Drug eluting stent

Biolimus eluting stent - Everolimus eluting stent - Paclitaxel eluting stent - Sirolimus eluting stent - Zotarolimus eluting stent      

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Trial Studied trt Control trt patientstagsROB Trial result

coronary artery disease

abciximab
Kim, 2010     abciximab-coated stentbare-metal stentExploratory -
biolimus eluting stent
LEADERS, 2008      NCTbiolimus eluting stentsirolimus eluting stentnegative
candesartan
SYNTAX (unprotected left main sub group), 2009     DESCABGRisk of bias suggesting
dactinomycin eluting stent
ACTION, 2004   dactinomycin eluting stentbare-metal stentsuggesting
drug-eluting stents
PASEO, 2009   drug-eluting stentsbare-metal stent -
DEDICATION, 2008      NCTdrug-eluting stentsbare-metal stentRisk of bias suggesting
GENIUS-STEMI, 2009     Genous stentbare-metal stentExploratory negative
Boudriot, 2008   DESCABGExploratory negative
FREEDOM, 2012      NCTPCI with drug-eluting stentsCABGRisk of bias negative
Hong, 2005     PCI withdrug-eluting stentsCABGRisk of bias -
everolimus eluting stent
FUTURE I, 2004     everolimus eluting stentbare-metal stentnegative
FUTURE II, 2006   everolimus eluting stentbare-metal stentLow risk of bias -
SPIRIT I, 2005    NCTeverolimus eluting stentbare-metal stentExploratory negative
BASKET-PROVE (EES), 2010   everolimus eluting stentbare-metal stentsuggesting
RESET, 2011    NCTeverolimus eluting stentsirolimus eluting stent -
PLATINUM, 2011      NCTeverolimus eluting stenteverolimus eluting stent -
SPIRIT II, 2006      NCTeverolimus eluting stentpaclitaxel eluting stentRisk of bias negative
SPIRIT IV, 2010          NCTeverolimus eluting stentpaclitaxel eluting stentRisk of bias suggesting
SPIRIT III, 2008        NCTeverolimus eluting stentpaclitaxel eluting stentExploratory suggesting
COMPARE, 2009        NCTeverolimus eluting stentpaclitaxel eluting stentRisk of bias suggesting
SPIRIT III (small vessel subgroup), 2009     everolimus eluting stentpaclitaxel eluting stentExploratory suggesting
SORT OUT IV, 2012      NCTeverolimus eluting stentsirolimus eluting stentRisk of bias -
ISAR-TEST 4 (EES vs SES)     everolimus eluting stentsirolimus eluting stentsuggesting
paclitaxel
ISAR-DESIRE (PES vs PTCA), 2005     paclitaxel eluting stentballoon angioplastysuggesting
TAXUS I, 2003     paclitaxel eluting stentbare-metal stentLow risk of bias negative
TAXUS II, 2003      NCTpaclitaxel eluting stentbare-metal stentLow risk of bias suggesting
TAXUS IV, 2004        NCTpaclitaxel eluting stentbare-metal stentLow risk of bias suggesting
SCORE, 2004   paclitaxel eluting stentbare-metal stentsuggesting
TAXUS V (all patients), 2005    NCTpaclitaxel eluting stentbare-metal stentLow risk of bias suggesting
TAXUS VI, 2005        NCTpaclitaxel eluting stentbare-metal stentLow risk of bias suggesting
PASSION, 2006     paclitaxel eluting stentbare-metal stentRisk of bias negative
HAAMU-STENT, 2006   paclitaxel eluting stentbare-metal stentExploratory negative
Erglis, 2007     paclitaxel eluting stentbare-metal stentsuggesting
HORIZONS-AMI Stent, 2008     paclitaxel eluting stentbare-metal stentsuggesting
TAXUS II (diabetics), 2003     paclitaxel eluting stentbare-metal stentLow risk of bias suggesting
TAXUS IV (diabetics), 2005      NCTpaclitaxel eluting stentbare-metal stentLow risk of bias suggesting
TAXUS V (diabetics), 2005   paclitaxel eluting stentbare-metal stentLow risk of bias suggesting
TAXUS VI (diabetics), 2005      NCTpaclitaxel eluting stentbare-metal stentLow risk of bias suggesting
SOS, 2008        NCTpaclitaxel eluting stentbare-metal stentExploratory suggesting
TAXUS V small vessels sub groups   paclitaxel eluting stentbare-metal stent -
ASPECT, 2003      NCTpaclitaxel, non-polymeric eluting stentbare-metal stentLow risk of bias suggesting
ELUTES, 2004     paclitaxel, non-polymeric eluting stentbare-metal stentnegative
DELIVER, 2004   paclitaxel, non-polymeric eluting stentbare-metal stentRisk of bias negative
PATENCY, 2002   paclitaxel, non-polymeric eluting stentbare-metal stentLow risk of bias negative
TAXUS V ISR, 2006      NCTpaclitaxel eluting balloonbrachytherapyRisk of bias -
SYNTAX, 2009          NCTpaclitaxel eluting stentCABGRisk of bias suggesting
ISAR-test (diabetics), 2006     paclitaxel eluting stentsirolimus eluting stentRisk of bias -
sirolimus eluting stent
ISAR-DESIRE (SES vs PTCA), 2005     sirolimus eluting stentballoon angioplastysuggesting
Kochiadakis, 2007     sirolimus eluting stentbare-metal stentExploratory -
RAVEL, 2002      NCTsirolimus eluting stentbare-metal stentLow risk of bias suggesting
SIRIUS, 2003            NCTsirolimus eluting stentbare-metal stentLow risk of bias suggesting
C-SIRIUS, 2004      NCTsirolimus eluting stentbare-metal stentLow risk of bias suggesting
E-SIRIUS, 2003      NCTsirolimus eluting stentbare-metal stentsuggesting
SES-SMART, 2004     sirolimus eluting stentbare-metal stentsuggesting
DIABETES, 2005       sirolimus eluting stentbare-metal stentsuggesting
Pache et al, 2005     sirolimus eluting stentbare-metal stentsuggesting
PRISON II, 2006      NCTsirolimus eluting stentbare-metal stentRisk of bias suggesting
SCANDSTENT, 2006      NCTsirolimus eluting stentbare-metal stentsuggesting
TYPHOON, 2006      NCTsirolimus eluting stentbare-metal stentsuggesting
SESAMI, 2007        NCTsirolimus eluting stentbare-metal stentRisk of bias suggesting
DECODE, 2005      NCTsirolimus eluting stentbare-metal stentsuggesting
SCORPIUS, 2007    NCTsirolimus eluting stentbare-metal stentsuggesting
MISSION, 2008   sirolimus eluting stentbare-metal stentRisk of bias suggesting
Ortolani et al, 2007     sirolimus eluting stentbare-metal stent -
Pasceri, 2003   sirolimus eluting stentbare-metal stent -
GISSOC II, 2010      NCTsirolimus eluting stentbare-metal stentExploratory suggesting
DEBATER (SES vs BMS), 2009   sirolimus eluting stentbare-metal stentsuggesting
BASKET-PROVE (SES), 2010   sirolimus eluting stentbare-metal stentRisk of bias suggesting
Ravel (diabetics), 2004     sirolimus eluting stentbare-metal stentsuggesting
SES-SMARt (diabetics), 2005     sirolimus eluting stentbare-metal stentsuggesting
DESSERT, 2008   sirolimus eluting stentbare-metal stentExploratory suggesting
SIRIUS (diabetics), 2003     sirolimus eluting stentbare-metal stentLow risk of bias -
Díaz de la Llera, 2007     sirolimus eluting stentbare-metal stent -
RRISC, 2006    NCTsirolimus eluting stentbare-metal stentRisk of bias suggesting
SCANDSTENT (subgroup), 2006     sirolimus eluting stentbare-metal stentExploratory suggesting
CRISTAL    NCTsirolimus eluting stentPTCA -
RIBS-II, 2008   sirolimus eluting stentPTCAsuggesting
SISR, 2007        NCTsirolimus eluting stentbrachytherapyRisk of bias suggesting
PRECOMBAT, 2011    NCTsirolimus eluting stentCABG -
Thiele, 2009    NCTPCI withsirolimus ESMIDCABRisk of bias -
Tomai, 2008     sirolimus eluting stentpaclitaxel eluting stent -
TAXi, 2005     sirolimus eluting stentpaclitaxel eluting stentRisk of bias negative
ISAR-DESIRE (SES vs PES), 2005     sirolimus eluting stentpaclitaxel eluting stentsuggesting
ISAR-DIABETES, 2005     sirolimus eluting stentpaclitaxel eluting stentnegative
SIRTAX (Windecker), 2005     sirolimus eluting stentpaclitaxel eluting stentRisk of bias suggesting
CORPAL, 2005   sirolimus eluting stentpaclitaxel eluting stentnegative
REALITY, 2006      NCTsirolimus eluting stentpaclitaxel eluting stentRisk of bias suggesting
ISAR-SMART 3, 2006      NCTsirolimus eluting stentpaclitaxel eluting stentnegative
Zhang (SES vs PES), 2006     sirolimus eluting stentpaclitaxel eluting stentExploratory negative
LONG DES II, 2006     sirolimus eluting stentpaclitaxel eluting stentRisk of bias suggesting
PROSIT, 2006   sirolimus eluting stentpaclitaxel eluting stentnegative
SORT OUT II, 2008      NCTsirolimus eluting stentpaclitaxel eluting stentnegative
Cervinka, 2006     sirolimus eluting stentpaclitaxel eluting stentnegative
Petronio et al, 2007     sirolimus eluting stentpaclitaxel eluting stentnegative
Han, 2006   sirolimus eluting stentpaclitaxel eluting stentnegative
BASKET (vs paclitaxel), 2005     sirolimus eluting stentpaclitaxel eluting stentnegative
Di Lorenzo et al., 2005     sirolimus eluting stentpaclitaxel eluting stentnegative
ISAR-TEST-1, 2006      NCTsirolimus eluting stentpaclitaxel eluting stentRisk of bias negative
ISAR-LEFT-MAIN, 2009      NCTsirolimus eluting stentpaclitaxel eluting stentnegative
Kim, 2008   sirolimus eluting stentpaclitaxel eluting stentnegative
Pan, 2007   sirolimus eluting stentpaclitaxel eluting stentExploratory suggesting
DES-DIABETES, 2008     sirolimus eluting stentpaclitaxel eluting stentRisk of bias suggesting
SIRTAX diabetics, 2005        NCTsirolimus eluting stentpaclitaxel eluting stent