fibrinolysis

Alteplase - Anistreplase - APSAC - Lanoteplase - Reteplase - Rt-PA - Saruplase - Streptokinase - T-pa - Tenecteplase - Urokinase      

Select            
Trial Studied trt Control trt patientstagsROB Trial result

acute coronary syndrome

anistreplase
UNASEM, 1992   anistreplaseplaceboLow risk of bias -
t-pa
Nicklas, 1989   t-PAplaceboLow risk of bias negative
Gold, 1987   t-PAplaceboExploratory -
Williams, 1990   t-PAplaceboLow risk of bias negative
Freeman, 1992   t-PAplaceboLow risk of bias negative
van der Brand, 1991     t-PAplaceboLow risk of bias negative
charbonnier, 1992   t-PAplaceboLow risk of bias -
Ardissino, 1990     t-PAplaceboLow risk of bias negative
TIMI 3B, 1995     t-PAplaceboLow risk of bias -
Topol, 1988   t-PAplaceboExploratory negative
TIMI 3A, 1993   t-PAplaceboLow risk of bias -

acute myocardial infarction

anistreplase
TEAM 2, 1991   anistreplasestreptokinaseLow risk of bias -
APSAC
APSIM, 1989   APSACcontrolnegative
AIMS, 1988   APSACplaceboLow risk of bias suggesting
German Multicenter Trial, 1988   APSACplacebosuggesting
ISIS III (SK/APSAC), 1992   APSACstreptokinaseLow risk of bias negative
TEAM 3, 1992   APSACt-PALow risk of bias -
lanoteplase
InTIME-II, 2000   lanoteplaseaccelerated t-PALow risk of bias negative
reteplase
GUSTO III, 1997       reteplaseaccelerated t-PAnegative
RAPID-2, 1996     reteplaseaccelerated t-PAExploratory suggesting
INJECT, 1995   reteplasestreptokinaseLow risk of bias negative
saruplase
COMPASS, 1998   saruplasestreptokinaseLow risk of bias negative
PRIMI (vs SK), 1989   saruplasestreptokinaseLow risk of bias -
SESAM, 1997     saruplaset-PAExploratory negative
PRIMI (vs UK), 1989   saruplaseurokinaseLow risk of bias -
streptokinase
ISAM, 1986   streptokinaseplaceboLow risk of bias negative
ISIS-2 (SK), 1988   streptokinaseplaceboLow risk of bias suggesting
Western Washington Intravenous Trial, 1988    NCTstreptokinaseplacebonegative
GISSI I, 1986   streptokinaseplacebosuggesting
EMERAS (all delay), 1993   streptokinaseplaceboLow risk of bias negative
ISIS 2 pilot, 1987   streptokinaseplaceboLow risk of bias -
EMERAS (7-12h), 1993   streptokinaseplaceboLow risk of bias -
GUSTO tPA-SK Hiv, 1993   t-PA + streptokinasestreptokinasenegative
t-pa
ASSET, 1988   t-PAplaceboLow risk of bias suggesting
LATE, 1993   t-PAplaceboLow risk of bias negative
TAMI 6, 1992   t-PAplaceboLow risk of bias negative
COBALT, 1997     bolus t-PAaccelerated t-PALow risk of bias negative
TAPS, 1992   accelerated t-PAAPSACnegative
TIMI 4, 1994   accelerated t-PAAPSACLow risk of bias -
GUSTO tPA Hiv, 1993   accelerated t-PAstreptokinasesuggesting
GISSI II, 1990   t-PAstreptokinasesuggesting
International Study Group, 1990   t-PAstreptokinaseLow risk of bias suggesting
ISIS III (SK/tPA), 1992   t-PAstreptokinaseLow risk of bias suggesting
Centre Illinois, 1993   t-PAstreptokinase -
Cherng, 1992   t-PAstreptokinasenegative
ECSG, 1985   t-PAstreptokinasenegative
PAIMS, 1989   t-PAstreptokinase -
TIMI-1, 1987    NCTt-PAstreptokinaseLow risk of bias -
White, 1989   t-PAstreptokinaseLow risk of bias -
RAAMI, 1992   accelerated t-PAt-PA -
KAMIT, 1991   t-PA half doset-PAExploratory negative
TAMI 5 (t-PA vs uroK), 1991   t-PAurokinase -
tenecteplase
ASSENT-2, 1999     tenecteplaseaccelerated t-PALow risk of bias suggesting
urokinase
USIM, 1991   urokinasecontrol -

cardiac arrest

t-pa
Abu-Laban, 2002     t-PAplaceboLow risk of bias negative
tenecteplase
TROICA, 2008      NCTtenecteplaseplaceboLow risk of bias negative
TICA, 2004     tenecteplaseplaceboLow risk of bias negative

pulmonary embolism

candesartan
Tebbe, 2009     desmoteplasealteplaseExploratory -
rt-PA
PAIMS 2, 1992   rt-PAno fibrinolysisExploratory negative
Goldhaber, 1993   rt-PAno fibrinolysisExploratory negative
PIOPED, 1990     rt-PAplaceboLow risk of bias negative
Levine, 1990     rt-PAplaceboLow risk of bias negative
Konstantinides, 2002     rt-PAplaceboLow risk of bias negative
streptokinase
Tibbutt, 1974   streptokinaseno fibrinolysisExploratory negative
Ly, 1978   streptokinaseno fibrinolysisExploratory negative
Jerjes-Sanchez, 1995   streptokinaseno fibrinolysisExploratory -
urokinase
Marini, 1988   urokinaseno fibrinolysisExploratory -
UPET, 1973   urokinaseplaceboLow risk of bias negative

venous thrombosis

heparin
Schweizer tPA, 1998   tPA+heparinno fibrinolysisnegative
streptokinase
Arneson, 1978   streptokinaseno fibrinolysisnegative
Common, 1976     streptokinaseno fibrinolysisnegative
Elsharawy, 2002     streptokinaseno fibrinolysisnegative
Schulman, 1986   streptokinaseno fibrinolysisnegative
Tsapogas, 1973   streptokinaseno fibrinolysisnegative
Kakkar (streptokinase), 1969   streptokinaseno fibrinolysisnegative
Schweizer (systemic SK), 2000     streptokinaseno fibrinolysis -
t-pa
Goldhaber (tPA alone), 1990   tPAno fibrinolysisnegative
Schweizer (local tPA), 2000     tPAno fibrinolysis -
Turpie, 1990     tPAno fibrinolysisLow risk of bias negative
Verhaeghe (high dose), 1989   tPAno fibrinolysisLow risk of bias -
Goldhaber (tPA+heparin), 1990   tPAno fibrinolysis -
Verhaeghe (low dose), 1989   tPAno fibrinolysisLow risk of bias -
urokinase
Kiil, 1981   urokinaseno fibrinolysisLow risk of bias negative
Schweizer (urokinase), 1998   urokinaseno fibrinolysisnegative
Schweizer (local urokinase), 2000     urokinaseno fibrinolysis -
Schweizer (systemic urokinase), 2000     urokinaseno fibrinolysis -