heparin (UFH or LMWH)

Tinzaparin      

Select            
Trial Studied trt Control trt patientstagsROB Trial resultAll cause deathMajor bleeding

acute coronary syndrome

dalteparin
FRISC (long term), 1996   dalteparinplacebo (on top of aspirin)Low risk of bias suggesting-15%
FRIC prolonged treatment phase (LWMH vs PBO), 1997     dalteparinplacebo (on top of aspirin)Low risk of bias negative61%
FRISC (short term), 1996   dalteparinplacebo (on top of aspirin)Low risk of bias -
FRIC (acute phase LMWH vs UFH), 1997     dalteparinUFH (on top of aspirin)Exploratory negative257%
enoxaparin
RESCUE    NCTenoxaparinunfractionated heparin -
EVET, 2005     enoxaparintinzaparinsuggesting-50%
ESSENCE, 1997     enoxaparinUFH (on top of aspirin)Low risk of bias suggesting -3%-7%
TIMI 11 B (short term), 1998   enoxaparinUFH (on top of aspirin)Low risk of bias suggesting -17%52%
SYNERGY, 2005          NCTenoxaparinUFH (on top of aspirin)negative 4%19%
INTERACT, 2006       enoxaparinUFH (on top of aspirin)suggesting -42%-60%
TIMI 11 B (long term), 1998   enoxaparinUFH (on top of aspirin)Low risk of bias negative -4%90%
nadroparin
FRAXIS (6days), 1998     nadroparinUFH (on top of aspirin)Low risk of bias negative6%
FRAXIS (14 days), 1998     nadroparinUFH (on top of aspirin)Low risk of bias negative26%
UFH
Holdright, 1994   UFHcontrol (on top of aspirin)negative-15%
RISC (heparin+aspirin vs ASP), 1990   UFHcontrol (on top of aspirin)negative
Theroux (heparin+ASP vs ASP), 1988   UFHcontrol (on top of aspirin)Low risk of bias suggesting
ATACS (Cohen), 1994   UFH, warfarincontrol (on top of aspirin)negative4%606%
Cohen (ATACS pilot) (heparin+aspirin vs asp), 1990     UFH, warfarincontrol (on top of aspirin)negative
Theroux (heparin vs PBO), 1988   UFHplaceboLow risk of bias suggesting-100%
RISC (heparin vs PBO), 1990   UFHplacebonegative
Theroux (heparin+aspirin vs PBO), 1988   UFH + aspirinplaceboLow risk of bias suggesting-100%
RISC (ASP+ heparin vs PBO), 1990   UFH + aspirinplacebosuggesting
Gurfinkel (UFH+aspririn vs aspirin), 1995     UFHplacebo (on top of aspirin)Low risk of bias negative421%
Cohen (ATACS pilot) (heparin vs asp), 1990     UFH, warfarinaspirinnegative

acute myocardial infarction

enoxaparin
HART II, 2001     EnoxaparinUFHnegative
Baird, 2002     EnoxaparinUFHnegative
UFH
DUCCS, 1994   UFHno heparinnegative
ECSG, 1992     UFHplaceboLow risk of bias negative

thrombosis prevention

ardeparin
Levine, 1996   ardeparinplaceboknee surgeryLow risk of bias suggesting
Godwin, 1993   ardeparinunfractionated heparinabdominal surgery -
Certoparin
Schmitz-Huebner, 1984   certoparinunfractionated heparinabdominal surgerynegative+Infini%
Sasahara, 1986   certoparinunfractionated heparinabdominal surgerysuggesting-61%
Voigt, 1986   certoparinunfractionated heparinabdominal surgerynegative-37%183%
Welzel, 1988   certoparinunfractionated heparinabdominal surgerysuggesting
Kakkar, 1989   certoparinunfractionated heparinabdominal surgerynegative+Infini%
Adolf, 1989   certoparinunfractionated heparinabdominal surgerynegative
Heilmann, 1989   certoparinunfractionated heparingynaecological surgerynegative-33%
Baumgartner, 1989   certoparinunfractionated heparinabdominal surgerynegative-48%
Hoffmann and Largiade, 1990   certoparinunfractionated heparinabdominal surgerynegative-3%
Koppenhagen, 1990   certoparinunfractionated heparinabdominal surgery -
Schielke, 1991   certoparinunfractionated heparinabdominal surgery -
Koppenhagen, 1992   certoparinunfractionated heparinabdominal surgery -
Hoffmann and Largiader, 1992   certoparinunfractionated heparinabdominal surgery -
Heilmann, 1997   certoparinunfractionated heparingynaecological surgery -
Haas, 1999   certoparinunfractionated heparingeneral surgery -
Haas , 1987   certoparine + DHEUnfractionated heparinhip surgerynegative
Lassen, 1988   certoparine + DHEUnfractionated heparinhip surgeryLow risk of bias suggesting
Lassen, 1989   certoparine + DHEUnfractionated heparinhip surgeryLow risk of bias negative109%
dalteparin
Jorgensen, 1989   dalteparinplacebohip surgeryLow risk of bias suggesting-100%
Torholm, 1991     dalteparinplacebohip surgeryLow risk of bias suggesting+Infini%
Ockelford , 1989   dalteparinplacebosuggesting-100%-7%
Eriksson , 1988   dalteparinDextranhip surgerysuggesting
Matzsch , 1988   dalteparinDextranhip surgerynegative
Matzsch , 1991   dalteparinDextranhip surgerysuggesting
Haas , 1985   dalteparinUnfractionated heparinhip surgerynegative
Binsack , 1986   dalteparinUnfractionated heparinhip surgerynegative
Barre , 1987   dalteparinUnfractionated heparinhip surgerynegative
Dechavanne , 1989   dalteparinUnfractionated heparinhip surgerynegative
Eriksson , 1989   dalteparinUnfractionated heparinhip surgerysuggesting-100%
Monreal , 1989   dalteparinUnfractionated heparinhip surgerynegative-36%
Bergqvist, 1986   dalteparinunfractionated heparinabdominal surgerynegative 236%
Onarheim, 1986   dalteparinunfractionated heparinabdominal surgerynegative8%
Koller, 1986   dalteparinunfractionated heparinabdominal surgerynegative 161%
Koller, 1986   dalteparinunfractionated heparinabdominal surgerynegative+Infini%
Fricker, 1988   dalteparinunfractionated heparinabdominal surgerynegative100%
Bergqvist, 1988   dalteparinunfractionated heparinabdominal surgerynegative -2%
Caen, 1988   dalteparinunfractionated heparinabdominal surgerynegative-35%-100%
Borstad, 1988   dalteparinunfractionated heparingynaecological surgerynegative5%
Briel, 1988   dalteparinunfractionated heparinnon orthopedic surgerynegative
Creperio, 1990   dalteparinunfractionated heparingeneral surgerynegative
Hartl, 1990   dalteparinunfractionated heparinabdominal surgerysuggesting48%-34%
Borstad, 1992   dalteparinunfractionated heparingynaecological surgery -
Kakkar, 1993   dalteparinunfractionated heparinabdominal surgery -
enoxaparin
Warwick, 1995     enoxaparinno treatmenthip surgerynegative
Ho [43]   enoxaparinno treatmentnegative
Turpie, 1986   enoxaparinplacebohip surgeryLow risk of bias suggesting-100%
Leclerc, 1991   enoxaparinplaceboknee surgeryLow risk of bias suggesting
Samama, 1997     enoxaparinplacebohip surgeryLow risk of bias suggesting
Kalodiki, 1996   enoxaparinplacebohip surgeryLow risk of bias -
Agnelli, 1998     enoxaparinplacebosuggesting
Melon, 1987   enoxaparinplacebonegative
DES Group , 1991   enoxaparinDextranhip surgerysuggesting+Infini%
Planes , 1988   enoxaparinUnfractionated heparinhip surgerysuggesting
Levine , 1991   enoxaparinUnfractionated heparinhip surgerynegative
Samama 1, 1988   enoxaparinunfractionated heparingeneral surgerynegative+Infini%-1%
Samama 2, 1988   enoxaparinunfractionated heparingeneral surgerynegative+Infini%+Infini%
Samama 3, 1988   enoxaparinunfractionated heparingeneral surgerynegative+Infini%-8%
Kaaja, 1992   enoxaparinunfractionated heparingynaecological surgery -
Gazzaniga (ISG), 1993   enoxaparinunfractionated heparingeneral surgery -
Nurmohamed, 1995   enoxaparinunfractionated heparingeneral surgery -
McLeod (Canadian), 1995   enoxaparinunfractionated heparinabdominal surgery -
Gonzalez, 1996   enoxaparinunfractionated heparinabdominal surgery -
ENOXACAN, 1997   enoxaparinunfractionated heparinabdominal surgery -
fraxiparin
Pezzuoli, 1989   nadroparinplacebosuggesting -55%151%
Leyvraz, 1991   nadroparinUnfractionated heparinhip surgerynegative-49%
nadroparin
Yoo, 1997     nadroparinno treatmenthip surgerynegative
Marassi [41]   nadroparinno treatmentnegative
Sourmelis, 1995   nadroparinplacebohip surgeryLow risk of bias suggesting
Balas [40]   nadroparinplacebonegative
Nurmohamed, 1996   nadroparinplacebonegative
Kakkar and Murray, 1985   nadroparinunfractionated heparingeneral surgerysuggesting-17%
EFS, 1988   nadroparinunfractionated heparinabdominal surgerysuggesting-11%
Dahan, 1989   nadroparinunfractionated heparinthoracic surgerynegative
Barbui, 1990   nadroparinunfractionated heparingeneral surgery -
Eurin, 1994   nadroparinunfractionated heparinabdominal surgery -
reviparin
Kakkar, 1993   reviparinunfractionated heparingeneral surgery -
tinzaparin
Lassen, 1991   tinzaparinplacebohip surgeryLow risk of bias suggesting13%
Bergqvist [42]   tinzaparinplacebonegative-100%+Infini%
Leizorovicz, 1991   tinzaparinunfractionated heparinabdominal surgery -
UFH
Cerrato, 1978   UFHno treatmentsuggesting

venous thrombosis

Bemiparin
Kakkar, 2003     BemiparinwarfarinRisk of bias negative
dalteparin
Das, 1996     DalteparinwarfarinRisk of bias negative
Lee, 2003       DalteparinwarfarinRisk of bias suggesting
Holmström, 1992   once daily dalteparintwice daily dalteparinnegative
Partsch, 1996     once daily dalteparintwice daily dalteparinnegative153%
Bratt et al , 1985   Dalteparinunfractionated heparinnegative
Holm et al , 1986   Dalteparinunfractionated heparinnegative
Bratt et al, 1990   Dalteparinunfractionated heparinnegative83%
Lindmarker et al , 1993   Dalteparinunfractionated heparinnegative-32%
enoxaparin
Veiga, 2000     EnoxaparinacenocoumarolRisk of bias negative
González-Fajardo, 2008     EnoxaparincoumarinRisk of bias -
Pini, 1994   EnoxaparinwarfarinRisk of bias negative
Gonzalez-Fajardo, 1999     EnoxaparinwarfarinRisk of bias suggesting
Meyer, 2002     EnoxaparinwarfarinRisk of bias negative
Deitcher, 2003   EnoxaparinwarfarinRisk of bias negative
Merli, 2001     once daily enoxaparintwice daily enoxaparinLow risk of bias negative65%
Merli (once daily vs UFH), 2001   once daily enoxaparinUFHLow risk of bias negative19%
Simonneau et al , 1993   Enoxaparinunfractionated heparinnegative50%
heparin
Krahenbuhl, 1979   subcutaneous heparinintravenous heparin -
Bentley, 1980     subcutaneous heparinintravenous heparinsuggesting-75%
Andersson, 1982     subcutaneous heparinintravenous heparin -
Hull, 1986   subcutaneous heparinintravenous heparinnegative 2%
Doyle, 1987   subcutaneous heparinintravenous heparinnegative104%
Walker, 1987   subcutaneous heparinintravenous heparinsuggesting
Lopaciuk   subcutaneous heparinintravenous heparinnegative92%
Pini, 1990   subcutaneous heparinintravenous heparinnegative-46%
logiparin
Siegbahn, 1989   once daily logiparintwice daily logiparinnegative
nadroparin
Lopaciuk, 1999     NadroparinacenocoumarolRisk of bias negative
Lopez-Beret, 2001     NadroparinacenocoumarolRisk of bias negative
Charbonnier, 1998     once daily nadroparintwice daily nadroparinLow risk of bias negative-27%
Collaborative European Multicentre, 1991   Nadroparinunfractionated heparinnegative89%
Prandoni et al , 1992   Nadroparinunfractionated heparinsuggesting-50%
Lopaciuk et al , 1992   Nadroparinunfractionated heparinnegative-100%
tinzaparin
Romera, 2009     TinzaparinacenocoumarolRisk of bias suggesting
Hull, 2002   TinzaparinwarfarinRisk of bias negative
Hull et al , 1992   Tinzaparinunfractionated heparinsuggesting-51%
warfarin
Schulman, 1995     6 months1.5 monthssuggesting-25%388%
Pinede, 2001     3-6 months1.5-3 monthsnegative32%73%
Levine, 1995   warfarindiscontinuationLow risk of bias suggesting-4%+Infini%
LAFIT (Kearon), 1999       warfarindiscontinuationsuggesting-65%+Infini%
Agnelli, 2001     warfarindiscontinuationnegative-1%99%
Agnelli, 2003