anti hypertensive agents

     

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Trial Studied trt Control trt patientstagsNCTROB Result

diabetes type 2

amlodipine
IDNT (amlodipine vs PBO), 2001amlodipineplaceboLow risk of bias negative
ALLHAT (amlodipine vs chlor, diabetic subgroup), 2002amlodipinechlorthalidoneExploratory negative
FACET, 1997amlodipinefosinoprilRisk of bias suggesting
candesartan
SCOPE (diabetic subgroup), 2003candesartancontrolExploratory negative
captopril
UKPDS 38, 1998captopril or atenololcontrolExploratory suggesting
UKPDS 39, 1998captoprilatenololExploratory negative
CAPP (diabetic subgroup), 1999captoprildiuretic and/or beta-blockersExploratory suggesting
chlorthalidone
SHEP (diabetic subgroup), 1996chlorthalidoneplaceboExploratory suggesting
intensive blood pressure lowering strategies
ABCD target (H) , 2000more intensive blood pressure lowering strategieless intensive blood pressure lowering strategie type 2 diabetes suggesting
ABCD target (N) , 2002more intensive blood pressure lowering strategieless intensive blood pressure lowering strategie type 2 diabetes suggesting
irbesartan
IPDM (150mg), 2001irbesartanplaceboExploratory suggesting
IDNT (irbesartan vs pbo), 2001irbesartanplaceboLow risk of bias suggesting
IDNT (irbesartan vs amlodipine), 2001irbesartanamlodipineLow risk of bias suggesting
lisinopril
ALLHAT (lisi vs chlor, diabetic subgroup), 2002lisinoprilchlorthalidoneExploratory negative
losartan
RENAAL, 2001losartanplaceboLow risk of bias suggesting
LIFE (diabetic subgroup), 2002losartanatenololExploratory suggesting
metoprolol
MERIT-HF, 2005metoprololplacebonegative
nidrendipine
Syst-Eur (diabetic subgroup), 1999nitrendipineplaceboExploratory suggesting
nifedipine
INSIGHT (diabetic subgroup), 2000nifedipinecoamilozideExploratory negative
nisoldipine
ABCD (hypertension), 1998nisoldipineenalaprilExploratory suggesting
olmesartan
ROADMAP, 2010olmesartanplaceboNCT00185159Low risk of bias suggesting
ORIENTolmesartanplaceboNCT00141453negative
ramipril
DIABHYCAR, 2004ramiprilplaceboLow risk of bias negative
DREAM, 2008ramiprilplacebonegative

hypertension

aliskiren
ACCELERATE, 2011aliskiren amlodipine NCT00797862 -
AVOID, 2008aliskirenplaceboNCT00097955Exploratory negative
Schmieder (vs HCTZ), 2009aliskirenhydrochlorothiazideExploratory negative
ALLAY, 2009aliskirenlosartanNCT00219141Exploratory negative
Andersen, 2008aliskirenramiprilExploratory -
amlodipine
IDNT (amlodipine vs PBO), 2001amlodipineplaceboLow risk of bias negative
IDNT (amlodipine vs pbo), 2001amlodipineplacebonegative
Tepel et al, 2008amlodipineplaceboNCT00124969negative
ASCOT-BPLA, 2005amlodipineatenololRisk of bias suggesting
ALLHAT (amlodipine vs chlor, diabetic subgroup), 2002amlodipinechlorthalidoneExploratory negative
ALLHAT (CCB vs diu), 2002amlodipinechlorthalidonenegative
FACET, 1997amlodipinefosinoprilRisk of bias suggesting
ACCOMPLISH, 2008amlodipine plus benazeprilhydrochlorothiazide plus benazeprilNCT00170950Low risk of bias suggesting
ALLHAT (CCB vs ACEI), 2002amlodipinelisinoprilsuggesting
AASK (amlodipine vs metoprolol), 2002amlodipinemetoprololnegative
atenolol
Coope, 1986atenololcontrol suggesting
Coope (subgroup ), 1986atenololcontrolnegative
MRC old (vs placebo), 1992atenololplacebonegative
MRC I (vs placebo), 1985atenololplacebosuggesting
Dutch TIA, 1993atenololplacebosuggesting
TEST, 1995atenololplacebonegative
MRC I (vs diuretics), 1985atenololbendroflumethiazideRisk of bias negative
MRC old (vs diuretics), 1992atenololhydrochlorothiazide+amiloridenegative
candesartan
Takahashi, 2006candesartancontrolExploratory negative
E-COST, 2005candesartanconventional treatmentRisk of bias suggesting
E-COST-R, 2005candesartanconventional treatmentRisk of bias negative
HIJ-CREATE, 2009candesartanconventional treatmentRisk of bias suggesting
SCOPE, 2003candesartanplaceboLow risk of bias negative
TROPHY, 2006candesartanplaceboNCT00227318Exploratory suggesting
HSCS, 1974deserpidine +methylclothiazideplacebonegative
Takahashi et al, 2006candesartanusual caresuggesting
Suzuki et al, 2008candesartanusual caresuggesting
CASE-J, 2008candesartanamlodipineRisk of bias suggesting
ALPINE, 2003candesartanhydrochlorothiazideLow risk of bias suggesting
captopril
UKPDS 38, 1998captopril or atenololcontrolExploratory suggesting
UKPDS 39, 1998captoprilatenololExploratory negative
CAPP (diabetic subgroup), 1999captoprildiuretic and/or beta-blockersExploratory suggesting
UKPDS-HDS, 1998captoprildiuretic or beta-blockernegative
CAPPP, 1999captoprildiuretic or beta-blockerRisk of bias negative
carvedilol
Cice et al, 2003carvedilolplacebosuggesting
Nakao et al, 2007carvedilolplacebo -
chlorthalidone
SHEP (diabetic subgroup), 1996chlorthalidoneplaceboExploratory suggesting
VA-NHLBI, 1977chlorthalidoneplacebonegative
SHEP, 1991chlorthalidoneplaceboNCT00000514suggesting
SHEP-pilot, 1989chlorthalidoneplacebonegative
SHEP-P (subgroup ), 1989chlorthalidoneplacebosuggesting
SHEP (subgroup ), 1991chlorthalidoneplacebosuggesting
diltiazem
NORDIL, 2000diltiazemdiuretic or beta-blockersuggesting
enalapril
ANBP2, 2003enalaprildiureticsRisk of bias negative
ABCD (H), 1998enalaprilnisoldipinesuggesting
fosinopril
Zannad et al, 2006fosinoprilplacebonegative
hydrochlorothiazide
EWPHE (subgroup ), 1985hydrochlorothiazideplacebonegative
Kuramoto, 1981hydrochlorothiazide + triamtereneplacebonegative
EWPHE, 1985hydrochlorothiazide + triamtereneplacebosuggesting
indapamide
HYVET pilot, 2003 -
HYVET, 2008indapamideplaceboNCT00122811suggesting
PATS, 1995indapamideplacebonegative
HAPPY, 1987negative
intensive blood pressure lowering strategies
ABCD target (H) , 2000more intensive blood pressure lowering strategieless intensive blood pressure lowering strategie type 2 diabetes suggesting
ABCD target (N) , 2002more intensive blood pressure lowering strategieless intensive blood pressure lowering strategie type 2 diabetes suggesting
irbesartan
IPDM (150mg), 2001irbesartanplaceboExploratory suggesting
IDNT (irbesartan vs pbo), 2001irbesartanplaceboLow risk of bias suggesting
IRMA 2, 2001irbesartanplaceboLow risk of bias negative
IDNT (irbesartan vs pbo), 2001irbesartanplaceboLow risk of bias negative
IDNT (irbesartan vs amlodipine), 2001irbesartanamlodipineLow risk of bias suggesting
isradipine
MIDAS, 1996isradipinehydrochlorothiazidenegative
lacidipine
ELSA, 2002lacidipineatenolol -
SHELL, 2003lacidipinechlorthalidone -
lisinopril
ALLHAT (ACEI vs amlodipine), 2002lisinoprilamlodipinesuggesting
ALLHAT (lisi vs chlor, diabetic subgroup), 2002lisinoprilchlorthalidoneExploratory negative
ALLHAT (ACEI vs chlorthalidone), 2002lisinoprildiureticsLow risk of bias negative
losartan
RENAAL, 2001losartanplaceboLow risk of bias suggesting
RENAAL, 2001losartanplaceboLow risk of bias -
LIFE (diabetic subgroup), 2002losartanatenololExploratory suggesting
LIFE, 2002losartanatenololLow risk of bias suggesting
nicardipine
NICS-EH, 1999nicardipinetrichlormethiazidenegative
nidrendipine
Syst-Eur (subgroup ), 1997nidrendipineplacebonegative
SYST-EUR, 1997nitrendipineplacebosuggesting
Syst-Eur (diabetic subgroup), 1999nitrendipineplaceboExploratory suggesting
nifedipine
Castel, 1994nifedipineatenolol+chlorthalidonenegative
INSIGHT (diabetic subgroup), 2000nifedipinecoamilozideExploratory negative
INSIGHT, 2000nifedipinehydrochlorothiazide+amiloridesuggesting
nisoldipine
ABCD (hypertension), 1998nisoldipineenalaprilExploratory suggesting
oxprenolol
IPPPSH, 1985oxprenololplacebonegative
propranolol
Berglund, 1986propranololbendroflumethiazidenegative
ramipril
Li et al, 2003ramiprilusual carenegative
AASK (ramipril vs amlodipine), 2002ramiprilamlodipinenegative
AASK (ramipril vs metoprolol), 2002ramiprilmetoprololnegative
telmisartan
PROPHESS, 2008telmisartanplaceboNCT00153062Low risk of bias negative
Cice et al, 2006telmisartanplacebosuggesting
thiazid diuretic
ANBPS (Australian ), 1980thiazide diureticscontrolnegative
Oslo (Hegeland), 1980thiazide diureticscontrolnegative
Carter, 1970thiazide diureticscontrolsuggesting
MCR 35-64 (diuretics vs pbo), 1985thiazide diureticsplacebosuggesting
various ACEI
STOP-2 (ACEI vs felodipine or isradipine), 1999various ACEIcalcium-channel blockersuggesting
STOP 2 (ACEI vs diurectic or beta-blocker), 1999various ACEIdiuretic or beta-blockersuggesting
JMIC-B, 2002various ACEInifedipine -
various beta blockers
STOP, 1991various beta-blockersplacebosuggesting
HAPPHY, 1988various beta-blockersdiureticsnegative
Yurenev, 1992various beta-blockersdiureticsnegative
various diuretics
HDFP, 1979High-dose diureticscontrolNCT00000485suggesting
VA-I, 1967High-dose diureticsplacebosuggesting
VA II, 1970High-dose diureticsplacebosuggesting
Barraclough, 1973High-dose diureticsplacebonegative
MRC (diu vs BB), 1985High-dose diureticsbeta-blockers -
verapamil
INVEST (Pepine), 2003verapamilatenololNCT00133692negative
VHAS, 1998verapamilchlorthalidonenegative
CONVINCE, 2003verapamildiuretic or beta-blockernegative

post stroke

telmisartan
PROFESS, 2008telmisartanplacebo -