antiarrythmic drugs

Amiodarone - Dronedarone - Flecainide - Lidocaine - Propafenone      

Select            
Trial Studied trt Control trt patientstagsROB Trial result

acute myocardial infarction

dofetilide
DIAMOND MI, 1997   dofetilideplaceboLow risk of bias -
magnesium
ISIS-4, 1995   magnesiumcontrolsuggesting
Wu, 1992   magnesiumcontrolLow risk of bias suggesting
Zhu, 2002   magnesiumcontrolsuggesting
Abraham, 1987   magnesiumplaceboLow risk of bias negative
MAGIC, 2000      NCTmagnesiumplaceboLow risk of bias negative
Bhargava, 1995     magnesiumplaceboLow risk of bias suggesting
Ceremuzynski, 1989   magnesiumplacebosuggesting
Chen, 1991   magnesiumplacebosuggesting
Feldstedt, 1991     magnesiumplaceboLow risk of bias negative
Gyamlani, 2000   magnesiumplaceboLow risk of bias suggesting
Ising, 1990   magnesiumplacebo -
Morton, 1984   magnesiumplaceboLow risk of bias negative
Nakashima, 2004     magnesiumplaceboLow risk of bias negative
Parikka, 1990     magnesiumplaceboLow risk of bias negative
Raghu, 1999     magnesiumplaceboLow risk of bias suggesting
Rasmussen, 1986   magnesiumplaceboLow risk of bias negative
Santoro, 2000   magnesiumplaceboLow risk of bias negative
Shechter, 1990     magnesiumplaceboLow risk of bias suggesting
Shechter, 1991   magnesiumplaceboLow risk of bias negative
Shechter, 1995     magnesiumplaceboLow risk of bias suggesting
Singh, 1990   magnesiumplaceboLow risk of bias suggesting
Smith, 1986   magnesiumplaceboLow risk of bias negative
Thogersen, 1995     magnesiumplaceboLow risk of bias negative
Urek, 1996   magnesiumplaceboLow risk of bias negative
Woods, 1992       magnesiumplaceboLow risk of bias suggesting
moricizine
CAST II (early treatment), 1992   moricizineplaceboLow risk of bias -

atrial fibrillation

amiodarone
Channer, 2004     amiodaroneplaceboLow risk of bias suggesting
GEFACA, 2001   amiodaroneplaceboLow risk of bias suggesting
Kochiadakis (amiodarone vs placebo), 2000       amiodaroneplacebosuggesting
SAFE-T (amiodarone vs placebo), 2005       amiodaroneplaceboLow risk of bias suggesting
AFFIRM Substudy (amiodarone vs class I drugs), 2003     amiodaroneclass I drugsRisk of bias suggesting
AFFIRM Substudy (sotalol vs class I drugs), 2003     amiodaroneclass I drugs -
Villani, 1992   amiodaronedisopyramidesuggesting
Kochiadakis a, 2004       amiodaronepropafenonenegative
Vitolo, 1981   amiodaronequinidinesuggesting
AFFIRM Substudy (amiodarone vs sotalol), 2003     amiodaronesotalolsuggesting
Kochiadakis (amiodarone vs sotalol), 2000     amiodaronesotalol -
SAFE-T (amiodarone vs sotalol), 2005     amiodaronesotalolLow risk of bias -
Azimilide
ASAP, 2003             AzimilideplaceboLow risk of bias negative
disopyramide
Karlson, 1998     disopyramideplacebonegative
Lloyd (Disopyramide vs placebo), 1984   disopyramideplaceboLow risk of bias negative
PRODIS, 1996   disopyramidepropafenoneLow risk of bias negative
Lloyd (Disopyramide vs quinidine), 1984   disopyramidequinidineLow risk of bias -
dofetilide
DIAMOND, 2001       dofetilideplaceboLow risk of bias suggesting
SAFIRE-D, 2000     dofetilideplaceboLow risk of bias suggesting
dronedarone
EURIDIS, 2007      NCTdronedaroneplaceboLow risk of bias suggesting
ADONIS, 2007    NCTdronedaroneplaceboLow risk of bias suggesting
DAFNE, 2003     dronedaroneplaceboLow risk of bias suggesting
EURIDIS ADONIS (pooled analysis), 2009   dronedaroneplaceboLow risk of bias negative
ATHENA, 2009      NCTdronedaroneplaceboLow risk of bias suggesting
PALLAS, 2011        NCTdronedaroneplaceboLow risk of bias negative
ERATO, 2008   dronedaroneplaceboLow risk of bias negative
DIONISOS, 2007      NCTdronedaroneamiodaroneLow risk of bias suggesting
flecainide
Van Gelder, 1989   flecainideno treatmentnegative
Carunchio (flecainide vs placebo), 1995   flecainideplacebosuggesting
Steinbeck (flecainide vs digoxin), 1988   flecainidedigoxinsuggesting
Aliot, 1996     flecainidepropafenonesuggesting
Naccarelli, 1996     flecainidequinidineLow risk of bias negative
metoprolol
Kuhlkamp, 2000     metoprololplacebonegative
propafenone
Bellandi (propafenone vs placebo), 2001     propafenoneplaceboLow risk of bias suggesting
Dogan, 2004   propafenoneplacebosuggesting
Kochiadakis b (propafenone vs placebo), 2004       propafenoneplacebosuggesting
RAFT, 2003     propafenoneplaceboLow risk of bias suggesting
Stroobandt, 1997     propafenoneplaceboLow risk of bias negative
FAPIS, 1996       propafenoneflecainidenegative
Richiardi, 1992   propafenonequinidinenegative
Reimold, 1993     propafenonesotalolnegative
quinidine
Hillestad, 1971     quinidineno treatmentnegative
Sodermark, 1975     quinidineno treatmentsuggesting
Lloyd (quinidine vs placebo), 1984   quinidineplaceboLow risk of bias negative
PAFAC (quinidine vs placebo), 2004       quinidineplaceboLow risk of bias suggesting
SOPAT (quinidine vs placebo), 2004       quinidineplaceboLow risk of bias suggesting
Byrne Quinn, 1979     quinidineplaceboLow risk of bias suggesting
Steinbeck (quinidine vs digoxin), 1988   quinidinedigoxinnegative
Lloyd (quinidine vs disopyramide), 1984   quinidinedisopyramideLow risk of bias -
Steinbeck (quinidine vs flecainide), 1988   quinidineflecainide -
Hohnloser, 1995     quinidinesotalolnegative
Juul-Moller, 1990   quinidinesotalolnegative
Kalusche, 1994   quinidinesotalolnegative
SOCESP, 1999     quinidinesotalolnegative
PAFAC (quinidine vs sotalol), 2004     quinidinesotalolLow risk of bias -
SOPAT (quinidine vs sotalol), 2004   quinidinesotalolLow risk of bias -
sotalol
Benditt, 1999     sotalolplaceboLow risk of bias negative
Singh, 1991   sotalolplaceboLow risk of bias suggesting
Bellandi (sotalol vs placebo), 2001   sotalolplaceboLow risk of bias suggesting
Carunchio (sotalol vs placebo), 1995   sotalolplacebosuggesting
Kochiadakis (sotalol vs placebo), 2000   sotalolplacebo -
Kochiadakis b (sotalol vs placebo), 2004     sotalolplacebosuggesting
PAFAC (sotalol vs placebo), 2004     sotalolplaceboLow risk of bias suggesting
SAFE-T (sotalol vs placebo), 2005       sotalolplaceboLow risk of bias suggesting
SOPAT (sotalol vs placebo), 2004   sotalolplaceboLow risk of bias negative
Plewan, 2001     sotalolbisoprololnegative
Carunchio (sotalol vs flecianide), 1995   sotalolflecainide -
Kochiadakis b (sotalol vs propafenome), 2004   sotalolpropafenone -

cardiac arrest

amiodarone
ARREST, 1999     amiodaroneplaceboLow risk of bias suggesting
ALIVE, 2002     amiodaronelidocaineLow risk of bias suggesting

heart failure

amiodarone
EPAMSA, 1985   amiodaroneno treatmentsuggesting
GESICA, 1994   amiodaroneno treatmentsuggesting
Hamer, 1989   amiodaroneplaceboLow risk of bias suggesting
Nicklas, 1991   amiodaroneplaceboLow risk of bias negative
STATCHF, 1995     amiodaroneplaceboLow risk of bias negative
AMIOVIRT, 2003     amiodaroneICDnegative
dronedarone
ANDROMEDA, 2008      NCTdronedaroneplaceboLow risk of bias negative

post myocardial infarction

amiodarone
BASIS, 1990   early amiodaronecontrolsuggesting
Navarro-Lopez, 1993   early amiodaronecontrolnegative
CAMIAT , 1991   early amiodaroneplaceboLow risk of bias negative
Ceremuzynski, 1992   early amiodaroneplaceboLow risk of bias negative
Hockings, 1987     early amiodaroneplaceboLow risk of bias negative
Azimilide
ALIVE, 2004       azimilideplaceboLow risk of bias -
dofetilide
DIAMOND MI, 1997   dofetilideplaceboLow risk of bias -
moricizine
CAST II (early treatment), 1992   moricizineplaceboLow risk of bias -
CAST II (late treatment), 1992   moricizineplaceboLow risk of bias -