inhibition of the renin-angiotensin system (ACEI or ARB)

     

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Trial Studied trt Control trt patientstagsNCTROB Result

heart failure

candesartan
CHARM preserved, 2003candesartanplaceboLow risk of bias -
irbesartan
I-PRESERVE (McMurray), 2008ibesartanplaceboNCT00095238Low risk of bias negative
perindopril
PEP CHF, 2006perindoprilplaceboLow risk of bias negative

patients at high risk for cardiovascular events

enalapril
CAMELOT (enalapril), 2004enalaprilplacebonegative
perindopril
EUROPA, 2003perindoprilplacebosuggesting
quinapril
QUIET, 2001quinaprilplacebonegative
ramipril
HOPE, 2000ramiprilplacebosuggesting
ONTARGET (association vs ramipril), 2008telmisartan + ramiprilramiprilNCT00153101negative
ONTARGET (association vs telmisartan), 2008telmisartan + ramipriltelmisartanNCT00153101suggesting
telmisartan
TRANSCEND, 2008telmisartanplaceboNCT00153101Low risk of bias suggesting
ONTARGET (telmisartan alone), 2008telmisartanramiprilNCT00153101Low risk of bias suggesting
trandolapril
PEACE, 2004trandolaprilplaceboNCT00000558suggesting