HDL increasing drugs

Torcetrapib      

Select            
Trial Studied trt Control trt patientstagsROB Trial result

cardiovascular prevention

anacetrapib
DEFINE, 2010    NCTanacetrapibplaceboExploratory negative
REALIZE, 2015      NCTanacetrapibplaceboLow risk of bias negative
bezafibrate
BECAIT, 1996     bezafibrateplacebosecondary preventionExploratory suggesting
BIP, 2000       bezafibrateplacebosecondary preventionLow risk of bias negative
SENDCAP, 1998     bezafibrateplacebo type 2 diabetes Exploratory suggesting
LEADER, 2002     bezafibrateplaceboLow risk of bias negative
clofibrate
WHO clofibrate, 1978   clofibrateplaceboLow risk of bias suggesting
CDP Clofibrate, 1975   clofibrateplaceboLow risk of bias suggesting
Scottish, 1971   clofibrateplaceboLow risk of bias negative
Newcastle, 1971   clofibrateplaceboLow risk of bias suggesting
Harrold, 1969   clofibrateplacebo type 2 diabetes Low risk of bias -
Begg, 1971   clofibrateplacebosecondary preventionExploratory negative
Acheson, 1972   clofibrateplacebosecondary prevention cerebral vascular disease Exploratory -
VA Neurology Section, 1974   clofibrateplaceboLow risk of bias -
Cullen, 1974   clofibrateplaceboLow risk of bias -
Hanefeld, 1991   clofibrateplacebo type 2 diabetes Low risk of bias negative
etofibrate
Emmerich, 2009     etofibrateplacebodiabetic type 2 diabetes Exploratory -
fenofibrate
FIELD, 2005             fenofibrateplacebodiabetic type 2 diabetes Low risk of bias suggesting
DAIS, 2001     fenofibrateplacebodiabetic type 2 diabetes Exploratory negative
ACCORD lipid, 2010    NCTfenofibrateplacebo (on top simvastatine)diabetic patientsLow risk of bias negative
gemfibrozil
VA-HIT, 1999      NCTgemfibrozilplaceboLow risk of bias suggesting
Helsinki (HHS), 1987   gemfibrozilplaceboLow risk of bias suggesting
HHS (Frick)(secondary prev subgroup), 1993   gemfibrozilplaceboExploratory negative
LOCAT, 1997     gemfibrozilplaceboExploratory negative
niacin
VA drugs, 1968   niacincontrolLow risk of bias negative
CDP niacin, 1975   niacinplaceboLow risk of bias suggesting
AIM-HIGH, 2011      NCTniacinplacebo (on top statin)Low risk of bias negative
HPS 2-Thrive      NCTniacinplacebo (on top statin)Low risk of bias negative
Oxford Niaspan Study, 2009    NCTniacinplacebo (on top statin)Exploratory -
ARBITER 2, 2009   niacinplacebo (on top statin)Exploratory negative
HATS, 2001   niacinplacebo (on top statin)Low risk of bias negative
ARBITER 6-HALTS (niacin vs ezetimibe), 2009        NCTniacinezetimibeExploratory suggesting
torcetrapib
RADIANCE 1, 2007      NCTtorcetrapibplaceboExploratory negative
ILLUMINATE, 2007      NCTtorcetrapibplaceboLow risk of bias negative
RADIANCE 2, 2007     torcetrapibplaceboLow risk of bias -
ILLUSTRATE, 2007      NCTtorcetrapibplaceboExploratory negative