antiplatelets drug

A EFFACER - Aspirin - Atopaxar - Cangrelor - Clopidogrel - Dipyridamol - Elinogrel - Prasugrel - Sulfinpyrazone - Ticagrelor - Ticlopidine - Triflusal - Vorapaxar      

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Trial Studied trt Control trt patientstagsROB Trial result

acute coronary syndrome

aspirin
ATACS-pilot, 1990   aspirincontrolnegative
Huddinge, 1988     aspirincontrolnegative
Frankfurt, 1976   aspirincontrolnegative
VA-pilot   aspirinplacebonegative
VA-main, 1983   aspirinplaceboLow risk of bias suggesting
RISC, 1990   aspirinplaceboLow risk of bias suggesting
ALDUSA-pilot   aspirinplacebonegative
Théroux, 1988   aspirinplaceboLow risk of bias suggesting
Canadian (Aspirin vs PBO), 1985   aspirinplaceboLow risk of bias -
Dutch-aspirin, 1990     aspirinplaceboLow risk of bias negative
ISIS-pilot, 1987     aspirinplaceboLow risk of bias negative
ISIS-2, 1988   aspirinplaceboLow risk of bias suggesting
APRICOT, 1993   aspirinplaceboLow risk of bias suggesting
Canadian (Aspirin + sulfinpyrazone), 1985   aspirin + sulfinpyrazoneplaceboLow risk of bias negative
atopaxar
J-LANCELOT, 2010   atopaxarplaceboExploratory -
LANCELOT ACS     atopaxarplaceboExploratory -
clopidogrel
COMMIT, 2005      NCTclopidogrelplaceboLow risk of bias suggesting
CLARITY-TIMI 28, 2005   clopidogrelplaceboLow risk of bias -
CURE, 2001     clopidogrel + aspirinaspirinLow risk of bias suggesting
CURRENT OASIS 7 (clopidogrel), 2010    NCTclopidogrel high-dose regimenclopidogrel standard-doseLow risk of bias negative
dipyridamol
Prandoni, 1991   aspirin + dipyridamolplaceboLow risk of bias negative
elinogrel
ERASE-MI, 2009     elinogrelplaceboLow risk of bias negative
prasugrel
TRILOGY ACS (overall population), 2012        NCTprasugrelclopidogrelLow risk of bias negative
TRITON-TIMI 38, 2007      NCTprasugrelclopidogrelLow risk of bias suggesting
sulfinpyrazone
Dutch sulphinpyrazone, 1986   sulfinpyrazonecontrolnegative
Canadian (sulfinpyrazone alone), 1985   sulfinpyrazoneplaceboLow risk of bias -
Wilcox, 1980   sulfinpyrazoneplacebonegative
Louvain sulphinpyrazone, 1983   sulfinpyrazoneplaceboLow risk of bias negative
ticagrelor
PLATO, 2009      NCTticagrelorclopidogrelLow risk of bias suggesting
DISPERSE-2 (90mg), 2007       ticagrelorclopidogrelLow risk of bias negative
ticlopidine
STAI, 1990   ticlopidinecontrolsuggesting
Knudsen-A, 1985   ticlopidinecontrolnegative
Florida UA   ticlopidineplacebonegative
trapidil
Modena   trapidilplacebosuggesting
triflusal
Plaza, 1993   triflusalplaceboLow risk of bias suggesting
vorapaxar
TRACER, 2011      NCTvorapaxarplacebo (on top standard therapy) Low risk of bias -

acute myocardial infarction

aspirin
Huddinge, 1988     aspirincontrolnegative
Frankfurt, 1976   aspirincontrolnegative
Dutch-aspirin, 1990     aspirinplaceboLow risk of bias negative
ISIS-pilot, 1987     aspirinplaceboLow risk of bias negative
ISIS-2, 1988   aspirinplaceboLow risk of bias suggesting
APRICOT, 1993   aspirinplaceboLow risk of bias suggesting
clopidogrel
COMMIT, 2005      NCTclopidogrelplaceboLow risk of bias suggesting
CLARITY-TIMI 28, 2005   clopidogrelplaceboLow risk of bias -
elinogrel
ERASE-MI, 2009     elinogrelplaceboLow risk of bias negative
sulfinpyrazone
Dutch sulphinpyrazone, 1986   sulfinpyrazonecontrolnegative
Wilcox, 1980   sulfinpyrazoneplacebonegative
Louvain sulphinpyrazone, 1983   sulfinpyrazoneplaceboLow risk of bias negative
ticlopidine
Knudsen-A, 1985   ticlopidinecontrolnegative

CABG surgery

aspirin
McEnany, 1982   aspirinplaceboLow risk of bias negative
Lorenz, 1984   aspirinplaceboLow risk of bias negative
GESIC (aspirin), 1990   aspirinplaceboLow risk of bias negative
Sydney, 1991   aspirinplaceboLow risk of bias -
Hockings, 1993   aspirinplaceboLow risk of bias -
clopidogrel
CASCADE, 2009      NCTclopidogrel+aspirinaspirinLow risk of bias -
dipyridamol
Pantely, 1979   aspirin + dipyridamolcontrolnegative
Brussels, 1987   aspirin + dipyridamolcontrolnegative
Czech, 1986   aspirin + dipyridamolcontrol -
Des Moines, 1980   aspirin + dipyridamolcontrol -
Toronto dipyridamole, 1987   dipyridamolcontrol -
Brooks, 1985     aspirin + dipyridamolplaceboLow risk of bias negative
Mayo-A, 1984   aspirin + dipyridamolplaceboLow risk of bias negative
Wadsworth, 1985   aspirin + dipyridamolplaceboLow risk of bias negative
Basel, 1989   aspirin + dipyridamolplaceboLow risk of bias negative
Leeds-B, 1985   aspirin + dipyridamolplaceboLow risk of bias -
Thaulow, 1987   aspirin + dipyridamolplaceboLow risk of bias -
GESIC (aspirin+dipyridamol), 1990   aspirin + dipyridamolplaceboLow risk of bias negative
Ekestrom, 1990   dipyridamolplaceboLow risk of bias -
sulfinpyrazone
Baur, 1982     sulfinpyrazoneplaceboLow risk of bias -
sulotroban
German sulotroban, 1989   sulotrobancontrol -
ticlopidine
Zurich, 1982   ticlopidinecontrol -
Knudsen-B, 1983   ticlopidinecontrol -
Romeo, 1983   ticlopidinecontrol -
Kohn, 1990   ticlopidinecontrol -
Liège-I, 1984   ticlopidineplaceboLow risk of bias negative
Liège-II, 1987   ticlopidineplaceboLow risk of bias negative

cardiovascular prevention

aspirin
JPAD, 2008      NCTaspirinno treatmentRisk of bias suggesting
PPP (diabetics sub group), 2003   aspirinno treatmentExploratory negative
British Doctor’s Trial, 1988   aspirinno treatmentprimary preventionRisk of bias negative
Primary Prevention Project, 2001     aspirinno treatmentprimary preventionRisk of bias negative
POPADAD aspirin, 2008     aspirinplaceboLow risk of bias negative
DAMAD, 1989   aspirinplaceboLow risk of bias negative
ETDRS, 1992   aspirinplaceboLow risk of bias suggesting
PHS (diabetics sub group), 1989   aspirinplaceboLow risk of bias suggesting
WHS (diabetics sub group), 2005   aspirinplaceboLow risk of bias suggesting
Physicians Health Study, 1989    NCTaspirinplaceboprimary preventionLow risk of bias suggesting
Thrombosis Prevention Trial, 1998        NCTaspirinplaceboprimary preventionLow risk of bias suggesting
HOT, 1998     aspirinplaceboprimary preventionLow risk of bias suggesting
Women’s Health Study, 2005       aspirinplaceboprimary preventionLow risk of bias suggesting
AAA, 2009     aspirinplacebosecondary preventionLow risk of bias negative
Schoop, 1983   aspirinplaceboLow risk of bias -
Hess, 1985   aspirinplacebo -
Munich A, 1975   aspirinplaceboLow risk of bias -
Munich B, 1975   aspirinplaceboLow risk of bias -
CLIPS, 2007     aspirinplaceboLow risk of bias suggesting
CDPA, 1976   aspirinplaceboLow risk of bias negative
Cardiff I, 1974   aspirinplaceboLow risk of bias negative
Cardiff II, 1979   aspirinplaceboLow risk of bias negative
Vogel, 1979   aspirinplaceboLow risk of bias suggesting
AMIS, 1980    NCTaspirinplaceboLow risk of bias suggesting
GAMIS, 1980   aspirinplaceboLow risk of bias negative
PARIS, 1980   aspirinplaceboLow risk of bias negative
JAMIS, 1999     aspirinplacebosuggesting
SAPAT, 1992   aspirinplaceboLow risk of bias suggesting
clopidogrel
CAPRIE, 1996   clopidogrelaspirinsecondary preventionLow risk of bias suggesting
CAPRIE (PAD subgroup), 1996   clopidogrelaspirinLow risk of bias suggesting
ASCET    NCTclopidogrelaspirinRisk of bias negative
CHARISMA, 2006      NCTclopidogrelplacebo (on top aspirin)secondary preventionLow risk of bias suggesting
dipyridamol
Atlanta (Sbar), 1967   dipyridamolcontrolLow risk of bias negative
Becker, 1967   dipyridamolcontrolLow risk of bias negative
Wirecki, 1967   dipyridamolcontrolLow risk of bias negative
Hess (2), 1985   aspirin + dipyridamolplaceboLow risk of bias -
Schoop (2), 1983   aspirin + dipyridamolplaceboLow risk of bias -
VA study, 1986   aspirin + dipyridamolplaceboLow risk of bias -
Igloe, 1970   dipyridamolplaceboLow risk of bias -
Zion, 1961   dipyridamolplaceboLow risk of bias -
Kinsella, 1962   dipyridamolplaceboLow risk of bias -
Leiberman, 1964   dipyridamolplaceboLow risk of bias -
Dewar, 1961   dipyridamolplaceboLow risk of bias -
Neumann, 1964   dipyridamolplaceboLow risk of bias -
Foulds, 1960   dipyridamolplaceboLow risk of bias -
PARIS, 1980   dipyridamol + aspirinplaceboLow risk of bias negative
PARIS-II, 1986   dipyridamol + aspirinplaceboLow risk of bias negative
PARIS, 1980   dipyridamol + aspirinaspirinLow risk of bias negative
ketanserine
PACK, 1996   ketanserineplaceboLow risk of bias -
Walden, 1991   ketanserineplaceboLow risk of bias -
Thulesius, 1987   ketanserineplaceboLow risk of bias -
picotamide
Cocozza, 1995     picotamideplaceboLow risk of bias negative
ADEP, 1993   picotamideplaceboLow risk of bias -
Neirotti, 1994   picotamideplaceboLow risk of bias -
Coto, 1989   picotamideplaceboLow risk of bias -
sulfinpyrazone
Dutch, 1980   sulfinyrazoneplacebonegative
suloctidil
Adriaensen, 1976   suloctidilplaceboLow risk of bias -
Verhaeghe, 1981   suloctidilplaceboLow risk of bias -
Jones, 1982   suloctidilplaceboLow risk of bias -
Holm, 1984   suloctidilplaceboLow risk of bias -
ticagrelor
EUCLID, 2016        NCTticagrelorclopidogrelLow risk of bias -
PEGASUS 60mg, 2015        NCTticagrelorplacebo (on top aspirin)secondary preventionLow risk of bias suggesting
PEGASUS 90mg, 2015        NCTticagrelorplacebo (on top aspirin)secondary preventionLow risk of bias suggesting
ticlopidine
Birmingham-A, 1979   ticlopidineplacebonegative
London diabetes, 1983   ticlopidineplacebonegative
TIMAD, 1984   ticlopidineplacebonegative
BTRS, 1992   ticlopidineplaceboLow risk of bias negative
Nyberg, 1984   ticlopidineplaceboLow risk of bias negative
EMATAP, 1993   ticlopidineplaceboLow risk of bias -
Katsumara, 1982   ticlopidineplaceboLow risk of bias -
Aukland, 1982   ticlopidineplaceboLow risk of bias -
Stiegler, 1984   ticlopidineplaceboLow risk of bias -
Ellis, 1986   ticlopidineplaceboLow risk of bias -
Cloarec, 1986   ticlopidineplaceboLow risk of bias -
Arcan, 1988   ticlopidineplaceboLow risk of bias -
Balsano, 1989   ticlopidineplaceboLow risk of bias -
STIMS, 1990   ticlopidineplaceboLow risk of bias -
Hurlow, 1980   ticlopidineplaceboLow risk of bias -
Krause, 1980   ticlopidineplaceboLow risk of bias -
Berglund, 1985   ticlopidineplaceboLow risk of bias negative
various
CRAMPS, 2000   cloricromeneplaceboLow risk of bias -
vorapaxar
TRA-2P TIMI 50, 2012        NCTvorapaxarplacebo (on top aspirin)secondary preventionLow risk of bias suggesting
TRA-2P TIMI 50 (no prior stroke sub group), 2012     vorapaxarplacebo (on top aspirin)secondary preventionExploratory suggesting
TRA-2P TIMI 50 (MI subgroup), 2012        NCTvorapaxarplacebo (on top aspirin)secondary preventionExploratory suggesting

diabetes type 2

aspirin
JPAD, 2008      NCTaspirinno treatmentRisk of bias suggesting
PPP (diabetics sub group), 2003   aspirinno treatmentExploratory