cholesterol lowering intervention

Atorvastatin - Bezafibrate - Cerivastatin - Cholestyramine - Clofibrate - Colestipol - Diet - Etofibrate - Ezetimibe - Fenofibrate - Fluvastatin - Gemfibrozil - Lovastatin - Niacin - Policosanol - Pravastatin - Probucol - Rosuvastatin - Simvastatin      

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Trial Studied trt Control trt patientstagsNCTROB Result

acute coronary syndrome

atorvastatin
MIRACL, 2001atorvastatinplaceboacute coronary syndrome early initiation Low risk of bias suggesting
Colivicchi, 2002atorvastatinusual careacute coronary syndrome early initiation Exploratory negative
ESTABLISH, 2004atorvastatinusual careacute coronary syndrome early initiation Exploratory negative
PROVE IT - TIMI 22, 2004atorvastatinpravastatinacute coronary syndrome early initiation suggesting
ezetimibe
IMPROVE-IT, 2014ezetimibecontrol early initiation NCT00202878suggesting
fluvastatin
LIPS (sub groups), 2002fluvastatinplaceboacute coronary syndrome early initiation Exploratory negative
FLORIDA, 2002fluvastatinplaceboacute coronary syndrome early initiation Low risk of bias negative
Czech trial ongoing fluvastatinplaceboacute coronary syndrome early initiation NCT00171275Exploratory ongoing
pravastatin
LAMIL, 1997pravastatinplaceboacute coronary syndrome early initiation Exploratory negative
RECIFE, 1999pravastatinplaceboacute coronary syndrome early initiation Exploratory negative
PAIS, 2001pravastatinplaceboacute coronary syndrome early initiation Exploratory negative
PACT, 2004pravastatinplaceboacute coronary syndrome early initiation Low risk of bias suggesting
L-CAD, 2000pravastatinusual careacute coronary syndrome early initiation Exploratory suggesting
PTT, 2002pravastatinusual careacute coronary syndrome early initiation Exploratory suggesting
simvastatin
A to Z, 2004simvastatinplaceboacute coronary syndrome early initiation negative

acute myocardial infarction

atorvastatin
PROVE-IT, 2004atorvastatin high dosepravastatindiabetic early initiation Low risk of bias suggesting

aortic stenosis

atorvastatin
SALTIRE, 2005atorvastatinplaceboaortic stenosisExploratory negative
rosuvastatin
ASTRONOMER, 2010rosuvastatinplaceboaortic stenosisISRCTN 32424163 -
simvastatin
SEAS, 2008ezetimibe+simvastatinplaceboaortic stenosisNCT00092677Low risk of bias negative

CABG surgery

atorvastatin
Chello et al., 2006preoperative atorvastatinplacebonegative
Patti et al., 2006preoperative atorvastatinplacebosuggesting
simvastatin
Christenson, 1999preoperative simvastatinno treatmentnegative

cardiovascular prevention

atorvastatin
ASCOT (diabetics sub group), 2003atorvastatinplacebodiabetic patients type 2 diabetes Exploratory negative
CARDS, 2004atorvastatinplacebodiabetic type 2 diabetes NCT00327418Low risk of bias conclusive
Deutsche Diabetes Dialyse Studie (4D), 2005atorvastatinplaceboLow risk of bias suggesting
ASPEN, 2006atorvastatinplacebodiabetic type 2 diabetes Low risk of bias negative
ASPEN, 2006atorvastatinplacebodiabetic patients trastuzumab-naif type 2 diabetes Low risk of bias negative
ASCOT, 2003atorvastatinplaceboat risk hypertensive hypertensive patients Low risk of bias conclusive
MIRACL, 2001atorvastatinplaceboacute coronary syndrome early initiation Low risk of bias suggesting
macin, 2005atorvastatinplaceboacute coronary syndrome squamous NSCLC Exploratory -
SALTIRE, 2005atorvastatinplaceboaortic stenosisExploratory negative
Mohler III, 2003atorvastatinplaceboPeripheral Arterial DiseaseExploratory -
SPARCL, 2006atorvastatinplacebopost stroke cerebral vascular disease NCT00147602Low risk of bias suggesting
Strey, 2005atorvastatinplaceboheart failure -
Mohler, 2003atorvastatinplacebosecondary preventionLow risk of bias -
ASPEN (primary prevention sub group), 2006atorvastatinplacebodiabetic type 2 diabetes Exploratory negative
ASCOT (women subgroup) , 2003AtorvastatinplacebowomenExploratory negative
Colivicchi, 2002atorvastatinusual careacute coronary syndrome early initiation Exploratory negative
ESTABLISH, 2004atorvastatinusual careacute coronary syndrome early initiation Exploratory negative
GREACE, 2002atorvastatinusual caresecondary preventionRisk of bias suggesting
AVERT, 1999atorvastatin high doseangioplastysecondary preventionRisk of bias negative
TNT (diabetic sub group), 2006atorvastatin high doseatorvastatindiabetic patients type 2 diabetes Exploratory suggesting
TNT, 2005atorvastatin high doseatorvastatinsecondary preventionNCT00327691Low risk of bias conclusive
Vascular basis, 2005atorvastatin high doselovastatinsecondary preventionExploratory negative
PROVE IT - TIMI 22, 2004atorvastatinpravastatinacute coronary syndrome early initiation suggesting
REVERSAL, 2004atorvastatin high dosepravastatinsecondary preventionExploratory negative
PROVE-IT, 2004atorvastatin high dosepravastatindiabetic early initiation Low risk of bias suggesting
SAGE, 2007atorvastatin high dosepravastatinsecondary preventionExploratory suggesting
IDEAL, 2005atorvastatin high dosesimvastatinsecondary preventionNCT00159835Risk of bias suggesting
bezafibrate
SENDCAP, 1998bezafibrateplacebo type 2 diabetes Exploratory suggesting
LEADER, 2002bezafibrateplaceboLow risk of bias negative
LEADER trial, 2000bezafibrateplaceboPeripheral Arterial DiseaseLow risk of bias -
BECAIT, 1996bezafibrateplacebosecondary preventionExploratory suggesting
BIP, 2000bezafibrateplacebosecondary preventionLow risk of bias negative
cerivastatin
Laufs, 2004cerivastatinplaceboheart failure -
cholestyramine
STARS (cholestyramine), 1992cholestyraminecontrolLow risk of bias negative
LRC, 1984cholestyramineplaceboLow risk of bias negative
NHLBI (Brensike), 1984cholestyramineplacebodiabeticNCT00000594Exploratory negative
clofibrate
WHO clofibrate, 1978clofibrateplaceboLow risk of bias suggesting
Cullen, 1974clofibrateplaceboLow risk of bias -
Harrold, 1969clofibrateplacebo type 2 diabetes Low risk of bias -
Hanefeld, 1991clofibrateplacebo type 2 diabetes Low risk of bias negative
Begg, 1971clofibrateplacebosecondary preventionExploratory negative
Acheson, 1972clofibrateplacebosecondary prevention cerebral vascular disease Exploratory -
VA Neurology Section, 1974clofibrateplaceboLow risk of bias -
CDP Clofibrate, 1975clofibrateplaceboLow risk of bias suggesting
Scottish, 1971clofibrateplaceboLow risk of bias negative
Newcastle, 1971clofibrateplaceboLow risk of bias suggesting
SCOR, 1990colestipol+clofibrateplacebodiabeticLow risk of bias negative
colestipol
UCS (Dorr), 1978colestipolplaceboLow risk of bias negative
Ryan, 1974colestipolplaceboLow risk of bias -
Gundersen, 1976colestipolplaceboExploratory -
Ruoff, 1978colestipolplaceboLow risk of bias negative
Gross, 1973colestipolplaceboLow risk of bias -
diet
Veterans Ad. (Dayton), 1969dietusual dietLow risk of bias suggesting
MRFIT, 1982dietusual dietRisk of bias -
Hjermann, 1981dietusual dietRisk of bias -
Finnish Mental Hospital (Miettinen), 1985dietusual dietprimary preventionExploratory -
WHO Collaborative, 1986dietusual dietLow risk of bias negative
Goteborg, 1986dietusual dietRisk of bias -
Rose, 1965dietusual dietExploratory negative
Singh, 1992dietusual dietRisk of bias -
STARS (St Thomas, diet), 1992dietusual dietExploratory negative
Los Angeles VA (Dayton), 1969dietusual dietRisk of bias -
Ornish, 1990dietusual dietExploratory negative
Kallio, 1979dietusual dietExploratory -
MRC Soya, 1968dietusual dietRisk of bias negative
Woodhill, 1966dietusual dietLow risk of bias negative
Oslo Diet Heart Study (Leren), 1966dietusual dietRisk of bias suggesting
MRC low fat, 1965dietusual dietRisk of bias negative
WHI low fat, 2005dietusual dietNCT00000611Exploratory negative
Göteborg (Wilhelmsen), 1986dietusual dietLow risk of bias negative
Black, 1994dietusual dietRisk of bias negative
Minnesota coronary survey (Frantz), 1975dietusual dietExploratory negative
Tuttle, 2008low fat dietmediterranean-style dietRisk of bias -
estrogen
Marmorstein, 1962estrogenplaceboLow risk of bias -
Stamler, 1963estrogenplaceboLow risk of bias -
CDP estrogen 5, 1975estrogenplaceboLow risk of bias -
CDP estrogen 2.5, 1975estrogenplaceboLow risk of bias -
VA Neurology Section (estrogen), 1966estrogenplaceboLow risk of bias -
VA drugs (Estrogen or thyroxine), 1968estrogen or thyroxineplaceboLow risk of bias suggesting
etofibrate
Emmerich, 2009etofibrateplacebodiabetic type 2 diabetes Exploratory -
ezetimibe
IMPROVE-IT, 2014ezetimibecontrol early initiation NCT00202878suggesting
Enhance, 2008ezetimibeplacebo -
SHARP, 2010ezetimibe+simvastatinplaceboNCT00125593Low risk of bias suggesting
SANDS, 2008aggressive treatmentstandard teatmentdiabetic type 2 diabetes NCT00047424Exploratory negative
ARBITER-HALTS 6, 2010ezetimibeniacinExploratory -
fenofibrate
FIELD, 2005fenofibrateplacebodiabetic patients type 2 diabetes ISRCTN64783481Low risk of bias suggesting
DAIS, 2001fenofibrateplacebodiabetic type 2 diabetes Exploratory negative
FIELD, 2005fenofibrateplacebodiabetic type 2 diabetes ISRCTN64783481Exploratory suggesting
ACCORD lipid, 2010fenofibrateplacebo (on top simvastatine)diabetic patients type 2 diabetes NCT00000620Low risk of bias negative
ACCORD lipid (subgroup Eye study), 2010fenofibrateplacebo (on top simvastatine)diabetic patients type 2 diabetes NCT00000620Exploratory suggesting
fluvastatin
LIPS (diabetic sub group), 2002fluvastatinplacebodiabetic patients type 2 diabetes Exploratory suggesting
ALERT (diabetic sub group), 2003fluvastatinplacebodiabetic patients type 2 diabetes Exploratory -
FLARE (elderly subgroup), 1999fluvastatinplaceboelderly elderly Exploratory negative
LIPS (elderly subgroup), 2002fluvastatinplaceboelderly elderly Exploratory suggesting
LIPS (sub groups), 2002fluvastatinplaceboacute coronary syndrome early initiation Exploratory negative
FLORIDA, 2002fluvastatinplaceboacute coronary syndrome early initiation Low risk of bias negative
LCAS, 1997fluvastatinplacebosecondary preventionExploratory negative
Riegger et al., 1999fluvastatinplacebosecondary preventionLow risk of bias negative
FLARE, 1999fluvastatinplacebosecondary preventionExploratory negative
BCAPS, 2001fluvastatinplaceboprimary prevention cerebral vascular disease Exploratory negative
ALERT, 2003fluvastatinplaceboCKD kidney diseases Low risk of bias suggesting
LIPS, 2002fluvastatinplacebosecondary preventionLow risk of bias suggesting
ALERT, 2003fluvastatinplaceboLow risk of bias negative
HYRIM, 2005fluvastatinplacebohypertensive hypertensive patients Exploratory negative
Czech trial ongoing fluvastatinplaceboacute coronary syndrome early initiation NCT00171275Exploratory ongoing
gemfibrozil
Helsinki (HHS), 1987gemfibrozilplaceboLow risk of bias suggesting
HHS (diabetic sub group), 1987gemfibrozilplacebodiabetic patients type 2 diabetes Exploratory -
VA-HIT (diabetic sub group), 1999gemfibrozilplacebodiabetic patients type 2 diabetes Exploratory negative
VA-HIT, 1999gemfibrozilplaceboNCT00283335Low risk of bias suggesting
HHS (Frick)(secondary prev subgroup), 1993gemfibrozilplaceboExploratory negative
LOCAT, 1997gemfibrozilplaceboExploratory negative
lovastatin
AFCAPS/TexCAPS, 1998lovastatinplaceboprimary preventionLow risk of bias conclusive
AFCAPS/TexCAPS (diabetic sub group), 1998lovastatinplacebodiabetic patients type 2 diabetes Exploratory -
CRISP 20mg, 1994lovastatinplacebodiabeticNCT00000477Exploratory -
ACAPS, 1994lovastatinplacebosecondary prevention cerebral vascular disease NCT00000469Exploratory suggesting
CCAIT, 1994lovastatinplacebosecondary preventionExploratory negative
MARS, 1993lovastatinplacebosecondary preventionNCT00116870Exploratory negative
Excel, 1991lovastatinplaceboExploratory negative
Weintraub, 1994lovastatinplacebosecondary preventionLow risk of bias negative
CRISP 40mg, 1994lovastatinplacebodiabeticNCT00000477Exploratory -
AFCAPS (women subgroup) , 1998LovastatinplacebowomenExploratory negative
Sahni, 1991lovastatinusual caresecondary preventionRisk of bias negative
CLAPT, 1999lovastatinusual caresecondary preventionExploratory negative
niacin
VA drugs, 1968niacincontrolLow risk of bias negative
Carlson (Stockholm), 1977clofibtate+niacinplacebosecondary preventionRisk of bias suggesting
CLAS, 1987colestipol-niacinplacebosecondary preventionExploratory negative
CLAS, 1987colestipol-niacinplaceboPeripheral Arterial DiseaseExploratory -
CDP niacin, 1975niacinplaceboLow risk of bias suggesting
AIM-HIGH, 2011niacinplacebo (on top statin)NCT00120289Low risk of bias negative
HPS 2-Thriveniacinplacebo (on top statin)NCT00461630Low risk of bias negative
Oxford Niaspan Study, 2009niacinplacebo (on top statin)NCT00232531Exploratory -
ARBITER 2, 2009niacinplacebo (on top statin)Exploratory negative
HATS, 2001niacinplacebo (on top statin)Risk of bias negative
ARBITER 6-HALTS (niacin vs ezetimibe), 2009niacinezetimibeNCT00397657Exploratory suggesting
policosanol
Castano, 2001policosanolcontroldiabeticExploratory negative
Más, 1999policosanolcontrolExploratory negative
Batista, 1996policosanolcontrolLow risk of bias -
pravastatin
MEGA, 2006pravastatincontrolprimary preventionNCT00211705Risk of bias suggesting
FAST Fukuoka pravastatin, 2002pravastatincontrolprimary preventionExploratory -
WOSCOPS, 1995pravastatinplaceboprimary preventionLow risk of bias conclusive
PROSPER diabetic (sub group), 2002pravastatinplacebodiabetic patients type 2 diabetes Exploratory negative
LIPID (diabetic sub group), 1998pravastatinplacebodiabetic patients type 2 diabetes Exploratory negative
CARE (diabetic sub group), 1998pravastatinplacebodiabetic patients type 2 diabetes Exploratory suggesting
WOSCOPS (diabetic sub group), 1996pravastatinplacebodiabetic patients type 2 diabetes Exploratory -
PROSPER, 2002pravastatinplacebosecondary prevention elderly Low risk of bias conclusive
CARE (elderly subgroup), 1998Pravastatinplaceboelderly elderly Exploratory suggesting
LIPID (elderly sub group), 2001Pravastatinplaceboelderly elderly Exploratory suggesting
PLAC I (elderly sub group), 1995Pravastatinplaceboelderly elderly Exploratory negative
REGRESS (elderly subgroup), 1995Pravastatinplaceboelderly elderly Exploratory negative
REGRESS, 1995pravastatinplacebosecondary preventionExploratory suggesting
PMSG, 1993pravastatinplaceboprimary preventionExploratory negative
LIPID, 1998pravastatinplacebosecondary preventionLow risk of bias conclusive
CARE, 1996pravastatinplacebosecondary preventionLow risk of bias conclusive
LAMIL, 1997pravastatinplaceboacute coronary syndrome early initiation Exploratory negative
RECIFE, 1999pravastatinplaceboacute coronary syndrome early initiation Exploratory negative
PAIS, 2001pravastatinplaceboacute coronary syndrome early initiation Exploratory negative
PACT, 2004pravastatinplaceboacute coronary syndrome early initiation Low risk of bias suggesting
CAIUS, 1996pravastatinplaceboprimary prevention cerebral vascular disease Exploratory negative
PREVEND IT, 2004pravastatinplaceborelated disease kidney diseases Low risk of bias negative
PLAC I, 1995pravastatinplacebosecondary preventionExploratory suggesting
PLAC II, 1995pravastatinplacebosecondary preventionExploratory negative
PACT, 2004pravastatinplacebosecondary preventionLow risk of bias negative
KAPS, 1995pravastatinplaceboprimary preventionExploratory negative
PHYLLIS, 2004pravastatinplacebodiabetic cerebral vascular disease hypertensive patients Exploratory -
PROSPER (primary prevention subgroup), 2002pravastatinplaceboprimary prevention elderly Exploratory negative
ALLHAT (women subgroup) , 2002PravastatinplacebowomenExploratory negative
MEGA (women subgroup) , 2006PravastatinplacebowomenExploratory suggesting
GISSI P (diabetic sub group), 2000pravastatinusual carediabetic patients type 2 diabetes Exploratory -
ALLHAT-LLT (diabetic sub group), 2002pravastatinusual carediabetic patients type 2 diabetes Exploratory negative
ALLHAT, 2002pravastatinusual careat risk hypertensive hypertensive patients NCT00000542Risk of bias negative
L-CAD, 2000pravastatinusual careacute coronary syndrome early initiation Exploratory suggesting
PTT, 2002pravastatinusual careacute coronary syndrome early initiation Exploratory suggesting
GISSI Prevenzione, 2000pravastatinusual caresecondary preventionRisk of bias negative
KLIS, 2000pravastatinusual careprimary preventionRisk of bias -
PROVE IT TIMI 22 (diabetic sub group), 2006pravastatin high dosepravastatindiabetic patients type 2 diabetes Exploratory -
probucol
FATS Fukosawa (probucol), 2002probucolcontrolprimary preventionExploratory -
McCaughan, 1981ProbucolplaceboExploratory -
Tardif, 1997ProbucolplaceboLow risk of bias negative
PQRST, 1994probucolplaceboPeripheral Arterial DiseaseExploratory -
PQRST, 1994probucolplaceboExploratory -
rosuvastatin
ASTEROID ongoing Rosuvastatincontrol ongoing
JUPITER (elderly sub group), 2009rosuvastatinplaceboelderly elderly Exploratory suggesting
JUPITER, 2008rosuvastatinplaceboprimary preventionNCT00239681Low risk of bias conclusive
ASTRONOMER, 2010rosuvastatinplaceboaortic stenosisISRCTN 32424163 -
METEOR, 2007rosuvastatinplacebodiabeticNCT00225589Exploratory negative
CORONA, 2007rosuvastatinplaceboheart failureNCT00206310Low risk of bias negative
Krum, 2007rosuvastatinplaceboheart failureExploratory negative
GISSI-HF rosuvastatine, 2008rosuvastatinplaceboheart failureNCT00336336Low risk of bias negative
AURORA, 2009rosuvastatinplaceboLow risk of bias negative
HOPE 3, 2016rosuvastatinplaceboprimary preventionNCT00468923Low risk of bias conclusive
JUPITER (women subgroup) , 2008RosuvastatinplacebowomenExploratory suggesting
simvastatin
Hong, 2005simvastatincontrolheart failureRisk of bias negative
SEAS, 2008ezetimibe+simvastatinplaceboaortic stenosisNCT00092677Low risk of bias negative
HPS (diabetic sub group), 2002simvastatinplacebodiabetic patients type 2 diabetes Exploratory suggesting
4S (diabetic sub group), 1999simvastatinplacebodiabetic patients type 2 diabetes Exploratory suggesting
HPS (diabetic primary prevention sub group), 2003simvastatinplacebodiabetic type 2 diabetes Exploratory -
4S (elderly subgroup), 1997simvastatinplaceboelderly elderly Exploratory suggesting
HPS (elderly subgroup), 2002simvastatinplaceboelderly elderly Exploratory suggesting
HPS, 2002simvastatinplacebosecondary preventionLow risk of bias conclusive
4S, 1994simvastatinplacebosecondary preventionLow risk of bias conclusive
A to Z, 2004simvastatinplaceboacute coronary syndrome early initiation negative
CIS, 1997simvastatinplacebosecondary preventionExploratory negative
Mondillo, 2003simvastatinplaceboPeripheral Arterial DiseaseExploratory -
Aronow , 2003simvastatinplaceboPeripheral Arterial DiseaseExploratory -
MAAS, 1994simvastatinplacebosecondary preventionExploratory negative
Node, 2003simvastatinplaceboheart failurenegative