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Trial Studied trt Control trt patientstagsNCTROB Result

diabetic kidney disease

amlodipine
IDNT (amlodipine vs PBO), 2001amlodipineplaceboLow risk of bias negative
finerenone
FIDELIO-DKD ongoing finerenoneplaceboNCT02540993 ongoing
FIGARO-DKD ongoing finerenoneplaceboNCT02545049 ongoing
irbesartan
IPDM (150mg), 2001irbesartanplaceboExploratory suggesting
IDNT (irbesartan vs pbo), 2001irbesartanplaceboLow risk of bias suggesting
IDNT (irbesartan vs amlodipine), 2001irbesartanamlodipineLow risk of bias suggesting
losartan
RENAAL, 2001losartanplaceboLow risk of bias suggesting
olmesartan
ORIENTolmesartanplaceboNCT00141453negative
ramipril
DIABHYCAR, 2004ramiprilplaceboLow risk of bias negative

heart failure with preserved LVEF

candesartan
CHARM preserved, 2003candesartanplaceboLow risk of bias -
irbesartan
I-PRESERVE (McMurray), 2008ibesartanplaceboNCT00095238Low risk of bias negative
perindopril
PEP CHF, 2006perindoprilplaceboLow risk of bias negative

obesity and overweight

Bupropion
Anderson, 2002Bupropionplacebo -
Croft, 2002Bupropionplacebo -
Jain, 2002Bupropionplacebo -
liraglutide
Astrup (NN8022-1807 ), 2009liraglutideplaceboNCT00422058 -
lorcaserin
BLOSSOM (10mg bid), 2009lorcaserinplaceboNCT00603902 -
BLOOM, 2010lorcaserinplaceboNCT00395135 -
BLOOM-DM (10mg bid)lorcaserinplaceboNCT00603291 -
orlistat
Bakris, 2002Orlistatplacebo -
Broom, 2002Orlistatplacebo -
Broom,, 2001Orlistatplacebo -
Davidson, 1999Orlistatplacebo -
Deerochanawong,, 2001Orlistatplacebo -
Derosa, 2003Orlistatplacebo -
Gotfredsen, 2001Orlistatplacebo -
Halpern, 2003Orlistatplacebo -
Hanefeld, 2002Orlistatplacebo -
Hauptman, 2000Orlistatplacebo -
Hill, 1999Orlistatplacebo -
Hollander, 1998Orlistatplacebo -
Karhunen, 2000Orlistatplacebo -
Kelley, 2002Orlistatplacebo -
Krempf, 2005Orlistatplacebo -
Lindgarde, 2000Orlistatplacebo -
Lucas, 2003Orlistatplacebo -
Micic, 1999Orlistatplacebo -
Miles, 2002Orlistatplacebo -
Muls, 2001Orlistatplacebo -
Naumov, 2002Orlistatplacebo -
Reaven, 2001Orlistatplacebo -
Rissanen, 2001Orlistatplacebo -
Rosenfalck, 2002Orlistatplacebo -
Rossner, 2000Orlistatplacebo -
Shi Yi, 2001Orlistatplacebo -
Sjostrom, 1998Orlistatplacebo -
Vidgren, 1999Orlistatplacebo -
phentermine and topiramate
CONQUER (high-dose) (OB 303)PHEN/TPM high doseplaceboNCT00553787 -
OB 302 (high-dose)PHEN/TPM high doseplacebo -
OB 301 (high-dose)PHEN/TPM high doseplacebo -
OB 302 (low-dose)PHEN/TPM low-doseplacebo -
OB 301 (mid-dose)PHEN/TPM mid-doseplacebo -
CONQUER (mid-dose) (OB 303)PHEN/TPM mid-doseplaceboNCT00553787 -
Sibutramine
McMahon, 2000Sibutramineplacebo -
McMahon, 2002Sibutramineplacebo -
Smith, 2001Sibutramineplacebo -
SCOUT, 2010sibutramineplaceboNCT00234832Low risk of bias -
topiramate
Bray, 2003Topiramateplacebo -
Caterson, 2003Topiramateplacebo -
Pud’homme, 2003Topiramateplacebo -
Rissanen, 2003Topiramateplacebo -
Stenlof, 2003Topiramateplacebo -
Tonstad, 2003Topiramateplacebo -

renal-cell carcinoma (advanced)

apitolisib
Powles, 2014apitolisibeverolimus -
axitinib
AXIS (Rini), 2011axitinibsorafenibNCT00678392suggesting
Qin, 2012axitinibsorafenib -
bevacizumab
CALGB 90206, 2010bevacizumab plus interferon alfainterferon alphasuggesting
AVOREN, 2007bevacizumab plus interferon alfainterferon alphasuggesting
Yang, 2003bevacizumabplaceboExploratory -
cabozantinib
METEOR, 2015cabozantinibeverolimus after VEGFR-targeted therapy failure 2nd line NCT01865747Risk of bias suggesting
CABOSUN, 2017cabozantinibsunitinibfirst-line therapy in patients with intermediate- or poor-risk 1st line NCT01835158Exploratory suggesting
dovitinib
GOLDdovitinibsorafenibNCT01223027negative
everolimus
RECORD-1, 2008everolimusplaceboNCT00410124suggesting
RECORD 3, 2014everolimussunitinibNCT00903175 -
nivolumab
CheckMate 025, 2015nivolumabeverolimusNCT01668784suggesting
pazopanib
VEG105192, 2010pazopanibplaceboNCT00334282suggesting
Sternberg, 2010pazopanibplacebosuggesting
COMPARZ, 2013pazopanibsunitinibNCT00720941negative
sorafenib
Escudier, 2009sorafenibinterferon alphaExploratory negative
TARGET, 2007sorafenibplaceboNCT00073307Low risk of bias suggesting
Ratain, 2006sorafenibplaceboExploratory -
sunitinib
Motzer, 2007sunitinibinterferon alphaNCT00083889suggesting
SWITCHsunitinibsorafenibNCT00732914 -
temsirolimus
ARCC (Hudes) temsirolimus alone, 2007temsirolimusinterferon alphaNCT00065468suggesting
INTORSECT, 2014temsirolimussorafenibNCT00474786negative
tivozanib
TIVO-1, 2013tivozanibsorafenibNCT01030783suggesting