anticoagulant

Acenocoumarol - Betrixaban - Phenindione      

Select            
Trial Studied trt Control trt patientstagsROB Trial result

acute coronary syndrome

apixaban
APPRAISE-1 (10mg od), 2009      NCTapixabanplaceboLow risk of bias negative
APPRAISE-1 (2.5 mg bid), 2009      NCTapixabanplaceboLow risk of bias negative
APPRAISE 2, 2011      NCTapixabanplaceboLow risk of bias negative
coumadin
ASPECT-2 (coumadin+asp vs asp), 2002     coumadincontrol (on top of aspirin)suggesting
ASPECT-2 (coumadin vs aspirin), 2002   coumadinaspirinsuggesting
dabigatran
REDEEM, 2009    NCTdabigatranplaceboLow risk of bias negative
otamixaban
SEPIA-ACS1 TIMI 42, 2009    NCTotamixabanunfractionated heparinLow risk of bias suggesting
rivaroxaban
ATLAS ACS 2 - TIMI 51 (2.5mg), 2011      NCTrivaroxaban 2.5mgplaceboLow risk of bias suggesting
ATLAS ACS-TIMI 46 (2.5mg), 2009      NCTrivaroxaban 2.5mgplaceboLow risk of bias negative
ATLAS ACS 2 - TIMI 51 (5mg), 2011      NCTrivaroxaban 5mgplacebosuggesting
ATLAS ACS-TIMI 46 (5mg), 2009      NCTrivaroxaban 5mgplaceboLow risk of bias negative
warfarin
ATACS (pilot study) (warfarin vs control), 1990     warfarincontrol (on top of aspirin)negative
ATACS, 1994   warfarincontrol (on top of aspirin)negative
CARS, 1997     warfarincontrol (on top of aspirin)negative
OASIS Pilot (phase 1), 1998     warfarincontrol (on top of aspirin)negative
OASIS Pilot (phase 2), 1998     warfarincontrol (on top of aspirin)negative
OASIS-2 Warfarin Substudy, 2001     warfarincontrol (on top of aspirin)negative
APRICOT-2, 2002     warfarincontrol (on top of aspirin)negative
CHAMP, 2002     warfarincontrol (on top of aspirin)negative
WARIS, 2002     warfarincontrol (on top of aspirin)suggesting
LoWASA, 2004     warfarincontrol (on top of aspirin)negative
Zibaeenezhad, 2004   warfarincontrol (on top of aspirin)negative
Williams, 1997     warfarinplacebo (on top of aspirin)Low risk of bias negative
Huyhn, 2001     warfarinplacebo (on top of aspirin)Low risk of bias negative
ATACS (pilot study) warfarin vs aspirin, 1990     warfarinaspirinnegative
ximelagatran
ESTEEM, 2003   ximelagatranplaceboExploratory -

acute myocardial infarction

coumadin
ASPECT-2 (coumadin+ASA vs ASA), 2002     coumadincontrol (on top of aspirin)negative
ASPECT, 1994   coumadinplaceboLow risk of bias suggesting
ASPECT-2 (coumadin alone), 2002     coumadinaspirinsuggesting
warfarin
APRICOT-2, 2002     warfarincontrol (on top of aspirin)suggesting
Zibaeenezhad, 2004   warfarincontrol (on top of aspirin)negative
WARIS, 1999   warfarincontrol (on top of aspirin)Low risk of bias -
CHAMP, 2002     warfarincontrol (on top of aspirin)negative
CARS (warafrin 3mg), 1997     warfarincontrol (on top of aspirin)Low risk of bias suggesting
LoWASA, 2004     warfarincontrol (on top of aspirin)Risk of bias suggesting
CARS (warfarin 1mg), 1997     warfarincontrol (on top of aspirin)Low risk of bias negative
WARIS II (warfarin+ASA), 2002     warfarincontrol (on top of aspirin)suggesting
Williams, 1997     warfarinplacebo (on top of aspirin)Low risk of bias suggesting
WARIS II (warfarin alone), 2002     warfarinaspirinsuggesting

cardiovascular prevention

dicoumarol
Apenstrom and Korsan-Bengtsen, 1964   dicoumarolno anticoagulant -
rivaroxaban
COMPASS (rivaroxaban alone), 2017    NCTrivaroxabanaspirinsecondary prevention -
COMPASS (rivaroxaban + aspirin), 2017      NCTrivaroxaban + aspirinaspirinsecondary preventionLow risk of bias -
wafarin
WARIS, 1990   warfarinplaceboLow risk of bias -
warfarin
Thrombosis Prevention trial (Warfarin), 1998        NCTwarfarinplaceboprimary preventionLow risk of bias suggesting
Thrombosis Prevention trial (W plus A), 1998        NCTwarfarin + aspirinplaceboprimary preventionLow risk of bias suggesting

coronary artery disease

dicoumarol
Apenstrom and Korsan-Bengtsen, 1964   dicoumarolno anticoagulant -
wafarin
WARIS, 1990   warfarinplaceboLow risk of bias -

percutaneous coronary intervention

bivalirudin
REPLACE-2, 2003         bivalirudinheparin + GP2b3a inhibitorsLow risk of bias -
HORIZONS-AMI (Stone), 2008        NCTbivalirudinheparin + GP2b3a inhibitorsRisk of bias suggesting
ACUITY (Stone) (bivalirudin alone), 2006      NCTbivalirudinheparin + GP2b3a inhibitorsRisk of bias -
Kleiman, 2002     bivalirudin + eptifibatideheparin + GP2b3a inhibitorsExploratory -
ISAR-REACT 3, 2008    NCTbivalirudinUFHLow risk of bias -
REPLACE-1, 2004     bivalirudinUFHExploratory negative
BAT (Bittl), 1995             bivalirudinUFHLow risk of bias suggesting
ARMYDA BIVALVE   bivalirudinUFH -
NAPLES (Tavano), 2009     bivalirudinUFH plus tirofibanRisk of bias suggesting
dalteparin
Natarajan (without antiGp2b3a), 2003   dalteparinUFH -
Natarajan (+ antiGp2b3a), 2003   dalteparinUFH + anti Gp2b3a -
enoxaparin
STEEPLE, 2006      NCTenoxaparinUFHRisk of bias -
Rabah, 1999     enoxaparinUFHExploratory negative
CRUISE, 2003     enoxaparinUFHExploratory negative
Galeote, 2001   enoxaparinUFHnegative
Dudek, 2000   enoxaparinUFHnegative
Dudek b (enox alone), 2000   enoxaparinUFH -
Drozd, 2001   enoxaparinUFHnegative
ATOLL, 2010   enoxaparinUFHRisk of bias -
Dubek b (+abciximal), 2001   enoxaparin+abciximabUFH -
reviparin
REDUCE, 1996     reviparinUFHLow risk of bias suggesting

peripheral vascular diseases

warfarin
Johnson, 2002   warfarincontrôle -
Sarac, 1998   warfarincontrôle -

post myocardial infarction

coumadin
ASPECT-2 (coumadin+ASA vs ASA), 2002     coumadincontrol (on top of aspirin)negative
ASPECT, 1994   coumadinplaceboLow risk of bias suggesting
ASPECT-2 (coumadin alone), 2002     coumadinaspirinsuggesting
warfarin
APRICOT-2, 2002     warfarincontrol (on top of aspirin)suggesting
Zibaeenezhad, 2004   warfarincontrol (on top of aspirin)negative
WARIS, 1999   warfarincontrol (on top of aspirin)Low risk of bias -
CHAMP, 2002     warfarincontrol (on top of aspirin)negative
CARS (warafrin 3mg), 1997     warfarincontrol (on top of aspirin)Low risk of bias suggesting
LoWASA, 2004     warfarincontrol (on top of aspirin)Risk of bias suggesting
CARS (warfarin 1mg), 1997     warfarincontrol (on top of aspirin)Low risk of bias negative
WARIS II (warfarin+ASA), 2002     warfarincontrol (on top of aspirin)suggesting
Williams, 1997     warfarinplacebo (on top of aspirin)Low risk of bias suggesting
WARIS II (warfarin alone), 2002     warfarinaspirinsuggesting

post stroke

dicoumarol
Howard, 1963   dicoumarolplacebonegative
Nat-Coop, 1962   dicoumarolplacebosuggesting
phenindione
Enger, 1965   phenindioneplacebonegative
Thygesen, 1964   phenindioneplacebonegative
rivaroxaban
NAVIGATE ESUS, 2018      NCTrivaroxabanaspirin -
warfarin
SWAT, 1998   warfarinaspirinnegative

thrombosis prevention

acenocoumarol
Hamulyak, 1994   AcenocoumarolNadroparinnegative
Samama, 2001     AcenocoumarolReviparinnegative
van Geloven, 1977   Acenocoumarolunfractionated heparinLow risk of bias -
apixaban
ADVANCE 3, 2010    NCTapixabanenoxaparinhip surgeryLow risk of bias suggesting
ADVANCE 2, 2010      NCTapixabanenoxaparin (europe regimen)knee surgeryLow risk of bias suggesting
APROPOS 2.5mg, 2007    NCTapixabanenoxaparin (US regimen)knee surgeryLow risk of bias negative
ADVANCE-1, 2008      NCTapixabanenoxaparin (US regimen)knee surgeryLow risk of bias suggesting
dabigatran
RE-NOVATE (150mg), 2007      NCTdabigatran 150mgenoxaparinhip surgeryLow risk of bias negative
RE-NOVATE (220mg), 2007      NCTdabigatran 220mgenoxaparinhip surgeryLow risk of bias negative
RE-NOVATE 2    NCTdabigatran 220mgenoxaparinhip surgeryLow risk of bias negative
RE-MODEL (150mg), 2007     dabigatran 150mgenoxaparin (europe regimen)knee surgeryLow risk of bias negative