anti hypertensive agents  

     

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Trial Studied trt Control trt patientstagsNCTROB Result

diabetes type 2

amlodipine
IDNT (amlodipine vs PBO), 2001amlodipineplaceboLow risk of bias negative
ALLHAT (amlodipine vs chlor, diabetic subgroup), 2002amlodipinechlorthalidoneLow risk of bias negative
FACET, 1997amlodipinefosinoprilRisk of bias suggesting
candesartan
SCOPE (diabetic subgroup), 2003candesartancontrolLow risk of bias negative
captopril
UKPDS 38, 1998captopril or atenololcontrolExploratory suggesting
UKPDS 39, 1998captoprilatenololExploratory negative
CAPP (diabetic subgroup), 1999captoprildiuretic and/or beta-blockersExploratory suggesting
chlorthalidone
SHEP (diabetic subgroup), 1996chlorthalidoneplaceboLow risk of bias suggesting
intensive blood pressure lowering strategies
ABCD target (H) , 2000more intensive blood pressure lowering strategieless intensive blood pressure lowering strategie type 2 diabetes suggesting
ABCD target (N) , 2002more intensive blood pressure lowering strategieless intensive blood pressure lowering strategie type 2 diabetes suggesting
irbesartan
IPDM (150mg), 2001irbesartanplaceboLow risk of bias suggesting
IDNT (irbesartan vs pbo), 2001irbesartanplaceboLow risk of bias suggesting
IDNT (irbesartan vs amlodipine), 2001irbesartanamlodipineLow risk of bias suggesting
lisinopril
ALLHAT (lisi vs chlor, diabetic subgroup), 2002lisinoprilchlorthalidoneLow risk of bias negative
losartan
RENAAL, 2001losartanplaceboLow risk of bias suggesting
LIFE (diabetic subgroup), 2002losartanatenololLow risk of bias suggesting
metoprolol
MERIT-HF, 2005metoprololplaceboLow risk of bias negative
nidrendipine
Syst-Eur (diabetic subgroup), 1999nitrendipineplaceboLow risk of bias suggesting
nifedipine
INSIGHT (diabetic subgroup), 2000nifedipinecoamilozideLow risk of bias negative
nisoldipine
ABCD (hypertension), 1998nisoldipineenalaprilLow risk of bias suggesting
olmesartan
ROADMAP, 2010olmesartanplaceboNCT00185159Low risk of bias suggesting
ORIENTolmesartanplaceboNCT00141453Low risk of bias negative
ramipril
DIABHYCAR, 2004ramiprilplaceboLow risk of bias negative
DREAM, 2008ramiprilplacebonegative

hypertension

aliskiren
ACCELERATE, 2011aliskiren amlodipine NCT00797862 -
AVOID, 2008aliskirenplaceboNCT00097955Low risk of bias negative
Schmieder (vs HCTZ), 2009aliskirenhydrochlorothiazideLow risk of bias negative
ALLAY, 2009aliskirenlosartanNCT00219141Exploratory negative
Andersen, 2008aliskirenramiprilLow risk of bias -
amlodipine
IDNT (amlodipine vs PBO), 2001amlodipineplaceboLow risk of bias negative
IDNT (amlodipine vs pbo), 2001amlodipineplaceboLow risk of bias negative
Tepel et al, 2008amlodipineplaceboNCT00124969Low risk of bias negative
ASCOT-BPLA, 2005amlodipineatenololRisk of bias suggesting
ALLHAT (amlodipine vs chlor, diabetic subgroup), 2002amlodipinechlorthalidoneLow risk of bias negative
ALLHAT (CCB vs diu), 2002amlodipinechlorthalidonenegative
FACET, 1997amlodipinefosinoprilRisk of bias suggesting
ACCOMPLISH, 2008amlodipine plus benazeprilhydrochlorothiazide plus benazeprilNCT00170950Low risk of bias suggesting
ALLHAT (CCB vs ACEI), 2002amlodipinelisinoprilsuggesting
AASK (amlodipine vs metoprolol), 2002amlodipinemetoprololnegative
atenolol
Coope, 1986atenololcontrol suggesting
Coope (subgroup ), 1986atenololcontrolLow risk of bias negative
MRC old (vs placebo), 1992atenololplaceboLow risk of bias negative
MRC I (vs placebo), 1985atenololplaceboLow risk of bias suggesting
Dutch TIA, 1993atenololplaceboLow risk of bias suggesting
TEST, 1995atenololplacebonegative
MRC I (vs diuretics), 1985atenololbendroflumethiazideLow risk of bias negative
MRC old (vs diuretics), 1992atenololhydrochlorothiazide+amilorideLow risk of bias negative
candesartan
Takahashi, 2006candesartancontrolExploratory negative
E-COST, 2005candesartanconventional treatmentRisk of bias suggesting
E-COST-R, 2005candesartanconventional treatmentRisk of bias negative
HIJ-CREATE, 2009candesartanconventional treatmentRisk of bias suggesting
SCOPE, 2003candesartanplaceboLow risk of bias negative
TROPHY, 2006candesartanplaceboNCT00227318Low risk of bias suggesting
HSCS, 1974deserpidine +methylclothiazideplaceboLow risk of bias negative
Takahashi et al, 2006candesartanusual caresuggesting
Suzuki et al, 2008candesartanusual caresuggesting
CASE-J, 2008candesartanamlodipineRisk of bias suggesting
ALPINE, 2003candesartanhydrochlorothiazideLow risk of bias suggesting
captopril
UKPDS 38, 1998captopril or atenololcontrolExploratory suggesting
UKPDS 39, 1998captoprilatenololExploratory negative
CAPP (diabetic subgroup), 1999captoprildiuretic and/or beta-blockersExploratory suggesting
UKPDS-HDS, 1998captoprildiuretic or beta-blockernegative
CAPPP, 1999captoprildiuretic or beta-blockerRisk of bias negative
carvedilol
Cice et al, 2003carvedilolplacebosuggesting
Nakao et al, 2007carvedilolplacebo -
chlorthalidone
SHEP (diabetic subgroup), 1996chlorthalidoneplaceboLow risk of bias suggesting
VA-NHLBI, 1977chlorthalidoneplacebonegative
SHEP, 1991chlorthalidoneplaceboNCT00000514Low risk of bias suggesting
SHEP-pilot, 1989chlorthalidoneplaceboLow risk of bias negative
SHEP-P (subgroup ), 1989chlorthalidoneplaceboLow risk of bias suggesting
SHEP (subgroup ), 1991chlorthalidoneplaceboLow risk of bias suggesting
diltiazem
NORDIL, 2000diltiazemdiuretic or beta-blockersuggesting
enalapril
ANBP2, 2003enalaprildiureticsRisk of bias negative
ABCD (H), 1998enalaprilnisoldipineLow risk of bias suggesting
fosinopril
Zannad et al, 2006fosinoprilplaceboLow risk of bias negative
hydrochlorothiazide
EWPHE (subgroup ), 1985hydrochlorothiazideplaceboLow risk of bias negative
Kuramoto, 1981hydrochlorothiazide + triamtereneplaceboLow risk of bias negative
EWPHE, 1985hydrochlorothiazide + triamtereneplaceboLow risk of bias suggesting
indapamide
HYVET pilot, 2003 -
HYVET, 2008indapamideplaceboNCT00122811Low risk of bias suggesting
PATS, 1995indapamideplaceboLow risk of bias negative
HAPPY, 1987negative
intensive blood pressure lowering strategies
ABCD target (H) , 2000more intensive blood pressure lowering strategieless intensive blood pressure lowering strategie type 2 diabetes suggesting
ABCD target (N) , 2002more intensive blood pressure lowering strategieless intensive blood pressure lowering strategie type 2 diabetes suggesting
irbesartan
IPDM (150mg), 2001irbesartanplaceboLow risk of bias suggesting
IDNT (irbesartan vs pbo), 2001irbesartanplaceboLow risk of bias suggesting
IRMA 2, 2001irbesartanplaceboLow risk of bias negative
IDNT (irbesartan vs pbo), 2001irbesartanplaceboLow risk of bias negative
IDNT (irbesartan vs amlodipine), 2001irbesartanamlodipineLow risk of bias suggesting
isradipine
MIDAS, 1996isradipinehydrochlorothiazidenegative
lacidipine
ELSA, 2002lacidipineatenololLow risk of bias -
SHELL, 2003lacidipinechlorthalidone -
lisinopril
ALLHAT (ACEI vs amlodipine), 2002lisinoprilamlodipineLow risk of bias suggesting
ALLHAT (lisi vs chlor, diabetic subgroup), 2002lisinoprilchlorthalidoneLow risk of bias negative
ALLHAT (ACEI vs chlorthalidone), 2002lisinoprildiureticsLow risk of bias negative
losartan
RENAAL, 2001losartanplaceboLow risk of bias suggesting
RENAAL, 2001losartanplaceboLow risk of bias -
LIFE (diabetic subgroup), 2002losartanatenololLow risk of bias suggesting
LIFE, 2002losartanatenololLow risk of bias suggesting
nicardipine
NICS-EH, 1999nicardipinetrichlormethiazideLow risk of bias negative
nidrendipine
Syst-Eur (subgroup ), 1997nidrendipineplaceboLow risk of bias negative
SYST-EUR, 1997nitrendipineplacebosuggesting
Syst-Eur (diabetic subgroup), 1999nitrendipineplaceboLow risk of bias suggesting
nifedipine
Castel, 1994nifedipineatenolol+chlorthalidonenegative
INSIGHT (diabetic subgroup), 2000nifedipinecoamilozideLow risk of bias negative
INSIGHT, 2000nifedipinehydrochlorothiazide+amilorideLow risk of bias suggesting
nisoldipine
ABCD (hypertension), 1998nisoldipineenalaprilLow risk of bias suggesting
oxprenolol
IPPPSH, 1985oxprenololplaceboLow risk of bias negative
propranolol
Berglund, 1986propranololbendroflumethiazidenegative
ramipril
Li et al, 2003ramiprilusual carenegative
AASK (ramipril vs amlodipine), 2002ramiprilamlodipineLow risk of bias negative
AASK (ramipril vs metoprolol), 2002ramiprilmetoprololLow risk of bias negative
telmisartan
PROPHESS, 2008telmisartanplaceboNCT00153062Low risk of bias negative
Cice et al, 2006telmisartanplacebosuggesting
thiazid diuretic
ANBPS (Australian ), 1980thiazide diureticscontrolLow risk of bias negative
Oslo (Hegeland), 1980thiazide diureticscontrolnegative
Carter, 1970thiazide diureticscontrolsuggesting
MCR 35-64 (diuretics vs pbo), 1985thiazide diureticsplacebosuggesting
various ACEI
STOP-2 (ACEI vs felodipine or isradipine), 1999various ACEIcalcium-channel blockersuggesting
STOP 2 (ACEI vs diurectic or beta-blocker), 1999various ACEIdiuretic or beta-blockersuggesting
JMIC-B, 2002various ACEInifedipine -
various beta blockers
STOP, 1991various beta-blockersplaceboLow risk of bias suggesting
HAPPHY, 1988various beta-blockersdiureticsnegative
Yurenev, 1992various beta-blockersdiureticsnegative
various diuretics
HDFP, 1979High-dose diureticscontrolNCT00000485suggesting
VA-I, 1967High-dose diureticsplacebosuggesting
VA II, 1970High-dose diureticsplacebosuggesting
Barraclough, 1973High-dose diureticsplacebonegative
MRC (diu vs BB), 1985High-dose diureticsbeta-blockers -
verapamil
INVEST (Pepine), 2003verapamilatenololNCT00133692negative
VHAS, 1998verapamilchlorthalidonenegative
CONVINCE, 2003verapamildiuretic or beta-blockerLow risk of bias negative

post stroke

telmisartan
PROFESS, 2008telmisartanplacebo -