angiotensin-Converting Enzyme Inhibitors

Benazepril - Captopril - Enalapril - Fosinopril - Lisinopril - Perindopril - Quinapril - Ramipril - Trandolapril - Various ACEI - Zofenopril      

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Trial Studied trt Control trt patientstagsNCTROB Result

acute myocardial infarction

captopril
ISIS-4, 1995captoprilplaceboLow risk of bias -
CCS-1, 1995captoprilplaceboLow risk of bias -
French, 1999captoprilplaceboExploratory -
CATS, 1996captoprilplaceboExploratory -
ECCE, 1997captoprilplaceboExploratory -
Sharpe, 1991captoprilplaceboExploratory -
Ray, 1993captoprilplaceboExploratory -
Nabel, 1991captoprilplaceboExploratory -
Bussmann, 1992captoprilplaceboExploratory -
Di Pasquale, 1994captoprilplaceboExploratory -
Di Pasquale, 1997captoprilplaceboExploratory -
Galcera, 1993captoprilplaceboExploratory -
Hargreaves, 1992captoprilplaceboExploratory -
SAVE, 1992captoprilplaceboLow risk of bias -
Pfeffer, 1988captoprilplaceboExploratory -
Sogaard, 1994captoprilplaceboExploratory -
Sharpe, 1988captoprilplaceboExploratory -
Mortarino, 1990captoprilplaceboExploratory -
PRACTICAL (captopril), 1994captopril or enalaprilplaceboExploratory -
enalapril
CONSENSUS 2, 1992enalaprilplaceboLow risk of bias -
Schulman, 1995enalaprilplaceboExploratory -
fosinopril
FAMIS, 1998fosinoprilplaceboExploratory -
irbesartan
GLOBAL ongoing irbesartancontrolNCT00125645Exploratory ongoing
lisinopril
GISSI 3, 1994lisinoprilplaceboRisk of bias -
ramipril
Wagner, 2002ramiprilplaceboExploratory -
AIRE, 1993ramiprilplaceboLow risk of bias -
trandolapril
TRACE, 1995trandolaprilplaceboLow risk of bias -
zofenopril
SMILE, 1995zofenoprilplaceboLow risk of bias suggesting

heart failure

benazepril
McGany, 1991benazeprilcontrolnegative
Colfer, 1992benazeprilplaceboExploratory negative
captopril
Magnani, 1986captoprilplaceboExploratory -
Bussmann, 1987captoprilplaceboExploratory negative
Captopril Digoxin Multicenter Research Group, 1988captoprilplaceboLow risk of bias negative
Barabino, 1991captoprilplaceboExploratory suggesting
Munich MHFT (Kleber), 1992captoprilplaceboLow risk of bias negative
Magnani, 1990captoprilplaceboExploratory -
CMRG, 1983captoprilplaceboExploratory -
Cilazapril-Captopril Multi-centre Group (capt vs pbo), 1995captoprilplaceboExploratory -
SAVE, 1992captoprilplaceboLow risk of bias -
Pfeffer, 1988captoprilplaceboExploratory -
Sogaard, 1994captoprilplaceboExploratory -
Sharpe, 1988captoprilplaceboExploratory -
Mortarino, 1990captoprilplaceboExploratory -
packer, 1986captoprilenalaprilExploratory -
cilazapril
Drexler, 1989cilazaprilplaceboExploratory negative
Dosseger, 1993cilazaprilplaceboExploratory -
Cilazapril-Captopril Multi-centre Group, 1995cilazaprilplaceboExploratory -
Cilazapril-Captopril Multi-centre Group (cila vs capt), 1995cilazaprilcaptoprilExploratory -
enalapril
Rucinska-b (enalapril), 1991enalaprilcontrolnegative
Enalapril CHF investigators, 1987enalaprilcontrolnegative
Rucinska-a (enalapril), 1991enalaprilcontrolnegative
SOLVD treatment, 1991enalaprilplaceboNCT00000516Low risk of bias suggesting
SOLVD prevention, 1992enalaprilplaceboNCT00000516Low risk of bias -
Cleland, 1985enalaprilplaceboExploratory negative
CONSENSUS, 1987enalaprilplaceboLow risk of bias negative
Dickstein, 1991enalaprilplaceboExploratory negative
Sharpe, 1984enalaprilplacebo -
McGrath, 1985enalaprilplacebo -
Chrysant, 1985enalaprilplaceboLow risk of bias -
CASSIS (enalapril), 1995enalaprilplaceboExploratory -
NETWORK (2.5 bid vs 10 bid), 1998enalaprilenalaprilLow risk of bias -
NETWORK (5 bid vs 10 bid), 1998enalaprilenalaprilLow risk of bias -
V-HeFT II, 1991enalaprilhydralazine+ISDNLow risk of bias -
fosinopril
Brown, 1995fosinoprilplaceboExploratory -
FEST (Erhardt), 1996fosinoprilplaceboExploratory -
lisinopril
Zwehl, 1990lisinoprilcontrolnegative
Giles, 1990lisinoprilcontrolnegative
Rucinska-c (lisinopril), 1000lisinoprilcontrolnegative
Gilbert, 1993lisinoprilplacebonegative
International Study Group (Lewis), 1989lisinoprilplaceboExploratory -
ATLAS, 1999lisinoprillisinoprilLow risk of bias -
perindopril
Lechat, 1993perindoprilplacebonegative
PEP CHF, 2006perindoprilplaceboLow risk of bias negative
quinapril
Uprichard-a, 1994controlnegative
Uprichard-b, 1994controlnegative
Uprichard-c, 1994controlnegative
Riegger, 1990placebonegative
Northridge, 1991placeboExploratory negative
Rieger, 1991placeboExploratory negative
Nussberger, 1994placeboExploratory -
Quinapril Heart Failure Trial Investigators, 1993placeboExploratory -
ramipril
Swedberg, 1991ramiprilcontrolnegative
Maass-a, 1991ramiprilplacebonegative
Gordon, 1991ramiprilplaceboExploratory suggesting
Maass-b, 1991ramiprilplaceboExploratory negative
Maass-c, 1991ramiprilplaceboExploratory negative
Lemarie, 1992ramiprilplaceboExploratory negative
Gundersen, 1994ramiprilplaceboExploratory -
AIRE, 1993ramiprilplaceboLow risk of bias -
trandolapril
Hampton, 1998trandolaprilplaceboExploratory -
TRACE, 1995trandolaprilplaceboLow risk of bias -

patients at high risk for cardiovascular events

enalapril
CAMELOT (enalapril), 2004enalaprilplacebonegative
perindopril
EUROPA, 2003perindoprilplacebosuggesting
quinapril
QUIET, 2001quinaprilplacebonegative
ramipril
HOPE, 2000ramiprilplacebosuggesting
ONTARGET (association vs ramipril), 2008telmisartan + ramiprilramiprilNCT00153101negative
ONTARGET (association vs telmisartan), 2008telmisartan + ramipriltelmisartanNCT00153101suggesting
trandolapril
PEACE, 2004trandolaprilplaceboNCT00000558suggesting