HR-slowing agents

Ivabradine      

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Trial Studied trt Control trt patientstagsNCTROB Result

heart failure

ivabradine
SHIFT, 2010ivabradineplaceboISRCTN70429960Low risk of bias suggesting
BEAUTIFUL, 2008ivabradine 15mgplaceboNCT00143507Low risk of bias negative

stable angina

ivabradine
Borer (CL2-009) 10mg, 2003ivabradine 10mgplacebo -
BEAUTIFUL, 2008ivabradine 15mgplaceboNCT00143507Low risk of bias negative
Borer (CL2-009) 20mg, 2003ivabradine 20mgplacebo -
SIGNIFY, 2014ivabradine 20mgplaceboISRCTN61576291negative
Borer (CL2-009) 5mg, 2003ivabradine 5mgplacebo -
BEAUTIFUL (angina subgroup)ivabradine 15mgplacebo (on top standard treatment)Exploratory suggesting
CL3-018 10mgivabradine 10mgplacebo on top of amlodipine -
CL3-018 15mgivabradine 15mgplacebo on top of amlodipine -
ASSOCIATE (Tardif), 2009ivabradine 15mgplacebo on top of atenololNCT00202566Low risk of bias -
CL3-023 (15mg)ivabradineamlodipineLow risk of bias -
CL3-023 (20mg)ivabradineamlodipineLow risk of bias -
Ruzyllo (CL3-023) 15mg, 2007ivabradine 15mgamlodipineLow risk of bias -
Ruzyllo (CL3-023) 20mg, 2007ivabradine 20mgamlodipineLow risk of bias -
INITIATIVE (CL3-017, Tardif) 15mg, 2005ivabradine 15mgatenolol -
INITIATIVE (CL3-017, Tardif) 20mg, 2005ivabradine 20mgatenololLow risk of bias -