direct factor Xa inhibitors

     

Select            
Trial Studied trt Control trt patientstagsROB Trial result

acute coronary syndrome

apixaban
APPRAISE-1 (10mg od), 2009      NCTapixabanplaceboLow risk of bias negative
APPRAISE-1 (2.5 mg bid), 2009      NCTapixabanplaceboLow risk of bias negative
APPRAISE 2, 2011      NCTapixabanplaceboLow risk of bias negative
dabigatran
REDEEM, 2009    NCTdabigatranplaceboLow risk of bias negative
otamixaban
SEPIA-ACS1 TIMI 42, 2009    NCTotamixabanunfractionated heparinLow risk of bias suggesting
rivaroxaban
ATLAS ACS 2 - TIMI 51 (2.5mg), 2011      NCTrivaroxaban 2.5mgplaceboLow risk of bias suggesting
ATLAS ACS-TIMI 46 (2.5mg), 2009      NCTrivaroxaban 2.5mgplaceboLow risk of bias negative
ATLAS ACS 2 - TIMI 51 (5mg), 2011      NCTrivaroxaban 5mgplacebosuggesting
ATLAS ACS-TIMI 46 (5mg), 2009      NCTrivaroxaban 5mgplaceboLow risk of bias negative
ximelagatran
ESTEEM, 2003   ximelagatranplaceboExploratory -

atrial fibrillation

apixaban
AVERROES, 2011        NCTapixabanaspirinineligible for VKALow risk of bias suggesting
ARISTOTLE, 2011        NCTapixabanwarfarin standard doseLow risk of bias conclusive
phase 2 apixaban    NCTapixabanwarfarin standard doseExploratory -
edoxaban
Weitz (edoxaban phase 2)    NCTedoxabanwarfarin standard doseExploratory -
phase 2 edoxaban    NCTedoxabanwarfarin standard doseExploratory -
ENGAGE-AF TIMI 48 High dose, 2013    NCTedoxaban high dosewarfarin standard doseLow risk of bias suggesting
rivaroxaban
ROCKET-AF, 2010        NCTrivaroxabanwarfarin standard doseLow risk of bias suggesting

cardiovascular prevention

rivaroxaban
COMPASS (rivaroxaban alone), 2017    NCTrivaroxabanaspirinsecondary prevention -
COMPASS (rivaroxaban + aspirin), 2017      NCTrivaroxaban + aspirinaspirinsecondary preventionLow risk of bias -

thrombosis prevention

apixaban
ADVANCE 3, 2010    NCTapixabanenoxaparinhip surgeryLow risk of bias suggesting
ADVANCE 2, 2010      NCTapixabanenoxaparin (europe regimen)knee surgeryLow risk of bias suggesting
APROPOS 2.5mg, 2007    NCTapixabanenoxaparin (US regimen)knee surgeryLow risk of bias negative
ADVANCE-1, 2008      NCTapixabanenoxaparin (US regimen)knee surgeryLow risk of bias suggesting
edoxaban
STARS J-V    NCTedoxabanenoxaparin (short duration)hip surgeryLow risk of bias suggesting
rivaroxaban
RECORD 1, 2008      NCTrivaroxabanenoxaparinhip surgeryLow risk of bias suggesting
RECORD 3, 2008    NCTrivaroxabanenoxaparin (europe regimen)knee surgeryLow risk of bias suggesting
ODIXa-HIP 10mg, 2006   rivaroxabanenoxaparin (short duration)hip surgeryLow risk of bias suggesting
RECORD 2, 2008    NCTrivaroxaban (long duration)enoxaparin (short duration)hip surgeryLow risk of bias suggesting
ODIXa-KNEE, 2005   rivaroxabanenoxaparin (US regimen)knee surgeryLow risk of bias negative
RECORD 4, 2009    NCTrivaroxabanenoxaparin (US regimen)knee surgeryLow risk of bias suggesting

venous thrombosis

ximelagatran
THRIVE III, 2003       ximelagatrandiscontinuationLow risk of bias suggesting