inhibition of the renin-angiotensin system (ACEI or ARB)

     

Select            
Trial Studied trt Control trt patientstagsROB Trial result

heart failure

candesartan
CHARM preserved, 2003   candesartanplaceboLow risk of bias -
irbesartan
I-PRESERVE (McMurray), 2008      NCTibesartanplaceboLow risk of bias negative
perindopril
PEP CHF, 2006   perindoprilplaceboLow risk of bias negative

patients at high risk for cardiovascular events

enalapril
CAMELOT (enalapril), 2004     enalaprilplaceboLow risk of bias negative
perindopril
EUROPA, 2003     perindoprilplaceboLow risk of bias suggesting
quinapril
QUIET, 2001     quinaprilplaceboLow risk of bias negative
ramipril
HOPE, 2000     ramiprilplaceboLow risk of bias suggesting
ONTARGET (association vs ramipril), 2008    NCTtelmisartan + ramiprilramiprilLow risk of bias negative
ONTARGET (association vs telmisartan), 2008    NCTtelmisartan + ramipriltelmisartanLow risk of bias suggesting
telmisartan
TRANSCEND, 2008    NCTtelmisartanplaceboLow risk of bias suggesting
ONTARGET (telmisartan alone), 2008      NCTtelmisartanramiprilLow risk of bias suggesting
trandolapril
PEACE, 2004      NCTtrandolaprilplaceboLow risk of bias suggesting