thrombosis prevention

     

Select            
Trial Studied trt Control trt patientstagsROB Trial resultDeep vein thrombosis non-fatal pulmonary embolism

anticoagulant

not classified
Borsgtrom, 1965   no treatment -
acenocoumarol
Hamulyak, 1994   AcenocoumarolNadroparinnegative18%
Samama, 2001     AcenocoumarolReviparinnegative 35%
van Geloven, 1977   Acenocoumarolunfractionated heparinLow risk of bias -
apixaban
ADVANCE 3, 2010    NCTapixabanenoxaparinhip surgeryLow risk of bias suggesting-68%-60%
ADVANCE 2, 2010      NCTapixabanenoxaparin (europe regimen)knee surgeryLow risk of bias suggesting-40%
APROPOS 2.5mg, 2007    NCTapixabanenoxaparin (US regimen)knee surgeryLow risk of bias negative
ADVANCE-1, 2008      NCTapixabanenoxaparin (US regimen)knee surgeryLow risk of bias suggesting-5%
dabigatran
RE-NOVATE (150mg), 2007      NCTdabigatran 150mgenoxaparinhip surgeryLow risk of bias negative -67%
RE-NOVATE (220mg), 2007      NCTdabigatran 220mgenoxaparinhip surgeryLow risk of bias negative70%
RE-NOVATE 2    NCTdabigatran 220mgenoxaparinhip surgeryLow risk of bias negative
RE-MODEL (150mg), 2007     dabigatran 150mgenoxaparin (europe regimen)knee surgeryLow risk of bias negative+Infini%
RE-MODEL (220mg), 2007   dabigatran 220mgenoxaparin (europe regimen)knee surgeryLow risk of bias negative
RE-MOBILIZE (150mg), 2008     dabigatran 150mgenoxaparin (US regimen)knee surgeryLow risk of bias negative -100%
RE-MOBILIZE (220mg), 2008     dabigatran 220mgenoxaparin (US regimen)knee surgeryLow risk of bias negative
edoxaban
STARS J-V    NCTedoxabanenoxaparin (short duration)hip surgeryLow risk of bias suggesting
phenindione
Eskeland, 1966   Phenindioneno treatment -
Hamilton, 1970     Phenindioneno treatment -
rivaroxaban
RECORD 1, 2008      NCTrivaroxabanenoxaparinhip surgeryLow risk of bias suggesting-77%291%
RECORD 3, 2008    NCTrivaroxabanenoxaparin (europe regimen)knee surgeryLow risk of bias suggesting-47%-100%
ODIXa-HIP 10mg, 2006   rivaroxabanenoxaparin (short duration)hip surgeryLow risk of bias suggesting-58%
RECORD 2, 2008    NCTrivaroxaban (long duration)enoxaparin (short duration)hip surgeryLow risk of bias suggesting-80%-75%
ODIXa-KNEE, 2005   rivaroxabanenoxaparin (US regimen)knee surgeryLow risk of bias negative
RECORD 4, 2009    NCTrivaroxabanenoxaparin (US regimen)knee surgeryLow risk of bias suggesting-51%
warfarin
Pinto, 1970   Warfarinno treatment -
Hume, 1973   Warfarinno treatment -
Morris, 1976     Warfarinno treatment -
Powers, 1989   Warfarinno treatment -
Myrhe, 1969   WarfarinplaceboLow risk of bias -
RD Heparin, 1994   WarfarinArdeparinsuggesting44%
Heit, 1997   WarfarinArdeparinLow risk of bias suggesting31%
Powers, 1989   WarfarinAspirin -
Lotke, 1997     WarfarinAspirin -
Francis, 1997     WarfarinDalteparinsuggesting77%
Hull, 2000     WarfarinDalteparinLow risk of bias suggesting 102%
Gerhart, 1991   WarfarinDanaparoid -
van Comp, 1998   WarfarinDanaparoid -
Myrhe, 1969   WarfarinDextranLow risk of bias -
Harris, 1972   WarfarinDextran -
Barber, 1977   WarfarinDextran -
Francis, 1983   WarfarinDextran -
Leclerc, 1996     WarfarinEnoxaparinLow risk of bias suggesting40%
Colwell, 1999     WarfarinEnoxaparinsuggesting407%
Fitzgerald, 2001     WarfarinEnoxaparinsuggesting 51%
Paiement, 1987   WarfarinIntermittent pneumatic compression -
Bailey, 1991   WarfarinIntermittent pneumatic compression -
Kaempffe, 1991     WarfarinIntermittent pneumatic compression -
Francis, 1992   WarfarinIntermittent pneumatic compression -
Hull, 1993     WarfarinLogiparinLow risk of bias suggesting19%
Hume, 1973   WarfarinSudoxicam -
Hume, 1973   Warfarinunfractionated heparin -
Barber, 1977   Warfarinunfractionated heparin -

antiplatelets drug

not classified
Veth, 1985   spcontrolRisk of bias -
Mocris-C , 1977   Flurbiprofenno treatmentExploratory negative8%
Massachusetts-I , 1981   Hydroxychloroquineno treatmentExploratory negative-100%
Denver-Il , 1980   dipyridamol + ASAplaceboLow risk of bias negative-86%-100%
Massachusetts-II, 1976   HydroxychloroquineplaceboExploratory suggesting-88%-100%
Cooke, 1977   HydroxychloroquineplaceboExploratory negative-17%150%
Hume-A, 1977   HydroxychloroquineplaceboExploratory negative
Stockholm-II, 1981   HydroxychloroquineplaceboExploratory negative3%
Danish-A , 1976   HydroxychloroquineplaceboExploratory negative-24%-65%
Danish-B , 1976   HydroxychloroquineplaceboExploratory suggesting-60%+Infini%
Carter IA, 1971   hydroxychloroquineplaceboLow risk of bias -
Carter IB, 1971   hydroxychloroquineplaceboLow risk of bias -
Carter II, 1974   hydroxychloroquineplaceboLow risk of bias -
New York, 1977   hydroxychloroquineplaceboLow risk of bias -
Vermont, 1975   hydroxychloroquineplaceboLow risk of bias -
Wood , 1973   RA233placeboExploratory negative43%
Athens, 1981   spplaceboLow risk of bias -
aspirin
Clagett, 1975   aspirincontrolRisk of bias -
Zekert VI, 1982   aspirincontrolRisk of bias -
Pasteyer, 1977   Aspirinno treatmentExploratory negative-100%
Rocha, 1986   Aspirinno treatmentExploratory suggesting-86%-100%
Stockholm-I, 1975   AspirinplaceboExploratory negative68%
Harris-I, 1977   AspirinplaceboLow risk of bias suggesting-51%-100%
McKenna-I, 1980   AspirinplaceboExploratory suggesting-56%-63%
Sautter, 1983   AspirinplaceboExploratory suggesting-28%-55%
McBride, 1983   AspirinplaceboExploratory negative5%
Zekert-I , 1974   AspirinplaceboExploratory suggesting-58%-66%
Powers , 1976   AspirinplaceboExploratory suggesting-11%-100%
Erfurt-B , 1979   AspirinplaceboExploratory negative-20%
PEP hip-fracture, 2000     aspirinplaceboLow risk of bias suggesting -29%-26%
MRC, 1972   aspirinplaceboLow risk of bias negative25%
Loew DVT, 1974   aspirinplaceboLow risk of bias -
Erfurt-A, 1979   aspirinplaceboLow risk of bias -
Zekert V, 1980   aspirinplaceboLow risk of bias -
Vinazzer I, 1980   aspirinplaceboLow risk of bias -
Vinazzer II, 1977   aspirinplaceboLow risk of bias -
PEP elective arthroplasty, 2000   aspirinplaceboLow risk of bias -
dipyridamol
Chicago, 1982   aspirin + dipyridamolcontrolExploratory negative-38%
Parodi I, 1973   dipyridamol + aspirincontrolExploratory suggesting-63%
Parodi II, 1973   dipyridamol + aspirincontrolRisk of bias -
Zekert-III, 1977   dipyridamol + aspirincontrolRisk of bias -
Australian I, 1975   dipyridamol + aspirincontrolRisk of bias -
Australian II, 1976   dipyridamol + aspirincontrolRisk of bias -
Toulouse I, 1979   dipyridamol + aspirincontrolRisk of bias -
Harjola DVT, 1982   dipyridamol + aspirincontrolRisk of bias -
Weiss, 1977   dipyridamol + aspirincontrolExploratory -
Lyon-I, 1975   aspirin + dipyridamolno treatmentExploratory suggesting-88%
Morris-B , 1977   aspirin + dipyridamolno treatmentExploratory negative-5%
Morris-A , 1977   dipyridamolno treatmentExploratory negative-6%
Hamburg, 1976   aspirin + dipyridamolplaceboExploratory negative-61%
Encke-II , 1976   aspirin + dipyridamolplaceboExploratory negative29%-26%
Frankfurt, 1981   aspirin + dipyridamolplaceboLow risk of bias negative100%
Encke IA, 1976   dipyridamol + aspirinplaceboLow risk of bias -
Encke IB, 1976   dipyridamol + aspirinplaceboLow risk of bias -
suloctidil
Turpie, 1985   SuloctidilplaceboLow risk of bias -
ticlopidine
McKenna-II, 1983   TiclopidineplaceboExploratory negative-13%-33%
Lyon-II   TiclopidineplaceboExploratory negative-38%+Infini%
Gardecki   TiclopidineplaceboExploratory negative-12%-68%
Lasierra, 1982   ticlopidineplaceboLow risk of bias -
Walker, 1974   ticlopidineplaceboLow risk of bias -
McKenna-II , 1983   ticlopidineplaceboLow risk of bias negative100%-100%
UFH
Morris, 1974     UFHno treatmentsuggesting-81%
Welin-Berger, 1982   UFHno treatmentnegative33%
Bergqvist , 1979   UFHno treatmentsuggesting-29%38%
VTCSG, 1975   UFHno treatmentnegative
Mannucci , 1976   UFHno treatmentsuggesting-69%
Dechavanne, 1974   UFHno treatmentsuggesting-85%+Infini%
Dechavanne, 1975   UFHno treatmentsuggesting-87%
Bergqvist, 1979   UFHno treatmentsuggesting-35%
Galasko , 1976   UFHno treatmentsuggesting-64%
Gallus , 1973   UFHno treatmentsuggesting-73%
Morris , 1977   UFHno treatmentnegative-25%
Williams , 1978   UFHplacebonegative 280%
Abraham-Inpijn , 1975   UFHplacebonegative-78%-100%
Hampson, 1974     UFHplacebonegative-35%
Moskovitz, 1978   UFHplacebosuggesting-62%174%
Lahnborg, 1980   UFHplacebosuggesting-47%+Infini%
Xabregas , 1977   UFHplacebonegative-100%
Moskovitz, 1978   UFHplacebonegative-1%+Infini%
Svend-Hansen, 1981   UFHplacebosuggesting-46%

antithrombotics

not classified
Veth, 1985   spcontrolRisk of bias -
Cohen (L8405), 2007     compression stocking groupcontrol (on top fondaparinux)hip surgeryRisk of bias negative
SAVE-HIP1, 2012      NCTsemuloparinenoxaparinhip surgerysuggesting-43%
SAVE-KNEE, 2012      NCTsemuloparinenoxaparinknee surgerynegative-13%
SAVE-HIP 2, 2012      NCTsemuloparinenoxaparinhip surgerynegative-23%
EXCLAIM, 2010      NCTExtended-duration prophylaxiserrormedical patientsLow risk of bias suggesting
Borsgtrom, 1965   no treatment -
Mocris-C , 1977   Flurbiprofenno treatmentExploratory negative8%
Massachusetts-I , 1981   Hydroxychloroquineno treatmentExploratory negative-100%
Denver-Il , 1980   dipyridamol + ASAplaceboLow risk of bias negative-86%-100%
Valle , 1988   fluxumplacebonegative
Massachusetts-II, 1976   HydroxychloroquineplaceboExploratory suggesting-88%-100%
Cooke, 1977   HydroxychloroquineplaceboExploratory negative-17%150%
Hume-A, 1977   HydroxychloroquineplaceboExploratory negative
Stockholm-II, 1981   HydroxychloroquineplaceboExploratory negative3%
Danish-A , 1976   HydroxychloroquineplaceboExploratory negative-24%-65%
Danish-B , 1976   HydroxychloroquineplaceboExploratory suggesting-60%+Infini%
Carter IA, 1971   hydroxychloroquineplaceboLow risk of bias -
Carter IB, 1971   hydroxychloroquineplaceboLow risk of bias -
Carter II, 1974   hydroxychloroquineplaceboLow risk of bias -
New York, 1977   hydroxychloroquineplaceboLow risk of bias -
Vermont, 1975   hydroxychloroquineplaceboLow risk of bias -
Dahan, 1986   Pharmukaplacebomedical patientsLow risk of bias suggesting-67%
Wood , 1973   RA233placeboExploratory negative43%
Athens, 1981