acute myocardial infarction  

     

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Trial Studied trt Control trt patientstagsNCTROB Result

angiotensin-Converting Enzyme Inhibitors

captopril
ISIS-4, 1995captoprilplaceboLow risk of bias -
CCS-1, 1995captoprilplaceboLow risk of bias -
French, 1999captoprilplaceboLow risk of bias -
CATS, 1996captoprilplaceboLow risk of bias -
ECCE, 1997captoprilplaceboLow risk of bias -
Sharpe, 1991captoprilplaceboLow risk of bias -
Ray, 1993captoprilplaceboLow risk of bias -
Nabel, 1991captoprilplaceboLow risk of bias -
Bussmann, 1992captoprilplaceboLow risk of bias -
Di Pasquale, 1994captoprilplaceboLow risk of bias -
Di Pasquale, 1997captoprilplaceboLow risk of bias -
Galcera, 1993captoprilplaceboLow risk of bias -
Hargreaves, 1992captoprilplaceboLow risk of bias -
SAVE, 1992captoprilplaceboLow risk of bias -
Pfeffer, 1988captoprilplaceboLow risk of bias -
Sogaard, 1994captoprilplaceboLow risk of bias -
Sharpe, 1988captoprilplaceboLow risk of bias -
Mortarino, 1990captoprilplaceboLow risk of bias -
PRACTICAL (captopril), 1994captopril or enalaprilplaceboLow risk of bias -
enalapril
CONSENSUS 2, 1992enalaprilplaceboLow risk of bias -
Schulman, 1995enalaprilplaceboLow risk of bias -
fosinopril
FAMIS, 1998fosinoprilplaceboLow risk of bias -
irbesartan
GLOBAL ongoing irbesartancontrolNCT00125645Exploratory ongoing
lisinopril
GISSI 3, 1994lisinoprilplaceboRisk of bias -
ramipril
Wagner, 2002ramiprilplaceboLow risk of bias -
AIRE, 1993ramiprilplaceboLow risk of bias -
trandolapril
TRACE, 1995trandolaprilplaceboLow risk of bias -
zofenopril
SMILE, 1995zofenoprilplaceboLow risk of bias suggesting

angiotensin-receptor blockers

losartan
OPTIMAAL, 2002LosartanCaptoprilLow risk of bias suggesting
valsartan
VALIANT (valsartan+capropril), 2003Valsartan+ACE inhibitor ACE inhibitor onlyLow risk of bias negative
VALIANT (valsartan alone), 2003ValsartanCaptoprilLow risk of bias negative

antiarrythmic drugs

not classified
Koster and Dunning, 1985IM lidocaine (without infusion)controlRisk of bias negative
Bennett, 1970IV lidocaine infusioncontrolRisk of bias negative
Pitt, 1971IV lidocaine infusioncontrolRisk of bias negative
Darby, 1972IV lidocaine infusioncontrolRisk of bias negative
SandlarIM lidocaine (without infusion)placeboLow risk of bias negative
Singh and Kocot, 1976IM lidocaine (without infusion)placeboLow risk of bias negative
Lie (IM), 1978IM lidocaine (without infusion)placeboLow risk of bias negative
Dunn, 1985IM lidocaine (without infusion)placeboLow risk of bias negative
Kostuk and BeanlandsIV lidocaine infusionplaceboLow risk of bias negative
Baker, 1971IV lidocaine infusionplaceboLow risk of bias negative
Chopra, 1971IV lidocaine infusionplaceboLow risk of bias negative
OIV lidocaine infusionplaceboLow risk of bias negative
Lie (IV), 1974IV lidocaine infusionplaceboLow risk of bias negative
Wyse, 1988IV lidocaine infusionplaceboLow risk of bias negative
dofetilide
DIAMOND MI, 1997dofetilideplaceboLow risk of bias -
magnesium
ISIS-4, 1995magnesiumcontrolsuggesting
Wu, 1992magnesiumcontrolLow risk of bias suggesting
Zhu, 2002magnesiumcontrolsuggesting
Abraham, 1987magnesiumplaceboLow risk of bias negative
MAGIC, 2000magnesiumplaceboNCT00000610Low risk of bias negative
Bhargava, 1995magnesiumplaceboLow risk of bias suggesting
Ceremuzynski, 1989magnesiumplacebosuggesting
Chen, 1991magnesiumplacebosuggesting
Feldstedt, 1991magnesiumplaceboLow risk of bias negative
Gyamlani, 2000magnesiumplaceboLow risk of bias suggesting
Ising, 1990magnesiumplacebo -
Morton, 1984magnesiumplaceboLow risk of bias negative
Nakashima, 2004magnesiumplaceboLow risk of bias negative
Parikka, 1990magnesiumplaceboLow risk of bias negative
Raghu, 1999magnesiumplaceboLow risk of bias suggesting
Rasmussen, 1986magnesiumplaceboLow risk of bias negative
Santoro, 2000magnesiumplaceboLow risk of bias negative
Shechter, 1990magnesiumplaceboLow risk of bias suggesting
Shechter, 1991magnesiumplaceboLow risk of bias negative
Shechter, 1995magnesiumplaceboLow risk of bias suggesting
Singh, 1990magnesiumplaceboLow risk of bias suggesting
Smith, 1986magnesiumplaceboLow risk of bias negative
Thogersen, 1995magnesiumplaceboLow risk of bias negative
Urek, 1996magnesiumplaceboLow risk of bias negative
Woods, 1992magnesiumplaceboLow risk of bias suggesting
moricizine
CAST II (early treatment), 1992moricizineplaceboLow risk of bias -

anticoagulant

not classified
Sixty Plus reinfarction Study, 1980any anticoagulantplaceboLow risk of bias -
German-Austrian Study Group (oac vs pbo), 1980phenprocoumonplaceboLow risk of bias negative
EPSIM, 1982any anticoagulantaspirinnegative
German-Austrian Study Group (oac vs asp), 1980phenprocoumonaspirinLow risk of bias negative
coumadin
ASPECT-2 (coumadin+ASA vs ASA), 2002coumadincontrol (on top of aspirin)negative
ASPECT, 1994coumadinplaceboLow risk of bias suggesting
ASPECT-2 (coumadin alone), 2002coumadinaspirinsuggesting
warfarin
APRICOT-2, 2002warfarincontrol (on top of aspirin)suggesting
Zibaeenezhad, 2004warfarincontrol (on top of aspirin)negative
WARIS, 1999warfarincontrol (on top of aspirin)Low risk of bias -
CHAMP, 2002warfarincontrol (on top of aspirin)negative
CARS (warafrin 3mg), 1997warfarincontrol (on top of aspirin)Low risk of bias suggesting
LoWASA, 2004warfarincontrol (on top of aspirin)Risk of bias suggesting
CARS (warfarin 1mg), 1997warfarincontrol (on top of aspirin)Low risk of bias negative
WARIS II (warfarin+ASA), 2002warfarincontrol (on top of aspirin)suggesting
Williams, 1997warfarinplacebo (on top of aspirin)Low risk of bias suggesting
WARIS II (warfarin alone), 2002warfarinaspirinsuggesting

antiplatelets drug

not classified
Jones, 1987dazoxibencontrolnegative
GRAND, 1987GR3219Bcontrolnegative
Gent-AMI, 1968misc.controlnegative
Johannessen, 1989misc.controlnegative
French, 1993flurbiprofenplaceboLow risk of bias suggesting
aspirin
Huddinge, 1988aspirincontrolnegative
Frankfurt, 1976aspirincontrolnegative
Dutch-aspirin, 1990aspirinplaceboLow risk of bias negative
ISIS-pilot, 1987aspirinplaceboLow risk of bias negative
ISIS-2, 1988aspirinplaceboLow risk of bias suggesting
APRICOT, 1993aspirinplaceboLow risk of bias suggesting
clopidogrel
COMMIT, 2005clopidogrelplaceboNCT00222573Low risk of bias suggesting
CLARITY-TIMI 28, 2005clopidogrelplaceboLow risk of bias -
elinogrel
INNOVATE ongoing elinogrelerrorNCT00751231 ongoing
ERASE-MI, 2009elinogrelplaceboLow risk of bias negative
sulfinpyrazone
Dutch sulphinpyrazone, 1986sulfinpyrazonecontrolnegative
Wilcox, 1980sulfinpyrazoneplacebonegative
Louvain sulphinpyrazone, 1983sulfinpyrazoneplaceboLow risk of bias negative
ticlopidine
Knudsen-A, 1985ticlopidinecontrolnegative

antithrombotics

not classified
Sixty Plus reinfarction Study, 1980any anticoagulantplaceboLow risk of bias -
German-Austrian Study Group (oac vs pbo), 1980phenprocoumonplaceboLow risk of bias negative
EPSIM, 1982any anticoagulantaspirinnegative
German-Austrian Study Group (oac vs asp), 1980phenprocoumonaspirinLow risk of bias negative
argatroban
ARGAMI-2, 1998Argatrobanheparin -
bivalirudin
HERO, 1997bivalirudinheparinLow risk of bias suggesting
coumadin
ASPECT-2 (coumadin+ASA vs ASA), 2002coumadincontrol (on top of aspirin)negative
ASPECT, 1994coumadinplaceboLow risk of bias suggesting
ASPECT-2 (coumadin alone), 2002coumadinaspirinsuggesting
dalteparin
FRAMI, 1997Dalteparinplacebo -
BIOMACS II, 1999DalteparinplaceboLow risk of bias -
ASSENT Plus, 2003DalteparinUFHnegative
enoxaparin
AMI-SK, 2002EnoxaparinplaceboLow risk of bias -
ASSENT 3, 2001EnoxaparinUFHsuggesting
HART II, 2001EnoxaparinUFHnegative
Baird, 2002EnoxaparinUFHnegative
ENTIRE-TIMI 2, 2002EnoxaparinUFHsuggesting
ASSENT 3 Plus, 2003EnoxaparinUFHnegative
fondaparinux
MICHELANGELO OASIS-6, 2006fondaparinuxplaceboNCT00064428Low risk of bias suggesting
hirudin
HIT-4, 1999HirudinheparinLow risk of bias -
TIMI 9B, 1996HirudinheparinRisk of bias -
reviparin
CREATE, 2005ReviparinplaceboLow risk of bias -
UFH
ISIS-2 Pilot, 1987UFHno heparinnegative
DUCCS, 1994UFHno heparinnegative
ECSG, 1992UFHplaceboLow risk of bias negative
OSIRIS, 1992UFHplaceboLow risk of bias negative
warfarin
APRICOT-2, 2002warfarincontrol (on top of aspirin)suggesting
Zibaeenezhad, 2004warfarincontrol (on top of aspirin)negative
WARIS, 1999warfarincontrol (on top of aspirin)Low risk of bias -
CHAMP, 2002warfarincontrol (on top of aspirin)negative
CARS (warafrin 3mg), 1997warfarincontrol (on top of aspirin)Low risk of bias suggesting
LoWASA, 2004warfarincontrol (on top of aspirin)Risk of bias suggesting
CARS (warfarin 1mg), 1997warfarincontrol (on top of aspirin)Low risk of bias negative
WARIS II (warfarin+ASA), 2002warfarincontrol (on top of aspirin)suggesting
Williams, 1997warfarinplacebo (on top of aspirin)Low risk of bias suggesting
WARIS II (warfarin alone), 2002warfarinaspirinsuggesting

beta-blockers

not classified
Julian , 1982Sotalol placeboLow risk of bias negative
acebutolol
Azancot, 1982Acebutololplacebonegative
APSI, 1990Acebutolol placeboLow risk of bias suggesting
alprenolol
Andersen , 1979Alprenolol placeboLow risk of bias negative
Wilhelmsson , 1974Alprenolol placeboLow risk of bias negative
atenolol
ISIS1 Collaborative Group , 1986Atenololplacebonegative
Van de Werf , 1993Atenololplacebonegative
Yusuf , 1980Atenololplacebonegative
betaxolol
Yang , 1987Betaxololplacebonegative
carvedilol
Basu , 1997Carvedilol placeboLow risk of bias suggesting
labetalol
Heber , 1987Labetalolplacebonegative
metoprolol
MIAMI Trial Research Group , 1985placebonegative
Von Essen , 1982placebonegative
TIMI IIB, 1989placebonegative
Hjalmarson , 1981MetoprololplaceboLow risk of bias suggesting
LIT Research Group , 1987Metoprolol placeboLow risk of bias negative
Manger Cats , 1983Metoprolol placeboLow risk of bias negative
Rehnqvist , 1983Metoprolol placeboLow risk of bias suggesting
Salathia , 1985MetoprololplaceboLow risk of bias suggesting
Waagstein , 1975Practololormetoprololplacebonegative
oxprenolol
CPRG , 1981Oxprenololplacebonegative
Fuccella , 1968Oxprenololplacebonegative
Lombardo , 1979Oxprenololplacebonegative
Wilcox , 1980Oxprenololplacebonegative
EIS , 1984Oxprenolol placeboLow risk of bias negative
Schwartz (high risk and low risk) , 1992Oxprenolol placeboLow risk of bias suggesting
Taylor , 1982Oxprenolol placeboLow risk of bias negative
pindolol
Owensby , 1984Pindololplacebonegative
Australian and Swedish study, 1983Pindolol placeboLow risk of bias negative
practolol
Evemy , 1978Practololplacebonegative
Johansson , 1980Practololplacebonegative
Macleod , 1980Practololplacebonegative
Snow , 1980Practololplacebonegative
Thompson , 1979Practololplacebonegative
Multicentre international , 1975Practolol placeboLow risk of bias suggesting
propranolol
Aronow , 1997Propranolol controlsuggesting
Balcon , 1966Propranololplacebonegative
Barber , 1976Propranololplacebonegative
Clausen , 1966Propranololplacebonegative
Curtis , 1991Propranololplacebonegative
Dotremont , 1968Propranololplacebonegative
Gupta , 1982Propranololplacebonegative
Gupta , 1984Propranololplacebonegative
Hutton , 1979Propranololplacebonegative
Kahler , 1968Propranololplacebonegative
Ledwich , 1968Propranololplacebonegative
Mueller , 1980Propranololplacebonegative
Multicentre , 1966Propranololplacebonegative
Nigam , 1983Propranololplacebonegative
Norris , 1968Propranololplacebonegative
Norris , 1978Propranololplacebonegative
Norris , 1984Propranololplacebonegative
Peter , 1978Propranololplacebonegative
Pitt , 1976Propranololplacebonegative
Roberts , 1984Propranololplacebonegative
Singh , 1985Propranololplacebonegative
Sloman , 1967Propranololplacebonegative
Baber , 1980Propranolol placeboLow risk of bias negative
BHAT , 1982Propranolol placeboNCT00000492Low risk of bias suggesting
Hansteen , 1982Propranolol placeboLow risk of bias suggesting