antithrombotics

Abciximab - Apixaban - Bivalirudin - Coumadin - Dabigatran - Deltaparin - Dicoumarol - Edoxaban - Eptifibatide - Fondaparinux - Fraxiparin - Heparin - Hirudin - Idraparinux - LMWH - Reviparin - Rivaroxaban - Tirofiban - UFH - Wafarin - Warfarin - Ximelagatran      

Select            
Trial Studied trt Control trt patientstagsROB Trial result

acute coronary syndrome

apixaban
APPRAISE-1 (10mg od), 2009      NCTapixabanplaceboLow risk of bias negative
APPRAISE-1 (2.5 mg bid), 2009      NCTapixabanplaceboLow risk of bias negative
APPRAISE 2, 2011      NCTapixabanplaceboLow risk of bias negative
argatroban
ARGAMI-2, 1998       Argatrobanheparin -
aspirin
ATACS-pilot, 1990   aspirincontrolnegative
VA-pilot   aspirinplacebonegative
VA-main, 1983   aspirinplaceboLow risk of bias suggesting
RISC, 1990   aspirinplaceboLow risk of bias suggesting
ALDUSA-pilot   aspirinplacebonegative
Théroux, 1988   aspirinplaceboLow risk of bias suggesting
Canadian (Aspirin vs PBO), 1985   aspirinplaceboLow risk of bias -
Canadian (Aspirin + sulfinpyrazone), 1985   aspirin + sulfinpyrazoneplaceboLow risk of bias negative
atopaxar
LANCELOT ACS     atopaxarplaceboExploratory -
J-LANCELOT, 2010   atopaxarplaceboExploratory -
bivalirudin
ACUITY (biva alone vs hep+aGP2b3a), 2006      NCTbivalirudinheparin + GP2b3a inhibitorsLow risk of bias suggesting
ACUITY (biva+aGP2b3a vs hep+aGP2b3a), 2006    NCTbivalirudin + GP2b3a inhibitorsheparin + GP2b3a inhibitorsLow risk of bias negative
PROTECT-TIMI 30, 2006      NCTbivalirudineptifibatide + heparinExploratory -
HERO, 1997     bivalirudinheparinLow risk of bias suggesting
BAT (Bittl), 1995     bivalirudinheparinLow risk of bias suggesting
ACUITY (sub groups PCI, bivalirudin alone) importé, 2007         bivalirudinheparin + GP2b3a inhibitorssuggesting
ACUITY (sub groups PCI, bivalirudin +aGP2b3a) importé, 2007     bivalirudin + GP2b3a inhibitorsheparin + GP2b3a inhibitorsnegative
clopidogrel
CURE (PCI sub study), 2001     clopidogrelplaceboLow risk of bias -
CURE, 2001     clopidogrel + aspirinaspirinLow risk of bias suggesting
CURRENT OASIS 7 (clopidogrel), 2010    NCTclopidogrel high-dose regimenclopidogrel standard-doseLow risk of bias negative
coumadin
ASPECT-2 (coumadin+asp vs asp), 2002     coumadincontrol (on top of aspirin)suggesting
ASPECT-2 (coumadin vs aspirin), 2002   coumadinaspirinsuggesting
dalteparin
FRISC (long term), 1996   dalteparinplacebo (on top of aspirin)Low risk of bias suggesting
FRIC prolonged treatment phase (LWMH vs PBO), 1997     dalteparinplacebo (on top of aspirin)Low risk of bias negative
FRISC (short term), 1996   dalteparinplacebo (on top of aspirin)Low risk of bias -
FRIC (acute phase LMWH vs UFH), 1997     dalteparinUFH (on top of aspirin)Exploratory negative
dipyridamol
Prandoni, 1991   aspirin + dipyridamolplaceboLow risk of bias negative
Efegatran
Klootwijk, 1999     EfegatranheparinExploratory -
enoxaparin
RESCUE    NCTenoxaparinunfractionated heparin -
EVET, 2005     enoxaparintinzaparinsuggesting
ESSENCE, 1997     enoxaparinUFH (on top of aspirin)Low risk of bias suggesting
TIMI 11 B (short term), 1998   enoxaparinUFH (on top of aspirin)Low risk of bias suggesting
SYNERGY, 2005          NCTenoxaparinUFH (on top of aspirin)negative
INTERACT, 2006       enoxaparinUFH (on top of aspirin)suggesting
TIMI 11 B (long term), 1998   enoxaparinUFH (on top of aspirin)Low risk of bias negative
fondaparinux
PENTUA, 2004     fondaparinuxenoxaparin -
OASIS 5, 2006      NCTfondaparinuxenoxaparinLow risk of bias -
hirudin
HIT-4, 1999     HirudinheparinLow risk of bias -
TIMI 9B, 1996     HirudinheparinRisk of bias -
GUSTO IIB, 1996     HirudinheparinRisk of bias -
OASIS pilot, 1997     HirudinheparinExploratory -
HELVETICA (Serruys), 1995     HirudinheparinLow risk of bias -
OASIS 2, 1999     HirudinheparinLow risk of bias -
OASIS, 1997   HirudinheparinRisk of bias -
inogatran
TRIM, 1997     InogatranheparinLow risk of bias -
nadroparin
FRAXIS (6days), 1998     nadroparinUFH (on top of aspirin)Low risk of bias negative
FRAXIS (14 days), 1998     nadroparinUFH (on top of aspirin)Low risk of bias negative
otamixaban
SEPIA-ACS1 TIMI 42, 2009    NCTotamixabanunfractionated heparinLow risk of bias suggesting
prasugrel
TRILOGY ACS (overall population), 2012        NCTprasugrelclopidogrelLow risk of bias negative
TRITON-TIMI 38, 2007      NCTprasugrelclopidogrelLow risk of bias suggesting
rivaroxaban
ATLAS ACS 2 - TIMI 51 (2.5mg), 2011      NCTrivaroxaban 2.5mgplaceboLow risk of bias suggesting
ATLAS ACS 2 - TIMI 51 (5mg), 2011      NCTrivaroxaban 5mgplacebosuggesting
sulfinpyrazone
Canadian (sulfinpyrazone alone), 1985   sulfinpyrazoneplaceboLow risk of bias -
ticagrelor
PLATO, 2009      NCTticagrelorclopidogrelLow risk of bias suggesting
DISPERSE-2 (90mg), 2007       ticagrelorclopidogrelLow risk of bias negative
ticlopidine
STAI, 1990   ticlopidinecontrolsuggesting
Florida UA   ticlopidineplacebonegative
trapidil
Modena   trapidilplacebosuggesting
triflusal
TIM, 2000     triflusalaspirinLow risk of bias -
Plaza, 1993   triflusalplaceboLow risk of bias suggesting
UFH
Holdright, 1994   UFHcontrol (on top of aspirin)negative
RISC (heparin+aspirin vs ASP), 1990   UFHcontrol (on top of aspirin)negative
Theroux (heparin+ASP vs ASP), 1988   UFHcontrol (on top of aspirin)Low risk of bias suggesting
ATACS (Cohen), 1994   UFH, warfarincontrol (on top of aspirin)negative
Cohen (ATACS pilot) (heparin+aspirin vs asp), 1990     UFH, warfarincontrol (on top of aspirin)negative
Theroux (heparin vs PBO), 1988   UFHplaceboLow risk of bias suggesting
RISC (heparin vs PBO), 1990   UFHplacebonegative
Theroux (heparin+aspirin vs PBO), 1988   UFH + aspirinplaceboLow risk of bias suggesting
RISC (ASP+ heparin vs PBO), 1990   UFH + aspirinplacebosuggesting
Gurfinkel (UFH+aspririn vs aspirin), 1995     UFHplacebo (on top of aspirin)Low risk of bias negative
Cohen (ATACS pilot) (heparin vs asp), 1990     UFH, warfarinaspirinnegative
vorapaxar
TRACER, 2011      NCTvorapaxarplacebo (on top standard therapy) Low risk of bias -
warfarin
ATACS (pilot study) (warfarin vs control), 1990     warfarincontrol (on top of aspirin)negative
ATACS, 1994   warfarincontrol (on top of aspirin)negative
CARS, 1997     warfarincontrol (on top of aspirin)negative
OASIS Pilot (phase 1), 1998     warfarincontrol (on top of aspirin)negative
OASIS Pilot (phase 2), 1998     warfarincontrol (on top of aspirin)negative
OASIS-2 Warfarin Substudy, 2001     warfarincontrol (on top of aspirin)negative
APRICOT-2, 2002     warfarincontrol (on top of aspirin)negative
CHAMP, 2002     warfarincontrol (on top of aspirin)negative
WARIS, 2002     warfarincontrol (on top of aspirin)suggesting
LoWASA, 2004     warfarincontrol (on top of aspirin)negative
Zibaeenezhad, 2004   warfarincontrol (on top of aspirin)negative
Williams, 1997     warfarinplacebo (on top of aspirin)Low risk of bias negative
Huyhn, 2001     warfarinplacebo (on top of aspirin)Low risk of bias negative
ATACS (pilot study) warfarin vs aspirin, 1990     warfarinaspirinnegative
ximelagatran
ESTEEM, 2003   ximelagatranplaceboExploratory -

acute myocardial infarction

argatroban
ARGAMI-2, 1998       Argatrobanheparin -
bivalirudin
HERO, 1997     bivalirudinheparinLow risk of bias suggesting
coumadin
ASPECT-2 (coumadin+ASA vs ASA), 2002     coumadincontrol (on top of aspirin)negative
ASPECT, 1994   coumadinplaceboLow risk of bias suggesting
ASPECT-2 (coumadin alone), 2002     coumadinaspirinsuggesting
dalteparin
FRAMI, 1997     Dalteparinplacebo -
BIOMACS II, 1999     DalteparinplaceboLow risk of bias -
ASSENT Plus, 2003     DalteparinUFHnegative
enoxaparin
AMI-SK, 2002     EnoxaparinplaceboLow risk of bias -
ASSENT 3, 2001     EnoxaparinUFHsuggesting
HART II, 2001     EnoxaparinUFHnegative
Baird, 2002     EnoxaparinUFHnegative
ENTIRE-TIMI 2, 2002     EnoxaparinUFHsuggesting
ASSENT 3 Plus, 2003     EnoxaparinUFHnegative
fondaparinux
MICHELANGELO OASIS-6, 2006      NCTfondaparinuxplaceboLow risk of bias suggesting
hirudin
HIT-4, 1999     HirudinheparinLow risk of bias -
TIMI 9B, 1996     HirudinheparinRisk of bias -
reviparin
CREATE, 2005     ReviparinplaceboLow risk of bias -
UFH
ISIS-2 Pilot, 1987     UFHno heparinnegative
DUCCS, 1994   UFHno heparinnegative
ECSG, 1992     UFHplaceboLow risk of bias negative
OSIRIS, 1992   UFHplaceboLow risk of bias negative
warfarin
APRICOT-2, 2002     warfarincontrol (on top of aspirin)suggesting
Zibaeenezhad, 2004   warfarincontrol (on top of aspirin)negative
WARIS, 1999   warfarincontrol (on top of aspirin)Low risk of bias -
CHAMP, 2002     warfarincontrol (on top of aspirin)negative
CARS (warafrin 3mg), 1997     warfarincontrol (on top of aspirin)Low risk of bias suggesting
LoWASA, 2004     warfarincontrol (on top of aspirin)Risk of bias suggesting
CARS (warfarin 1mg), 1997     warfarincontrol (on top of aspirin)Low risk of bias negative
WARIS II (warfarin+ASA), 2002     warfarincontrol (on top of aspirin)suggesting
Williams, 1997     warfarinplacebo (on top of aspirin)Low risk of bias