acute myocardial infarction

     

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Trial Studied trt Control trt patientstagsNCTROB Result

angiotensin-Converting Enzyme Inhibitors

captopril
ISIS-4, 1995captoprilplaceboLow risk of bias -
CCS-1, 1995captoprilplaceboLow risk of bias -
French, 1999captoprilplaceboExploratory -
CATS, 1996captoprilplaceboExploratory -
ECCE, 1997captoprilplaceboExploratory -
Sharpe, 1991captoprilplaceboExploratory -
Ray, 1993captoprilplaceboExploratory -
Nabel, 1991captoprilplaceboExploratory -
Bussmann, 1992captoprilplaceboExploratory -
Di Pasquale, 1994captoprilplaceboExploratory -
Di Pasquale, 1997captoprilplaceboExploratory -
Galcera, 1993captoprilplaceboExploratory -
Hargreaves, 1992captoprilplaceboExploratory -
SAVE, 1992captoprilplaceboLow risk of bias -
Pfeffer, 1988captoprilplaceboExploratory -
Sogaard, 1994captoprilplaceboExploratory -
Sharpe, 1988captoprilplaceboExploratory -
Mortarino, 1990captoprilplaceboExploratory -
PRACTICAL (captopril), 1994captopril or enalaprilplaceboExploratory -
enalapril
CONSENSUS 2, 1992enalaprilplaceboLow risk of bias -
Schulman, 1995enalaprilplaceboExploratory -
fosinopril
FAMIS, 1998fosinoprilplaceboExploratory -
irbesartan
GLOBAL ongoing irbesartancontrolNCT00125645Exploratory ongoing
lisinopril
GISSI 3, 1994lisinoprilplaceboRisk of bias -
ramipril
Wagner, 2002ramiprilplaceboExploratory -
AIRE, 1993ramiprilplaceboLow risk of bias -
trandolapril
TRACE, 1995trandolaprilplaceboLow risk of bias -
zofenopril
SMILE, 1995zofenoprilplaceboLow risk of bias suggesting

angiotensin-receptor blockers

losartan
OPTIMAAL, 2002LosartanCaptoprilsuggesting
valsartan
VALIANT (valsartan+capropril), 2003Valsartan+ACE inhibitor ACE inhibitor onlynegative
VALIANT (valsartan alone), 2003ValsartanCaptoprilnegative

antiarrythmic drugs

not classified
Koster and Dunning, 1985IM lidocaine (without infusion)controlRisk of bias negative
Bennett, 1970IV lidocaine infusioncontrolRisk of bias negative
Pitt, 1971IV lidocaine infusioncontrolRisk of bias negative
Darby, 1972IV lidocaine infusioncontrolRisk of bias negative
SandlarIM lidocaine (without infusion)placeboLow risk of bias negative
Singh and Kocot, 1976IM lidocaine (without infusion)placeboLow risk of bias negative
Lie (IM), 1978IM lidocaine (without infusion)placeboLow risk of bias negative
Dunn, 1985IM lidocaine (without infusion)placeboLow risk of bias negative
Kostuk and BeanlandsIV lidocaine infusionplaceboLow risk of bias negative
Baker, 1971IV lidocaine infusionplaceboLow risk of bias negative
Chopra, 1971IV lidocaine infusionplaceboLow risk of bias negative
OIV lidocaine infusionplaceboLow risk of bias negative
Lie (IV), 1974IV lidocaine infusionplaceboLow risk of bias negative
Wyse, 1988IV lidocaine infusionplaceboLow risk of bias negative
dofetilide
DIAMOND MI, 1997dofetilideplacebo -
magnesium
ISIS-4, 1995magnesiumcontrolsuggesting
Wu, 1992magnesiumcontrolsuggesting
Zhu, 2002magnesiumcontrolsuggesting
Abraham, 1987magnesiumplacebonegative
MAGIC, 2000magnesiumplaceboNCT00000610negative
Bhargava, 1995magnesiumplacebosuggesting
Ceremuzynski, 1989magnesiumplacebosuggesting
Chen, 1991magnesiumplacebosuggesting
Feldstedt, 1991magnesiumplacebonegative
Gyamlani, 2000magnesiumplacebosuggesting
Ising, 1990magnesiumplacebo -
Morton, 1984magnesiumplacebonegative
Nakashima, 2004magnesiumplacebonegative
Parikka, 1990magnesiumplacebonegative
Raghu, 1999magnesiumplacebosuggesting
Rasmussen, 1986magnesiumplacebonegative
Santoro, 2000magnesiumplacebonegative
Shechter, 1990magnesiumplacebosuggesting
Shechter, 1991magnesiumplacebonegative
Shechter, 1995magnesiumplacebosuggesting
Singh, 1990magnesiumplacebosuggesting
Smith, 1986magnesiumplacebonegative
Thogersen, 1995magnesiumplacebonegative
Urek, 1996magnesiumplacebonegative
Woods, 1992magnesiumplacebosuggesting
moricizine
CAST II (early treatment), 1992moricizineplacebo -

anticoagulant

not classified
Sixty Plus reinfarction Study, 1980any anticoagulantplacebo -
German-Austrian Study Group (oac vs pbo), 1980phenprocoumonplacebonegative
EPSIM, 1982any anticoagulantaspirinnegative
German-Austrian Study Group (oac vs asp), 1980phenprocoumonaspirinnegative
coumadin
ASPECT-2 (coumadin+ASA vs ASA), 2002coumadincontrol (on top of aspirin)negative
ASPECT, 1994coumadinplacebosuggesting
ASPECT-2 (coumadin alone), 2002coumadinaspirinsuggesting
warfarin
APRICOT-2, 2002warfarincontrol (on top of aspirin)suggesting
Zibaeenezhad, 2004warfarincontrol (on top of aspirin)negative
WARIS, 1999warfarincontrol (on top of aspirin) -
CHAMP, 2002warfarincontrol (on top of aspirin)negative
CARS (warafrin 3mg), 1997warfarincontrol (on top of aspirin)suggesting
LoWASA, 2004warfarincontrol (on top of aspirin)Risk of bias suggesting
CARS (warfarin 1mg), 1997warfarincontrol (on top of aspirin)negative
WARIS II (warfarin+ASA), 2002warfarincontrol (on top of aspirin)suggesting
Williams, 1997warfarinplacebo (on top of aspirin)suggesting
WARIS II (warfarin alone), 2002warfarinaspirinsuggesting

antiplatelets drug

not classified
Jones, 1987dazoxibencontrolnegative
GRAND, 1987GR3219Bcontrolnegative
Gent-AMI, 1968misc.controlnegative
Johannessen, 1989misc.controlnegative
French, 1993flurbiprofenplacebosuggesting
aspirin
Huddinge, 1988aspirincontrolnegative
Frankfurt, 1976aspirincontrolnegative
Dutch-aspirin, 1990aspirinplacebonegative
ISIS-pilot, 1987aspirinplacebonegative
ISIS-2, 1988aspirinplacebosuggesting
APRICOT, 1993aspirinplacebosuggesting
clopidogrel
COMMIT, 2005clopidogrelplaceboNCT00222573suggesting
CLARITY-TIMI 28, 2005clopidogrelplacebo -
elinogrel
INNOVATE ongoing elinogrelerrorNCT00751231 ongoing
ERASE-MI, 2009elinogrelplaceboExploratory negative
sulfinpyrazone
Dutch sulphinpyrazone, 1986sulfinpyrazonecontrolnegative
Wilcox, 1980sulfinpyrazoneplacebonegative
Louvain sulphinpyrazone, 1983sulfinpyrazoneplacebonegative
ticlopidine
Knudsen-A, 1985ticlopidinecontrolnegative

antithrombotics

not classified
Sixty Plus reinfarction Study, 1980any anticoagulantplacebo -
German-Austrian Study Group (oac vs pbo), 1980phenprocoumonplacebonegative
EPSIM, 1982any anticoagulantaspirinnegative
German-Austrian Study Group (oac vs asp), 1980phenprocoumonaspirinnegative
argatroban
ARGAMI-2, 1998Argatrobanheparin -
bivalirudin
HERO, 1997bivalirudinheparinExploratory suggesting
coumadin
ASPECT-2 (coumadin+ASA vs ASA), 2002coumadincontrol (on top of aspirin)negative
ASPECT, 1994coumadinplacebosuggesting
ASPECT-2 (coumadin alone), 2002coumadinaspirinsuggesting
dalteparin
FRAMI, 1997Dalteparinplacebo -
BIOMACS II, 1999Dalteparinplacebo -
ASSENT Plus, 2003DalteparinUFHnegative
enoxaparin
AMI-SK, 2002Enoxaparinplacebo -
ASSENT 3, 2001EnoxaparinUFHsuggesting
HART II, 2001EnoxaparinUFHnegative
Baird, 2002EnoxaparinUFHnegative
ENTIRE-TIMI 2, 2002EnoxaparinUFHsuggesting
ASSENT 3 Plus, 2003EnoxaparinUFHnegative
fondaparinux
MICHELANGELO OASIS-6, 2006fondaparinuxplaceboNCT00064428Low risk of bias suggesting
hirudin
HIT-4, 1999HirudinheparinExploratory -
TIMI 9B, 1996HirudinheparinRisk of bias -
reviparin
CREATE, 2005Reviparinplacebo -
UFH
ISIS-2 Pilot, 1987UFHno heparinnegative
DUCCS, 1994UFHno heparinnegative
ECSG, 1992UFHplacebonegative
OSIRIS, 1992UFHplacebonegative
warfarin
APRICOT-2, 2002warfarincontrol (on top of aspirin)suggesting
Zibaeenezhad, 2004warfarincontrol (on top of aspirin)negative
WARIS, 1999warfarincontrol (on top of aspirin) -
CHAMP, 2002warfarincontrol (on top of aspirin)negative
CARS (warafrin 3mg), 1997warfarincontrol (on top of aspirin)suggesting
LoWASA, 2004warfarincontrol (on top of aspirin)Risk of bias suggesting
CARS (warfarin 1mg), 1997warfarincontrol (on top of aspirin)negative
WARIS II (warfarin+ASA), 2002warfarincontrol (on top of aspirin)suggesting
Williams, 1997warfarinplacebo (on top of aspirin)suggesting
WARIS II (warfarin alone), 2002warfarinaspirinsuggesting

beta-blockers

not classified
Julian , 1982Sotalol placebonegative
acebutolol
Azancot, 1982Acebutololplacebonegative
APSI, 1990Acebutolol placebosuggesting
alprenolol
Andersen , 1979Alprenolol placebonegative
Wilhelmsson , 1974Alprenolol placebonegative
atenolol
ISIS1 Collaborative Group , 1986Atenololplacebonegative
Van de Werf , 1993Atenololplacebonegative
Yusuf , 1980Atenololplacebonegative
betaxolol
Yang , 1987Betaxololplacebonegative
carvedilol
Basu , 1997Carvedilol placebosuggesting
labetalol
Heber , 1987Labetalolplacebonegative
metoprolol
MIAMI Trial Research Group , 1985placebonegative
Von Essen , 1982placebonegative
TIMI IIB, 1989placebonegative
Hjalmarson , 1981Metoprololplacebosuggesting
LIT Research Group , 1987Metoprolol placebonegative
Manger Cats , 1983Metoprolol placebonegative
Rehnqvist , 1983Metoprolol placebosuggesting
Salathia , 1985Metoprololplacebosuggesting
Waagstein , 1975Practololormetoprololplacebonegative
oxprenolol
CPRG , 1981Oxprenololplacebonegative
Fuccella , 1968Oxprenololplacebonegative
Lombardo , 1979Oxprenololplacebonegative
Wilcox , 1980Oxprenololplacebonegative
EIS , 1984Oxprenolol placebonegative
Schwartz (high risk and low risk) , 1992Oxprenolol placebosuggesting
Taylor , 1982Oxprenolol placebonegative
pindolol
Owensby , 1984Pindololplacebonegative
Australian and Swedish study, 1983Pindolol placebonegative
practolol
Evemy , 1978Practololplacebonegative
Johansson , 1980Practololplacebonegative
Macleod , 1980Practololplacebonegative
Snow , 1980Practololplacebonegative
Thompson , 1979Practololplacebonegative
Multicentre international , 1975Practolol placebosuggesting
propranolol
Aronow , 1997Propranolol controlsuggesting
Balcon , 1966Propranololplacebonegative
Barber , 1976Propranololplacebonegative
Clausen , 1966Propranololplacebonegative
Curtis , 1991Propranololplacebonegative
Dotremont , 1968Propranololplacebonegative
Gupta , 1982Propranololplacebonegative
Gupta , 1984Propranololplacebonegative
Hutton , 1979Propranololplacebonegative
Kahler , 1968Propranololplacebonegative
Ledwich , 1968Propranololplacebonegative
Mueller , 1980Propranololplacebonegative
Multicentre , 1966Propranololplacebonegative
Nigam , 1983Propranololplacebonegative
Norris , 1968Propranololplacebonegative
Norris , 1978Propranololplacebonegative
Norris , 1984Propranololplacebonegative
Peter , 1978Propranololplacebonegative
Pitt , 1976Propranololplacebonegative
Roberts , 1984Propranololplacebonegative
Singh , 1985Propranololplacebonegative
Sloman , 1967Propranololplacebonegative
Baber , 1980Propranolol placebonegative
BHAT , 1982Propranolol placeboNCT00000492suggesting
Hansteen , 1982Propranolol placebosuggesting
Wilcox , 1980Propranolol or atenolol placebosuggesting
sotalol
Lloyd , 1988Sotalolplacebonegative
timolol
Campbell , 1984Timololplacebonegative
Federman , 1984Timololplacebonegative
ICSG , 1984Timololplacebonegative
Ranganathan , 1988Timololplacebonegative
Tonkin , 1981Timololplacebonegative
UKCSG , 1983Timololplacebonegative
Norwegian Multicentre Study Group , 1981Timolol placebosuggesting
xamoterol
McMurray , 1991Xamoterolplacebonegative

calcium channel blockers

not classified
Eichler, 1985Tiapamilcontrolnegative
diltiazem
Machecourt, 1986diltiazemnegative
Gibson, 1986diltiazemplacebonegative
MDPIT, 1988diltiazemplacebonegative
Zannad, 1988diltiazemplacebonegative
nifedipine
Muller, 1984nifedipinenegative
Gordon, 1984nifedipinenegative
MI study group, 1979nifedipine -
Eisenberg, 1985nifedipineplacebonegative
Bradagan, 1986nifedipineplacebonegative
Jaffe, 1987nifedipineplacebonegative
Gottlieb, 1988nifedipineplacebonegative
Erbel, 1988nifedipineplacebonegative
SPRINT I, 1988nifedipineplacebonegative
SPRINT II, 1993nifedipineplacebonegative
Loogna, 1985nifedipineplacebonegative
TRENT (Wilcox), 1986nifedipineplacebonegative
Walker, 1988nifedipineplacebonegative
Sirnes, 1984nifedipineplacebonegative
verapamil
Bussman, 1984verapamilcontrolnegative
DAVIT I, 1984verapamilplacebo -
Crea, 1985verapamilplacebonegative
DAVIT II, 1990verapamilplacebonegative
CRIS, 1996verapamilplacebonegative
Danish study, 1984verapamilplacebonegative

cell-based therapies

not classified
MAGIC (cell infusion ), 2004autologous bone marrow stem cellscontrol -
Suarez de Lezo (cell), 2007autologous bone marrow stem cellscontrol -
TCT-STAMI (Ge), 2006autologous bone marrow stem cellscontrolnegative
Huang, 2006autologous bone marrow stem cellscontrol -
MAGIC Cell-3-DES (Kang), 2006autologous bone marrow stem cellscontrolnegative
Karpov, 2005autologous bone marrow stem cellscontrol -
Li, 2007autologous bone marrow stem cellscontrol -
ASTAMi (Lunde), 2006autologous bone marrow stem cellscontrolnegative
Meluzin LD, 2006autologous bone marrow stem cellscontrolnegative
Meluzin HD, 2006autologous bone marrow stem cellscontrolnegative
BOOSt (Meyer), 2004autologous bone marrow stem cellscontrolnegative
Penicka, 2007autologous bone marrow stem cellscontrolnegative
Ruan, 2005autologous bone marrow stem cellscontrol -
Chen, 2004autologous bone marrow stem cellscontrol -
CADUCEUS ongoing cardiosphere-derived stem cellscontrolNCT00893360 ongoing
FIRSTLINE-AMI (Ince), 2005G-CSFcontrolnegative
MAGIC Cell-3-DES (Kang), 2006G-CSFcontrolnegative
MAGIC (G-CSF) (Kang), 2004G-CSFcontrolnegative
MAGIC 1 (Kang), 2007G-CSFcontrolnegative
Takano, 2007G-CSFcontrolnegative
RIGENERA (Leone), 2007G-CSFcontrolnegative
Suarez de Lezo (G-CSF), 2007G-CSFcontrolnegative
Suzuki, 2006G-CSFcontrol -
Deng, 2006G-CSFcontrolnegative
SWISS-AMI ongoing errorerror ongoing
COMPARE AMI ongoing errorerror ongoing
Janssens, 2006autologous bone marrow stem cellsplacebonegative
REPAIR-AMI (Schachinger), 2006autologous bone marrow stem cellsplaceboNCT00279175negative
TIME ongoing autologous bone marrow stem cellsplaceboExploratory ongoing
NCT00975234 ongoing Autologous Skeletal MyoblastsplaceboNCT00975234 ongoing
ENACT-AMI ongoing E-CMMplaceboExploratory ongoing
REVIVAL-2 (Zohlnhöfer ), 2006G-CSFplaceboNCT00126100Exploratory negative
STEMMI (Ripa), 2006G-CSFplacebonegative
G-CSF-STEMI (Engelmann), 2006G-CSFplacebonegative
Valgimigli, 2005G-CSFplacebonegative
Ellis, 2006G-CSFplaceboNCT00215124negative
MARVEL ongoing percutaneous skeletal-myoblast cell therapyplaceboExploratory ongoing

cholesterol lowering intervention

atorvastatin
PROVE-IT, 2004atorvastatin high dosepravastatindiabetic early initiation Low risk of bias suggesting

complement inhibition

pexelizumab
APEX-AMI, 2007pexelizumabplaceboNCT00091637Low risk of bias negative
COMMA, 2003pexelizumabplacebonegative
COMPLY, 2003pexelizumabplacebonegative

fibrinolysis

not classified
STAR, 1995recombinant staphylokinaset-PAnegative
TAMI 5 (t-PA+uroK vs tPA), 1991t-PA + urokinaset-PA -
anistreplase
TEAM 2, 1991anistreplasestreptokinase -
APSAC
APSIM, 1989APSACcontrolnegative
AIMS, 1988APSACplacebosuggesting
German Multicenter Trial, 1988APSACplacebosuggesting
ISIS III (SK/APSAC), 1992APSACstreptokinasenegative
TEAM 3, 1992APSACt-PA -
lanoteplase
InTIME-II, 2000lanoteplaseaccelerated t-PAnegative
reteplase
GUSTO III, 1997reteplaseaccelerated t-PAnegative
RAPID-2, 1996reteplaseaccelerated t-PAExploratory suggesting
INJECT, 1995reteplasestreptokinasenegative
saruplase
COMPASS, 1998saruplasestreptokinasenegative
PRIMI (vs SK), 1989saruplasestreptokinase -
SESAM, 1997saruplaset-PAExploratory negative
PRIMI (vs UK), 1989saruplaseurokinase -
streptokinase
ISAM, 1986streptokinaseplacebonegative
ISIS-2 (SK), 1988streptokinaseplacebosuggesting
Western Washington Intravenous Trial, 1988streptokinaseplaceboNCT00000507negative