New P2Y12 Inhibitors

     

Select            
Trial Studied trt Control trt patientstagsROB Trial resultMajor bleedingAll cause death

acute coronary syndrome

cangrelor
CHAMPION-PCI, 2009      NCTcangrelor up frontclopidogrel up frontLow risk of bias negative59%
CHAMPION-PLATFORM, 2009    NCTcangrelor up frontdelayed clopidogrelLow risk of bias negative
elinogrel
ERASE-MI, 2009     elinogrelplaceboLow risk of bias negative
prasugrel
JUMBO-TIMI 26, 2005   prasugrelclopidogrelLow risk of bias negative
TRITON-TIMI 38, 2007      NCTprasugrelclopidogrelLow risk of bias suggesting 31%-5%
ticagrelor
PLATO, 2009      NCTticagrelorclopidogrelLow risk of bias suggesting3%-22%
DISPERSE-2 (90mg), 2007       ticagrelorclopidogrelLow risk of bias negative-2%37%