PCSK9 Inhibitors  

Alirocumab - Bococizumab - Evolocumab      

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Trial Studied trt Control trt patientstagsNCTROB Result

cardiovascular prevention

alirocumab
ODYSSEY OPTIONS Ialirocumabezetimibe (on top statin)negative
ODYSSEY OPTIONS IIalirocumabezetimibe (on top statin)negative
ODYSSEY MONOalirocumabezetimibe aloneNCT01644474Low risk of bias negative
ODYSSEY Long-Term, 2015alirocumabplacebo (on top statins)NCT01507831Exploratory suggesting
ODYSSEY Alternativealirocumabplacebo (on top statins)NCT01709513Low risk of bias negative
ODYSSEY FH 1alirocumabplacebo (on top statins)NCT01623115Low risk of bias -
ODYSSEY FH 2alirocumabplacebo (on top statins)NCT01709500Low risk of bias -
ODYSSEY HIGH FH alirocumabplacebo (on top statins)NCT01617655negative
ODYSSEY COMBOalirocumabplacebo (on top statins)NCT01644175Low risk of bias negative
ODYSSEY COMBO IIalirocumabplacebo (on top statins)NCT01644188Low risk of bias negative
bococizumab
SPIRE-1 ongoing bococizumabplaceboNCT01975376Low risk of bias ongoing
SPIRE-2 ongoing bococizumabplaceboNCT01975389Low risk of bias ongoing
SPIRE-SI ongoing bococizumabplaceboNCT02135029Low risk of bias ongoing
SPIRE-HR ongoing bococizumabplaceboNCT01968954Low risk of bias ongoing
SPIRE-LDL ongoing bococizumabplaceboNCT01968967Low risk of bias ongoing
SPIRE-FH ongoing bococizumabplaceboNCT01968980Low risk of bias ongoing
SPIRE-LL ongoing bococizumabplaceboNCT02100514Low risk of bias ongoing
evolocumab
MENDEl 2evolocumabNCT01763827 -
Mendel 1, 2012evolocumabNCT01375777 -
YUKAWA-1, 2014evolocumab -
GAUSS 2evolocumabezetimibe aloneNCT01763905negative
GAUSS 1, 2012evolocumabplaceboNCT01375764negative
DESCARTES, 2014evolocumabplacebo (on top statins)NCT01516879negative
LAPLACE-TIMI 57evolocumabplacebo (on top statins)NCT01380730 -
RUTHERFORD-1evolocumabplacebo (on top statins)NCT01375751negative
LAPLACE 2, 2014evolocumabplacebo (on top statins)NCT01763866negative
RUTHERFORD-2, 2015evolocumabplacebo (on top statins)NCT01763918negative
FOURIER, 2017evolocumabplacebo (on top statins)NCT01764633Low risk of bias suggesting