statins

     

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Trial Studied trt Control trt patientstagsNCTROB Result

cardiovascular prevention

atorvastatin
Mohler, 2003atorvastatinplacebosecondary preventionLow risk of bias -
CARDS, 2004atorvastatinplacebodiabetic type 2 diabetes NCT00327418Low risk of bias conclusive
ASPEN, 2006atorvastatinplacebodiabetic type 2 diabetes Low risk of bias negative
ASCOT, 2003atorvastatinplaceboat risk hypertensive hypertensive patients Low risk of bias conclusive
GREACE, 2002atorvastatinusual caresecondary preventionRisk of bias suggesting
AVERT, 1999atorvastatin high doseangioplastysecondary preventionRisk of bias negative
TNT, 2005atorvastatin high doseatorvastatinsecondary preventionNCT00327691Low risk of bias conclusive
Vascular basis, 2005atorvastatin high doselovastatinsecondary preventionExploratory negative
REVERSAL, 2004atorvastatin high dosepravastatinsecondary preventionExploratory negative
SAGE, 2007atorvastatin high dosepravastatinsecondary preventionExploratory suggesting
IDEAL, 2005atorvastatin high dosesimvastatinsecondary preventionNCT00159835Risk of bias suggesting
fluvastatin
BCAPS, 2001fluvastatinplaceboprimary prevention cerebral vascular disease Exploratory negative
LIPS, 2002fluvastatinplacebosecondary preventionLow risk of bias suggesting
LCAS, 1997fluvastatinplacebosecondary preventionExploratory negative
Riegger et al., 1999fluvastatinplacebosecondary preventionLow risk of bias negative
FLARE, 1999fluvastatinplacebosecondary preventionExploratory negative
HYRIM, 2005fluvastatinplacebohypertensive hypertensive patients Exploratory negative
lovastatin
CCAIT, 1994lovastatinplacebosecondary preventionExploratory negative
MARS, 1993lovastatinplacebosecondary preventionNCT00116870Exploratory negative
AFCAPS/TexCAPS, 1998lovastatinplaceboprimary preventionLow risk of bias conclusive
Weintraub, 1994lovastatinplacebosecondary preventionLow risk of bias negative
ACAPS, 1994lovastatinplacebosecondary prevention cerebral vascular disease NCT00000469Exploratory suggesting
CRISP 20mg, 1994lovastatinplacebodiabeticNCT00000477Exploratory -
CRISP 40mg, 1994lovastatinplacebodiabeticNCT00000477Exploratory -
Sahni, 1991lovastatinusual caresecondary preventionRisk of bias negative
CLAPT, 1999lovastatinusual caresecondary preventionExploratory negative
pravastatin
MEGA, 2006pravastatincontrolprimary preventionNCT00211705Risk of bias suggesting
FAST Fukuoka pravastatin, 2002pravastatincontrolprimary preventionExploratory -
WOSCOPS, 1995pravastatinplaceboprimary preventionLow risk of bias conclusive
PMSG, 1993pravastatinplaceboprimary preventionExploratory negative
CAIUS, 1996pravastatinplaceboprimary prevention cerebral vascular disease Exploratory negative
PROSPER (primary prevention subgroup), 2002pravastatinplaceboprimary prevention elderly Exploratory negative
PROSPER, 2002pravastatinplacebosecondary prevention elderly Low risk of bias conclusive
PLAC I, 1995pravastatinplacebosecondary preventionExploratory suggesting
PLAC II, 1995pravastatinplacebosecondary preventionExploratory negative
PACT, 2004pravastatinplacebosecondary preventionLow risk of bias negative
LIPID, 1998pravastatinplacebosecondary preventionLow risk of bias conclusive
CARE, 1996pravastatinplacebosecondary preventionLow risk of bias conclusive
REGRESS, 1995pravastatinplacebosecondary preventionExploratory suggesting
PHYLLIS, 2004pravastatinplacebodiabetic cerebral vascular disease hypertensive patients Exploratory -
KLIS, 2000pravastatinusual careprimary preventionRisk of bias -
GISSI Prevenzione, 2000pravastatinusual caresecondary preventionRisk of bias negative
ALLHAT, 2002pravastatinusual careat risk hypertensive hypertensive patients NCT00000542Risk of bias negative
rosuvastatin
JUPITER, 2008rosuvastatinplaceboprimary preventionNCT00239681Low risk of bias conclusive
HOPE 3, 2016rosuvastatinplaceboprimary preventionNCT00468923Low risk of bias conclusive
METEOR, 2007rosuvastatinplacebodiabeticNCT00225589Exploratory negative
simvastatin
MAAS, 1994simvastatinplacebosecondary preventionExploratory negative
HPS, 2002simvastatinplacebosecondary preventionLow risk of bias conclusive
4S, 1994simvastatinplacebosecondary preventionLow risk of bias conclusive
CIS, 1997simvastatinplacebosecondary preventionExploratory negative
HPS (diabetic primary prevention sub group), 2003simvastatinplacebodiabetic type 2 diabetes Exploratory -
SEARCH, 2010simvastatin high dosesimvastatinsecondary preventionNCT00124072Low risk of bias suggesting

heart failure

atorvastatin
Wojnicz, 2006atorvastatincontrolheart failurenegative
Yamada, 2007atorvastatincontrolheart failurenegative
Strey, 2005atorvastatinplaceboheart failure -
Sola, 2006atorvastatinplaceboheart failurenegative
cerivastatin
Laufs, 2004cerivastatinplaceboheart failure -
rosuvastatin
CORONA, 2007rosuvastatinplaceboheart failureNCT00206310Low risk of bias negative
Krum, 2007rosuvastatinplaceboheart failureExploratory negative
GISSI-HF rosuvastatine, 2008rosuvastatinplaceboheart failureNCT00336336Low risk of bias negative
simvastatin
Hong, 2005simvastatincontrolheart failureRisk of bias negative
Node, 2003simvastatinplaceboheart failurenegative
Landmesser, 2005simvastatinezetimibeheart failure -

percutaneous coronary intervention

atorvastatin
NAPLES II (Briguori), 2009atorvastatincontrolsuggesting
ESTATE ongoing AtorvastatincontrolNCT00979940 ongoing
ARMYDA, 2004atorvastatinplacebosuggesting
ARMYDA-RECAPTURE, 2009atorvastatin reloadplaceboLow risk of bias suggesting
GAIN, 2001atorvastatinusual carenegative
fluvastatin
FLARE, 1999fluvastatinplacebonegative
LIPS, 2002fluvastatinplacebonegative
pravastatin
PREDICT, 1997pravastatinplacebonegative