All mechanism

     

Select            
Trial Studied trt Control trt patientstagsROB Trial resultAll cause deathhyperhemia or ocular redness

diabetic kidney disease

amlodipine
IDNT (amlodipine vs PBO), 2001       amlodipineplaceboLow risk of bias negative-12%
irbesartan
IPDM (150mg), 2001     irbesartanplaceboLow risk of bias suggesting
IDNT (irbesartan vs pbo), 2001     irbesartanplaceboLow risk of bias suggesting-8%
IDNT (irbesartan vs amlodipine), 2001     irbesartanamlodipineLow risk of bias suggesting4%
losartan
RENAAL, 2001     losartanplaceboLow risk of bias suggesting2%
olmesartan
ORIENT    NCTolmesartanplaceboLow risk of bias negative-4%
ramipril
DIABHYCAR, 2004     ramiprilplaceboLow risk of bias negative 4%

heart failure with preserved LVEF

candesartan
CHARM preserved, 2003   candesartanplaceboLow risk of bias -
irbesartan
I-PRESERVE (McMurray), 2008      NCTibesartanplaceboLow risk of bias negative2%
perindopril
PEP CHF, 2006   perindoprilplaceboLow risk of bias negative -10%

melanoma

Interferon alpha
EORTC18952 (Eggermont), 2005   ID IFN alpha-2b (I M)observationadjuvantnegative
Nordic IFN Trial, 2011     ID IFN alpha-2b (I M)observationadjuvantsuggesting
EORTC18991 (Eggermont), 2008   PEG IFN alpha-2b (I M)observationadjuvantsuggesting
EORTC18871/DKG 80-1 (Kleeberg), 2004   rIFN alpha-2bobservationadjuvantnegative
ipilimumab
EORTC 18071 (Eggermont), 2015        NCTipilimumabplaceboadjuvant adjuvant Low risk of bias conclusive
nivolumab
CheckMate 238, 2017      NCTnivolumabipilimumabadjuvant adjuvant Low risk of bias conclusive
pembrolizumab
KEYNOTE-054, 2018      NCTpembrolizumabplaceboadjuvant adjuvant Low risk of bias conclusive
trametinib + dabrafenib
COMBI-AD, 2017      NCTtrametinib and dabrafenibplaceboadjuvantLow risk of bias suggesting
COMBI neo, 2018      NCTtrametinib and dabrafenib SOCadjuvant -
vemurafenib
BRIM 8, 2018      NCTvemurafenibplaceboadjuvantsuggesting

obesity and overweight

Bupropion
Anderson, 2002     BupropionplaceboLow risk of bias -
Croft, 2002   Bupropionplacebo -
Jain, 2002     BupropionplaceboLow risk of bias -
liraglutide
Astrup (NN8022-1807 ), 2009    NCTliraglutideplaceboLow risk of bias -
lorcaserin
BLOSSOM (10mg bid), 2009      NCTlorcaserinplaceboLow risk of bias -
BLOOM, 2010    NCTlorcaserinplaceboLow risk of bias -
BLOOM-DM (10mg bid)    NCTlorcaserinplaceboLow risk of bias -
orlistat
Bakris, 2002     OrlistatplaceboLow risk of bias -
Broom, 2002   OrlistatplaceboLow risk of bias -
Broom,, 2001   Orlistatplacebo -
Davidson, 1999     OrlistatplaceboLow risk of bias -
Deerochanawong,, 2001   Orlistatplacebo -
Derosa, 2003     OrlistatplaceboLow risk of bias -
Gotfredsen, 2001     Orlistatplacebo -
Halpern, 2003     OrlistatplaceboLow risk of bias -
Hanefeld, 2002     Orlistatplacebo -
Hauptman, 2000     OrlistatplaceboLow risk of bias -
Hill, 1999     OrlistatplaceboLow risk of bias -
Hollander, 1998     Orlistatplacebo -
Karhunen, 2000   Orlistatplacebo -
Kelley, 2002     OrlistatplaceboLow risk of bias -
Krempf, 2005     Orlistatplacebo -
Lindgarde, 2000     Orlistatplacebo -
Lucas, 2003     Orlistatplacebo -
Micic, 1999   OrlistatplaceboLow risk of bias -
Miles, 2002     OrlistatplaceboLow risk of bias -
Muls, 2001     OrlistatplaceboLow risk of bias -
Naumov, 2002   Orlistatplacebo -
Reaven, 2001     Orlistatplacebo -
Rissanen, 2001     OrlistatplaceboLow risk of bias -
Rosenfalck, 2002     Orlistatplacebo -
Rossner, 2000     OrlistatplaceboLow risk of bias -
Shi Yi, 2001   Orlistatplacebo -
Sjostrom, 1998     OrlistatplaceboLow risk of bias -
Vidgren, 1999   Orlistatplacebo -
phentermine and topiramate
CONQUER (high-dose) (OB 303)      NCTPHEN/TPM high doseplacebo -
OB 302 (high-dose)   PHEN/TPM high doseplacebo -
OB 301 (high-dose)   PHEN/TPM high doseplacebo -
OB 302 (low-dose)   PHEN/TPM low-doseplacebo -
OB 301 (mid-dose)   PHEN/TPM mid-doseplacebo -
CONQUER (mid-dose) (OB 303)      NCTPHEN/TPM mid-doseplacebo -
Sibutramine
McMahon, 2000     Sibutramineplacebo -
McMahon, 2002   Sibutramineplacebo -
Smith, 2001     Sibutramineplacebo -
SCOUT, 2010        NCTsibutramineplaceboLow risk of bias -
topiramate
Bray, 2003     Topiramateplacebo -
Caterson, 2003   Topiramateplacebo -
Pud’homme, 2003   Topiramateplacebo -
Rissanen, 2003   Topiramateplacebo -
Stenlof, 2003   Topiramateplacebo -
Tonstad, 2003   Topiramateplacebo -