acute coronary syndrome

     

Select            
Trial Studied trt Control trt patientstagsROB Trial result

anti-anginal drugs

ranolazine
MERLIN TIMI 36, 2007      NCTranolazine placeboLow risk of bias suggesting

anticoagulant

apixaban
APPRAISE-1 (10mg od), 2009      NCTapixabanplaceboLow risk of bias negative
APPRAISE-1 (2.5 mg bid), 2009      NCTapixabanplaceboLow risk of bias negative
APPRAISE 2, 2011      NCTapixabanplaceboLow risk of bias negative
coumadin
ASPECT-2 (coumadin+asp vs asp), 2002     coumadincontrol (on top of aspirin)suggesting
ASPECT-2 (coumadin vs aspirin), 2002   coumadinaspirinsuggesting
dabigatran
REDEEM, 2009    NCTdabigatranplaceboLow risk of bias negative
otamixaban
SEPIA-ACS1 TIMI 42, 2009    NCTotamixabanunfractionated heparinLow risk of bias suggesting
rivaroxaban
ATLAS ACS 2 - TIMI 51 (2.5mg), 2011      NCTrivaroxaban 2.5mgplaceboLow risk of bias suggesting
ATLAS ACS-TIMI 46 (2.5mg), 2009      NCTrivaroxaban 2.5mgplaceboLow risk of bias negative
ATLAS ACS 2 - TIMI 51 (5mg), 2011      NCTrivaroxaban 5mgplacebosuggesting
ATLAS ACS-TIMI 46 (5mg), 2009      NCTrivaroxaban 5mgplaceboLow risk of bias negative
warfarin
ATACS (pilot study) (warfarin vs control), 1990     warfarincontrol (on top of aspirin)negative
ATACS, 1994   warfarincontrol (on top of aspirin)negative
CARS, 1997     warfarincontrol (on top of aspirin)negative
OASIS Pilot (phase 1), 1998     warfarincontrol (on top of aspirin)negative
OASIS Pilot (phase 2), 1998     warfarincontrol (on top of aspirin)negative
OASIS-2 Warfarin Substudy, 2001     warfarincontrol (on top of aspirin)negative
APRICOT-2, 2002     warfarincontrol (on top of aspirin)negative
CHAMP, 2002     warfarincontrol (on top of aspirin)negative
WARIS, 2002     warfarincontrol (on top of aspirin)suggesting
LoWASA, 2004     warfarincontrol (on top of aspirin)negative
Zibaeenezhad, 2004   warfarincontrol (on top of aspirin)negative
Williams, 1997     warfarinplacebo (on top of aspirin)Low risk of bias negative
Huyhn, 2001     warfarinplacebo (on top of aspirin)Low risk of bias negative
ATACS (pilot study) warfarin vs aspirin, 1990     warfarinaspirinnegative
ximelagatran
ESTEEM, 2003   ximelagatranplaceboExploratory -

antiplatelets drug

not classified
Jones, 1987   dazoxibencontrolnegative
GRAND, 1987   GR3219Bcontrolnegative
Gent-AMI, 1968   misc.controlnegative
Johannessen, 1989     misc.controlnegative
French, 1993     flurbiprofenplaceboLow risk of bias suggesting
CURRENT - OASIS 7 (ASA), 2010    NCTASA high doseASA low doseRisk of bias suggesting
aspirin
ATACS-pilot, 1990   aspirincontrolnegative
Huddinge, 1988     aspirincontrolnegative
Frankfurt, 1976   aspirincontrolnegative
VA-pilot   aspirinplacebonegative
VA-main, 1983   aspirinplaceboLow risk of bias suggesting
RISC, 1990   aspirinplaceboLow risk of bias suggesting
ALDUSA-pilot   aspirinplacebonegative
Théroux, 1988   aspirinplaceboLow risk of bias suggesting
Canadian (Aspirin vs PBO), 1985   aspirinplaceboLow risk of bias -
Dutch-aspirin, 1990     aspirinplaceboLow risk of bias negative
ISIS-pilot, 1987     aspirinplaceboLow risk of bias negative
ISIS-2, 1988   aspirinplaceboLow risk of bias suggesting
APRICOT, 1993   aspirinplaceboLow risk of bias suggesting
Canadian (Aspirin + sulfinpyrazone), 1985   aspirin + sulfinpyrazoneplaceboLow risk of bias negative
atopaxar
J-LANCELOT, 2010   atopaxarplaceboExploratory -
LANCELOT ACS     atopaxarplaceboExploratory -
clopidogrel
COMMIT, 2005      NCTclopidogrelplaceboLow risk of bias suggesting
CLARITY-TIMI 28, 2005   clopidogrelplaceboLow risk of bias -
CURE, 2001     clopidogrel + aspirinaspirinLow risk of bias suggesting
CURRENT OASIS 7 (clopidogrel), 2010    NCTclopidogrel high-dose regimenclopidogrel standard-doseLow risk of bias negative
dipyridamol
Prandoni, 1991   aspirin + dipyridamolplaceboLow risk of bias negative
elinogrel
ERASE-MI, 2009     elinogrelplaceboLow risk of bias negative
prasugrel
TRILOGY ACS (overall population), 2012        NCTprasugrelclopidogrelLow risk of bias negative
TRITON-TIMI 38, 2007      NCTprasugrelclopidogrelLow risk of bias suggesting
sulfinpyrazone
Dutch sulphinpyrazone, 1986   sulfinpyrazonecontrolnegative
Canadian (sulfinpyrazone alone), 1985   sulfinpyrazoneplaceboLow risk of bias -
Wilcox, 1980   sulfinpyrazoneplacebonegative
Louvain sulphinpyrazone, 1983   sulfinpyrazoneplaceboLow risk of bias negative
ticagrelor
PLATO, 2009      NCTticagrelorclopidogrelLow risk of bias suggesting
DISPERSE-2 (90mg), 2007       ticagrelorclopidogrelLow risk of bias negative
ticlopidine
STAI, 1990   ticlopidinecontrolsuggesting
Knudsen-A, 1985   ticlopidinecontrolnegative
Florida UA   ticlopidineplacebonegative
trapidil
Modena   trapidilplacebosuggesting
triflusal
Plaza, 1993   triflusalplaceboLow risk of bias suggesting
vorapaxar
TRACER, 2011      NCTvorapaxarplacebo (on top standard therapy) Low risk of bias -

antithrombotics

not classified
Gurfinkel (LMWH+asp vs asp), 1995     LMWHplacebo (on top of aspirin)suggesting
CURRENT - OASIS 7 (ASA), 2010    NCTASA high doseASA low doseRisk of bias suggesting
Gurfinkel (LMWH+asp vs UFH+asp), 1995   LMWHUFH (on top of aspirin)suggesting
apixaban
APPRAISE-1 (10mg od), 2009      NCTapixabanplaceboLow risk of bias negative
APPRAISE-1 (2.5 mg bid), 2009      NCTapixabanplaceboLow risk of bias negative
APPRAISE 2, 2011      NCTapixabanplaceboLow risk of bias negative
argatroban
ARGAMI-2, 1998       Argatrobanheparin -
aspirin
ATACS-pilot, 1990   aspirincontrolnegative
VA-pilot   aspirinplacebonegative
VA-main, 1983   aspirinplaceboLow risk of bias suggesting
RISC, 1990   aspirinplaceboLow risk of bias suggesting
ALDUSA-pilot   aspirinplacebonegative
Théroux, 1988   aspirinplaceboLow risk of bias suggesting
Canadian (Aspirin vs PBO), 1985   aspirinplaceboLow risk of bias -
Canadian (Aspirin + sulfinpyrazone), 1985   aspirin + sulfinpyrazoneplaceboLow risk of bias negative
atopaxar
LANCELOT ACS     atopaxarplaceboExploratory -
J-LANCELOT, 2010   atopaxarplaceboExploratory -
bivalirudin
ACUITY (biva alone vs hep+aGP2b3a), 2006      NCTbivalirudinheparin + GP2b3a inhibitorsLow risk of bias suggesting
ACUITY (biva+aGP2b3a vs hep+aGP2b3a), 2006    NCTbivalirudin + GP2b3a inhibitorsheparin + GP2b3a inhibitorsLow risk of bias negative
PROTECT-TIMI 30, 2006      NCTbivalirudineptifibatide + heparinExploratory -
HERO, 1997     bivalirudinheparinLow risk of bias suggesting
BAT (Bittl), 1995     bivalirudinheparinLow risk of bias suggesting
ACUITY (sub groups PCI, bivalirudin alone) importé, 2007         bivalirudinheparin + GP2b3a inhibitorssuggesting
ACUITY (sub groups PCI, bivalirudin +aGP2b3a) importé, 2007     bivalirudin + GP2b3a inhibitorsheparin + GP2b3a inhibitorsnegative
clopidogrel
CURE (PCI sub study), 2001     clopidogrelplaceboLow risk of bias -
CURE, 2001     clopidogrel + aspirinaspirinLow risk of bias suggesting
CURRENT OASIS 7 (clopidogrel), 2010    NCTclopidogrel high-dose regimenclopidogrel standard-doseLow risk of bias negative
coumadin
ASPECT-2 (coumadin+asp vs asp), 2002     coumadincontrol (on top of aspirin)suggesting
ASPECT-2 (coumadin vs aspirin), 2002   coumadinaspirinsuggesting
dalteparin
FRISC (long term), 1996   dalteparinplacebo (on top of aspirin)Low risk of bias suggesting
FRIC prolonged treatment phase (LWMH vs PBO), 1997     dalteparinplacebo (on top of aspirin)Low risk of bias negative
FRISC (short term), 1996   dalteparinplacebo (on top of aspirin)Low risk of bias -
FRIC (acute phase LMWH vs UFH), 1997     dalteparinUFH (on top of aspirin)Exploratory negative
dipyridamol
Prandoni, 1991   aspirin + dipyridamolplaceboLow risk of bias negative
Efegatran
Klootwijk, 1999     EfegatranheparinExploratory -
enoxaparin
RESCUE    NCTenoxaparinunfractionated heparin -
EVET, 2005     enoxaparintinzaparinsuggesting
ESSENCE, 1997     enoxaparinUFH (on top of aspirin)Low risk of bias suggesting
TIMI 11 B (short term), 1998   enoxaparinUFH (on top of aspirin)Low risk of bias suggesting
SYNERGY, 2005          NCTenoxaparinUFH (on top of aspirin)negative
INTERACT, 2006       enoxaparinUFH (on top of aspirin)suggesting
TIMI 11 B (long term), 1998   enoxaparinUFH (on top of aspirin)Low risk of bias negative