angiotensin-Converting Enzyme Inhibitors  

Benazepril - Captopril - Enalapril - Fosinopril - Lisinopril - Perindopril - Quinapril - Ramipril - Trandolapril - Various ACEI - Zofenopril      

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Trial Studied trt Control trt patientstagsNCTROB Result

acute myocardial infarction

captopril
ISIS-4, 1995captoprilplaceboLow risk of bias -
CCS-1, 1995captoprilplaceboLow risk of bias -
French, 1999captoprilplaceboLow risk of bias -
CATS, 1996captoprilplaceboLow risk of bias -
ECCE, 1997captoprilplaceboLow risk of bias -
Sharpe, 1991captoprilplaceboLow risk of bias -
Ray, 1993captoprilplaceboLow risk of bias -
Nabel, 1991captoprilplaceboLow risk of bias -
Bussmann, 1992captoprilplaceboLow risk of bias -
Di Pasquale, 1994captoprilplaceboLow risk of bias -
Di Pasquale, 1997captoprilplaceboLow risk of bias -
Galcera, 1993captoprilplaceboLow risk of bias -
Hargreaves, 1992captoprilplaceboLow risk of bias -
SAVE, 1992captoprilplaceboLow risk of bias -
Pfeffer, 1988captoprilplaceboLow risk of bias -
Sogaard, 1994captoprilplaceboLow risk of bias -
Sharpe, 1988captoprilplaceboLow risk of bias -
Mortarino, 1990captoprilplaceboLow risk of bias -
PRACTICAL (captopril), 1994captopril or enalaprilplaceboLow risk of bias -
enalapril
CONSENSUS 2, 1992enalaprilplaceboLow risk of bias -
Schulman, 1995enalaprilplaceboLow risk of bias -
fosinopril
FAMIS, 1998fosinoprilplaceboLow risk of bias -
irbesartan
GLOBAL ongoing irbesartancontrolNCT00125645Exploratory ongoing
lisinopril
GISSI 3, 1994lisinoprilplaceboRisk of bias -
ramipril
Wagner, 2002ramiprilplaceboLow risk of bias -
AIRE, 1993ramiprilplaceboLow risk of bias -
trandolapril
TRACE, 1995trandolaprilplaceboLow risk of bias -
zofenopril
SMILE, 1995zofenoprilplaceboLow risk of bias suggesting

heart failure

benazepril
McGany, 1991benazeprilcontrolnegative
Colfer, 1992benazeprilplaceboLow risk of bias negative
captopril
Magnani, 1986captoprilplaceboLow risk of bias -
Bussmann, 1987captoprilplaceboLow risk of bias negative
Captopril Digoxin Multicenter Research Group, 1988captoprilplaceboLow risk of bias negative
Barabino, 1991captoprilplaceboLow risk of bias suggesting
Munich MHFT (Kleber), 1992captoprilplaceboLow risk of bias negative
Magnani, 1990captoprilplaceboLow risk of bias -
CMRG, 1983captoprilplaceboLow risk of bias -
Cilazapril-Captopril Multi-centre Group (capt vs pbo), 1995captoprilplaceboLow risk of bias -
SAVE, 1992captoprilplaceboLow risk of bias -
Pfeffer, 1988captoprilplaceboLow risk of bias -
Sogaard, 1994captoprilplaceboLow risk of bias -
Sharpe, 1988captoprilplaceboLow risk of bias -
Mortarino, 1990captoprilplaceboLow risk of bias -
packer, 1986captoprilenalaprilExploratory -
cilazapril
Drexler, 1989cilazaprilplaceboLow risk of bias negative
Dosseger, 1993cilazaprilplaceboLow risk of bias -
Cilazapril-Captopril Multi-centre Group, 1995cilazaprilplaceboLow risk of bias -
Cilazapril-Captopril Multi-centre Group (cila vs capt), 1995cilazaprilcaptoprilLow risk of bias -
enalapril
Rucinska-b (enalapril), 1991enalaprilcontrolnegative
Enalapril CHF investigators, 1987enalaprilcontrolnegative
Rucinska-a (enalapril), 1991enalaprilcontrolnegative
SOLVD treatment, 1991enalaprilplaceboNCT00000516Low risk of bias suggesting
SOLVD prevention, 1992enalaprilplaceboNCT00000516Low risk of bias -
Cleland, 1985enalaprilplaceboLow risk of bias negative
CONSENSUS, 1987enalaprilplaceboLow risk of bias negative
Dickstein, 1991enalaprilplaceboLow risk of bias negative
Sharpe, 1984enalaprilplaceboLow risk of bias -
McGrath, 1985enalaprilplaceboLow risk of bias -
Chrysant, 1985enalaprilplaceboLow risk of bias -
CASSIS (enalapril), 1995enalaprilplaceboLow risk of bias -
NETWORK (2.5 bid vs 10 bid), 1998enalaprilenalaprilLow risk of bias -
NETWORK (5 bid vs 10 bid), 1998enalaprilenalaprilLow risk of bias -
V-HeFT II, 1991enalaprilhydralazine+ISDNLow risk of bias -
fosinopril
Brown, 1995fosinoprilplaceboLow risk of bias -
FEST (Erhardt), 1996fosinoprilplaceboLow risk of bias -
lisinopril
Zwehl, 1990lisinoprilcontrolnegative
Giles, 1990lisinoprilcontrolnegative
Rucinska-c (lisinopril), 1000lisinoprilcontrolnegative
Gilbert, 1993lisinoprilplaceboLow risk of bias negative
International Study Group (Lewis), 1989lisinoprilplaceboLow risk of bias -
ATLAS, 1999lisinoprillisinoprilLow risk of bias -
perindopril
Lechat, 1993perindoprilplaceboLow risk of bias negative
PEP CHF, 2006perindoprilplaceboLow risk of bias negative
quinapril
Uprichard-a, 1994controlnegative
Uprichard-b, 1994controlnegative
Uprichard-c, 1994controlnegative
Riegger, 1990placeboLow risk of bias negative
Northridge, 1991placeboLow risk of bias negative
Rieger, 1991placeboLow risk of bias negative
Nussberger, 1994placeboLow risk of bias -
Quinapril Heart Failure Trial Investigators, 1993placeboLow risk of bias -
ramipril
Swedberg, 1991ramiprilcontrolnegative
Maass-a, 1991ramiprilplacebonegative
Gordon, 1991ramiprilplaceboLow risk of bias suggesting
Maass-b, 1991ramiprilplaceboLow risk of bias negative
Maass-c, 1991ramiprilplaceboLow risk of bias negative
Lemarie, 1992ramiprilplaceboLow risk of bias negative
Gundersen, 1994ramiprilplaceboLow risk of bias -
AIRE, 1993ramiprilplaceboLow risk of bias -
trandolapril
Hampton, 1998trandolaprilplaceboLow risk of bias -
TRACE, 1995trandolaprilplaceboLow risk of bias -

patients at high risk for cardiovascular events

enalapril
CAMELOT (enalapril), 2004enalaprilplaceboLow risk of bias negative
perindopril
EUROPA, 2003perindoprilplaceboLow risk of bias suggesting
quinapril
QUIET, 2001quinaprilplaceboLow risk of bias negative
ramipril
HOPE, 2000ramiprilplaceboLow risk of bias suggesting
ONTARGET (association vs ramipril), 2008telmisartan + ramiprilramiprilNCT00153101Low risk of bias negative
ONTARGET (association vs telmisartan), 2008telmisartan + ramipriltelmisartanNCT00153101Low risk of bias suggesting
trandolapril
PEACE, 2004trandolaprilplaceboNCT00000558Low risk of bias suggesting