antiarrythmic drugs  

Amiodarone - Dronedarone - Flecainide - Lidocaine - Propafenone      

Select
Display
Trial Studied trt Control trt patientstagsNCTROB Result

acute myocardial infarction

dofetilide
DIAMOND MI, 1997dofetilideplaceboLow risk of bias -
magnesium
ISIS-4, 1995magnesiumcontrolsuggesting
Wu, 1992magnesiumcontrolLow risk of bias suggesting
Zhu, 2002magnesiumcontrolsuggesting
Abraham, 1987magnesiumplaceboLow risk of bias negative
MAGIC, 2000magnesiumplaceboNCT00000610Low risk of bias negative
Bhargava, 1995magnesiumplaceboLow risk of bias suggesting
Ceremuzynski, 1989magnesiumplacebosuggesting
Chen, 1991magnesiumplacebosuggesting
Feldstedt, 1991magnesiumplaceboLow risk of bias negative
Gyamlani, 2000magnesiumplaceboLow risk of bias suggesting
Ising, 1990magnesiumplacebo -
Morton, 1984magnesiumplaceboLow risk of bias negative
Nakashima, 2004magnesiumplaceboLow risk of bias negative
Parikka, 1990magnesiumplaceboLow risk of bias negative
Raghu, 1999magnesiumplaceboLow risk of bias suggesting
Rasmussen, 1986magnesiumplaceboLow risk of bias negative
Santoro, 2000magnesiumplaceboLow risk of bias negative
Shechter, 1990magnesiumplaceboLow risk of bias suggesting
Shechter, 1991magnesiumplaceboLow risk of bias negative
Shechter, 1995magnesiumplaceboLow risk of bias suggesting
Singh, 1990magnesiumplaceboLow risk of bias suggesting
Smith, 1986magnesiumplaceboLow risk of bias negative
Thogersen, 1995magnesiumplaceboLow risk of bias negative
Urek, 1996magnesiumplaceboLow risk of bias negative
Woods, 1992magnesiumplaceboLow risk of bias suggesting
moricizine
CAST II (early treatment), 1992moricizineplaceboLow risk of bias -

atrial fibrillation

amiodarone
Channer, 2004amiodaroneplaceboLow risk of bias suggesting
GEFACA, 2001amiodaroneplaceboLow risk of bias suggesting
Kochiadakis (amiodarone vs placebo), 2000amiodaroneplacebosuggesting
SAFE-T (amiodarone vs placebo), 2005amiodaroneplaceboLow risk of bias suggesting
AFFIRM Substudy (amiodarone vs class I drugs), 2003amiodaroneclass I drugsRisk of bias suggesting
AFFIRM Substudy (sotalol vs class I drugs), 2003amiodaroneclass I drugs -
Villani, 1992amiodaronedisopyramidesuggesting
Kochiadakis a, 2004amiodaronepropafenonenegative
Vitolo, 1981amiodaronequinidinesuggesting
AFFIRM Substudy (amiodarone vs sotalol), 2003amiodaronesotalolsuggesting
Kochiadakis (amiodarone vs sotalol), 2000amiodaronesotalol -
SAFE-T (amiodarone vs sotalol), 2005amiodaronesotalolLow risk of bias -
Azimilide
ASAP, 2003AzimilideplaceboLow risk of bias negative
disopyramide
Karlson, 1998disopyramideplacebonegative
Lloyd (Disopyramide vs placebo), 1984disopyramideplaceboLow risk of bias negative
PRODIS, 1996disopyramidepropafenoneLow risk of bias negative
Lloyd (Disopyramide vs quinidine), 1984disopyramidequinidineLow risk of bias -
dofetilide
DIAMOND, 2001dofetilideplaceboLow risk of bias suggesting
SAFIRE-D, 2000dofetilideplaceboLow risk of bias suggesting
dronedarone
EURIDIS, 2007dronedaroneplaceboNCT00259428Low risk of bias suggesting
ADONIS, 2007dronedaroneplaceboNCT00259376Low risk of bias suggesting
DAFNE, 2003dronedaroneplaceboLow risk of bias suggesting
EURIDIS ADONIS (pooled analysis), 2009dronedaroneplaceboLow risk of bias negative
ATHENA, 2009dronedaroneplaceboNCT00174785Low risk of bias suggesting
PALLAS, 2011dronedaroneplaceboNCT01151137Low risk of bias negative
ERATO, 2008dronedaroneplacebo18760136Low risk of bias negative
DIONISOS, 2007dronedaroneamiodaroneNCT00489736Low risk of bias suggesting
flecainide
Van Gelder, 1989flecainideno treatmentnegative
Carunchio (flecainide vs placebo), 1995flecainideplacebosuggesting
Steinbeck (flecainide vs digoxin), 1988flecainidedigoxinsuggesting
Aliot, 1996flecainidepropafenonesuggesting
Naccarelli, 1996flecainidequinidineLow risk of bias negative
metoprolol
Kuhlkamp, 2000metoprololplacebonegative
propafenone
Bellandi (propafenone vs placebo), 2001propafenoneplaceboLow risk of bias suggesting
Dogan, 2004propafenoneplacebosuggesting
Kochiadakis b (propafenone vs placebo), 2004propafenoneplacebosuggesting
RAFT, 2003propafenoneplaceboLow risk of bias suggesting
Stroobandt, 1997propafenoneplaceboLow risk of bias negative
FAPIS, 1996propafenoneflecainidenegative
Richiardi, 1992propafenonequinidinenegative
Reimold, 1993propafenonesotalolnegative
quinidine
Hillestad, 1971quinidineno treatmentnegative
Sodermark, 1975quinidineno treatmentsuggesting
Lloyd (quinidine vs placebo), 1984quinidineplaceboLow risk of bias negative
PAFAC (quinidine vs placebo), 2004quinidineplaceboLow risk of bias suggesting
SOPAT (quinidine vs placebo), 2004quinidineplaceboLow risk of bias suggesting
Byrne Quinn, 1979quinidineplaceboLow risk of bias suggesting
Steinbeck (quinidine vs digoxin), 1988quinidinedigoxinnegative
Lloyd (quinidine vs disopyramide), 1984quinidinedisopyramideLow risk of bias -
Steinbeck (quinidine vs flecainide), 1988quinidineflecainide -
Hohnloser, 1995quinidinesotalolnegative
Juul-Moller, 1990quinidinesotalolnegative
Kalusche, 1994quinidinesotalolnegative
SOCESP, 1999quinidinesotalolnegative
PAFAC (quinidine vs sotalol), 2004quinidinesotalolLow risk of bias -
SOPAT (quinidine vs sotalol), 2004quinidinesotalolLow risk of bias -
sotalol
Benditt, 1999sotalolplaceboLow risk of bias negative
Singh, 1991sotalolplaceboLow risk of bias suggesting
Bellandi (sotalol vs placebo), 2001sotalolplaceboLow risk of bias suggesting
Carunchio (sotalol vs placebo), 1995sotalolplacebosuggesting
Kochiadakis (sotalol vs placebo), 2000sotalolplacebo -
Kochiadakis b (sotalol vs placebo), 2004sotalolplacebosuggesting
PAFAC (sotalol vs placebo), 2004sotalolplaceboLow risk of bias suggesting
SAFE-T (sotalol vs placebo), 2005sotalolplaceboLow risk of bias suggesting
SOPAT (sotalol vs placebo), 2004sotalolplaceboLow risk of bias negative
Plewan, 2001sotalolbisoprololnegative
Carunchio (sotalol vs flecianide), 1995sotalolflecainide -
Kochiadakis b (sotalol vs propafenome), 2004sotalolpropafenone -

cardiac arrest

amiodarone
ARREST, 1999amiodaroneplaceboLow risk of bias suggesting
ALIVE, 2002amiodaronelidocaineLow risk of bias suggesting

heart failure

amiodarone
EPAMSA, 1985amiodaroneno treatmentsuggesting
GESICA, 1994amiodaroneno treatmentsuggesting
Hamer, 1989amiodaroneplaceboLow risk of bias suggesting
Nicklas, 1991amiodaroneplaceboLow risk of bias negative
STATCHF, 1995amiodaroneplaceboLow risk of bias negative
AMIOVIRT, 2003amiodaroneICDnegative
dronedarone
ANDROMEDA, 2008dronedaroneplaceboNCT00543699Low risk of bias negative

post myocardial infarction

amiodarone
BASIS, 1990early amiodaronecontrolsuggesting
Navarro-Lopez, 1993early amiodaronecontrolnegative
CAMIAT , 1991early amiodaroneplaceboLow risk of bias negative
Ceremuzynski, 1992early amiodaroneplaceboLow risk of bias negative
Hockings, 1987early amiodaroneplaceboLow risk of bias negative
Azimilide
ALIVE, 2004azimilideplaceboLow risk of bias -
dofetilide
DIAMOND MI, 1997dofetilideplaceboLow risk of bias -
moricizine
CAST II (early treatment), 1992moricizineplaceboLow risk of bias -
CAST II (late treatment), 1992moricizineplaceboLow risk of bias -