antiarrythmic drugs

Amiodarone - Dronedarone - Flecainide - Lidocaine - Propafenone      

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Trial Studied trt Control trt patientstagsNCTROB Result

acute myocardial infarction

dofetilide
DIAMOND MI, 1997dofetilideplacebo -
magnesium
ISIS-4, 1995magnesiumcontrolsuggesting
Wu, 1992magnesiumcontrolsuggesting
Zhu, 2002magnesiumcontrolsuggesting
Abraham, 1987magnesiumplacebonegative
MAGIC, 2000magnesiumplaceboNCT00000610negative
Bhargava, 1995magnesiumplacebosuggesting
Ceremuzynski, 1989magnesiumplacebosuggesting
Chen, 1991magnesiumplacebosuggesting
Feldstedt, 1991magnesiumplacebonegative
Gyamlani, 2000magnesiumplacebosuggesting
Ising, 1990magnesiumplacebo -
Morton, 1984magnesiumplacebonegative
Nakashima, 2004magnesiumplacebonegative
Parikka, 1990magnesiumplacebonegative
Raghu, 1999magnesiumplacebosuggesting
Rasmussen, 1986magnesiumplacebonegative
Santoro, 2000magnesiumplacebonegative
Shechter, 1990magnesiumplacebosuggesting
Shechter, 1991magnesiumplacebonegative
Shechter, 1995magnesiumplacebosuggesting
Singh, 1990magnesiumplacebosuggesting
Smith, 1986magnesiumplacebonegative
Thogersen, 1995magnesiumplacebonegative
Urek, 1996magnesiumplacebonegative
Woods, 1992magnesiumplacebosuggesting
moricizine
CAST II (early treatment), 1992moricizineplacebo -

atrial fibrillation

amiodarone
Channer, 2004amiodaroneplacebosuggesting
GEFACA, 2001amiodaroneplacebosuggesting
Kochiadakis (amiodarone vs placebo), 2000amiodaroneplacebosuggesting
SAFE-T (amiodarone vs placebo), 2005amiodaroneplaceboLow risk of bias suggesting
AFFIRM Substudy (amiodarone vs class I drugs), 2003amiodaroneclass I drugsRisk of bias suggesting
AFFIRM Substudy (sotalol vs class I drugs), 2003amiodaroneclass I drugs -
Villani, 1992amiodaronedisopyramidesuggesting
Kochiadakis a, 2004amiodaronepropafenonenegative
Vitolo, 1981amiodaronequinidinesuggesting
AFFIRM Substudy (amiodarone vs sotalol), 2003amiodaronesotalolsuggesting
Kochiadakis (amiodarone vs sotalol), 2000amiodaronesotalol -
SAFE-T (amiodarone vs sotalol), 2005amiodaronesotalol -
Azimilide
ASAP, 2003Azimilideplacebonegative
disopyramide
Karlson, 1998disopyramideplacebonegative
Lloyd (Disopyramide vs placebo), 1984disopyramideplacebonegative
PRODIS, 1996disopyramidepropafenonenegative
Lloyd (Disopyramide vs quinidine), 1984disopyramidequinidine -
dofetilide
DIAMOND, 2001dofetilideplacebosuggesting
SAFIRE-D, 2000dofetilideplacebosuggesting
dronedarone
EURIDIS, 2007dronedaroneplaceboNCT00259428Low risk of bias suggesting
ADONIS, 2007dronedaroneplaceboNCT00259376Low risk of bias suggesting
DAFNE, 2003dronedaroneplacebosuggesting
EURIDIS ADONIS (pooled analysis), 2009dronedaroneplacebonegative
ATHENA, 2009dronedaroneplaceboNCT00174785Low risk of bias suggesting
PALLAS, 2011dronedaroneplaceboNCT01151137Low risk of bias negative
ERATO, 2008dronedaroneplacebo18760136Exploratory negative
DIONISOS, 2007dronedaroneamiodaroneNCT00489736suggesting
flecainide
Van Gelder, 1989flecainideno treatmentnegative
Carunchio (flecainide vs placebo), 1995flecainideplacebosuggesting
Steinbeck (flecainide vs digoxin), 1988flecainidedigoxinsuggesting
Aliot, 1996flecainidepropafenonesuggesting
Naccarelli, 1996flecainidequinidinenegative
metoprolol
Kuhlkamp, 2000metoprololplacebonegative
propafenone
Bellandi (propafenone vs placebo), 2001propafenoneplacebosuggesting
Dogan, 2004propafenoneplacebosuggesting
Kochiadakis b (propafenone vs placebo), 2004propafenoneplacebosuggesting
RAFT, 2003propafenoneplacebosuggesting
Stroobandt, 1997propafenoneplacebonegative
FAPIS, 1996propafenoneflecainidenegative
Richiardi, 1992propafenonequinidinenegative
Reimold, 1993propafenonesotalolnegative
quinidine
Hillestad, 1971quinidineno treatmentnegative
Sodermark, 1975quinidineno treatmentsuggesting
Lloyd (quinidine vs placebo), 1984quinidineplacebonegative
PAFAC (quinidine vs placebo), 2004quinidineplacebosuggesting
SOPAT (quinidine vs placebo), 2004quinidineplacebosuggesting
Byrne Quinn, 1979quinidineplacebosuggesting
Steinbeck (quinidine vs digoxin), 1988quinidinedigoxinnegative
Lloyd (quinidine vs disopyramide), 1984quinidinedisopyramide -
Steinbeck (quinidine vs flecainide), 1988quinidineflecainide -
Hohnloser, 1995quinidinesotalolnegative
Juul-Moller, 1990quinidinesotalolnegative
Kalusche, 1994quinidinesotalolnegative
SOCESP, 1999quinidinesotalolnegative
PAFAC (quinidine vs sotalol), 2004quinidinesotalol -
SOPAT (quinidine vs sotalol), 2004quinidinesotalol -
sotalol
Benditt, 1999sotalolplacebonegative
Singh, 1991sotalolplacebosuggesting
Bellandi (sotalol vs placebo), 2001sotalolplacebosuggesting
Carunchio (sotalol vs placebo), 1995sotalolplacebosuggesting
Kochiadakis (sotalol vs placebo), 2000sotalolplacebo -
Kochiadakis b (sotalol vs placebo), 2004sotalolplacebosuggesting
PAFAC (sotalol vs placebo), 2004sotalolplacebosuggesting
SAFE-T (sotalol vs placebo), 2005sotalolplacebosuggesting
SOPAT (sotalol vs placebo), 2004sotalolplacebonegative
Plewan, 2001sotalolbisoprololnegative
Carunchio (sotalol vs flecianide), 1995sotalolflecainide -
Kochiadakis b (sotalol vs propafenome), 2004sotalolpropafenone -

cardiac arrest

amiodarone
ARREST, 1999amiodaroneplacebosuggesting
ALIVE, 2002amiodaronelidocainesuggesting

heart failure

amiodarone
EPAMSA, 1985amiodaroneno treatmentsuggesting
GESICA, 1994amiodaroneno treatmentsuggesting
Hamer, 1989amiodaroneplacebosuggesting
Nicklas, 1991amiodaroneplacebonegative
STATCHF, 1995amiodaroneplacebonegative
AMIOVIRT, 2003amiodaroneICDnegative
dronedarone
ANDROMEDA, 2008dronedaroneplaceboNCT00543699negative

post myocardial infarction

amiodarone
BASIS, 1990early amiodaronecontrolsuggesting
Navarro-Lopez, 1993early amiodaronecontrolnegative
CAMIAT , 1991early amiodaroneplacebonegative
Ceremuzynski, 1992early amiodaroneplacebonegative
Hockings, 1987early amiodaroneplacebonegative
Azimilide
ALIVE, 2004azimilideplacebo -
dofetilide
DIAMOND MI, 1997dofetilideplacebo -
moricizine
CAST II (early treatment), 1992moricizineplacebo -
CAST II (late treatment), 1992moricizineplacebo -