cholesterol lowering intervention

Atorvastatin - Bezafibrate - Cerivastatin - Cholestyramine - Clofibrate - Colestipol - Diet - Etofibrate - Ezetimibe - Fenofibrate - Fluvastatin - Gemfibrozil - Lovastatin - Niacin - Policosanol - Pravastatin - Probucol - Rosuvastatin - Simvastatin      

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Trial Studied trt Control trt patientstagsROB Trial result

acute coronary syndrome

atorvastatin
MIRACL, 2001     atorvastatinplaceboacute coronary syndrome early initiation Low risk of bias suggesting
Colivicchi, 2002     atorvastatinusual careacute coronary syndrome early initiation Exploratory negative
ESTABLISH, 2004     atorvastatinusual careacute coronary syndrome early initiation Exploratory negative
PROVE IT - TIMI 22, 2004     atorvastatinpravastatinacute coronary syndrome early initiation Low risk of bias suggesting
ezetimibe
IMPROVE-IT, 2014      NCTezetimibeplacebo (on top statins) early initiation Low risk of bias conclusive
fluvastatin
LIPS (sub groups), 2002     fluvastatinplaceboacute coronary syndrome early initiation Low risk of bias negative
FLORIDA, 2002     fluvastatinplaceboacute coronary syndrome early initiation Low risk of bias negative
pravastatin
LAMIL, 1997   pravastatinplaceboacute coronary syndrome early initiation Low risk of bias negative
RECIFE, 1999     pravastatinplaceboacute coronary syndrome early initiation Low risk of bias negative
PAIS, 2001   pravastatinplaceboacute coronary syndrome early initiation Low risk of bias negative
PACT, 2004     pravastatinplaceboacute coronary syndrome early initiation Low risk of bias suggesting
L-CAD, 2000     pravastatinusual careacute coronary syndrome early initiation Exploratory suggesting
PTT, 2002   pravastatinusual careacute coronary syndrome early initiation Exploratory suggesting
simvastatin
A to Z, 2004     simvastatinplaceboacute coronary syndrome early initiation negative

acute myocardial infarction

atorvastatin
PROVE-IT, 2004         atorvastatin high dosepravastatindiabetic early initiation Low risk of bias suggesting

aortic stenosis

atorvastatin
SALTIRE, 2005     atorvastatinplaceboaortic stenosisLow risk of bias negative
rosuvastatin
ASTRONOMER, 2010   rosuvastatinplaceboaortic stenosisLow risk of bias -
simvastatin
SEAS, 2008    NCTezetimibe+simvastatinplaceboaortic stenosisLow risk of bias negative

CABG surgery

atorvastatin
Chello et al., 2006     preoperative atorvastatinplaceboLow risk of bias negative
Patti et al., 2006     preoperative atorvastatinplaceboLow risk of bias suggesting
simvastatin
Christenson, 1999     preoperative simvastatinno treatmentnegative

cardiovascular prevention

atorvastatin
ASCOT (diabetics sub group), 2003   atorvastatinplacebodiabetic patients primary prevention Exploratory negative
CARDS, 2004      NCTatorvastatinplacebodiabetic type 2 diabetes Low risk of bias conclusive
Deutsche Diabetes Dialyse Studie (4D), 2005   atorvastatinplaceboLow risk of bias suggesting
ASPEN, 2006     atorvastatinplacebodiabetic type 2 diabetes Low risk of bias negative
ASPEN, 2006     atorvastatinplacebodiabetic patientsLow risk of bias negative
ASCOT, 2003   atorvastatinplaceboat risk hypertensive hypertensive patients Low risk of bias conclusive
MIRACL, 2001     atorvastatinplaceboacute coronary syndrome early initiation Low risk of bias suggesting
macin, 2005     atorvastatinplaceboacute coronary syndrome squamous NSCLC Low risk of bias -
SALTIRE, 2005     atorvastatinplaceboaortic stenosisLow risk of bias negative
Mohler III, 2003   atorvastatinplaceboPeripheral Arterial DiseaseExploratory -
SPARCL, 2006      NCTatorvastatinplacebopost stroke cerebral vascular disease Low risk of bias suggesting
Strey, 2005     atorvastatinplaceboheart failure -
Mohler, 2003     atorvastatinplacebosecondary preventionLow risk of bias -
ASPEN (primary prevention sub group), 2006     atorvastatinplacebodiabetic type 2 diabetes Low risk of bias negative
ASCOT (women subgroup) , 2003     AtorvastatinplacebowomenExploratory negative
Colivicchi, 2002     atorvastatinusual careacute coronary syndrome early initiation Exploratory negative
ESTABLISH, 2004     atorvastatinusual careacute coronary syndrome early initiation Exploratory negative
GREACE, 2002     atorvastatinusual caresecondary preventionRisk of bias suggesting
AVERT, 1999     atorvastatin high doseangioplastysecondary preventionRisk of bias negative
TNT (diabetic sub group), 2006     atorvastatin high doseatorvastatindiabetic patients secondary prevention Low risk of bias suggesting
TNT, 2005            NCTatorvastatin high doseatorvastatinsecondary preventionLow risk of bias conclusive
Vascular basis, 2005     atorvastatin high doselovastatinsecondary preventionExploratory negative
PROVE IT - TIMI 22, 2004     atorvastatinpravastatinacute coronary syndrome early initiation Low risk of bias suggesting
REVERSAL, 2004     atorvastatin high dosepravastatinsecondary preventionExploratory negative
PROVE-IT, 2004         atorvastatin high dosepravastatindiabetic early initiation Low risk of bias suggesting
SAGE, 2007     atorvastatin high dosepravastatinsecondary preventionExploratory suggesting
IDEAL, 2005        NCTatorvastatin high dosesimvastatinsecondary preventionRisk of bias suggesting
bezafibrate
SENDCAP, 1998     bezafibrateplacebo type 2 diabetes Exploratory suggesting
LEADER, 2002     bezafibrateplaceboLow risk of bias negative
LEADER trial, 2000   bezafibrateplaceboPeripheral Arterial DiseaseLow risk of bias -
BECAIT, 1996     bezafibrateplacebosecondary preventionExploratory suggesting
BIP, 2000       bezafibrateplacebosecondary preventionLow risk of bias negative
cerivastatin
Laufs, 2004     cerivastatinplaceboheart failureLow risk of bias -
cholestyramine
STARS (cholestyramine), 1992     cholestyraminecontrolLow risk of bias negative
LRC, 1984   cholestyramineplaceboLow risk of bias negative
NHLBI (Brensike), 1984    NCTcholestyramineplacebodiabeticExploratory negative
clofibrate
WHO clofibrate, 1978   clofibrateplaceboLow risk of bias suggesting
Cullen, 1974   clofibrateplaceboLow risk of bias -
Harrold, 1969   clofibrateplacebo type 2 diabetes Low risk of bias -
Hanefeld, 1991   clofibrateplacebo type 2 diabetes Low risk of bias negative
Begg, 1971   clofibrateplacebosecondary preventionExploratory negative
Acheson, 1972   clofibrateplacebosecondary prevention cerebral vascular disease Exploratory -
VA Neurology Section, 1974   clofibrateplaceboLow risk of bias -
CDP Clofibrate, 1975   clofibrateplaceboLow risk of bias suggesting
Scottish, 1971   clofibrateplaceboLow risk of bias negative
Newcastle, 1971   clofibrateplaceboLow risk of bias suggesting
SCOR, 1990     colestipol+clofibrateplacebodiabeticLow risk of bias negative
colestipol
UCS (Dorr), 1978   colestipolplaceboLow risk of bias negative
Ryan, 1974   colestipolplaceboLow risk of bias -
Gundersen, 1976   colestipolplaceboLow risk of bias -
Ruoff, 1978   colestipolplaceboLow risk of bias negative
Gross, 1973   colestipolplaceboLow risk of bias -
diet
Veterans Ad. (Dayton), 1969   dietusual dietLow risk of bias suggesting
MRFIT, 1982   dietusual dietRisk of bias -
Hjermann, 1981   dietusual dietRisk of bias -
Finnish Mental Hospital (Miettinen), 1985     dietusual dietprimary preventionExploratory -
WHO Collaborative, 1986   dietusual dietLow risk of bias negative
Goteborg, 1986     dietusual dietRisk of bias -
Rose, 1965   dietusual dietExploratory negative
Singh, 1992   dietusual dietRisk of bias -
STARS (St Thomas, diet), 1992     dietusual dietExploratory negative
Los Angeles VA (Dayton), 1969   dietusual dietLow risk of bias -
Ornish, 1990     dietusual dietExploratory negative
Kallio, 1979   dietusual dietExploratory -
MRC Soya, 1968   dietusual dietRisk of bias negative
Woodhill, 1966   dietusual dietLow risk of bias negative
Oslo Diet Heart Study (Leren), 1966   dietusual dietRisk of bias suggesting
MRC low fat, 1965   dietusual dietRisk of bias negative
WHI low fat, 2005    NCTdietusual dietExploratory negative
Göteborg (Wilhelmsen), 1986     dietusual dietLow risk of bias negative
Black, 1994     dietusual dietRisk of bias negative
Minnesota coronary survey (Frantz), 1975   dietusual dietExploratory negative
Tuttle, 2008     low fat dietmediterranean-style dietRisk of bias -
estrogen
Marmorstein, 1962   estrogenplaceboLow risk of bias -
Stamler, 1963   estrogenplaceboLow risk of bias -
CDP estrogen 5, 1975   estrogenplaceboLow risk of bias -
CDP estrogen 2.5, 1975   estrogenplaceboLow risk of bias -
VA Neurology Section (estrogen), 1966   estrogenplaceboLow risk of bias -
VA drugs (Estrogen or thyroxine), 1968   estrogen or thyroxineplaceboLow risk of bias suggesting
etofibrate
Emmerich, 2009     etofibrateplacebodiabetic type 2 diabetes Exploratory -
ezetimibe
SHARP, 2010      NCTezetimibe+simvastatinplaceboLow risk of bias suggesting
IMPROVE-IT, 2014      NCTezetimibeplacebo (on top statins) early initiation Low risk of bias conclusive
Enhance, 2008   ezetimibeplacebo (on top statins)Low risk of bias -
SANDS, 2008      NCTaggressive treatmentstandard teatmentdiabetic type 2 diabetes Exploratory negative
ARBITER-HALTS 6, 2010   ezetimibeniacinExploratory -
fenofibrate
FIELD, 2005     fenofibrateplacebodiabetic patientsLow risk of bias suggesting
DAIS, 2001     fenofibrateplacebodiabetic type 2 diabetes Exploratory negative
FIELD, 2005             fenofibrateplacebodiabetic type 2 diabetes Low risk of bias suggesting
ACCORD lipid, 2010    NCTfenofibrateplacebo (on top simvastatine)diabetic patientsLow risk of bias negative
fluvastatin
LIPS (diabetic sub group), 2002     fluvastatinplacebodiabetic patients secondary prevention Exploratory suggesting
ALERT (diabetic sub group), 2003     fluvastatinplacebodiabetic patientsLow risk of bias -
FLARE (elderly subgroup), 1999       fluvastatinplaceboelderly elderly Low risk of bias negative
LIPS (elderly subgroup), 2002     fluvastatinplaceboelderly elderly Low risk of bias suggesting
LIPS (sub groups), 2002     fluvastatinplaceboacute coronary syndrome early initiation Low risk of bias negative
FLORIDA, 2002     fluvastatinplaceboacute coronary syndrome early initiation Low risk of bias negative
LCAS, 1997     fluvastatinplacebosecondary preventionExploratory negative
Riegger et al., 1999     fluvastatinplacebosecondary preventionLow risk of bias negative
FLARE, 1999     fluvastatinplacebosecondary preventionExploratory negative
BCAPS, 2001     fluvastatinplaceboprimary prevention cerebral vascular disease Low risk of bias negative
ALERT, 2003     fluvastatinplaceboCKD kidney diseases Low risk of bias suggesting
LIPS, 2002     fluvastatinplacebosecondary preventionLow risk of bias suggesting
ALERT, 2003     fluvastatinplaceboLow risk of bias negative
HYRIM, 2005   fluvastatinplacebohypertensive hypertensive patients Exploratory negative
gemfibrozil
Helsinki (HHS), 1987   gemfibrozilplaceboLow risk of bias suggesting
HHS (diabetic sub group), 1987   gemfibrozilplacebodiabetic patients primary prevention Low risk of bias -
VA-HIT (diabetic sub group), 1999     gemfibrozilplacebodiabetic patients secondary prevention Low risk of bias negative
VA-HIT, 1999      NCTgemfibrozilplaceboLow risk of bias suggesting
HHS (Frick)(secondary prev subgroup), 1993   gemfibrozilplaceboExploratory negative
LOCAT, 1997     gemfibrozilplaceboExploratory negative
lovastatin
AFCAPS/TexCAPS, 1998     lovastatinplaceboprimary preventionLow risk of bias conclusive
AFCAPS/TexCAPS (diabetic sub group), 1998     lovastatinplacebo