HDL increasing drugs

Torcetrapib      

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Trial Studied trt Control trt patientstagsNCTROB Result

cardiovascular prevention

anacetrapib
DEFINE, 2010anacetrapibplaceboNCT00685776Exploratory negative
REALIZE, 2015anacetrapibplaceboNCT01524289negative
bezafibrate
BECAIT, 1996bezafibrateplacebosecondary preventionExploratory suggesting
BIP, 2000bezafibrateplacebosecondary preventionLow risk of bias negative
SENDCAP, 1998bezafibrateplacebo type 2 diabetes Exploratory suggesting
LEADER, 2002bezafibrateplaceboLow risk of bias negative
clofibrate
WHO clofibrate, 1978clofibrateplaceboLow risk of bias suggesting
CDP Clofibrate, 1975clofibrateplaceboLow risk of bias suggesting
Scottish, 1971clofibrateplaceboLow risk of bias negative
Newcastle, 1971clofibrateplaceboLow risk of bias suggesting
Harrold, 1969clofibrateplacebo type 2 diabetes Low risk of bias -
Begg, 1971clofibrateplacebosecondary preventionExploratory negative
Acheson, 1972clofibrateplacebosecondary prevention cerebral vascular disease Exploratory -
VA Neurology Section, 1974clofibrateplaceboLow risk of bias -
Cullen, 1974clofibrateplaceboLow risk of bias -
Hanefeld, 1991clofibrateplacebo type 2 diabetes Low risk of bias negative
etofibrate
Emmerich, 2009etofibrateplacebodiabetic type 2 diabetes Exploratory -
fenofibrate
FIELD, 2005fenofibrateplacebodiabetic type 2 diabetes ISRCTN64783481Exploratory suggesting
DAIS, 2001fenofibrateplacebodiabetic type 2 diabetes Exploratory negative
ACCORD lipid, 2010fenofibrateplacebo (on top simvastatine)diabetic patients type 2 diabetes NCT00000620Low risk of bias negative
gemfibrozil
VA-HIT, 1999gemfibrozilplaceboNCT00283335Low risk of bias suggesting
Helsinki (HHS), 1987gemfibrozilplaceboLow risk of bias suggesting
HHS (Frick)(secondary prev subgroup), 1993gemfibrozilplaceboExploratory negative
LOCAT, 1997gemfibrozilplaceboExploratory negative
niacin
VA drugs, 1968niacincontrolLow risk of bias negative
CDP niacin, 1975niacinplaceboLow risk of bias suggesting
AIM-HIGH, 2011niacinplacebo (on top statin)NCT00120289Low risk of bias negative
HPS 2-Thriveniacinplacebo (on top statin)NCT00461630Low risk of bias negative
Oxford Niaspan Study, 2009niacinplacebo (on top statin)NCT00232531Exploratory -
ARBITER 2, 2009niacinplacebo (on top statin)Exploratory negative
HATS, 2001niacinplacebo (on top statin)Risk of bias negative
ARBITER 6-HALTS (niacin vs ezetimibe), 2009niacinezetimibeNCT00397657Exploratory suggesting
torcetrapib
RADIANCE 1, 2007torcetrapibplaceboNCT00136981Exploratory negative
ILLUMINATE, 2007torcetrapibplaceboNCT00134264negative
RADIANCE 2, 2007torcetrapibplaceboExploratory -
ILLUSTRATE, 2007torcetrapibplaceboNCT00134173Exploratory negative