PCSK9 Inhibitors

Alirocumab - Bococizumab - Evolocumab      

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Trial Studied trt Control trt patientstagsNCTROB Result

cardiovascular prevention

alirocumab
ODYSSEY OPTIONS Ialirocumabezetimibe (on top statin)negative
ODYSSEY OPTIONS IIalirocumabezetimibe (on top statin)negative
ODYSSEY MONOalirocumabezetimibe aloneNCT01644474negative
ODYSSEY Long-Term, 2015alirocumabplacebo (on top statins)NCT01507831Exploratory suggesting
ODYSSEY Alternativealirocumabplacebo (on top statins)NCT01709513negative
ODYSSEY FH 1alirocumabplacebo (on top statins)NCT01623115 -
ODYSSEY FH 2alirocumabplacebo (on top statins)NCT01709500 -
ODYSSEY HIGH FH alirocumabplacebo (on top statins)NCT01617655negative
ODYSSEY COMBOalirocumabplacebo (on top statins)NCT01644175negative
ODYSSEY COMBO IIalirocumabplacebo (on top statins)NCT01644188negative
bococizumab
SPIRE-1 ongoing bococizumabplaceboNCT01975376 ongoing
SPIRE-2 ongoing bococizumabplaceboNCT01975389 ongoing
SPIRE-SI ongoing bococizumabplaceboNCT02135029 ongoing
SPIRE-HR ongoing bococizumabplaceboNCT01968954 ongoing
SPIRE-LDL ongoing bococizumabplaceboNCT01968967 ongoing
SPIRE-FH ongoing bococizumabplaceboNCT01968980 ongoing
SPIRE-LL ongoing bococizumabplaceboNCT02100514 ongoing
evolocumab
MENDEl 2evolocumabNCT01763827 -
Mendel 1, 2012evolocumabNCT01375777 -
YUKAWA-1, 2014evolocumab -
GAUSS 2evolocumabezetimibe aloneNCT01763905negative
GAUSS 1, 2012evolocumabplaceboNCT01375764negative
DESCARTES, 2014evolocumabplacebo (on top statins)NCT01516879negative
LAPLACE-TIMI 57evolocumabplacebo (on top statins)NCT01380730 -
RUTHERFORD-1evolocumabplacebo (on top statins)NCT01375751negative
LAPLACE 2, 2014evolocumabplacebo (on top statins)NCT01763866negative
RUTHERFORD-2, 2015evolocumabplacebo (on top statins)NCT01763918negative
FOURIER, 2017evolocumabplacebo (on top statins)NCT01764633suggesting