antithrombotics  

Abciximab - Apixaban - Bivalirudin - Coumadin - Dabigatran - Deltaparin - Dicoumarol - Edoxaban - Eptifibatide - Fondaparinux - Fraxiparin - Heparin - Hirudin - Idraparinux - LMWH - Reviparin - Rivaroxaban - Tirofiban - UFH - Wafarin - Warfarin - Ximelagatran      

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Trial Studied trt Control trt patientstagsNCTROB Result

acute coronary syndrome

apixaban
APPRAISE-1 (10mg od), 2009apixabanplaceboNCT00313300Low risk of bias negative
APPRAISE-1 (2.5 mg bid), 2009apixabanplaceboNCT00313300 Low risk of bias negative
APPRAISE 2, 2011apixabanplaceboNCT00831441Low risk of bias negative
APPRAISE japan ongoing apixabanplaceboNCT00852397Low risk of bias ongoing
argatroban
ARGAMI-2, 1998Argatrobanheparin -
aspirin
ATACS-pilot, 1990aspirincontrolnegative
VA-pilotaspirinplacebonegative
VA-main, 1983aspirinplaceboLow risk of bias suggesting
RISC, 1990aspirinplaceboLow risk of bias suggesting
ALDUSA-pilotaspirinplacebonegative
Théroux, 1988aspirinplaceboLow risk of bias suggesting
Canadian (Aspirin vs PBO), 1985aspirinplaceboLow risk of bias -
Canadian (Aspirin + sulfinpyrazone), 1985aspirin + sulfinpyrazoneplaceboLow risk of bias negative
atopaxar
LANCELOT ACSatopaxarplaceboExploratory -
J-LANCELOT, 2010atopaxarplaceboExploratory -
bivalirudin
ACUITY (biva alone vs hep+aGP2b3a), 2006bivalirudinheparin + GP2b3a inhibitorsNCT00093158Low risk of bias suggesting
ACUITY (biva+aGP2b3a vs hep+aGP2b3a), 2006bivalirudin + GP2b3a inhibitorsheparin + GP2b3a inhibitorsNCT00093158Low risk of bias negative
PROTECT-TIMI 30, 2006bivalirudineptifibatide + heparinNCT00250471Exploratory -
HERO, 1997bivalirudinheparinLow risk of bias suggesting
BAT (Bittl), 1995bivalirudinheparinLow risk of bias suggesting
ACUITY (sub groups PCI, bivalirudin alone) importé, 2007bivalirudinheparin + GP2b3a inhibitorssuggesting
ACUITY (sub groups PCI, bivalirudin +aGP2b3a) importé, 2007bivalirudin + GP2b3a inhibitorsheparin + GP2b3a inhibitorsnegative
clopidogrel
CURE (PCI sub study), 2001clopidogrelplaceboLow risk of bias -
CURE, 2001clopidogrel + aspirinaspirinLow risk of bias suggesting
CURRENT OASIS 7 (clopidogrel), 2010clopidogrel high-dose regimenclopidogrel standard-doseNCT00335452Low risk of bias negative
coumadin
ASPECT-2 (coumadin+asp vs asp), 2002coumadincontrol (on top of aspirin)suggesting
ASPECT-2 (coumadin vs aspirin), 2002coumadinaspirinsuggesting
dalteparin
FRISC (long term), 1996dalteparinplacebo (on top of aspirin)Low risk of bias suggesting
FRIC prolonged treatment phase (LWMH vs PBO), 1997dalteparinplacebo (on top of aspirin)Low risk of bias negative
FRISC (short term), 1996dalteparinplacebo (on top of aspirin)Low risk of bias -
FRIC (acute phase LMWH vs UFH), 1997dalteparinUFH (on top of aspirin)Exploratory negative
dipyridamol
Prandoni, 1991aspirin + dipyridamolplaceboLow risk of bias negative
Efegatran
Klootwijk, 1999EfegatranheparinExploratory -
enoxaparin
RESCUEenoxaparinunfractionated heparinNCT00077818 -
EVET, 2005enoxaparintinzaparinsuggesting
ESSENCE, 1997enoxaparinUFH (on top of aspirin)Low risk of bias suggesting
TIMI 11 B (short term), 1998enoxaparinUFH (on top of aspirin)Low risk of bias suggesting
SYNERGY, 2005enoxaparinUFH (on top of aspirin)NCT00043784negative
INTERACT, 2006enoxaparinUFH (on top of aspirin)suggesting
TIMI 11 B (long term), 1998enoxaparinUFH (on top of aspirin)Low risk of bias negative
fondaparinux
PENTUA, 2004fondaparinuxenoxaparin -
OASIS 5, 2006fondaparinuxenoxaparinNCT00139815Low risk of bias -
hirudin
HIT-4, 1999HirudinheparinLow risk of bias -
TIMI 9B, 1996HirudinheparinRisk of bias -
GUSTO IIB, 1996HirudinheparinRisk of bias -
OASIS pilot, 1997HirudinheparinExploratory -
HELVETICA (Serruys), 1995HirudinheparinLow risk of bias -
OASIS 2, 1999HirudinheparinLow risk of bias -
OASIS, 1997HirudinheparinRisk of bias -
inogatran
TRIM, 1997InogatranheparinLow risk of bias -
nadroparin
FRAXIS (6days), 1998nadroparinUFH (on top of aspirin)Low risk of bias negative
FRAXIS (14 days), 1998nadroparinUFH (on top of aspirin)Low risk of bias negative
otamixaban
SEPIA-ACS1 TIMI 42, 2009otamixabanunfractionated heparinNCT00317395Low risk of bias suggesting
prasugrel
TRILOGY ACS (overall population), 2012prasugrelclopidogrelNCT00699998Low risk of bias negative
TRITON-TIMI 38, 2007prasugrelclopidogrelNCT00097591Low risk of bias suggesting
ACAPULCO ongoing prasugrelclopidogrel ongoing
rivaroxaban
ATLAS ACS 2 - TIMI 51 (2.5mg), 2011rivaroxaban 2.5mgplaceboNCT00809965Low risk of bias suggesting
ATLAS ACS 2 - TIMI 51 (5mg), 2011rivaroxaban 5mgplaceboNCT00809965suggesting
sulfinpyrazone
Canadian (sulfinpyrazone alone), 1985sulfinpyrazoneplaceboLow risk of bias -
ticagrelor
PLATO, 2009ticagrelorclopidogrelNCT00391872Low risk of bias suggesting
DISPERSE-2 (90mg), 2007ticagrelorclopidogrelLow risk of bias negative
ticlopidine
STAI, 1990ticlopidinecontrolsuggesting
Florida UAticlopidineplacebonegative
trapidil
Modenatrapidilplacebosuggesting
triflusal
TIM, 2000triflusalaspirinLow risk of bias -
Plaza, 1993triflusalplaceboLow risk of bias suggesting
UFH
Holdright, 1994UFHcontrol (on top of aspirin)negative
RISC (heparin+aspirin vs ASP), 1990UFHcontrol (on top of aspirin)negative
Theroux (heparin+ASP vs ASP), 1988UFHcontrol (on top of aspirin)Low risk of bias suggesting
ATACS (Cohen), 1994UFH, warfarincontrol (on top of aspirin)negative
Cohen (ATACS pilot) (heparin+aspirin vs asp), 1990UFH, warfarincontrol (on top of aspirin)negative
Theroux (heparin vs PBO), 1988UFHplaceboLow risk of bias suggesting
RISC (heparin vs PBO), 1990UFHplacebonegative
Theroux (heparin+aspirin vs PBO), 1988UFH + aspirinplaceboLow risk of bias suggesting
RISC (ASP+ heparin vs PBO), 1990UFH + aspirinplacebosuggesting
Gurfinkel (UFH+aspririn vs aspirin), 1995UFHplacebo (on top of aspirin)Low risk of bias negative
Cohen (ATACS pilot) (heparin vs asp), 1990UFH, warfarinaspirinnegative
vorapaxar
TRACER, 2011vorapaxarplacebo (on top standard therapy) NCT00527943Low risk of bias -
warfarin
ATACS (pilot study) (warfarin vs control), 1990warfarincontrol (on top of aspirin)negative
ATACS, 1994warfarincontrol (on top of aspirin)negative
CARS, 1997warfarincontrol (on top of aspirin)negative
OASIS Pilot (phase 1), 1998warfarincontrol (on top of aspirin)negative
OASIS Pilot (phase 2), 1998warfarincontrol (on top of aspirin)negative
OASIS-2 Warfarin Substudy, 2001warfarincontrol (on top of aspirin)negative
APRICOT-2, 2002warfarincontrol (on top of aspirin)negative
CHAMP, 2002warfarincontrol (on top of aspirin)negative
WARIS, 2002warfarincontrol (on top of aspirin)suggesting
LoWASA, 2004warfarincontrol (on top of aspirin)negative
Zibaeenezhad, 2004warfarincontrol (on top of aspirin)negative
Williams, 1997warfarinplacebo (on top of aspirin)Low risk of bias negative
Huyhn, 2001warfarinplacebo (on top of aspirin)Low risk of bias negative
ATACS (pilot study) warfarin vs aspirin, 1990warfarinaspirinnegative
ximelagatran
ESTEEM, 2003ximelagatranplaceboExploratory -

acute myocardial infarction

argatroban
ARGAMI-2, 1998Argatrobanheparin -
bivalirudin
HERO, 1997bivalirudinheparinLow risk of bias suggesting
coumadin
ASPECT-2 (coumadin+ASA vs ASA), 2002coumadincontrol (on top of aspirin)negative
ASPECT, 1994coumadinplaceboLow risk of bias suggesting
ASPECT-2 (coumadin alone), 2002coumadinaspirinsuggesting
dalteparin
FRAMI, 1997Dalteparinplacebo -
BIOMACS II, 1999DalteparinplaceboLow risk of bias -
ASSENT Plus, 2003DalteparinUFHnegative
enoxaparin
AMI-SK, 2002EnoxaparinplaceboLow risk of bias -
ASSENT 3, 2001EnoxaparinUFHsuggesting
HART II, 2001EnoxaparinUFHnegative
Baird, 2002EnoxaparinUFHnegative
ENTIRE-TIMI 2, 2002EnoxaparinUFHsuggesting
ASSENT 3 Plus, 2003EnoxaparinUFHnegative
fondaparinux
MICHELANGELO OASIS-6, 2006fondaparinuxplaceboNCT00064428Low risk of bias suggesting
hirudin
HIT-4, 1999HirudinheparinLow risk of bias -
TIMI 9B, 1996HirudinheparinRisk of bias -
reviparin
CREATE, 2005ReviparinplaceboLow risk of bias -
UFH
ISIS-2 Pilot, 1987UFHno heparinnegative
DUCCS, 1994UFHno heparinnegative
ECSG, 1992UFHplaceboLow risk of bias negative
OSIRIS, 1992UFHplaceboLow risk of bias negative
warfarin
APRICOT-2, 2002warfarincontrol (on top of aspirin)suggesting
Zibaeenezhad, 2004warfarincontrol (on top of aspirin)negative
WARIS, 1999warfarincontrol (on top of aspirin)Low risk of bias -
CHAMP, 2002warfarincontrol (on top of aspirin)negative
CARS (warafrin 3mg), 1997warfarincontrol (on top of aspirin)Low risk of bias suggesting
LoWASA, 2004warfarincontrol (on top of aspirin)Risk of bias suggesting
CARS (warfarin 1mg), 1997warfarincontrol (on top of aspirin)Low risk of bias negative
WARIS II (warfarin+ASA), 2002warfarincontrol (on top of aspirin)suggesting
Williams, 1997warfarinplacebo (on top of aspirin)Low risk of bias suggesting
WARIS II (warfarin alone), 2002warfarinaspirinsuggesting

atrial fibrillation

apixaban
AVERROES, 2011apixabanaspirinineligible for VKANCT00496769Low risk of bias suggesting
ARISTOTLE, 2011apixabanwarfarin standard doseNCT00412984Low risk of bias conclusive
phase 2 apixabanapixabanwarfarin standard doseNCT00787150Exploratory -
aspirin
LASAF(aspirin vs no treatment), 1999aspirincontrol -
AFASAK (aspirin vs placebo), 1989aspirinplaceboLow risk of bias negative
SPAF (aspirin,warfarin ineligible arm), 1991aspirinplaceboineligible for VKALow risk of bias negative
SPAF (aspirin , warfarin eligible arm), 1991aspirinplaceboLow risk of bias suggesting
EAFT, 1993aspirinplaceboLow risk of bias negative
FFAACS , 2001aspirinplacebo (on top fluidione)Low risk of bias negative
PATAF (vs coumadin low dose), 1999aspirincoumadin low doseRisk of bias negative
PATAF (vs coumadin standard dose), 1999aspirincoumadin standard doseRisk of bias negative
AFASAK II (aspirin vs warfarin low dose), 1998aspirinwarfarin low doseRisk of bias negative
SPAF II (aspirin vs warfarin standard dose, age<75), 1994aspirinwarfarin standard doseRisk of bias negative
AFASAK II (aspirin vs warfarin standard dose), 1998aspirinwarfarin standard doseRisk of bias negative
SPAF II (aspirin vs warfarin standard dose, age>75), 1994aspirinwarfarin standard doseRisk of bias negative
AFASAK (aspirin vs warfarin standard dose), 1989aspirinwarfarin standard doseRisk of bias negative
BAFTA (aspirin vs warfarin standard dose) ongoing aspirinwarfarin standard dose ongoing
clopidogrel
ACTIVE W, 2006aspirin + clopidogrelanticoagulantNCT00243178Risk of bias suggesting
ACTIVE A, 2009aspirin + clopidogrelaspirinNCT00249873Low risk of bias suggesting
coumadin
PATAF (coumadin low dose vs coumadin standard dose), 1999coumadin low dosecoumadin standard doseRisk of bias negative
dabigatran
RE-LY 110mg (2nd prevention subgroup) , 2010dabigatran 100mgwarfarinExploratory suggesting