anti hypertensive agents

     

Select            
Trial Studied trt Control trt patientstagsROB Trial result

diabetes type 2

amlodipine
IDNT (amlodipine vs PBO), 2001       amlodipineplaceboLow risk of bias negative
ALLHAT (amlodipine vs chlor, diabetic subgroup), 2002       amlodipinechlorthalidoneLow risk of bias negative
FACET, 1997     amlodipinefosinoprilRisk of bias suggesting
candesartan
SCOPE (diabetic subgroup), 2003       candesartancontrolLow risk of bias negative
captopril
UKPDS 38, 1998     captopril or atenololcontrolExploratory suggesting
UKPDS 39, 1998     captoprilatenololExploratory negative
CAPP (diabetic subgroup), 1999       captoprildiuretic and/or beta-blockersExploratory suggesting
chlorthalidone
SHEP (diabetic subgroup), 1996   chlorthalidoneplaceboLow risk of bias suggesting
intensive blood pressure lowering strategies
ABCD target (H) , 2000   more intensive blood pressure lowering strategieless intensive blood pressure lowering strategie type 2 diabetes suggesting
ABCD target (N) , 2002     more intensive blood pressure lowering strategieless intensive blood pressure lowering strategie type 2 diabetes suggesting
irbesartan
IPDM (150mg), 2001     irbesartanplaceboLow risk of bias suggesting
IDNT (irbesartan vs pbo), 2001     irbesartanplaceboLow risk of bias suggesting
IDNT (irbesartan vs amlodipine), 2001     irbesartanamlodipineLow risk of bias suggesting
lisinopril
ALLHAT (lisi vs chlor, diabetic subgroup), 2002       lisinoprilchlorthalidoneLow risk of bias negative
losartan
RENAAL, 2001     losartanplaceboLow risk of bias suggesting
LIFE (diabetic subgroup), 2002       losartanatenololLow risk of bias suggesting
metoprolol
MERIT-HF, 2005     metoprololplaceboLow risk of bias negative
nidrendipine
Syst-Eur (diabetic subgroup), 1999     nitrendipineplaceboLow risk of bias suggesting
nifedipine
INSIGHT (diabetic subgroup), 2000       nifedipinecoamilozideLow risk of bias negative
nisoldipine
ABCD (hypertension), 1998     nisoldipineenalaprilLow risk of bias suggesting
olmesartan
ROADMAP, 2010        NCTolmesartanplaceboLow risk of bias suggesting
ORIENT    NCTolmesartanplaceboLow risk of bias negative
ramipril
DIABHYCAR, 2004     ramiprilplaceboLow risk of bias negative
DREAM, 2008       ramiprilplacebonegative

hypertension

aliskiren
ACCELERATE, 2011    NCTaliskiren amlodipine -
AVOID, 2008      NCTaliskirenplaceboLow risk of bias negative
Schmieder (vs HCTZ), 2009     aliskirenhydrochlorothiazideLow risk of bias negative
ALLAY, 2009      NCTaliskirenlosartanExploratory negative
Andersen, 2008     aliskirenramiprilLow risk of bias -
amlodipine
IDNT (amlodipine vs PBO), 2001       amlodipineplaceboLow risk of bias negative
IDNT (amlodipine vs pbo), 2001     amlodipineplaceboLow risk of bias negative
Tepel et al, 2008      NCTamlodipineplaceboLow risk of bias negative
ASCOT-BPLA, 2005     amlodipineatenololRisk of bias suggesting
ALLHAT (amlodipine vs chlor, diabetic subgroup), 2002       amlodipinechlorthalidoneLow risk of bias negative
ALLHAT (CCB vs diu), 2002     amlodipinechlorthalidonenegative
FACET, 1997     amlodipinefosinoprilRisk of bias suggesting
ACCOMPLISH, 2008        NCTamlodipine plus benazeprilhydrochlorothiazide plus benazeprilLow risk of bias suggesting
ALLHAT (CCB vs ACEI), 2002     amlodipinelisinoprilsuggesting
AASK (amlodipine vs metoprolol), 2002     amlodipinemetoprololnegative
atenolol
Coope, 1986   atenololcontrol suggesting
Coope (subgroup ), 1986   atenololcontrolLow risk of bias negative
MRC old (vs placebo), 1992   atenololplaceboLow risk of bias negative
MRC I (vs placebo), 1985   atenololplaceboLow risk of bias suggesting
Dutch TIA, 1993   atenololplaceboLow risk of bias suggesting
TEST, 1995   atenololplacebonegative
MRC I (vs diuretics), 1985   atenololbendroflumethiazideLow risk of bias negative
MRC old (vs diuretics), 1992   atenololhydrochlorothiazide+amilorideLow risk of bias negative
candesartan
Takahashi, 2006     candesartancontrolExploratory negative
E-COST, 2005     candesartanconventional treatmentRisk of bias suggesting
E-COST-R, 2005     candesartanconventional treatmentRisk of bias negative
HIJ-CREATE, 2009     candesartanconventional treatmentRisk of bias suggesting
SCOPE, 2003   candesartanplaceboLow risk of bias negative
TROPHY, 2006      NCTcandesartanplaceboLow risk of bias suggesting
HSCS, 1974   deserpidine +methylclothiazideplaceboLow risk of bias negative
Takahashi et al, 2006     candesartanusual caresuggesting
Suzuki et al, 2008     candesartanusual caresuggesting
CASE-J, 2008     candesartanamlodipineRisk of bias suggesting
ALPINE, 2003   candesartanhydrochlorothiazideLow risk of bias suggesting
captopril
UKPDS 38, 1998     captopril or atenololcontrolExploratory suggesting
UKPDS 39, 1998     captoprilatenololExploratory negative
CAPP (diabetic subgroup), 1999       captoprildiuretic and/or beta-blockersExploratory suggesting
UKPDS-HDS, 1998       captoprildiuretic or beta-blockernegative
CAPPP, 1999     captoprildiuretic or beta-blockerRisk of bias negative
carvedilol
Cice et al, 2003     carvedilolplacebosuggesting
Nakao et al, 2007   carvedilolplacebo -
chlorthalidone
SHEP (diabetic subgroup), 1996   chlorthalidoneplaceboLow risk of bias suggesting
VA-NHLBI, 1977   chlorthalidoneplacebonegative
SHEP, 1991      NCTchlorthalidoneplaceboLow risk of bias suggesting
SHEP-pilot, 1989   chlorthalidoneplaceboLow risk of bias negative
SHEP-P (subgroup ), 1989   chlorthalidoneplaceboLow risk of bias suggesting
SHEP (subgroup ), 1991   chlorthalidoneplaceboLow risk of bias suggesting
diltiazem
NORDIL, 2000     diltiazemdiuretic or beta-blockersuggesting
enalapril
ANBP2, 2003     enalaprildiureticsRisk of bias negative
ABCD (H), 1998     enalaprilnisoldipineLow risk of bias suggesting
fosinopril
Zannad et al, 2006     fosinoprilplaceboLow risk of bias negative
hydrochlorothiazide
EWPHE (subgroup ), 1985   hydrochlorothiazideplaceboLow risk of bias negative
Kuramoto, 1981   hydrochlorothiazide + triamtereneplaceboLow risk of bias negative
EWPHE, 1985   hydrochlorothiazide + triamtereneplaceboLow risk of bias suggesting
indapamide
HYVET pilot, 2003   -
HYVET, 2008    NCTindapamideplaceboLow risk of bias suggesting
PATS, 1995   indapamideplaceboLow risk of bias negative
HAPPY, 1987   negative
intensive blood pressure lowering strategies
ABCD target (H) , 2000   more intensive blood pressure lowering strategieless intensive blood pressure lowering strategie type 2 diabetes suggesting
ABCD target (N) , 2002     more intensive blood pressure lowering strategieless intensive blood pressure lowering strategie type 2 diabetes suggesting
irbesartan
IPDM (150mg), 2001     irbesartanplaceboLow risk of bias suggesting
IDNT (irbesartan vs pbo), 2001     irbesartanplaceboLow risk of bias suggesting
IRMA 2, 2001     irbesartanplaceboLow risk of bias negative
IDNT (irbesartan vs pbo), 2001       irbesartanplaceboLow risk of bias negative
IDNT (irbesartan vs amlodipine), 2001     irbesartanamlodipineLow risk of bias suggesting
isradipine
MIDAS, 1996   isradipinehydrochlorothiazidenegative
lacidipine
ELSA, 2002     lacidipineatenololLow risk of bias -
SHELL, 2003   lacidipinechlorthalidone -
lisinopril
ALLHAT (ACEI vs amlodipine), 2002     lisinoprilamlodipineLow risk of bias suggesting
ALLHAT (lisi vs chlor, diabetic subgroup), 2002       lisinoprilchlorthalidoneLow risk of bias negative
ALLHAT (ACEI vs chlorthalidone), 2002     lisinoprildiureticsLow risk of bias negative
losartan
RENAAL, 2001     losartanplaceboLow risk of bias suggesting
RENAAL, 2001     losartanplaceboLow risk of bias -
LIFE (diabetic subgroup), 2002       losartanatenololLow risk of bias suggesting
LIFE, 2002     losartanatenololLow risk of bias suggesting
nicardipine
NICS-EH, 1999     nicardipinetrichlormethiazideLow risk of bias negative
nidrendipine
Syst-Eur (subgroup ), 1997     nidrendipineplaceboLow risk of bias negative
SYST-EUR, 1997     nitrendipineplacebosuggesting
Syst-Eur (diabetic subgroup), 1999     nitrendipineplaceboLow risk of bias suggesting
nifedipine
Castel, 1994   nifedipineatenolol+chlorthalidonenegative
INSIGHT (diabetic subgroup), 2000       nifedipinecoamilozideLow risk of bias negative
INSIGHT, 2000     nifedipinehydrochlorothiazide+amilorideLow risk of bias suggesting
nisoldipine
ABCD (hypertension), 1998     nisoldipineenalaprilLow risk of bias suggesting
oxprenolol
IPPPSH, 1985   oxprenololplaceboLow risk of bias negative
propranolol
Berglund, 1986   propranololbendroflumethiazidenegative
ramipril
Li et al, 2003     ramiprilusual carenegative
AASK (ramipril vs amlodipine), 2002     ramiprilamlodipineLow risk of bias negative
AASK (ramipril vs metoprolol), 2002     ramiprilmetoprololLow risk of bias negative
telmisartan
PROPHESS, 2008      NCTtelmisartanplaceboLow risk of bias negative
Cice et al, 2006   telmisartanplacebosuggesting
thiazid diuretic
ANBPS (Australian ), 1980     thiazide diureticscontrolLow risk of bias negative