fibrinolysis  

Alteplase - Anistreplase - APSAC - Lanoteplase - Reteplase - Rt-PA - Saruplase - Streptokinase - T-pa - Tenecteplase - Urokinase      

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Trial Studied trt Control trt patientstagsNCTROB Result

acute coronary syndrome

anistreplase
UNASEM, 1992anistreplaseplaceboLow risk of bias -
t-pa
Nicklas, 1989t-PAplaceboLow risk of bias negative
Gold, 1987t-PAplaceboExploratory -
Williams, 1990t-PAplaceboLow risk of bias negative
Freeman, 1992t-PAplaceboLow risk of bias negative
van der Brand, 1991t-PAplaceboLow risk of bias negative
charbonnier, 1992t-PAplaceboLow risk of bias -
Ardissino, 1990t-PAplaceboLow risk of bias negative
TIMI 3B, 1995t-PAplaceboLow risk of bias -
Topol, 1988t-PAplaceboExploratory negative
TIMI 3A, 1993t-PAplaceboLow risk of bias -

acute myocardial infarction

anistreplase
TEAM 2, 1991anistreplasestreptokinaseLow risk of bias -
APSAC
APSIM, 1989APSACcontrolnegative
AIMS, 1988APSACplaceboLow risk of bias suggesting
German Multicenter Trial, 1988APSACplacebosuggesting
ISIS III (SK/APSAC), 1992APSACstreptokinaseLow risk of bias negative
TEAM 3, 1992APSACt-PALow risk of bias -
lanoteplase
InTIME-II, 2000lanoteplaseaccelerated t-PALow risk of bias negative
reteplase
GUSTO III, 1997reteplaseaccelerated t-PAnegative
RAPID-2, 1996reteplaseaccelerated t-PAExploratory suggesting
INJECT, 1995reteplasestreptokinaseLow risk of bias negative
saruplase
COMPASS, 1998saruplasestreptokinaseLow risk of bias negative
PRIMI (vs SK), 1989saruplasestreptokinaseLow risk of bias -
SESAM, 1997saruplaset-PAExploratory negative
PRIMI (vs UK), 1989saruplaseurokinaseLow risk of bias -
streptokinase
ISAM, 1986streptokinaseplaceboLow risk of bias negative
ISIS-2 (SK), 1988streptokinaseplaceboLow risk of bias suggesting
Western Washington Intravenous Trial, 1988streptokinaseplaceboNCT00000507negative
GISSI I, 1986streptokinaseplacebosuggesting
EMERAS (all delay), 1993streptokinaseplaceboLow risk of bias negative
ISIS 2 pilot, 1987streptokinaseplaceboLow risk of bias -
EMERAS (7-12h), 1993streptokinaseplaceboLow risk of bias -
GUSTO tPA-SK Hiv, 1993t-PA + streptokinasestreptokinasenegative
t-pa
ASSET, 1988t-PAplaceboLow risk of bias suggesting
LATE, 1993t-PAplaceboLow risk of bias negative
TAMI 6, 1992t-PAplaceboLow risk of bias negative
COBALT, 1997bolus t-PAaccelerated t-PALow risk of bias negative
TAPS, 1992accelerated t-PAAPSACnegative
TIMI 4, 1994accelerated t-PAAPSACLow risk of bias -
GUSTO tPA Hiv, 1993accelerated t-PAstreptokinasesuggesting
GISSI II, 1990t-PAstreptokinasesuggesting
International Study Group, 1990t-PAstreptokinaseLow risk of bias suggesting
ISIS III (SK/tPA), 1992t-PAstreptokinaseLow risk of bias suggesting
Centre Illinois, 1993t-PAstreptokinase -
Cherng, 1992t-PAstreptokinasenegative
ECSG, 1985t-PAstreptokinasenegative
PAIMS, 1989t-PAstreptokinase -
TIMI-1, 1987t-PAstreptokinaseNCT00000505Low risk of bias -
White, 1989t-PAstreptokinaseLow risk of bias -
RAAMI, 1992accelerated t-PAt-PA -
KAMIT, 1991t-PA half doset-PAExploratory negative
TAMI 5 (t-PA vs uroK), 1991t-PAurokinase -
tenecteplase
ASSENT-2, 1999tenecteplaseaccelerated t-PALow risk of bias suggesting
urokinase
USIM, 1991urokinasecontrol -

cardiac arrest

t-pa
Abu-Laban, 2002t-PAplaceboLow risk of bias negative
tenecteplase
TROICA, 2008tenecteplaseplaceboNCT00157261Low risk of bias negative
TICA, 2004tenecteplaseplaceboLow risk of bias negative

pulmonary embolism

candesartan
Tebbe, 2009desmoteplasealteplaseExploratory -
rt-PA
PAIMS 2, 1992rt-PAno fibrinolysisExploratory negative
Goldhaber, 1993rt-PAno fibrinolysisExploratory negative
PIOPED, 1990rt-PAplaceboLow risk of bias negative
Levine, 1990rt-PAplaceboLow risk of bias negative
Konstantinides, 2002rt-PAplaceboLow risk of bias negative
streptokinase
Tibbutt, 1974streptokinaseno fibrinolysisExploratory negative
Ly, 1978streptokinaseno fibrinolysisExploratory negative
Jerjes-Sanchez, 1995streptokinaseno fibrinolysisExploratory -
tenecteplase
PEITHO ongoing tenecteplaseplaceboNCT00639743Low risk of bias ongoing
urokinase
Marini, 1988urokinaseno fibrinolysisExploratory -
UPET, 1973urokinaseplaceboLow risk of bias negative

venous thrombosis

heparin
Schweizer tPA, 1998tPA+heparinno fibrinolysisnegative
streptokinase
Arneson, 1978streptokinaseno fibrinolysisnegative
Common, 1976streptokinaseno fibrinolysisnegative
Elsharawy, 2002streptokinaseno fibrinolysisnegative
Schulman, 1986streptokinaseno fibrinolysisnegative
Tsapogas, 1973streptokinaseno fibrinolysisnegative
Kakkar (streptokinase), 1969streptokinaseno fibrinolysisnegative
Schweizer (systemic SK), 2000streptokinaseno fibrinolysis -
t-pa
Goldhaber (tPA alone), 1990tPAno fibrinolysisnegative
Schweizer (local tPA), 2000tPAno fibrinolysis -
Turpie, 1990tPAno fibrinolysisLow risk of bias negative
Verhaeghe (high dose), 1989tPAno fibrinolysisLow risk of bias -
Goldhaber (tPA+heparin), 1990tPAno fibrinolysis -
Verhaeghe (low dose), 1989tPAno fibrinolysisLow risk of bias -
urokinase
Kiil, 1981urokinaseno fibrinolysisLow risk of bias negative
Schweizer (urokinase), 1998urokinaseno fibrinolysisnegative
Schweizer (local urokinase), 2000urokinaseno fibrinolysis -
Schweizer (systemic urokinase), 2000urokinaseno fibrinolysis -