thrombosis prevention

     

Select            
Trial Studied trt Control trt patientstagsROB Trial result

anticoagulant

not classified
Borsgtrom, 1965   no treatment -
acenocoumarol
Hamulyak, 1994   AcenocoumarolNadroparinnegative
Samama, 2001     AcenocoumarolReviparinnegative
van Geloven, 1977   Acenocoumarolunfractionated heparinLow risk of bias -
apixaban
ADVANCE 3, 2010    NCTapixabanenoxaparinhip surgeryLow risk of bias suggesting
ADVANCE 2, 2010      NCTapixabanenoxaparin (europe regimen)knee surgeryLow risk of bias suggesting
APROPOS 2.5mg, 2007    NCTapixabanenoxaparin (US regimen)knee surgeryLow risk of bias negative
ADVANCE-1, 2008      NCTapixabanenoxaparin (US regimen)knee surgeryLow risk of bias suggesting
dabigatran
RE-NOVATE (150mg), 2007      NCTdabigatran 150mgenoxaparinhip surgeryLow risk of bias negative
RE-NOVATE (220mg), 2007      NCTdabigatran 220mgenoxaparinhip surgeryLow risk of bias negative
RE-NOVATE 2    NCTdabigatran 220mgenoxaparinhip surgeryLow risk of bias negative
RE-MODEL (150mg), 2007     dabigatran 150mgenoxaparin (europe regimen)knee surgeryLow risk of bias negative
RE-MODEL (220mg), 2007   dabigatran 220mgenoxaparin (europe regimen)knee surgeryLow risk of bias negative
RE-MOBILIZE (150mg), 2008     dabigatran 150mgenoxaparin (US regimen)knee surgeryLow risk of bias negative
RE-MOBILIZE (220mg), 2008     dabigatran 220mgenoxaparin (US regimen)knee surgeryLow risk of bias negative
edoxaban
STARS J-V    NCTedoxabanenoxaparin (short duration)hip surgeryLow risk of bias suggesting
phenindione
Eskeland, 1966   Phenindioneno treatment -
Hamilton, 1970     Phenindioneno treatment -
rivaroxaban
RECORD 1, 2008      NCTrivaroxabanenoxaparinhip surgeryLow risk of bias suggesting
RECORD 3, 2008    NCTrivaroxabanenoxaparin (europe regimen)knee surgeryLow risk of bias suggesting
ODIXa-HIP 10mg, 2006   rivaroxabanenoxaparin (short duration)hip surgeryLow risk of bias suggesting
RECORD 2, 2008    NCTrivaroxaban (long duration)enoxaparin (short duration)hip surgeryLow risk of bias suggesting
ODIXa-KNEE, 2005   rivaroxabanenoxaparin (US regimen)knee surgeryLow risk of bias negative
RECORD 4, 2009    NCTrivaroxabanenoxaparin (US regimen)knee surgeryLow risk of bias suggesting
warfarin
Pinto, 1970   Warfarinno treatment -
Hume, 1973   Warfarinno treatment -
Morris, 1976     Warfarinno treatment -
Powers, 1989   Warfarinno treatment -
Myrhe, 1969   WarfarinplaceboLow risk of bias -
RD Heparin, 1994   WarfarinArdeparinsuggesting
Heit, 1997   WarfarinArdeparinLow risk of bias suggesting
Powers, 1989   WarfarinAspirin -
Lotke, 1997     WarfarinAspirin -
Francis, 1997     WarfarinDalteparinsuggesting
Hull, 2000     WarfarinDalteparinLow risk of bias suggesting
Gerhart, 1991   WarfarinDanaparoid -
van Comp, 1998   WarfarinDanaparoid -
Myrhe, 1969   WarfarinDextranLow risk of bias -
Harris, 1972   WarfarinDextran -
Barber, 1977   WarfarinDextran -
Francis, 1983   WarfarinDextran -
Leclerc, 1996     WarfarinEnoxaparinLow risk of bias suggesting
Colwell, 1999     WarfarinEnoxaparinsuggesting
Fitzgerald, 2001     WarfarinEnoxaparinsuggesting
Paiement, 1987   WarfarinIntermittent pneumatic compression -
Bailey, 1991   WarfarinIntermittent pneumatic compression -
Kaempffe, 1991     WarfarinIntermittent pneumatic compression -
Francis, 1992   WarfarinIntermittent pneumatic compression -
Hull, 1993     WarfarinLogiparinLow risk of bias suggesting
Hume, 1973   WarfarinSudoxicam -
Hume, 1973   Warfarinunfractionated heparin -
Barber, 1977   Warfarinunfractionated heparin -

antiplatelets drug

not classified
Veth, 1985   spcontrolRisk of bias -
Mocris-C , 1977   Flurbiprofenno treatmentExploratory negative
Massachusetts-I , 1981   Hydroxychloroquineno treatmentExploratory negative
Denver-Il , 1980   dipyridamol + ASAplaceboLow risk of bias negative
Massachusetts-II, 1976   HydroxychloroquineplaceboExploratory suggesting
Cooke, 1977   HydroxychloroquineplaceboExploratory negative
Hume-A, 1977   HydroxychloroquineplaceboExploratory negative
Stockholm-II, 1981   HydroxychloroquineplaceboExploratory negative
Danish-A , 1976   HydroxychloroquineplaceboExploratory negative
Danish-B , 1976   HydroxychloroquineplaceboExploratory suggesting
Carter IA, 1971   hydroxychloroquineplaceboLow risk of bias -
Carter IB, 1971   hydroxychloroquineplaceboLow risk of bias -
Carter II, 1974   hydroxychloroquineplaceboLow risk of bias -
New York, 1977   hydroxychloroquineplaceboLow risk of bias -
Vermont, 1975   hydroxychloroquineplaceboLow risk of bias -
Wood , 1973   RA233placeboExploratory negative
Athens, 1981   spplaceboLow risk of bias -
aspirin
Clagett, 1975   aspirincontrolRisk of bias -
Zekert VI, 1982   aspirincontrolRisk of bias -
Pasteyer, 1977   Aspirinno treatmentExploratory negative
Rocha, 1986   Aspirinno treatmentExploratory suggesting
Stockholm-I, 1975   AspirinplaceboExploratory negative
Harris-I, 1977   AspirinplaceboLow risk of bias suggesting
McKenna-I, 1980   AspirinplaceboExploratory suggesting
Sautter, 1983   AspirinplaceboExploratory suggesting
McBride, 1983   AspirinplaceboExploratory negative
Zekert-I , 1974   AspirinplaceboExploratory suggesting
Powers , 1976   AspirinplaceboExploratory suggesting
Erfurt-B , 1979   AspirinplaceboExploratory negative
PEP hip-fracture, 2000     aspirinplaceboLow risk of bias suggesting
MRC, 1972   aspirinplaceboLow risk of bias negative
Loew DVT, 1974   aspirinplaceboLow risk of bias -
Erfurt-A, 1979   aspirinplaceboLow risk of bias -
Zekert V, 1980   aspirinplaceboLow risk of bias -
Vinazzer I, 1980   aspirinplaceboLow risk of bias -
Vinazzer II, 1977   aspirinplaceboLow risk of bias -
PEP elective arthroplasty, 2000   aspirinplaceboLow risk of bias -
dipyridamol
Chicago, 1982   aspirin + dipyridamolcontrolExploratory negative
Parodi I, 1973   dipyridamol + aspirincontrolExploratory suggesting
Parodi II, 1973   dipyridamol + aspirincontrolRisk of bias -
Zekert-III, 1977   dipyridamol + aspirincontrolRisk of bias -
Australian I, 1975   dipyridamol + aspirincontrolRisk of bias -
Australian II, 1976   dipyridamol + aspirincontrolRisk of bias -
Toulouse I, 1979   dipyridamol + aspirincontrolRisk of bias -
Harjola DVT, 1982   dipyridamol + aspirincontrolRisk of bias -
Weiss, 1977   dipyridamol + aspirincontrolExploratory -
Lyon-I, 1975   aspirin + dipyridamolno treatmentExploratory suggesting
Morris-B , 1977   aspirin + dipyridamolno treatmentExploratory negative
Morris-A , 1977   dipyridamolno treatmentExploratory negative
Hamburg, 1976   aspirin + dipyridamolplaceboExploratory negative
Encke-II , 1976   aspirin + dipyridamolplaceboExploratory negative
Frankfurt, 1981   aspirin + dipyridamolplaceboLow risk of bias negative
Encke IA, 1976   dipyridamol + aspirinplaceboLow risk of bias -
Encke IB, 1976   dipyridamol + aspirinplaceboLow risk of bias -
suloctidil
Turpie, 1985   SuloctidilplaceboLow risk of bias -
ticlopidine
McKenna-II, 1983   TiclopidineplaceboExploratory negative
Lyon-II   TiclopidineplaceboExploratory negative
Gardecki   TiclopidineplaceboExploratory negative
Lasierra, 1982   ticlopidineplaceboLow risk of bias -
Walker, 1974   ticlopidineplaceboLow risk of bias -
McKenna-II , 1983   ticlopidineplaceboLow risk of bias negative
UFH
Morris, 1974     UFHno treatmentsuggesting
Welin-Berger, 1982   UFHno treatmentnegative
Bergqvist , 1979   UFHno treatmentsuggesting
VTCSG, 1975   UFHno treatmentnegative
Mannucci , 1976   UFHno treatmentsuggesting
Dechavanne, 1974   UFHno treatmentsuggesting
Dechavanne, 1975   UFHno treatmentsuggesting
Bergqvist, 1979   UFHno treatmentsuggesting
Galasko , 1976   UFHno treatmentsuggesting
Gallus , 1973   UFHno treatmentsuggesting
Morris , 1977   UFHno treatmentnegative
Williams , 1978   UFHplacebonegative
Abraham-Inpijn , 1975   UFHplacebonegative
Hampson, 1974     UFHplacebonegative
Moskovitz, 1978   UFHplacebosuggesting
Lahnborg, 1980   UFHplacebosuggesting
Xabregas , 1977   UFHplacebonegative
Moskovitz, 1978   UFHplacebonegative
Svend-Hansen, 1981   UFHplacebosuggesting

antithrombotics

not classified
Veth, 1985   spcontrolRisk of bias -
Cohen (L8405), 2007     compression stocking groupcontrol (on top fondaparinux)hip surgeryRisk of bias negative
SAVE-HIP1, 2012      NCTsemuloparinenoxaparinhip surgerysuggesting
SAVE-KNEE, 2012      NCTsemuloparinenoxaparinknee surgerynegative
SAVE-HIP 2, 2012      NCTsemuloparinenoxaparinhip surgerynegative
EXCLAIM, 2010      NCTExtended-duration prophylaxiserrormedical patientsLow risk of bias suggesting
Borsgtrom, 1965   no treatment -
Mocris-C , 1977   Flurbiprofenno treatmentExploratory negative
Massachusetts-I , 1981   Hydroxychloroquineno treatmentExploratory negative
Denver-Il , 1980   dipyridamol + ASAplaceboLow risk of bias negative
Valle , 1988   fluxumplacebonegative
Massachusetts-II, 1976   HydroxychloroquineplaceboExploratory suggesting
Cooke, 1977   HydroxychloroquineplaceboExploratory negative
Hume-A, 1977   HydroxychloroquineplaceboExploratory negative
Stockholm-II, 1981   HydroxychloroquineplaceboExploratory negative
Danish-A , 1976   HydroxychloroquineplaceboExploratory negative
Danish-B , 1976   HydroxychloroquineplaceboExploratory suggesting
Carter IA, 1971   hydroxychloroquineplaceboLow risk of bias -
Carter IB, 1971   hydroxychloroquineplaceboLow risk of bias -
Carter II, 1974   hydroxychloroquineplaceboLow risk of bias -
New York, 1977   hydroxychloroquineplaceboLow risk of bias -
Vermont, 1975   hydroxychloroquineplaceboLow risk of bias -
Dahan, 1986   Pharmukaplacebomedical patientsLow risk of bias suggesting
Wood , 1973   RA233placeboExploratory negative
Athens, 1981   spplaceboLow risk of bias -
Marlovits, 2007     extended-duration thromboprophylaxisstandard-duration thromboprophylaxisRisk of bias suggesting
DRIVE, 2008    NCTSR123781Aenoxaparinhip surgeryLow risk of bias -
PENTHIFRA–PLUS (Eriksson), 2003     extended prophylaxisstandard prophylaxiship surgeryLow risk of bias -
Lausen, 1998   extended prophylaxisstandard prophylaxisnegative
ENOXACAN II (Bergqvist), 2002     extended prophylaxisstandard prophylaxisLow risk of bias suggesting
FAME (Rasmussen), 2006     extended prophylaxisstandard prophylaxissuggesting
Limmer, 1994   antixarinunfractionated heparingeneral surgery -
Chiapuzzo , 1988   fluxumUnfractionated heparinhip surgerynegative
Pini , 1989   fluxumUnfractionated heparinhip surgerynegative
Catania, 1988   parnaparinunfractionated heparinabdominal surgerynegative
Salcuni, 1988   parnaparinunfractionated heparinabdominal surgerynegative
Verardi, 1989   parnaparinunfractionated heparinabdominal surgerynegative
Garcea, 1992   parnaparinunfractionated heparinabdominal surgery -
ToÈrngren, 1984   SSHAunfractionated heparingeneral surgerynegative
acenocoumarol
Hamulyak, 1994   AcenocoumarolNadroparinnegative
Samama, 2001     AcenocoumarolReviparinnegative
van Geloven, 1977   Acenocoumarolunfractionated heparinLow risk of bias -
apixaban
ADOPT, 2011      NCTapixabanenoxaparinmedical patientsLow risk of bias suggesting
ADVANCE 3, 2010    NCTapixabanenoxaparinhip surgeryLow risk of bias suggesting
ADVANCE 2, 2010      NCTapixabanenoxaparin (europe regimen)knee surgeryLow risk of bias suggesting