new drug under development

     

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Trial Studied trt Control trt patientstagsNCTROB Result

acute heart failure

levosimendan
REVIVE II, 2013levosimendanplaceboNCT00048425Exploratory -
REVIVE-I, 2003levosimendanplaceboExploratory -
RUSSLAN, 2002levosimendanplaceboExploratory -
SURVIVE, 2007levosimendandobutamineNCT00348504Low risk of bias negative
CASINOlevosimendandobutamineLow risk of bias -
LIDO, 2002levosimendandobutamineExploratory -
nesiritide
NSGET (comparative trial), 2000nesiritidecontrolLow risk of bias -
NSGET (efficacy trial), 2000nesiritideplaceboLow risk of bias negative
PROACTION, 2003nesiritideplaceboLow risk of bias negative
BNP-CARDS, 2007nesiritideplaceboNCT00186329Exploratory -
FUSION 2, 2008nesiritideplaceboNCT00091520Low risk of bias -
ASCEND-HF, 2011nesiritideplaceboNCT00475852Low risk of bias negative
VMAC (intravenous neseritide), 2002nesiritideplaceboNCT00083772Low risk of bias -
PRECEDENT, 2002nesiritidedobutamineNCT00270400Exploratory -
VMAC (24h), 2002nesiritidenitroglycerinNCT00083772Risk of bias negative
FUSION 1, 2004nesiritidestandard careNCT00270361Low risk of bias -
rolofylline
PROTECT, 2010rolofyllineplaceboNCT00328692Low risk of bias negative
REACH UP ongoing rolofyllineplaceboNCT00443690 ongoing
PROTECT-2 ongoing rolofyllineplaceboNCT00354458 ongoing
PROTECT-1 ongoing rolofyllineplaceboNCT00328692 ongoing
7418-503 ongoing rolofyllineplaceboNCT00729222 ongoing
2007_806 ongoing rolofyllineplaceboNCT00652782 ongoing
serelaxin
Pre-RELAX-AHF, 2009serelaxinplaceboNCT00520806Exploratory -
RELAX-AHF, 2013serelaxinplaceboNCT00520806 -
RELAX-AHF-2 ongoing serelaxinplaceboNCT01870778 ongoing
tonapofylline
TRIDENT-1 ongoing tonapofyllineplaceboNCT00709865 ongoing
POSEIDON ongoing tonapofyllineplaceboNCT00745316 ongoing