antiplatelets drug  

A EFFACER - Aspirin - Atopaxar - Cangrelor - Clopidogrel - Dipyridamol - Elinogrel - Prasugrel - Sulfinpyrazone - Ticagrelor - Ticlopidine - Triflusal - Vorapaxar      

Select
Display
Trial Studied trt Control trt patientstagsNCTROB Result

acute coronary syndrome

aspirin
ATACS-pilot, 1990aspirincontrolnegative
Huddinge, 1988aspirincontrolnegative
Frankfurt, 1976aspirincontrolnegative
VA-pilotaspirinplacebonegative
VA-main, 1983aspirinplaceboLow risk of bias suggesting
RISC, 1990aspirinplaceboLow risk of bias suggesting
ALDUSA-pilotaspirinplacebonegative
Théroux, 1988aspirinplaceboLow risk of bias suggesting
Canadian (Aspirin vs PBO), 1985aspirinplaceboLow risk of bias -
Dutch-aspirin, 1990aspirinplaceboLow risk of bias negative
ISIS-pilot, 1987aspirinplaceboLow risk of bias negative
ISIS-2, 1988aspirinplaceboLow risk of bias suggesting
APRICOT, 1993aspirinplaceboLow risk of bias suggesting
Canadian (Aspirin + sulfinpyrazone), 1985aspirin + sulfinpyrazoneplaceboLow risk of bias negative
atopaxar
J-LANCELOT, 2010atopaxarplaceboExploratory -
LANCELOT ACSatopaxarplaceboExploratory -
clopidogrel
COMMIT, 2005clopidogrelplaceboNCT00222573Low risk of bias suggesting
CLARITY-TIMI 28, 2005clopidogrelplaceboLow risk of bias -
CURE, 2001clopidogrel + aspirinaspirinLow risk of bias suggesting
CURRENT OASIS 7 (clopidogrel), 2010clopidogrel high-dose regimenclopidogrel standard-doseNCT00335452Low risk of bias negative
dipyridamol
Prandoni, 1991aspirin + dipyridamolplaceboLow risk of bias negative
elinogrel
INNOVATE ongoing elinogrelerrorNCT00751231 ongoing
ERASE-MI, 2009elinogrelplaceboLow risk of bias negative
prasugrel
TRILOGY ACS (overall population), 2012prasugrelclopidogrelNCT00699998Low risk of bias negative
TRITON-TIMI 38, 2007prasugrelclopidogrelNCT00097591Low risk of bias suggesting
ACAPULCO ongoing prasugrelclopidogrel ongoing
sulfinpyrazone
Dutch sulphinpyrazone, 1986sulfinpyrazonecontrolnegative
Canadian (sulfinpyrazone alone), 1985sulfinpyrazoneplaceboLow risk of bias -
Wilcox, 1980sulfinpyrazoneplacebonegative
Louvain sulphinpyrazone, 1983sulfinpyrazoneplaceboLow risk of bias negative
ticagrelor
PLATO, 2009ticagrelorclopidogrelNCT00391872Low risk of bias suggesting
DISPERSE-2 (90mg), 2007ticagrelorclopidogrelLow risk of bias negative
ticlopidine
STAI, 1990ticlopidinecontrolsuggesting
Knudsen-A, 1985ticlopidinecontrolnegative
Florida UAticlopidineplacebonegative
trapidil
Modenatrapidilplacebosuggesting
triflusal
Plaza, 1993triflusalplaceboLow risk of bias suggesting
vorapaxar
TRACER, 2011vorapaxarplacebo (on top standard therapy) NCT00527943Low risk of bias -

acute myocardial infarction

aspirin
Huddinge, 1988aspirincontrolnegative
Frankfurt, 1976aspirincontrolnegative
Dutch-aspirin, 1990aspirinplaceboLow risk of bias negative
ISIS-pilot, 1987aspirinplaceboLow risk of bias negative
ISIS-2, 1988aspirinplaceboLow risk of bias suggesting
APRICOT, 1993aspirinplaceboLow risk of bias suggesting
clopidogrel
COMMIT, 2005clopidogrelplaceboNCT00222573Low risk of bias suggesting
CLARITY-TIMI 28, 2005clopidogrelplaceboLow risk of bias -
elinogrel
INNOVATE ongoing elinogrelerrorNCT00751231 ongoing
ERASE-MI, 2009elinogrelplaceboLow risk of bias negative
sulfinpyrazone
Dutch sulphinpyrazone, 1986sulfinpyrazonecontrolnegative
Wilcox, 1980sulfinpyrazoneplacebonegative
Louvain sulphinpyrazone, 1983sulfinpyrazoneplaceboLow risk of bias negative
ticlopidine
Knudsen-A, 1985ticlopidinecontrolnegative

CABG surgery

aspirin
McEnany, 1982aspirinplaceboLow risk of bias negative
Lorenz, 1984aspirinplaceboLow risk of bias negative
GESIC (aspirin), 1990aspirinplaceboLow risk of bias negative
Sydney, 1991aspirinplaceboLow risk of bias -
Hockings, 1993aspirinplaceboLow risk of bias -
cangrelor
Bridge ongoing cangrelor placeboNCT00767507Low risk of bias ongoing
clopidogrel
CASCADE, 2009clopidogrel+aspirinaspirinNCT00228423Low risk of bias -
dipyridamol
Pantely, 1979aspirin + dipyridamolcontrolnegative
Brussels, 1987aspirin + dipyridamolcontrolnegative
Czech, 1986aspirin + dipyridamolcontrol -
Des Moines, 1980aspirin + dipyridamolcontrol -
Toronto dipyridamole, 1987dipyridamolcontrol -
Brooks, 1985aspirin + dipyridamolplaceboLow risk of bias negative
Mayo-A, 1984aspirin + dipyridamolplaceboLow risk of bias negative
Wadsworth, 1985aspirin + dipyridamolplaceboLow risk of bias negative
Basel, 1989aspirin + dipyridamolplaceboLow risk of bias negative
Leeds-B, 1985aspirin + dipyridamolplaceboLow risk of bias -
Thaulow, 1987aspirin + dipyridamolplaceboLow risk of bias -
GESIC (aspirin+dipyridamol), 1990aspirin + dipyridamolplaceboLow risk of bias negative
Ekestrom, 1990dipyridamolplaceboLow risk of bias -
sulfinpyrazone
Baur, 1982sulfinpyrazoneplaceboLow risk of bias -
sulotroban
German sulotroban, 1989sulotrobancontrol -
ticlopidine
Zurich, 1982ticlopidinecontrol -
Knudsen-B, 1983ticlopidinecontrol -
Romeo, 1983ticlopidinecontrol -
Kohn, 1990ticlopidinecontrol -
Liège-I, 1984ticlopidineplaceboLow risk of bias negative
Liège-II, 1987ticlopidineplaceboLow risk of bias negative

cardiovascular prevention

aspirin
JPPP ongoing aspirinno aspirinprimary preventionNCT00225849Risk of bias ongoing
JPAD, 2008aspirinno treatmentNCT00110448Risk of bias suggesting
PPP (diabetics sub group), 2003aspirinno treatmentExploratory negative
British Doctor’s Trial, 1988aspirinno treatmentprimary preventionRisk of bias negative
Primary Prevention Project, 2001aspirinno treatmentprimary preventionRisk of bias negative
POPADAD aspirin, 2008aspirinplaceboISRCTN53295293Low risk of bias negative
DAMAD, 1989aspirinplaceboLow risk of bias negative
ETDRS, 1992aspirinplaceboLow risk of bias suggesting
PHS (diabetics sub group), 1989aspirinplaceboLow risk of bias suggesting
WHS (diabetics sub group), 2005aspirinplaceboLow risk of bias suggesting
Physicians Health Study, 1989aspirinplaceboprimary preventionNCT00000500Low risk of bias suggesting
Thrombosis Prevention Trial, 1998aspirinplaceboprimary preventionNCT00000614Low risk of bias suggesting
HOT, 1998aspirinplaceboprimary preventionLow risk of bias suggesting
Women’s Health Study, 2005aspirinplaceboprimary preventionLow risk of bias suggesting
AAA, 2009aspirinplacebosecondary preventionISRCTN66587262Low risk of bias negative
Schoop, 1983aspirinplaceboLow risk of bias -
Hess, 1985aspirinplacebo -
Munich A, 1975aspirinplaceboLow risk of bias -
Munich B, 1975aspirinplaceboLow risk of bias -
CLIPS, 2007aspirinplaceboLow risk of bias suggesting
CDPA, 1976aspirinplaceboLow risk of bias negative
Cardiff I, 1974aspirinplaceboLow risk of bias negative
Cardiff II, 1979aspirinplaceboLow risk of bias negative
Vogel, 1979aspirinplaceboLow risk of bias suggesting
AMIS, 1980aspirinplaceboNCT00000491Low risk of bias suggesting
GAMIS, 1980aspirinplaceboLow risk of bias negative
PARIS, 1980aspirinplaceboLow risk of bias negative
JAMIS, 1999aspirinplacebosuggesting
SAPAT, 1992aspirinplaceboLow risk of bias suggesting
ASCEND (aspirin) ongoing aspirinplaceboNCT00135226Low risk of bias ongoing
ACCEPT-D ongoing aspirinplaceboISRCTN48110081Risk of bias ongoing
clopidogrel
CAPRIE, 1996clopidogrelaspirinsecondary preventionLow risk of bias suggesting
CAPRIE (PAD subgroup), 1996clopidogrelaspirinLow risk of bias suggesting
ASCETclopidogrelaspirinNCT00222261Risk of bias negative
CHARISMA, 2006clopidogrelplacebo (on top aspirin)secondary preventionNCT00050817Low risk of bias suggesting
dipyridamol
Atlanta (Sbar), 1967dipyridamolcontrolLow risk of bias negative
Becker, 1967dipyridamolcontrolLow risk of bias negative
Wirecki, 1967dipyridamolcontrolLow risk of bias negative
Hess (2), 1985aspirin + dipyridamolplaceboLow risk of bias -
Schoop (2), 1983aspirin + dipyridamolplaceboLow risk of bias -
VA study, 1986aspirin + dipyridamolplaceboLow risk of bias -
Igloe, 1970dipyridamolplaceboLow risk of bias -
Zion, 1961dipyridamolplaceboLow risk of bias -
Kinsella, 1962dipyridamolplaceboLow risk of bias -
Leiberman, 1964dipyridamolplaceboLow risk of bias -
Dewar, 1961dipyridamolplaceboLow risk of bias -
Neumann, 1964dipyridamolplaceboLow risk of bias -
Foulds, 1960dipyridamolplaceboLow risk of bias -
PARIS, 1980dipyridamol + aspirinplaceboLow risk of bias negative
PARIS-II, 1986dipyridamol + aspirinplaceboLow risk of bias negative
PARIS, 1980dipyridamol + aspirinaspirinLow risk of bias negative
ketanserine
PACK, 1996ketanserineplaceboLow risk of bias -
Walden, 1991ketanserineplaceboLow risk of bias -
Thulesius, 1987ketanserineplaceboLow risk of bias -
picotamide
Cocozza, 1995picotamideplaceboLow risk of bias negative
ADEP, 1993picotamideplaceboLow risk of bias -
Neirotti, 1994picotamideplaceboLow risk of bias -
Coto, 1989picotamideplaceboLow risk of bias -
sulfinpyrazone
Dutch, 1980sulfinyrazoneplacebonegative
suloctidil
Adriaensen, 1976suloctidilplaceboLow risk of bias -
Verhaeghe, 1981suloctidilplaceboLow risk of bias -
Jones, 1982suloctidilplaceboLow risk of bias -
Holm, 1984suloctidilplaceboLow risk of bias -
ticagrelor
EUCLID, 2016ticagrelorclopidogrelNCT01732822Low risk of bias -
PEGASUS 60mg, 2015ticagrelorplacebo (on top aspirin)secondary preventionNCT01225562Low risk of bias suggesting
PEGASUS 90mg, 2015ticagrelorplacebo (on top aspirin)secondary preventionNCT01225562Low risk of bias suggesting
ticlopidine
Birmingham-A, 1979ticlopidineplacebonegative
London diabetes, 1983ticlopidineplacebonegative
TIMAD, 1984ticlopidineplacebonegative
BTRS, 1992ticlopidineplaceboLow risk of bias negative
Nyberg, 1984ticlopidineplaceboLow risk of bias negative
EMATAP, 1993ticlopidineplaceboLow risk of bias -
Katsumara, 1982ticlopidineplaceboLow risk of bias -
Aukland, 1982ticlopidineplaceboLow risk of bias -
Stiegler, 1984ticlopidineplaceboLow risk of bias -
Ellis, 1986ticlopidineplaceboLow risk of bias -
Cloarec, 1986ticlopidineplaceboLow risk of bias -
Arcan, 1988ticlopidineplaceboLow risk of bias -
Balsano, 1989ticlopidineplaceboLow risk of bias -
STIMS, 1990ticlopidineplaceboLow risk of bias -
Hurlow, 1980ticlopidineplaceboLow risk of bias -
Krause, 1980ticlopidineplaceboLow risk of bias -
Berglund, 1985ticlopidineplaceboLow risk of bias negative
various
CRAMPS, 2000cloricromeneplaceboLow risk of bias -
vorapaxar
TRA-2P TIMI 50, 2012vorapaxarplacebo (on top aspirin)secondary preventionNCT00526474Low risk of bias suggesting
TRA-2P TIMI 50 (no prior stroke sub group), 2012vorapaxarplacebo (on top aspirin)secondary preventionExploratory suggesting
TRA-2P TIMI 50 (MI subgroup), 2012vorapaxarplacebo (on top aspirin)secondary preventionNCT00526474Exploratory suggesting

diabetes type 2

aspirin
JPAD, 2008aspirinno treatmentNCT00110448Risk of bias suggesting
PPP (diabetics sub group), 2003aspirinno treatmentExploratory negative
POPADAD aspirin, 2008aspirinplaceboISRCTN53295293Low risk of bias negative
DAMAD, 1989aspirinplaceboLow risk of bias negative
ETDRS, 1992aspirinplaceboLow risk of bias suggesting
PHS (diabetics sub group), 1989aspirinplaceboLow risk of bias suggesting
WHS (diabetics sub group), 2005aspirinplaceboLow risk of bias suggesting
ASCEND (aspirin) ongoing aspirinplaceboNCT00135226Low risk of bias ongoing
ACCEPT-D ongoing aspirinplaceboISRCTN48110081Risk of bias ongoing
picotamide
Cocozza, 1995picotamideplaceboLow risk of bias negative
sulfinpyrazone
Dutch, 1980sulfinyrazoneplacebonegative
ticlopidine
Birmingham-A, 1979ticlopidineplacebonegative
London diabetes, 1983ticlopidineplacebonegative
TIMAD, 1984ticlopidineplacebonegative
BTRS, 1992ticlopidineplaceboLow risk of bias negative
Nyberg, 1984ticlopidineplaceboLow risk of bias negative

hypertension

aspirin
HOT, 1998aspirinplaceboprimary preventionLow risk of bias suggesting

percutaneous coronary intervention

cilostazol
Kunishima, 1997cilostazolaspirinnegative
Sekiya, 1998cilostazol + aspirinaspirinnegative
Kozuma, 2001cilostazol + aspirinticlopidine + aspirinnegative
Ochiai, 1999cilostazol + aspirinticlopidine + aspirinnegative
Park, 1999cilostazol + aspirinticlopidine + aspirinnegative
Yoon, 1999cilostazol + aspirinticlopidine + aspirinnegative
Kamishirado, 2002cilostazol + aspirinticlopidine + aspirinnegative
clopidogrel
REAL-LATE, ZEST-LATE, 2010clopidogrel+aspirinaspirinNCT00484926negative
GRAVITAS, 2011high-dose clopidogrelnormal-dose clopidogrelNCT00645918Risk of bias negative
Müller, 2000clopidogrel + aspirinticlopidine + aspirinnegative
CLASSICS, 2000clopidogrel + aspirinticlopidine + aspirinnegative
TOPPS, 2001clopidogrel + aspirinticlopidine + aspirinnegative
Piamsomboon, 2001clopidogrel + aspirinticlopidine + aspirinnegative
ticlopidine
STARS (vs aspirin), 1998ticlopidine + aspirinaspirinsuggesting
Hall, 1996ticlopidine + aspirinaspirinnegative
FANTASTIC, 1998ticlopidine + aspirincoumadin + aspirinnegative
ISAR, 1996ticlopidine + aspirincoumadin + aspirinsuggesting
Foussas, 2000ticlopidine + aspirincoumadin + aspirinsuggesting
MATTIS, 1998ticlopidine + aspirincoumadin + aspirinnegative
STARS (vs coumadin+asp), 1998ticlopidine + aspirincoumadin + aspirinsuggesting

peripheral vascular diseases

aspirin
Schoop, 1983aspirinplaceboLow risk of bias -
Hess, 1985aspirinplacebo -
Munich A, 1975aspirinplaceboLow risk of bias -
Munich B, 1975aspirinplaceboLow risk of bias -
CLIPS, 2007aspirinplaceboLow risk of bias suggesting
clopidogrel
CAPRIE (PAD subgroup), 1996clopidogrelaspirinLow risk of bias suggesting
dipyridamol
Hess (2), 1985aspirin + dipyridamolplaceboLow risk of bias -
Schoop (2), 1983aspirin + dipyridamolplaceboLow risk of bias -
VA study, 1986aspirin + dipyridamolplaceboLow risk of bias -
ketanserine
PACK, 1996ketanserineplaceboLow risk of bias -
Walden, 1991ketanserineplaceboLow risk of bias -
Thulesius, 1987ketanserineplaceboLow risk of bias -
picotamide
ADEP, 1993picotamideplaceboLow risk of bias -
Neirotti, 1994picotamideplaceboLow risk of bias -
Coto, 1989picotamideplaceboLow risk of bias -
suloctidil
Adriaensen, 1976suloctidilplaceboLow risk of bias -
Verhaeghe, 1981suloctidilplaceboLow risk of bias -
Jones, 1982suloctidilplaceboLow risk of bias