HR-slowing agents

Ivabradine      

Select            
Trial Studied trt Control trt patientstagsROB Trial result

heart failure

ivabradine
SHIFT, 2010       ivabradineplaceboLow risk of bias suggesting
BEAUTIFUL, 2008    NCTivabradine 15mgplaceboLow risk of bias negative

stable angina

ivabradine
Borer (CL2-009) 10mg, 2003     ivabradine 10mgplaceboLow risk of bias -
BEAUTIFUL, 2008    NCTivabradine 15mgplaceboLow risk of bias negative
Borer (CL2-009) 20mg, 2003   ivabradine 20mgplaceboLow risk of bias -
SIGNIFY, 2014     ivabradine 20mgplaceboLow risk of bias negative
Borer (CL2-009) 5mg, 2003     ivabradine 5mgplaceboLow risk of bias -
BEAUTIFUL (angina subgroup)   ivabradine 15mgplacebo (on top standard treatment)Low risk of bias suggesting
CL3-018 10mg   ivabradine 10mgplacebo on top of amlodipine -
CL3-018 15mg   ivabradine 15mgplacebo on top of amlodipine -
ASSOCIATE (Tardif), 2009    NCTivabradine 15mgplacebo on top of atenololLow risk of bias -
CL3-023 (15mg)   ivabradineamlodipineLow risk of bias -
CL3-023 (20mg)   ivabradineamlodipineLow risk of bias -
Ruzyllo (CL3-023) 15mg, 2007     ivabradine 15mgamlodipineLow risk of bias -
Ruzyllo (CL3-023) 20mg, 2007     ivabradine 20mgamlodipineLow risk of bias -
INITIATIVE (CL3-017, Tardif) 15mg, 2005   ivabradine 15mgatenololLow risk of bias -
INITIATIVE (CL3-017, Tardif) 20mg, 2005   ivabradine 20mgatenololLow risk of bias -