angiotensin-Converting Enzyme Inhibitors

Benazepril - Captopril - Enalapril - Fosinopril - Lisinopril - Perindopril - Quinapril - Ramipril - Trandolapril - Various ACEI - Zofenopril      

Select            
Trial Studied trt Control trt patientstagsROB Trial resultAll cause deathDeath from any cause or hospitalization for any reason

acute myocardial infarction

captopril
ISIS-4, 1995   captoprilplaceboLow risk of bias - -6%
CCS-1, 1995   captoprilplaceboLow risk of bias -
French, 1999     captoprilplaceboLow risk of bias -
CATS, 1996     captoprilplaceboLow risk of bias -
ECCE, 1997   captoprilplaceboLow risk of bias -
Sharpe, 1991     captoprilplaceboLow risk of bias -
Ray, 1993     captoprilplaceboLow risk of bias -
Nabel, 1991   captoprilplaceboLow risk of bias -
Bussmann, 1992   captoprilplaceboLow risk of bias -
Di Pasquale, 1994   captoprilplaceboLow risk of bias -
Di Pasquale, 1997   captoprilplaceboLow risk of bias -
Galcera, 1993   captoprilplaceboLow risk of bias -
Hargreaves, 1992   captoprilplaceboLow risk of bias -
SAVE, 1992   captoprilplaceboLow risk of bias -
Pfeffer, 1988   captoprilplaceboLow risk of bias -
Sogaard, 1994   captoprilplaceboLow risk of bias -
Sharpe, 1988     captoprilplaceboLow risk of bias -
Mortarino, 1990   captoprilplaceboLow risk of bias -
PRACTICAL (captopril), 1994   captopril or enalaprilplaceboLow risk of bias -
enalapril
CONSENSUS 2, 1992   enalaprilplaceboLow risk of bias -
Schulman, 1995     enalaprilplaceboLow risk of bias -
fosinopril
FAMIS, 1998     fosinoprilplaceboLow risk of bias -
lisinopril
GISSI 3, 1994   lisinoprilplaceboRisk of bias -
ramipril
Wagner, 2002   ramiprilplaceboLow risk of bias -
AIRE, 1993   ramiprilplaceboLow risk of bias -
trandolapril
TRACE, 1995     trandolaprilplaceboLow risk of bias -
zofenopril
SMILE, 1995     zofenoprilplaceboLow risk of bias suggesting

heart failure

benazepril
McGany, 1991   benazeprilcontrolnegative-8%
Colfer, 1992   benazeprilplaceboLow risk of bias negative -75%
captopril
Magnani, 1986   captoprilplaceboLow risk of bias -
Bussmann, 1987   captoprilplaceboLow risk of bias negative-39%
Captopril Digoxin Multicenter Research Group, 1988   captoprilplaceboLow risk of bias negative -13%
Barabino, 1991   captoprilplaceboLow risk of bias suggesting-50%
Munich MHFT (Kleber), 1992   captoprilplaceboLow risk of bias negative5%
Magnani, 1990   captoprilplaceboLow risk of bias -
CMRG, 1983   captoprilplaceboLow risk of bias -
Cilazapril-Captopril Multi-centre Group (capt vs pbo), 1995   captoprilplaceboLow risk of bias -
SAVE, 1992   captoprilplaceboLow risk of bias -
Pfeffer, 1988   captoprilplaceboLow risk of bias -
Sogaard, 1994   captoprilplaceboLow risk of bias -
Sharpe, 1988     captoprilplaceboLow risk of bias -
Mortarino, 1990   captoprilplaceboLow risk of bias -
packer, 1986   captoprilenalaprilExploratory -
cilazapril
Drexler, 1989   cilazaprilplaceboLow risk of bias negative-9%
Dosseger, 1993   cilazaprilplaceboLow risk of bias -
Cilazapril-Captopril Multi-centre Group, 1995   cilazaprilplaceboLow risk of bias -
Cilazapril-Captopril Multi-centre Group (cila vs capt), 1995   cilazaprilcaptoprilLow risk of bias -
enalapril
Rucinska-b (enalapril), 1991   enalaprilcontrolnegative-100%
Enalapril CHF investigators, 1987   enalaprilcontrolnegative-48%
Rucinska-a (enalapril), 1991   enalaprilcontrolnegative-51%
SOLVD treatment, 1991    NCTenalaprilplaceboLow risk of bias suggesting -11%-17%
SOLVD prevention, 1992    NCTenalaprilplaceboLow risk of bias -
Cleland, 1985   enalaprilplaceboLow risk of bias negative
CONSENSUS, 1987   enalaprilplaceboLow risk of bias negative -3%
Dickstein, 1991   enalaprilplaceboLow risk of bias negative-100%
Sharpe, 1984   enalaprilplaceboLow risk of bias -
McGrath, 1985     enalaprilplaceboLow risk of bias -
Chrysant, 1985   enalaprilplaceboLow risk of bias -
CASSIS (enalapril), 1995   enalaprilplaceboLow risk of bias -
NETWORK (2.5 bid vs 10 bid), 1998   enalaprilenalaprilLow risk of bias -
NETWORK (5 bid vs 10 bid), 1998   enalaprilenalaprilLow risk of bias -
V-HeFT II, 1991   enalaprilhydralazine+ISDNLow risk of bias -
fosinopril
Brown, 1995     fosinoprilplaceboLow risk of bias -
FEST (Erhardt), 1996     fosinoprilplaceboLow risk of bias -
lisinopril
Zwehl, 1990   lisinoprilcontrolnegative-16%
Giles, 1990   lisinoprilcontrolnegative-68%
Rucinska-c (lisinopril), 1000   lisinoprilcontrolnegative7%
Gilbert, 1993   lisinoprilplaceboLow risk of bias negative
International Study Group (Lewis), 1989   lisinoprilplaceboLow risk of bias -
ATLAS, 1999   lisinoprillisinoprilLow risk of bias -
perindopril
Lechat, 1993   perindoprilplaceboLow risk of bias negative -100%
PEP CHF, 2006   perindoprilplaceboLow risk of bias negative -10%-31%
quinapril
Uprichard-a, 1994   controlnegative-52%
Uprichard-b, 1994   controlnegative-35%
Uprichard-c, 1994   controlnegative+Infini%
Riegger, 1990   placeboLow risk of bias negative
Northridge, 1991     placeboLow risk of bias negative
Rieger, 1991   placeboLow risk of bias negative
Nussberger, 1994   placeboLow risk of bias -
Quinapril Heart Failure Trial Investigators, 1993   placeboLow risk of bias -
ramipril
Swedberg, 1991   ramiprilcontrolnegative-56%
Maass-a, 1991   ramiprilplacebonegative3%
Gordon, 1991     ramiprilplaceboLow risk of bias suggesting-79%
Maass-b, 1991   ramiprilplaceboLow risk of bias negative-39%
Maass-c, 1991     ramiprilplaceboLow risk of bias negative-32%
Lemarie, 1992     ramiprilplaceboLow risk of bias negative-23%
Gundersen, 1994     ramiprilplaceboLow risk of bias -
AIRE, 1993   ramiprilplaceboLow risk of bias -
trandolapril
Hampton, 1998     trandolaprilplaceboLow risk of bias -
TRACE, 1995     trandolaprilplaceboLow risk of bias -

patients at high risk for cardiovascular events

enalapril
CAMELOT (enalapril), 2004     enalaprilplaceboLow risk of bias negative30%
perindopril
EUROPA, 2003     perindoprilplaceboLow risk of bias suggesting -11%
quinapril
QUIET, 2001     quinaprilplaceboLow risk of bias negative-1%
ramipril
HOPE, 2000     ramiprilplaceboLow risk of bias suggesting -15%
ONTARGET (association vs ramipril), 2008    NCTtelmisartan + ramiprilramiprilLow risk of bias negative 6%
ONTARGET (association vs telmisartan), 2008    NCTtelmisartan + ramipriltelmisartanLow risk of bias suggesting 8%
trandolapril
PEACE, 2004      NCTtrandolaprilplaceboLow risk of bias suggesting-11%