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Trial Studied trt Control trt patientstagsROB Trial result

diabetic kidney disease

amlodipine
IDNT (amlodipine vs PBO), 2001       amlodipineplaceboLow risk of bias negative
irbesartan
IPDM (150mg), 2001     irbesartanplaceboLow risk of bias suggesting
IDNT (irbesartan vs pbo), 2001     irbesartanplaceboLow risk of bias suggesting
IDNT (irbesartan vs amlodipine), 2001     irbesartanamlodipineLow risk of bias suggesting
losartan
RENAAL, 2001     losartanplaceboLow risk of bias suggesting
olmesartan
ORIENT    NCTolmesartanplaceboLow risk of bias negative
ramipril
DIABHYCAR, 2004     ramiprilplaceboLow risk of bias negative

heart failure with preserved LVEF

candesartan
CHARM preserved, 2003   candesartanplaceboLow risk of bias -
irbesartan
I-PRESERVE (McMurray), 2008      NCTibesartanplaceboLow risk of bias negative
perindopril
PEP CHF, 2006   perindoprilplaceboLow risk of bias negative

melanoma

Interferon alpha
EORTC18952 (Eggermont), 2005   ID IFN alpha-2b (I M)observationadjuvantnegative
Nordic IFN Trial, 2011     ID IFN alpha-2b (I M)observationadjuvantsuggesting
EORTC18991 (Eggermont), 2008   PEG IFN alpha-2b (I M)observationadjuvantsuggesting
EORTC18871/DKG 80-1 (Kleeberg), 2004   rIFN alpha-2bobservationadjuvantnegative
ipilimumab
EORTC 18071 (Eggermont), 2015        NCTipilimumabplaceboadjuvant adjuvant Low risk of bias conclusive
nivolumab
CheckMate 238, 2017      NCTnivolumabipilimumabadjuvant adjuvant Low risk of bias conclusive
pembrolizumab
KEYNOTE-054, 2018      NCTpembrolizumabplaceboadjuvant adjuvant Low risk of bias conclusive
trametinib + dabrafenib
COMBI-AD, 2017      NCTtrametinib and dabrafenibplaceboadjuvantLow risk of bias suggesting
COMBI neo, 2018      NCTtrametinib and dabrafenib SOCadjuvant -
vemurafenib
BRIM 8, 2018      NCTvemurafenibplaceboadjuvantsuggesting

obesity and overweight

Bupropion
Anderson, 2002     BupropionplaceboLow risk of bias -
Croft, 2002   Bupropionplacebo -
Jain, 2002     BupropionplaceboLow risk of bias -
liraglutide
Astrup (NN8022-1807 ), 2009    NCTliraglutideplaceboLow risk of bias -
lorcaserin
BLOSSOM (10mg bid), 2009      NCTlorcaserinplaceboLow risk of bias -
BLOOM, 2010    NCTlorcaserinplaceboLow risk of bias -
BLOOM-DM (10mg bid)    NCTlorcaserinplaceboLow risk of bias -
orlistat
Bakris, 2002     OrlistatplaceboLow risk of bias -
Broom, 2002   OrlistatplaceboLow risk of bias -
Broom,, 2001   Orlistatplacebo -
Davidson, 1999     OrlistatplaceboLow risk of bias -
Deerochanawong,, 2001   Orlistatplacebo -
Derosa, 2003     OrlistatplaceboLow risk of bias -
Gotfredsen, 2001     Orlistatplacebo -
Halpern, 2003     OrlistatplaceboLow risk of bias -
Hanefeld, 2002     Orlistatplacebo -
Hauptman, 2000     OrlistatplaceboLow risk of bias -
Hill, 1999     OrlistatplaceboLow risk of bias -
Hollander, 1998     Orlistatplacebo -
Karhunen, 2000   Orlistatplacebo -
Kelley, 2002     OrlistatplaceboLow risk of bias -
Krempf, 2005     Orlistatplacebo -
Lindgarde, 2000     Orlistatplacebo -
Lucas, 2003     Orlistatplacebo -
Micic, 1999   OrlistatplaceboLow risk of bias -
Miles, 2002     OrlistatplaceboLow risk of bias -
Muls, 2001     OrlistatplaceboLow risk of bias -
Naumov, 2002   Orlistatplacebo -
Reaven, 2001     Orlistatplacebo -
Rissanen, 2001     OrlistatplaceboLow risk of bias -
Rosenfalck, 2002     Orlistatplacebo -
Rossner, 2000     OrlistatplaceboLow risk of bias -
Shi Yi, 2001   Orlistatplacebo -
Sjostrom, 1998     OrlistatplaceboLow risk of bias -
Vidgren, 1999   Orlistatplacebo -
phentermine and topiramate
CONQUER (high-dose) (OB 303)      NCTPHEN/TPM high doseplacebo -
OB 302 (high-dose)   PHEN/TPM high doseplacebo -
OB 301 (high-dose)   PHEN/TPM high doseplacebo -
OB 302 (low-dose)   PHEN/TPM low-doseplacebo -
OB 301 (mid-dose)   PHEN/TPM mid-doseplacebo -
CONQUER (mid-dose) (OB 303)      NCTPHEN/TPM mid-doseplacebo -
Sibutramine
McMahon, 2000     Sibutramineplacebo -
McMahon, 2002   Sibutramineplacebo -
Smith, 2001     Sibutramineplacebo -
SCOUT, 2010        NCTsibutramineplaceboLow risk of bias -
topiramate
Bray, 2003     Topiramateplacebo -
Caterson, 2003   Topiramateplacebo -
Pud’homme, 2003   Topiramateplacebo -
Rissanen, 2003   Topiramateplacebo -
Stenlof, 2003   Topiramateplacebo -
Tonstad, 2003   Topiramateplacebo -