acute coronary syndrome  

     

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Trial Studied trt Control trt patientstagsNCTROB Result

anti-anginal drugs

ranolazine
MERLIN TIMI 36, 2007ranolazine placeboNCT00099788Low risk of bias suggesting

anticoagulant

apixaban
APPRAISE-1 (10mg od), 2009apixabanplaceboNCT00313300Low risk of bias negative
APPRAISE-1 (2.5 mg bid), 2009apixabanplaceboNCT00313300 Low risk of bias negative
APPRAISE 2, 2011apixabanplaceboNCT00831441Low risk of bias negative
APPRAISE japan ongoing apixabanplaceboNCT00852397Low risk of bias ongoing
coumadin
ASPECT-2 (coumadin+asp vs asp), 2002coumadincontrol (on top of aspirin)suggesting
ASPECT-2 (coumadin vs aspirin), 2002coumadinaspirinsuggesting
dabigatran
REDEEM, 2009dabigatranplaceboNCT00621855Low risk of bias negative
otamixaban
SEPIA-ACS1 TIMI 42, 2009otamixabanunfractionated heparinNCT00317395Low risk of bias suggesting
rivaroxaban
ATLAS ACS 2 - TIMI 51 (2.5mg), 2011rivaroxaban 2.5mgplaceboNCT00809965Low risk of bias suggesting
ATLAS ACS-TIMI 46 (2.5mg), 2009rivaroxaban 2.5mgplaceboNCT00402597Low risk of bias negative
ATLAS ACS 2 - TIMI 51 (5mg), 2011rivaroxaban 5mgplaceboNCT00809965suggesting
ATLAS ACS-TIMI 46 (5mg), 2009rivaroxaban 5mgplaceboNCT00402597Low risk of bias negative
warfarin
ATACS (pilot study) (warfarin vs control), 1990warfarincontrol (on top of aspirin)negative
ATACS, 1994warfarincontrol (on top of aspirin)negative
CARS, 1997warfarincontrol (on top of aspirin)negative
OASIS Pilot (phase 1), 1998warfarincontrol (on top of aspirin)negative
OASIS Pilot (phase 2), 1998warfarincontrol (on top of aspirin)negative
OASIS-2 Warfarin Substudy, 2001warfarincontrol (on top of aspirin)negative
APRICOT-2, 2002warfarincontrol (on top of aspirin)negative
CHAMP, 2002warfarincontrol (on top of aspirin)negative
WARIS, 2002warfarincontrol (on top of aspirin)suggesting
LoWASA, 2004warfarincontrol (on top of aspirin)negative
Zibaeenezhad, 2004warfarincontrol (on top of aspirin)negative
Williams, 1997warfarinplacebo (on top of aspirin)Low risk of bias negative
Huyhn, 2001warfarinplacebo (on top of aspirin)Low risk of bias negative
ATACS (pilot study) warfarin vs aspirin, 1990warfarinaspirinnegative
ximelagatran
ESTEEM, 2003ximelagatranplaceboExploratory -

antiplatelets drug

not classified
Jones, 1987dazoxibencontrolnegative
GRAND, 1987GR3219Bcontrolnegative
Gent-AMI, 1968misc.controlnegative
Johannessen, 1989misc.controlnegative
French, 1993flurbiprofenplaceboLow risk of bias suggesting
CURRENT - OASIS 7 (ASA), 2010ASA high doseASA low doseNCT00335452Risk of bias suggesting
aspirin
ATACS-pilot, 1990aspirincontrolnegative
Huddinge, 1988aspirincontrolnegative
Frankfurt, 1976aspirincontrolnegative
VA-pilotaspirinplacebonegative
VA-main, 1983aspirinplaceboLow risk of bias suggesting
RISC, 1990aspirinplaceboLow risk of bias suggesting
ALDUSA-pilotaspirinplacebonegative
Théroux, 1988aspirinplaceboLow risk of bias suggesting
Canadian (Aspirin vs PBO), 1985aspirinplaceboLow risk of bias -
Dutch-aspirin, 1990aspirinplaceboLow risk of bias negative
ISIS-pilot, 1987aspirinplaceboLow risk of bias negative
ISIS-2, 1988aspirinplaceboLow risk of bias suggesting
APRICOT, 1993aspirinplaceboLow risk of bias suggesting
Canadian (Aspirin + sulfinpyrazone), 1985aspirin + sulfinpyrazoneplaceboLow risk of bias negative
atopaxar
J-LANCELOT, 2010atopaxarplaceboExploratory -
LANCELOT ACSatopaxarplaceboExploratory -
clopidogrel
COMMIT, 2005clopidogrelplaceboNCT00222573Low risk of bias suggesting
CLARITY-TIMI 28, 2005clopidogrelplaceboLow risk of bias -
CURE, 2001clopidogrel + aspirinaspirinLow risk of bias suggesting
CURRENT OASIS 7 (clopidogrel), 2010clopidogrel high-dose regimenclopidogrel standard-doseNCT00335452Low risk of bias negative
dipyridamol
Prandoni, 1991aspirin + dipyridamolplaceboLow risk of bias negative
elinogrel
INNOVATE ongoing elinogrelerrorNCT00751231 ongoing
ERASE-MI, 2009elinogrelplaceboLow risk of bias negative
prasugrel
TRILOGY ACS (overall population), 2012prasugrelclopidogrelNCT00699998Low risk of bias negative
TRITON-TIMI 38, 2007prasugrelclopidogrelNCT00097591Low risk of bias suggesting
ACAPULCO ongoing prasugrelclopidogrel ongoing
sulfinpyrazone
Dutch sulphinpyrazone, 1986sulfinpyrazonecontrolnegative
Canadian (sulfinpyrazone alone), 1985sulfinpyrazoneplaceboLow risk of bias -
Wilcox, 1980sulfinpyrazoneplacebonegative
Louvain sulphinpyrazone, 1983sulfinpyrazoneplaceboLow risk of bias negative
ticagrelor
PLATO, 2009ticagrelorclopidogrelNCT00391872Low risk of bias suggesting
DISPERSE-2 (90mg), 2007ticagrelorclopidogrelLow risk of bias negative
ticlopidine
STAI, 1990ticlopidinecontrolsuggesting
Knudsen-A, 1985ticlopidinecontrolnegative
Florida UAticlopidineplacebonegative
trapidil
Modenatrapidilplacebosuggesting
triflusal
Plaza, 1993triflusalplaceboLow risk of bias suggesting
vorapaxar
TRACER, 2011vorapaxarplacebo (on top standard therapy) NCT00527943Low risk of bias -

antithrombotics

not classified
Gurfinkel (LMWH+asp vs asp), 1995LMWHplacebo (on top of aspirin)suggesting
CURRENT - OASIS 7 (ASA), 2010ASA high doseASA low doseNCT00335452Risk of bias suggesting
Gurfinkel (LMWH+asp vs UFH+asp), 1995LMWHUFH (on top of aspirin)suggesting
apixaban
APPRAISE-1 (10mg od), 2009apixabanplaceboNCT00313300Low risk of bias negative
APPRAISE-1 (2.5 mg bid), 2009apixabanplaceboNCT00313300 Low risk of bias negative
APPRAISE 2, 2011apixabanplaceboNCT00831441Low risk of bias negative
APPRAISE japan ongoing apixabanplaceboNCT00852397Low risk of bias ongoing
argatroban
ARGAMI-2, 1998Argatrobanheparin -
aspirin
ATACS-pilot, 1990aspirincontrolnegative
VA-pilotaspirinplacebonegative
VA-main, 1983aspirinplaceboLow risk of bias suggesting
RISC, 1990aspirinplaceboLow risk of bias suggesting
ALDUSA-pilotaspirinplacebonegative
Théroux, 1988aspirinplaceboLow risk of bias suggesting
Canadian (Aspirin vs PBO), 1985aspirinplaceboLow risk of bias -
Canadian (Aspirin + sulfinpyrazone), 1985aspirin + sulfinpyrazoneplaceboLow risk of bias negative
atopaxar
LANCELOT ACSatopaxarplaceboExploratory -
J-LANCELOT, 2010atopaxarplaceboExploratory -
bivalirudin
ACUITY (biva alone vs hep+aGP2b3a), 2006bivalirudinheparin + GP2b3a inhibitorsNCT00093158Low risk of bias suggesting
ACUITY (biva+aGP2b3a vs hep+aGP2b3a), 2006bivalirudin + GP2b3a inhibitorsheparin + GP2b3a inhibitorsNCT00093158Low risk of bias negative
PROTECT-TIMI 30, 2006bivalirudineptifibatide + heparinNCT00250471Exploratory -
HERO, 1997bivalirudinheparinLow risk of bias suggesting
BAT (Bittl), 1995bivalirudinheparinLow risk of bias suggesting
ACUITY (sub groups PCI, bivalirudin alone) importé, 2007bivalirudinheparin + GP2b3a inhibitorssuggesting
ACUITY (sub groups PCI, bivalirudin +aGP2b3a) importé, 2007bivalirudin + GP2b3a inhibitorsheparin + GP2b3a inhibitorsnegative
clopidogrel
CURE (PCI sub study), 2001clopidogrelplaceboLow risk of bias -
CURE, 2001clopidogrel + aspirinaspirinLow risk of bias suggesting
CURRENT OASIS 7 (clopidogrel), 2010clopidogrel high-dose regimenclopidogrel standard-doseNCT00335452Low risk of bias negative
coumadin
ASPECT-2 (coumadin+asp vs asp), 2002coumadincontrol (on top of aspirin)suggesting
ASPECT-2 (coumadin vs aspirin), 2002coumadinaspirinsuggesting
dalteparin
FRISC (long term), 1996dalteparinplacebo (on top of aspirin)Low risk of bias suggesting
FRIC prolonged treatment phase (LWMH vs PBO), 1997dalteparinplacebo (on top of aspirin)Low risk of bias negative
FRISC (short term), 1996dalteparinplacebo (on top of aspirin)Low risk of bias -
FRIC (acute phase LMWH vs UFH), 1997dalteparinUFH (on top of aspirin)Exploratory negative
dipyridamol
Prandoni, 1991aspirin + dipyridamolplaceboLow risk of bias negative
Efegatran
Klootwijk, 1999EfegatranheparinExploratory -
enoxaparin
RESCUEenoxaparinunfractionated heparinNCT00077818 -
EVET, 2005enoxaparintinzaparinsuggesting
ESSENCE, 1997enoxaparinUFH (on top of aspirin)Low risk of bias suggesting
TIMI 11 B (short term), 1998enoxaparinUFH (on top of aspirin)Low risk of bias suggesting
SYNERGY, 2005enoxaparinUFH (on top of aspirin)NCT00043784negative
INTERACT, 2006enoxaparinUFH (on top of aspirin)suggesting
TIMI 11 B (long term), 1998enoxaparinUFH (on top of aspirin)Low risk of bias negative
fondaparinux
PENTUA, 2004fondaparinuxenoxaparin -
OASIS 5, 2006fondaparinuxenoxaparinNCT00139815Low risk of bias -
hirudin
HIT-4, 1999HirudinheparinLow risk of bias -
TIMI 9B, 1996HirudinheparinRisk of bias -
GUSTO IIB, 1996HirudinheparinRisk of bias -
OASIS pilot, 1997HirudinheparinExploratory -
HELVETICA (Serruys), 1995HirudinheparinLow risk of bias -
OASIS 2, 1999HirudinheparinLow risk of bias -
OASIS, 1997HirudinheparinRisk of bias -
inogatran
TRIM, 1997InogatranheparinLow risk of bias -
nadroparin
FRAXIS (6days), 1998nadroparinUFH (on top of aspirin)Low risk of bias negative
FRAXIS (14 days), 1998nadroparinUFH (on top of aspirin)Low risk of bias negative
otamixaban
SEPIA-ACS1 TIMI 42, 2009otamixabanunfractionated heparinNCT00317395Low risk of bias suggesting
prasugrel
TRILOGY ACS (overall population), 2012prasugrelclopidogrelNCT00699998Low risk of bias negative
TRITON-TIMI 38, 2007prasugrelclopidogrelNCT00097591Low risk of bias suggesting
ACAPULCO ongoing prasugrelclopidogrel ongoing
rivaroxaban
ATLAS ACS 2 - TIMI 51 (2.5mg), 2011rivaroxaban 2.5mgplaceboNCT00809965Low risk of bias suggesting
ATLAS ACS 2 - TIMI 51 (5mg), 2011rivaroxaban 5mgplaceboNCT00809965suggesting
sulfinpyrazone
Canadian (sulfinpyrazone alone), 1985sulfinpyrazoneplaceboLow risk of bias -
ticagrelor
PLATO, 2009ticagrelorclopidogrelNCT00391872Low risk of bias suggesting
DISPERSE-2 (90mg), 2007ticagrelorclopidogrelLow risk of bias negative
ticlopidine
STAI, 1990ticlopidinecontrolsuggesting
Florida UAticlopidineplacebonegative
trapidil
Modenatrapidilplacebosuggesting
triflusal
TIM, 2000triflusalaspirinLow risk of bias -
Plaza, 1993triflusalplaceboLow risk of bias suggesting
UFH
Holdright, 1994UFHcontrol (on top of aspirin)</