anticoagulant

Acenocoumarol - Betrixaban - Phenindione      

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Trial Studied trt Control trt patientstagsNCTROB Result

acute coronary syndrome

apixaban
APPRAISE-1 (10mg od), 2009apixabanplaceboNCT00313300Exploratory negative
APPRAISE-1 (2.5 mg bid), 2009apixabanplaceboNCT00313300 negative
APPRAISE 2, 2011apixabanplaceboNCT00831441Low risk of bias negative
APPRAISE japan ongoing apixabanplaceboNCT00852397Exploratory ongoing
coumadin
ASPECT-2 (coumadin+asp vs asp), 2002coumadincontrol (on top of aspirin)suggesting
ASPECT-2 (coumadin vs aspirin), 2002coumadinaspirinsuggesting
dabigatran
REDEEM, 2009dabigatranplaceboNCT00621855negative
otamixaban
SEPIA-ACS1 TIMI 42, 2009otamixabanunfractionated heparinNCT00317395Exploratory suggesting
rivaroxaban
ATLAS ACS 2 - TIMI 51 (2.5mg), 2011rivaroxaban 2.5mgplaceboNCT00809965Low risk of bias suggesting
ATLAS ACS-TIMI 46 (2.5mg), 2009rivaroxaban 2.5mgplaceboNCT00402597negative
ATLAS ACS 2 - TIMI 51 (5mg), 2011rivaroxaban 5mgplaceboNCT00809965suggesting
ATLAS ACS-TIMI 46 (5mg), 2009rivaroxaban 5mgplaceboNCT00402597negative
warfarin
ATACS (pilot study) (warfarin vs control), 1990warfarincontrol (on top of aspirin)negative
ATACS, 1994warfarincontrol (on top of aspirin)negative
CARS, 1997warfarincontrol (on top of aspirin)negative
OASIS Pilot (phase 1), 1998warfarincontrol (on top of aspirin)negative
OASIS Pilot (phase 2), 1998warfarincontrol (on top of aspirin)negative
OASIS-2 Warfarin Substudy, 2001warfarincontrol (on top of aspirin)negative
APRICOT-2, 2002warfarincontrol (on top of aspirin)negative
CHAMP, 2002warfarincontrol (on top of aspirin)negative
WARIS, 2002warfarincontrol (on top of aspirin)suggesting
LoWASA, 2004warfarincontrol (on top of aspirin)negative
Zibaeenezhad, 2004warfarincontrol (on top of aspirin)negative
Williams, 1997warfarinplacebo (on top of aspirin)negative
Huyhn, 2001warfarinplacebo (on top of aspirin)negative
ATACS (pilot study) warfarin vs aspirin, 1990warfarinaspirinnegative
ximelagatran
ESTEEM, 2003ximelagatranplaceboExploratory -

acute myocardial infarction

coumadin
ASPECT-2 (coumadin+ASA vs ASA), 2002coumadincontrol (on top of aspirin)negative
ASPECT, 1994coumadinplacebosuggesting
ASPECT-2 (coumadin alone), 2002coumadinaspirinsuggesting
warfarin
APRICOT-2, 2002warfarincontrol (on top of aspirin)suggesting
Zibaeenezhad, 2004warfarincontrol (on top of aspirin)negative
WARIS, 1999warfarincontrol (on top of aspirin) -
CHAMP, 2002warfarincontrol (on top of aspirin)negative
CARS (warafrin 3mg), 1997warfarincontrol (on top of aspirin)suggesting
LoWASA, 2004warfarincontrol (on top of aspirin)Risk of bias suggesting
CARS (warfarin 1mg), 1997warfarincontrol (on top of aspirin)negative
WARIS II (warfarin+ASA), 2002warfarincontrol (on top of aspirin)suggesting
Williams, 1997warfarinplacebo (on top of aspirin)suggesting
WARIS II (warfarin alone), 2002warfarinaspirinsuggesting

cardiovascular prevention

dicoumarol
Apenstrom and Korsan-Bengtsen, 1964dicoumarolno anticoagulant -
rivaroxaban
COMPASS (rivaroxaban alone), 2017rivaroxabanaspirinsecondary preventionNCT01776424 -
COMPASS (rivaroxaban + aspirin), 2017rivaroxaban + aspirinaspirinsecondary preventionNCT01776424Low risk of bias -
COMMANDER HF ongoing rivaroxabanplaceboNCT01877915 ongoing
wafarin
WARIS, 1990warfarinplacebo -
warfarin
Thrombosis Prevention trial (Warfarin), 1998warfarinplaceboprimary preventionNCT00000614Low risk of bias suggesting
Thrombosis Prevention trial (W plus A), 1998warfarin + aspirinplaceboprimary preventionNCT00000614Exploratory suggesting

coronary artery disease

dicoumarol
Apenstrom and Korsan-Bengtsen, 1964dicoumarolno anticoagulant -
wafarin
WARIS, 1990warfarinplacebo -

DVT prophylaxis

acenocoumarol
Hamulyak, 1994AcenocoumarolNadroparinnegative
Samama, 2001AcenocoumarolReviparinnegative
van Geloven, 1977Acenocoumarolunfractionated heparin -
apixaban
ADVANCE 3, 2010apixabanenoxaparinNCT00423319Low risk of bias suggesting
ADVANCE 2, 2010apixabanenoxaparin (europe regimen)NCT00452530Low risk of bias suggesting
APROPOS 2.5mg, 2007apixabanenoxaparin (US regimen)NCT00097357Exploratory negative
ADVANCE-1, 2008apixabanenoxaparin (US regimen)NCT00371683Low risk of bias suggesting
dabigatran
RE-NOVATE (150mg), 2007dabigatran 150mgenoxaparinNCT00168818Low risk of bias negative
RE-NOVATE (220mg), 2007dabigatran 220mgenoxaparinNCT00168818Low risk of bias negative
RE-NOVATE 2dabigatran 220mgenoxaparinNCT00657150Low risk of bias negative
RE-MODEL (150mg), 2007dabigatran 150mgenoxaparin (europe regimen)Low risk of bias negative
RE-MODEL (220mg), 2007dabigatran 220mgenoxaparin (europe regimen)Low risk of bias negative
RE-MOBILIZE (150mg), 2008dabigatran 150mgenoxaparin (US regimen)Low risk of bias negative
RE-MOBILIZE (220mg), 2008dabigatran 220mgenoxaparin (US regimen)Low risk of bias negative
edoxaban
DU176b-04 ongoing edoxabanplaceboNCT01203072 ongoing
DU176b-B-J302 ongoing edoxabanenoxaparinNCT01181102 ongoing
DU176b-B-J303 ongoing edoxabanenoxaparinNCT01181141 ongoing
DU176b-B-J304 ongoing edoxabanenoxaparinNCT01181167 ongoing
STARS J-Vedoxabanenoxaparin (short duration)NCT01181167Low risk of bias suggesting
phenindione
Eskeland, 1966Phenindioneno treatment -
Hamilton, 1970Phenindioneno treatment -
rivaroxaban
RECORD 1, 2008rivaroxabanenoxaparinNCT00329628Low risk of bias suggesting
RECORD 3, 2008rivaroxabanenoxaparin (europe regimen)NCT00361894Low risk of bias suggesting
ODIXa-HIP 10mg, 2006rivaroxabanenoxaparin (short duration)Exploratory suggesting
RECORD 2, 2008rivaroxaban (long duration)enoxaparin (short duration)NCT00332020Low risk of bias suggesting
ODIXa-KNEE, 2005rivaroxabanenoxaparin (US regimen)Exploratory negative
RECORD 4, 2009rivaroxabanenoxaparin (US regimen)NCT00362232Low risk of bias suggesting
warfarin
Pinto, 1970Warfarinno treatment -
Hume, 1973Warfarinno treatment -
Morris, 1976Warfarinno treatment -
Powers, 1989Warfarinno treatment -
Myrhe, 1969Warfarinplacebo -
RD Heparin, 1994WarfarinArdeparinsuggesting
Heit, 1997WarfarinArdeparinsuggesting
Powers, 1989WarfarinAspirin -
Lotke, 1997WarfarinAspirin -
Francis, 1997WarfarinDalteparinsuggesting
Hull, 2000WarfarinDalteparinsuggesting
Gerhart, 1991WarfarinDanaparoid -
van Comp, 1998WarfarinDanaparoid -
Myrhe, 1969WarfarinDextran -
Harris, 1972WarfarinDextran -
Barber, 1977WarfarinDextran -
Francis, 1983WarfarinDextran -
Leclerc, 1996WarfarinEnoxaparinsuggesting
Colwell, 1999WarfarinEnoxaparinsuggesting
Fitzgerald, 2001WarfarinEnoxaparinsuggesting
Paiement, 1987WarfarinIntermittent pneumatic compression -
Bailey, 1991WarfarinIntermittent pneumatic compression -
Kaempffe, 1991WarfarinIntermittent pneumatic compression -
Francis, 1992WarfarinIntermittent pneumatic compression -
Hull, 1993WarfarinLogiparinsuggesting
Hume, 1973WarfarinSudoxicam -
Hume, 1973Warfarinunfractionated heparin -
Barber, 1977Warfarinunfractionated heparin -

percutaneous coronary intervention

bivalirudin
REPLACE-2, 2003bivalirudinheparin + GP2b3a inhibitors -
HORIZONS-AMI (Stone), 2008bivalirudinheparin + GP2b3a inhibitorsNCT00433966Risk of bias suggesting
ACUITY (Stone) (bivalirudin alone), 2006bivalirudinheparin + GP2b3a inhibitorsNCT00093158Risk of bias -
Kleiman, 2002bivalirudin + eptifibatideheparin + GP2b3a inhibitorsExploratory -
ISAR-REACT 3, 2008bivalirudinUFHNCT00262054Low risk of bias -
REPLACE-1, 2004bivalirudinUFHExploratory negative
BAT (Bittl), 1995bivalirudinUFHLow risk of bias suggesting
ARMYDA BIVALVEbivalirudinUFH -
NAPLES (Tavano), 2009bivalirudinUFH plus tirofibanRisk of bias suggesting
dalteparin
Natarajan (without antiGp2b3a), 2003dalteparinUFH -
Natarajan (+ antiGp2b3a), 2003dalteparinUFH + anti Gp2b3a -
enoxaparin
STEEPLE, 2006enoxaparinUFHNCT00077844Risk of bias -
Rabah, 1999enoxaparinUFHExploratory negative
CRUISE, 2003enoxaparinUFHExploratory negative
Galeote, 2001enoxaparinUFHnegative
Dudek, 2000enoxaparinUFHnegative
Dudek b (enox alone), 2000enoxaparinUFH -
Drozd, 2001enoxaparinUFHnegative
ATOLL, 2010enoxaparinUFHRisk of bias -
Dubek b (+abciximal), 2001enoxaparin+abciximabUFH -
fondaparinux
SWITCH III ongoing fondaparinuxunfractionated heparin or bivalirudinNCT00464087 ongoing
reviparin
REDUCE, 1996reviparinUFHLow risk of bias suggesting

peripheral vascular diseases

warfarin
Johnson, 2002warfarincontrôle -
Sarac, 1998warfarincontrôle -

post myocardial infarction

coumadin
ASPECT-2 (coumadin+ASA vs ASA), 2002coumadincontrol (on top of aspirin)negative
ASPECT, 1994coumadinplacebosuggesting
ASPECT-2 (coumadin alone), 2002coumadinaspirinsuggesting
warfarin
APRICOT-2, 2002warfarincontrol (on top of aspirin)suggesting
Zibaeenezhad, 2004warfarincontrol (on top of aspirin)negative
WARIS, 1999warfarincontrol (on top of aspirin) -
CHAMP, 2002warfarincontrol (on top of aspirin)negative
CARS (warafrin 3mg), 1997warfarincontrol (on top of aspirin)suggesting
LoWASA, 2004warfarincontrol (on top of aspirin)Risk of bias suggesting
CARS (warfarin 1mg), 1997warfarincontrol (on top of aspirin)negative
WARIS II (warfarin+ASA), 2002warfarincontrol (on top of aspirin)suggesting
Williams, 1997warfarinplacebo (on top of aspirin)suggesting
WARIS II (warfarin alone), 2002warfarinaspirinsuggesting

post stroke

dicoumarol
Howard, 1963dicoumarolplacebonegative
Nat-Coop, 1962dicoumarolplacebosuggesting
phenindione
Enger, 1965phenindioneplacebonegative
Thygesen, 1964phenindioneplacebonegative
warfarin
SWAT, 1998warfarinaspirinnegative