heparin (UFH or LMWH)  


Trial Studied trt Control trt patientstagsNCTROB Result

acute coronary syndrome

FRISC (long term), 1996dalteparinplacebo (on top of aspirin)Low risk of bias suggesting
FRIC prolonged treatment phase (LWMH vs PBO), 1997dalteparinplacebo (on top of aspirin)Low risk of bias negative
FRISC (short term), 1996dalteparinplacebo (on top of aspirin)Low risk of bias -
FRIC (acute phase LMWH vs UFH), 1997dalteparinUFH (on top of aspirin)Exploratory negative
RESCUEenoxaparinunfractionated heparinNCT00077818 -
EVET, 2005enoxaparintinzaparinsuggesting
ESSENCE, 1997enoxaparinUFH (on top of aspirin)Low risk of bias suggesting
TIMI 11 B (short term), 1998enoxaparinUFH (on top of aspirin)Low risk of bias suggesting
SYNERGY, 2005enoxaparinUFH (on top of aspirin)NCT00043784negative
INTERACT, 2006enoxaparinUFH (on top of aspirin)suggesting
TIMI 11 B (long term), 1998enoxaparinUFH (on top of aspirin)Low risk of bias negative
FRAXIS (6days), 1998nadroparinUFH (on top of aspirin)Low risk of bias negative
FRAXIS (14 days), 1998nadroparinUFH (on top of aspirin)Low risk of bias negative
Holdright, 1994UFHcontrol (on top of aspirin)negative
RISC (heparin+aspirin vs ASP), 1990UFHcontrol (on top of aspirin)negative
Theroux (heparin+ASP vs ASP), 1988UFHcontrol (on top of aspirin)Low risk of bias suggesting
ATACS (Cohen), 1994UFH, warfarincontrol (on top of aspirin)negative
Cohen (ATACS pilot) (heparin+aspirin vs asp), 1990UFH, warfarincontrol (on top of aspirin)negative
Theroux (heparin vs PBO), 1988UFHplaceboLow risk of bias suggesting
RISC (heparin vs PBO), 1990UFHplacebonegative
Theroux (heparin+aspirin vs PBO), 1988UFH + aspirinplaceboLow risk of bias suggesting
RISC (ASP+ heparin vs PBO), 1990UFH + aspirinplacebosuggesting
Gurfinkel (UFH+aspririn vs aspirin), 1995UFHplacebo (on top of aspirin)Low risk of bias negative
Cohen (ATACS pilot) (heparin vs asp), 1990UFH, warfarinaspirinnegative

acute myocardial infarction

HART II, 2001EnoxaparinUFHnegative
Baird, 2002EnoxaparinUFHnegative
DUCCS, 1994UFHno heparinnegative
ECSG, 1992UFHplaceboLow risk of bias negative

thrombosis prevention

Levine, 1996ardeparinplaceboLow risk of bias suggesting
Godwin, 1993ardeparinunfractionated heparin -
Schmitz-Huebner, 1984certoparinunfractionated heparinnegative
Sasahara, 1986certoparinunfractionated heparinsuggesting
Voigt, 1986certoparinunfractionated heparinnegative
Welzel, 1988certoparinunfractionated heparinsuggesting
Kakkar, 1989certoparinunfractionated heparinnegative
Adolf, 1989certoparinunfractionated heparinnegative
Heilmann, 1989certoparinunfractionated heparinnegative
Baumgartner, 1989certoparinunfractionated heparinnegative
Hoffmann and Largiade, 1990certoparinunfractionated heparinnegative
Koppenhagen, 1990certoparinunfractionated heparin -
Schielke, 1991certoparinunfractionated heparin -
Koppenhagen, 1992certoparinunfractionated heparin -
Hoffmann and Largiader, 1992certoparinunfractionated heparin -
Heilmann, 1997certoparinunfractionated heparin -
Haas, 1999certoparinunfractionated heparin -
Haas , 1987certoparine + DHEUnfractionated heparinnegative
Lassen, 1988certoparine + DHEUnfractionated heparinLow risk of bias suggesting
Lassen, 1989certoparine + DHEUnfractionated heparinLow risk of bias negative
Jorgensen, 1989dalteparinplaceboLow risk of bias suggesting
Torholm, 1991dalteparinplaceboLow risk of bias suggesting
Ockelford , 1989dalteparinplacebosuggesting
Eriksson , 1988dalteparinDextransuggesting
Matzsch , 1988dalteparinDextrannegative
Matzsch , 1991dalteparinDextransuggesting
Haas , 1985dalteparinUnfractionated heparinnegative
Binsack , 1986dalteparinUnfractionated heparinnegative
Barre , 1987dalteparinUnfractionated heparinnegative
Dechavanne , 1989dalteparinUnfractionated heparinnegative
Eriksson , 1989dalteparinUnfractionated heparinsuggesting
Monreal , 1989dalteparinUnfractionated heparinnegative
Bergqvist, 1986dalteparinunfractionated heparinnegative
Onarheim, 1986dalteparinunfractionated heparinnegative
Koller, 1986dalteparinunfractionated heparinnegative
Koller, 1986dalteparinunfractionated heparinnegative
Fricker, 1988dalteparinunfractionated heparinnegative
Bergqvist, 1988dalteparinunfractionated heparinnegative
Caen, 1988dalteparinunfractionated heparinnegative
Borstad, 1988dalteparinunfractionated heparinnegative
Briel, 1988dalteparinunfractionated heparinnegative
Creperio, 1990dalteparinunfractionated heparinnegative
Hartl, 1990dalteparinunfractionated heparinsuggesting
Borstad, 1992dalteparinunfractionated heparin -
Kakkar, 1993dalteparinunfractionated heparin -
Warwick, 1995enoxaparinno treatmentnegative
Ho [43]enoxaparinno treatmentnegative
Turpie, 1986enoxaparinplaceboLow risk of bias suggesting
Leclerc, 1991enoxaparinplaceboLow risk of bias suggesting
Samama, 1997enoxaparinplaceboLow risk of bias suggesting
Kalodiki, 1996enoxaparinplaceboLow risk of bias -
Agnelli, 1998enoxaparinplacebosuggesting
Melon, 1987enoxaparinplacebonegative
DES Group , 1991enoxaparinDextransuggesting
Planes , 1988enoxaparinUnfractionated heparinsuggesting
Levine , 1991enoxaparinUnfractionated heparinnegative
Samama 1, 1988enoxaparinunfractionated heparinnegative
Samama 2, 1988enoxaparinunfractionated heparinnegative
Samama 3, 1988enoxaparinunfractionated heparinnegative
Kaaja, 1992enoxaparinunfractionated heparin -
Gazzaniga (ISG), 1993enoxaparinunfractionated heparin -
Nurmohamed, 1995enoxaparinunfractionated heparin -
McLeod (Canadian), 1995enoxaparinunfractionated heparin -
Gonzalez, 1996enoxaparinunfractionated heparin -
ENOXACAN, 1997enoxaparinunfractionated heparin -
Pezzuoli, 1989nadroparinplacebosuggesting
Leyvraz, 1991nadroparinUnfractionated heparinnegative
Yoo, 1997nadroparinno treatmentnegative
Marassi [41]nadroparinno treatmentnegative
Sourmelis, 1995nadroparinplaceboLow risk of bias suggesting
Balas [40]nadroparinplacebonegative
Nurmohamed, 1996nadroparinplacebonegative
Kakkar and Murray, 1985nadroparinunfractionated heparinsuggesting
EFS, 1988nadroparinunfractionated heparinsuggesting
Dahan, 1989nadroparinunfractionated heparinnegative
Barbui, 1990nadroparinunfractionated heparin -
Eurin, 1994nadroparinunfractionated heparin -
Kakkar, 1993reviparinunfractionated heparin -
Lassen, 1991tinzaparinplaceboLow risk of bias suggesting
Bergqvist [42]tinzaparinplacebonegative
Leizorovicz, 1991tinzaparinunfractionated heparin -
Cerrato, 1978UFHno treatmentsuggesting

venous thrombosis

Kakkar, 2003BemiparinwarfarinRisk of bias negative
Das, 1996DalteparinwarfarinRisk of bias negative
Lee, 2003DalteparinwarfarinRisk of bias suggesting
Holmström, 1992once daily dalteparintwice daily dalteparinnegative
Partsch, 1996once daily dalteparintwice daily dalteparinnegative
Bratt et al , 1985Dalteparinunfractionated heparinnegative
Holm et al , 1986Dalteparinunfractionated heparinnegative
Bratt et al, 1990Dalteparinunfractionated heparinnegative
Lindmarker et al , 1993Dalteparinunfractionated heparinnegative
Veiga, 2000EnoxaparinacenocoumarolRisk of bias negative
González-Fajardo, 2008EnoxaparincoumarinRisk of bias -
Pini, 1994EnoxaparinwarfarinRisk of bias negative
Gonzalez-Fajardo, 1999EnoxaparinwarfarinRisk of bias suggesting
Meyer, 2002EnoxaparinwarfarinRisk of bias negative
Deitcher, 2003EnoxaparinwarfarinRisk of bias negative
Merli, 2001once daily enoxaparintwice daily enoxaparinLow risk of bias negative
Merli (once daily vs UFH), 2001once daily enoxaparinUFHLow risk of bias negative
Simonneau et al , 1993Enoxaparinunfractionated heparinnegative
Krahenbuhl, 1979subcutaneous heparinintravenous heparin -
Bentley, 1980subcutaneous heparinintravenous heparinsuggesting
Andersson, 1982subcutaneous heparinintravenous heparin -
Hull, 1986subcutaneous heparinintravenous heparinnegative
Doyle, 1987subcutaneous heparinintravenous heparinnegative
Walker, 1987subcutaneous heparinintravenous heparinsuggesting
Lopaciuksubcutaneous heparinintravenous heparinnegative
Pini, 1990subcutaneous heparinintravenous heparinnegative
Siegbahn, 1989once daily logiparintwice daily logiparinnegative
Lopaciuk, 1999NadroparinacenocoumarolRisk of bias negative
Lopez-Beret, 2001NadroparinacenocoumarolRisk of bias negative
Charbonnier, 1998once daily nadroparintwice daily nadroparinLow risk of bias negative
Collaborative European Multicentre, 1991Nadroparinunfractionated heparinnegative
Prandoni et al , 1992Nadroparinunfractionated heparinsuggesting
Lopaciuk et al , 1992Nadroparinunfractionated heparinnegative
Romera, 2009TinzaparinacenocoumarolRisk of bias suggesting
Hull, 2002TinzaparinwarfarinRisk of bias negative
Hull et al , 1992Tinzaparinunfractionated heparinsuggesting
Schulman, 19956 months1.5 monthssuggesting
Pinede, 20013-6 months1.5-3 monthsnegative
Levine, 1995warfarindiscontinuationLow risk of bias suggesting
LAFIT (Kearon), 1999warfarindiscontinuationsuggesting
Agnelli, 2001warfarindiscontinuationnegative
Agnelli, 2003warfarindiscontinuationnegative
PREVENT (Ridker), 2003warfarindiscontinuationsuggesting
ELAET (Kearon), 2004warfarindiscontinuationLow risk of bias negative
DURAC (Schulman), 1997warfarindiscontinuationsuggesting