antiplatelets drug

A EFFACER - Aspirin - Atopaxar - Cangrelor - Clopidogrel - Dipyridamol - Elinogrel - Prasugrel - Sulfinpyrazone - Ticagrelor - Ticlopidine - Triflusal - Vorapaxar      

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Trial Studied trt Control trt patientstagsNCTROB Result

acute coronary syndrome

aspirin
ATACS-pilot, 1990aspirincontrolnegative
Huddinge, 1988aspirincontrolnegative
Frankfurt, 1976aspirincontrolnegative
VA-pilotaspirinplacebonegative
VA-main, 1983aspirinplacebosuggesting
RISC, 1990aspirinplacebosuggesting
ALDUSA-pilotaspirinplacebonegative
Théroux, 1988aspirinplacebosuggesting
Canadian (Aspirin vs PBO), 1985aspirinplacebo -
Dutch-aspirin, 1990aspirinplacebonegative
ISIS-pilot, 1987aspirinplacebonegative
ISIS-2, 1988aspirinplacebosuggesting
APRICOT, 1993aspirinplacebosuggesting
Canadian (Aspirin + sulfinpyrazone), 1985aspirin + sulfinpyrazoneplacebonegative
atopaxar
J-LANCELOT, 2010atopaxarplaceboExploratory -
LANCELOT ACSatopaxarplaceboExploratory -
clopidogrel
COMMIT, 2005clopidogrelplaceboNCT00222573suggesting
CLARITY-TIMI 28, 2005clopidogrelplacebo -
CURE, 2001clopidogrel + aspirinaspirinsuggesting
CURRENT OASIS 7 (clopidogrel), 2010clopidogrel high-dose regimenclopidogrel standard-doseNCT00335452Low risk of bias negative
dipyridamol
Prandoni, 1991aspirin + dipyridamolplacebonegative
elinogrel
INNOVATE ongoing elinogrelerrorNCT00751231 ongoing
ERASE-MI, 2009elinogrelplaceboExploratory negative
prasugrel
TRILOGY ACS (overall population), 2012prasugrelclopidogrelNCT00699998Low risk of bias negative
TRITON-TIMI 38, 2007prasugrelclopidogrelNCT00097591Low risk of bias suggesting
ACAPULCO ongoing prasugrelclopidogrel ongoing
sulfinpyrazone
Dutch sulphinpyrazone, 1986sulfinpyrazonecontrolnegative
Canadian (sulfinpyrazone alone), 1985sulfinpyrazoneplacebo -
Wilcox, 1980sulfinpyrazoneplacebonegative
Louvain sulphinpyrazone, 1983sulfinpyrazoneplacebonegative
ticagrelor
PLATO, 2009ticagrelorclopidogrelNCT00391872Low risk of bias suggesting
DISPERSE-2 (90mg), 2007ticagrelorclopidogrelExploratory negative
ticlopidine
STAI, 1990ticlopidinecontrolsuggesting
Knudsen-A, 1985ticlopidinecontrolnegative
Florida UAticlopidineplacebonegative
trapidil
Modenatrapidilplacebosuggesting
triflusal
Plaza, 1993triflusalplacebosuggesting
vorapaxar
TRACER, 2011vorapaxarplacebo (on top standard therapy) NCT00527943Low risk of bias -

acute myocardial infarction

aspirin
Huddinge, 1988aspirincontrolnegative
Frankfurt, 1976aspirincontrolnegative
Dutch-aspirin, 1990aspirinplacebonegative
ISIS-pilot, 1987aspirinplacebonegative
ISIS-2, 1988aspirinplacebosuggesting
APRICOT, 1993aspirinplacebosuggesting
clopidogrel
COMMIT, 2005clopidogrelplaceboNCT00222573suggesting
CLARITY-TIMI 28, 2005clopidogrelplacebo -
elinogrel
INNOVATE ongoing elinogrelerrorNCT00751231 ongoing
ERASE-MI, 2009elinogrelplaceboExploratory negative
sulfinpyrazone
Dutch sulphinpyrazone, 1986sulfinpyrazonecontrolnegative
Wilcox, 1980sulfinpyrazoneplacebonegative
Louvain sulphinpyrazone, 1983sulfinpyrazoneplacebonegative
ticlopidine
Knudsen-A, 1985ticlopidinecontrolnegative

CABG surgery

aspirin
McEnany, 1982aspirinplacebonegative
Lorenz, 1984aspirinplacebonegative
GESIC (aspirin), 1990aspirinplacebonegative
Sydney, 1991aspirinplacebo -
Hockings, 1993aspirinplacebo -
cangrelor
Bridge ongoing cangrelor placeboNCT00767507 ongoing
clopidogrel
CASCADE, 2009clopidogrel+aspirinaspirinNCT00228423Exploratory -
dipyridamol
Pantely, 1979aspirin + dipyridamolcontrolnegative
Brussels, 1987aspirin + dipyridamolcontrolnegative
Czech, 1986aspirin + dipyridamolcontrol -
Des Moines, 1980aspirin + dipyridamolcontrol -
Toronto dipyridamole, 1987dipyridamolcontrol -
Brooks, 1985aspirin + dipyridamolplacebonegative
Mayo-A, 1984aspirin + dipyridamolplacebonegative
Wadsworth, 1985aspirin + dipyridamolplacebonegative
Basel, 1989aspirin + dipyridamolplacebonegative
Leeds-B, 1985aspirin + dipyridamolplacebo -
Thaulow, 1987aspirin + dipyridamolplacebo -
GESIC (aspirin+dipyridamol), 1990aspirin + dipyridamolplacebonegative
Ekestrom, 1990dipyridamolplacebo -
sulfinpyrazone
Baur, 1982sulfinpyrazoneplacebo -
sulotroban
German sulotroban, 1989sulotrobancontrol -
ticlopidine
Zurich, 1982ticlopidinecontrol -
Knudsen-B, 1983ticlopidinecontrol -
Romeo, 1983ticlopidinecontrol -
Kohn, 1990ticlopidinecontrol -
Liège-I, 1984ticlopidineplacebonegative
Liège-II, 1987ticlopidineplacebonegative

cardiovascular prevention

aspirin
JPPP ongoing aspirinno aspirinprimary preventionNCT00225849Risk of bias ongoing
JPAD, 2008aspirinno treatmentNCT00110448Risk of bias suggesting
PPP (diabetics sub group), 2003aspirinno treatmentExploratory negative
British Doctor’s Trial, 1988aspirinno treatmentprimary preventionRisk of bias negative
Primary Prevention Project, 2001aspirinno treatmentprimary preventionRisk of bias negative
POPADAD aspirin, 2008aspirinplaceboISRCTN53295293Low risk of bias negative
DAMAD, 1989aspirinplaceboLow risk of bias negative
ETDRS, 1992aspirinplaceboLow risk of bias suggesting
PHS (diabetics sub group), 1989aspirinplaceboLow risk of bias suggesting
WHS (diabetics sub group), 2005aspirinplaceboExploratory suggesting
Physicians Health Study, 1989aspirinplaceboprimary preventionNCT00000500Low risk of bias suggesting
Thrombosis Prevention Trial, 1998aspirinplaceboprimary preventionNCT00000614Low risk of bias suggesting
HOT, 1998aspirinplaceboprimary preventionLow risk of bias suggesting
Women’s Health Study, 2005aspirinplaceboprimary preventionLow risk of bias suggesting
AAA, 2009aspirinplacebosecondary preventionISRCTN66587262Low risk of bias negative
Schoop, 1983aspirinplacebo -
Hess, 1985aspirinplacebo -
Munich A, 1975aspirinplacebo -
Munich B, 1975aspirinplacebo -
CLIPS, 2007aspirinplaceboLow risk of bias suggesting
CDPA, 1976aspirinplacebonegative
Cardiff I, 1974aspirinplacebonegative
Cardiff II, 1979aspirinplacebonegative
Vogel, 1979aspirinplacebosuggesting
AMIS, 1980aspirinplaceboNCT00000491suggesting
GAMIS, 1980aspirinplacebonegative
PARIS, 1980aspirinplacebonegative
JAMIS, 1999aspirinplacebosuggesting
SAPAT, 1992aspirinplaceboLow risk of bias suggesting
ASCEND (aspirin) ongoing aspirinplaceboNCT00135226 ongoing
ACCEPT-D ongoing aspirinplaceboISRCTN48110081Risk of bias ongoing
clopidogrel
CAPRIE, 1996clopidogrelaspirinsecondary preventionLow risk of bias suggesting
CAPRIE, 1996clopidogrelaspirin -
ASCETclopidogrelaspirinNCT00222261Risk of bias negative
CHARISMA, 2006clopidogrelplacebo (on top aspirin)secondary preventionNCT00050817Low risk of bias suggesting
dipyridamol
Atlanta (Sbar), 1967dipyridamolcontrolExploratory negative
Becker, 1967dipyridamolcontrolExploratory negative
Wirecki, 1967dipyridamolcontrolExploratory negative
Hess (2), 1985aspirin + dipyridamolplacebo -
Schoop (2), 1983aspirin + dipyridamolplacebo -
VA study, 1986aspirin + dipyridamolplacebo -
Igloe, 1970dipyridamolplaceboExploratory -
Zion, 1961dipyridamolplaceboExploratory -
Kinsella, 1962dipyridamolplaceboExploratory -
Leiberman, 1964dipyridamolplaceboExploratory -
Dewar, 1961dipyridamolplaceboExploratory -
Neumann, 1964dipyridamolplaceboExploratory -
Foulds, 1960dipyridamolplaceboExploratory -
PARIS, 1980dipyridamol + aspirinplacebonegative
PARIS-II, 1986dipyridamol + aspirinplacebonegative
PARIS, 1980dipyridamol + aspirinaspirinnegative
ketanserine
PACK, 1996ketanserineplacebo -
Walden, 1991ketanserineplacebo -
Thulesius, 1987ketanserineplacebo -
picotamide
Cocozza, 1995picotamideplaceboExploratory negative
ADEP, 1993picotamideplacebo -
Neirotti, 1994picotamideplacebo -
Coto, 1989picotamideplacebo -
sulfinpyrazone
Dutch, 1980sulfinyrazoneplacebonegative
suloctidil
Adriaensen, 1976suloctidilplacebo -
Verhaeghe, 1981suloctidilplacebo -
Jones, 1982suloctidilplacebo -
Holm, 1984suloctidilplacebo -
ticagrelor
EUCLID, 2016ticagrelorclopidogrelNCT01732822 -
PEGASUS 60mg, 2015ticagrelorplacebo (on top aspirin)secondary preventionNCT01225562Low risk of bias suggesting
PEGASUS 90mg, 2015ticagrelorplacebo (on top aspirin)secondary preventionNCT01225562suggesting
ticlopidine
Birmingham-A, 1979ticlopidineplacebonegative
London diabetes, 1983ticlopidineplacebonegative
TIMAD, 1984ticlopidineplacebonegative
BTRS, 1992ticlopidineplacebonegative
Nyberg, 1984ticlopidineplaceboLow risk of bias negative
EMATAP, 1993ticlopidineplacebo -
Katsumara, 1982ticlopidineplacebo -
Aukland, 1982ticlopidineplacebo -
Stiegler, 1984ticlopidineplacebo -
Ellis, 1986ticlopidineplacebo -
Cloarec, 1986ticlopidineplacebo -
Arcan, 1988ticlopidineplacebo -
Balsano, 1989ticlopidineplacebo -
STIMS, 1990ticlopidineplacebo -
Hurlow, 1980ticlopidineplacebo -
Krause, 1980ticlopidineplacebo -
Berglund, 1985ticlopidineplaceboExploratory negative
various
CRAMPS, 2000cloricromeneplacebo -
vorapaxar
TRA-2P TIMI 50, 2012vorapaxarplacebo (on top aspirin)secondary preventionNCT00526474Low risk of bias suggesting
TRA-2P TIMI 50 (no prior stroke sub group), 2012vorapaxarplacebo (on top aspirin)secondary preventionExploratory suggesting
TRA-2P TIMI 50 (MI subgroup), 2012vorapaxarplacebo (on top aspirin)secondary preventionNCT00526474Exploratory suggesting

diabetes type 2

aspirin
JPAD, 2008aspirinno treatmentNCT00110448Risk of bias suggesting
PPP (diabetics sub group), 2003aspirinno treatmentExploratory negative
POPADAD aspirin, 2008aspirinplaceboISRCTN53295293Low risk of bias negative
DAMAD, 1989aspirinplaceboLow risk of bias negative
ETDRS, 1992aspirinplaceboLow risk of bias suggesting
PHS (diabetics sub group), 1989aspirinplaceboLow risk of bias suggesting
WHS (diabetics sub group), 2005aspirinplaceboExploratory suggesting
ASCEND (aspirin) ongoing aspirinplaceboNCT00135226 ongoing
ACCEPT-D ongoing aspirinplaceboISRCTN48110081Risk of bias ongoing
picotamide
Cocozza, 1995picotamideplaceboExploratory negative
sulfinpyrazone
Dutch, 1980sulfinyrazoneplacebonegative
ticlopidine
Birmingham-A, 1979ticlopidineplacebonegative
London diabetes, 1983ticlopidineplacebonegative
TIMAD, 1984ticlopidineplacebonegative
BTRS, 1992ticlopidineplacebonegative
Nyberg, 1984ticlopidineplaceboLow risk of bias negative

DVT prophylaxis

aspirin
Clagett, 1975aspirincontrolRisk of bias -
Zekert VI, 1982aspirincontrolRisk of bias -
Pasteyer, 1977Aspirinno treatmentExploratory negative
Rocha, 1986Aspirinno treatmentExploratory suggesting
Stockholm-I, 1975AspirinplaceboExploratory negative
Harris-I, 1977AspirinplaceboLow risk of bias suggesting
McKenna-I, 1980AspirinplaceboExploratory suggesting
Sautter, 1983AspirinplaceboExploratory suggesting
McBride, 1983AspirinplaceboExploratory negative
Zekert-I , 1974AspirinplaceboExploratory suggesting
Powers , 1976AspirinplaceboExploratory suggesting
Erfurt-B , 1979AspirinplaceboExploratory negative
PEP hip-fracture, 2000aspirinplaceboLow risk of bias suggesting
MRC, 1972aspirinplaceboLow risk of bias negative
Loew DVT, 1974aspirinplaceboLow risk of bias -
Erfurt-A, 1979aspirinplaceboLow risk of bias -
Zekert V, 1980aspirinplaceboLow risk of bias -
Vinazzer I, 1980aspirinplaceboLow risk of bias -
Vinazzer II, 1977aspirinplaceboLow risk of bias -
PEP elective arthroplasty, 2000aspirinplaceboLow risk of bias -
dipyridamol
Chicago, 1982aspirin + dipyridamolcontrolExploratory negative
Parodi I, 1973dipyridamol + aspirincontrolExploratory suggesting
Parodi II, 1973dipyridamol + aspirincontrolRisk of bias -
Zekert-III, 1977dipyridamol + aspirincontrolRisk of bias -
Australian I, 1975dipyridamol + aspirincontrolRisk of bias -
Australian II, 1976dipyridamol + aspirincontrolRisk of bias -
Toulouse I, 1979dipyridamol + aspirincontrolRisk of bias -
Harjola DVT, 1982dipyridamol + aspirincontrolRisk of bias -
Weiss, 1977dipyridamol + aspirincontrolExploratory -
Lyon-I, 1975aspirin + dipyridamolno treatmentExploratory suggesting
Morris-B , 1977aspirin + dipyridamolno treatmentExploratory negative
Morris-A , 1977dipyridamolno treatmentExploratory negative
Hamburg, 1976aspirin + dipyridamolplaceboExploratory negative
Encke-II , 1976aspirin + dipyridamolplaceboExploratory negative
Frankfurt, 1981aspirin + dipyridamolplaceboExploratory negative
Encke IA, 1976dipyridamol + aspirinplaceboExploratory -
Encke IB, 1976dipyridamol + aspirinplaceboExploratory -
suloctidil
Turpie, 1985SuloctidilplaceboLow risk of bias -
ticlopidine
McKenna-II, 1983TiclopidineplaceboExploratory negative
Lyon-IITiclopidineplaceboExploratory negative
GardeckiTiclopidineplaceboExploratory negative
Lasierra, 1982ticlopidineplaceboExploratory -
Walker, 1974ticlopidineplaceboExploratory -
McKenna-II , 1983ticlopidineplacebonegative
UFH
Morris, 1974UFHno treatmentsuggesting
Welin-Berger, 1982UFHno treatmentnegative
Bergqvist , 1979UFHno treatmentsuggesting
VTCSG, 1975UFHno treatmentnegative
Mannucci , 1976UFHno treatmentsuggesting
Dechavanne, 1974UFHno treatmentsuggesting
Dechavanne, 1975UFHno treatmentsuggesting
Bergqvist, 1979UFHno treatmentsuggesting
Galasko , 1976UFHno treatmentsuggesting
Gallus , 1973UFHno treatmentsuggesting
Morris , 1977UFHno treatmentnegative
Williams , 1978UFHplacebonegative
Abraham-Inpijn , 1975UFHplacebonegative
Hampson, 1974UFHplacebonegative
Moskovitz, 1978UFHplacebosuggesting
Lahnborg, 1980UFHplacebosuggesting
Xabregas , 1977UFHplacebonegative
Moskovitz, 1978UFHplacebonegative
Svend-Hansen, 1981UFHplacebosuggesting

hypertension

aspirin
HOT, 1998aspirinplaceboprimary preventionLow risk of bias suggesting

percutaneous coronary intervention

cilostazol
Kunishima, 1997cilostazolaspirinnegative
Sekiya, 1998cilostazol + aspirinaspirinnegative
Kozuma, 2001cilostazol + aspirinticlopidine + aspirinnegative
Ochiai, 1999cilostazol + aspirinticlopidine + aspirinnegative
Park, 1999cilostazol + aspirinticlopidine + aspirinnegative
Yoon, 1999cilostazol + aspirinticlopidine + aspirinnegative
Kamishirado, 2002cilostazol + aspirinticlopidine + aspirinnegative
clopidogrel
REAL-LATE, ZEST-LATE, 2010clopidogrel+aspirinaspirinNCT00484926negative
GRAVITAS, 2011high-dose clopidogrelnormal-dose clopidogrelNCT00645918Risk of bias negative
Müller, 2000clopidogrel + aspirinticlopidine + aspirinnegative
CLASSICS, 2000clopidogrel + aspirinticlopidine + aspirinnegative
TOPPS, 2001clopidogrel + aspirinticlopidine + aspirinnegative
Piamsomboon, 2001clopidogrel + aspirinticlopidine + aspirinnegative
ticlopidine
STARS (vs aspirin), 1998ticlopidine + aspirinaspirinsuggesting
Hall, 1996ticlopidine + aspirinaspirinnegative
FANTASTIC, 1998ticlopidine + aspirincoumadin + aspirinnegative
ISAR, 1996ticlopidine + aspirincoumadin + aspirinsuggesting
Foussas, 2000ticlopidine + aspirincoumadin + aspirinsuggesting
MATTIS, 1998ticlopidine + aspirincoumadin + aspirinnegative
STARS (vs coumadin+asp), 1998ticlopidine + aspirincoumadin + aspirinsuggesting

peripheral vascular diseases

aspirin
Schoop, 1983aspirinplacebo -
Hess, 1985aspirinplacebo -
Munich A, 1975aspirinplacebo -
Munich B, 1975aspirinplacebo -