiprilRamiprilLow risk of bias negative
telmisartan
PROPHESS, 2008telmisartanplaceboNCT00153062Low risk of bias negative
DETAIL, 2004TelmisartanEnalaprilLow risk of bias negative
ONTARGET/Tel, 2008TelmisartanRamiprilLow risk of bias negative
valsartan
VALIANT/Val, 2003ValsartanCaptoprilLow risk of bias negative

miscellaneous

candesartan
Takahashi, 2006candesartancontrolExploratory negative
E-COST, 2005candesartanconventional treatmentRisk of bias suggesting
E-COST-R, 2005candesartanconventional treatmentRisk of bias negative
HIJ-CREATE, 2009candesartanconventional treatmentRisk of bias suggesting
SCOPE, 2003candesartanplaceboLow risk of bias negative
TROPHY, 2006candesartanplaceboNCT00227318Exploratory suggesting
CASE-J, 2008candesartanamlodipineRisk of bias suggesting
ALPINE, 2003candesartanhydrochlorothiazideLow risk of bias suggesting
irbesartan
IDNT (irbesartan vs pbo), 2001irbesartanplaceboLow risk of bias negative
IRMA 2, 2001irbesartanplaceboLow risk of bias negative
losartan
RENAAL, 2001losartanplaceboLow risk of bias -
LIFE, 2002losartanatenololLow risk of bias suggesting
olmesartan
ROADMAP, 2010olmesartanplaceboNCT00185159Low risk of bias suggesting
ORIENTolmesartanplaceboNCT00141453negative
ramipril
ONTARGET (association vs ramipril), 2008telmisartan + ramiprilramiprilNCT00153101negative
ONTARGET (association vs telmisartan), 2008telmisartan + ramipriltelmisartanNCT00153101suggesting
telmisartan
TRANSCEND, 2008telmisartanplaceboNCT00153101Low risk of bias suggesting
PROPHESS, 2008telmisartanplaceboNCT00153062Low risk of bias negative
ONTARGET (telmisartan alone), 2008telmisartanramiprilNCT00153101Low risk of bias suggesting

patients at high risk for cardiovascular events

candesartan
SCOPE, 2003candesartanplaceboLow risk of bias negative
losartan
RENAAL, 2001losartanplaceboLow risk of bias -
LIFE, 2002losartanatenololLow risk of bias suggesting
ramipril
ONTARGET (association vs ramipril), 2008telmisartan + ramiprilramiprilNCT00153101negative
ONTARGET (association vs telmisartan), 2008telmisartan + ramipriltelmisartanNCT00153101suggesting
telmisartan
TRANSCEND, 2008telmisartanplaceboNCT00153101Low risk of bias suggesting
PROPHESS, 2008telmisartanplaceboNCT00153062Low risk of bias negative
ONTARGET (telmisartan alone), 2008telmisartanramiprilNCT00153101Low risk of bias suggesting