DVT prophylaxis

     

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Trial Studied trt Control trt patientstagsNCTROB Result

anticoagulant

not classified
Borsgtrom, 1965no treatment -
acenocoumarol
Hamulyak, 1994AcenocoumarolNadroparinnegative
Samama, 2001AcenocoumarolReviparinnegative
van Geloven, 1977Acenocoumarolunfractionated heparin -
apixaban
ADVANCE 3, 2010apixabanenoxaparinNCT00423319Low risk of bias suggesting
ADVANCE 2, 2010apixabanenoxaparin (europe regimen)NCT00452530Low risk of bias suggesting
APROPOS 2.5mg, 2007apixabanenoxaparin (US regimen)NCT00097357Exploratory negative
ADVANCE-1, 2008apixabanenoxaparin (US regimen)NCT00371683Low risk of bias suggesting
dabigatran
RE-NOVATE (150mg), 2007dabigatran 150mgenoxaparinNCT00168818Low risk of bias negative
RE-NOVATE (220mg), 2007dabigatran 220mgenoxaparinNCT00168818Low risk of bias negative
RE-NOVATE 2dabigatran 220mgenoxaparinNCT00657150Low risk of bias negative
RE-MODEL (150mg), 2007dabigatran 150mgenoxaparin (europe regimen)Low risk of bias negative
RE-MODEL (220mg), 2007dabigatran 220mgenoxaparin (europe regimen)Low risk of bias negative
RE-MOBILIZE (150mg), 2008dabigatran 150mgenoxaparin (US regimen)Low risk of bias negative
RE-MOBILIZE (220mg), 2008dabigatran 220mgenoxaparin (US regimen)Low risk of bias negative
edoxaban
DU176b-04 ongoing edoxabanplaceboNCT01203072 ongoing
DU176b-B-J302 ongoing edoxabanenoxaparinNCT01181102 ongoing
DU176b-B-J303 ongoing edoxabanenoxaparinNCT01181141 ongoing
DU176b-B-J304 ongoing edoxabanenoxaparinNCT01181167 ongoing
STARS J-Vedoxabanenoxaparin (short duration)NCT01181167Low risk of bias suggesting
phenindione
Eskeland, 1966Phenindioneno treatment -
Hamilton, 1970Phenindioneno treatment -
rivaroxaban
RECORD 1, 2008rivaroxabanenoxaparinNCT00329628Low risk of bias suggesting
RECORD 3, 2008rivaroxabanenoxaparin (europe regimen)NCT00361894Low risk of bias suggesting
ODIXa-HIP 10mg, 2006rivaroxabanenoxaparin (short duration)Exploratory suggesting
RECORD 2, 2008rivaroxaban (long duration)enoxaparin (short duration)NCT00332020Low risk of bias suggesting
ODIXa-KNEE, 2005rivaroxabanenoxaparin (US regimen)Exploratory negative
RECORD 4, 2009rivaroxabanenoxaparin (US regimen)NCT00362232Low risk of bias suggesting
warfarin
Pinto, 1970Warfarinno treatment -
Hume, 1973Warfarinno treatment -
Morris, 1976Warfarinno treatment -
Powers, 1989Warfarinno treatment -
Myrhe, 1969Warfarinplacebo -
RD Heparin, 1994WarfarinArdeparinsuggesting
Heit, 1997WarfarinArdeparinsuggesting
Powers, 1989WarfarinAspirin -
Lotke, 1997WarfarinAspirin -
Francis, 1997WarfarinDalteparinsuggesting
Hull, 2000WarfarinDalteparinsuggesting
Gerhart, 1991WarfarinDanaparoid -
van Comp, 1998WarfarinDanaparoid -
Myrhe, 1969WarfarinDextran -
Harris, 1972WarfarinDextran -
Barber, 1977WarfarinDextran -
Francis, 1983WarfarinDextran -
Leclerc, 1996WarfarinEnoxaparinsuggesting
Colwell, 1999WarfarinEnoxaparinsuggesting
Fitzgerald, 2001WarfarinEnoxaparinsuggesting
Paiement, 1987WarfarinIntermittent pneumatic compression -
Bailey, 1991WarfarinIntermittent pneumatic compression -
Kaempffe, 1991WarfarinIntermittent pneumatic compression -
Francis, 1992WarfarinIntermittent pneumatic compression -
Hull, 1993WarfarinLogiparinsuggesting
Hume, 1973WarfarinSudoxicam -
Hume, 1973Warfarinunfractionated heparin -
Barber, 1977Warfarinunfractionated heparin -

antiplatelets drug

not classified
Veth, 1985spcontrolRisk of bias -
Mocris-C , 1977Flurbiprofenno treatmentExploratory negative
Massachusetts-I , 1981Hydroxychloroquineno treatmentExploratory negative
Denver-I errorplacebonegative
Denver-Il , 1980errorplaceboExploratory negative
Toulouse-Il errorplacebonegative
Den Ottolander , 1982errorplacebonegative
GRAND , 1987errorplacebonegative
Jones , 1987errorplacebonegative
Massachusetts-II, 1976HydroxychloroquineplaceboExploratory suggesting
Cooke, 1977HydroxychloroquineplaceboExploratory negative
Hume-A, 1977HydroxychloroquineplaceboExploratory negative
Stockholm-II, 1981HydroxychloroquineplaceboExploratory negative
Danish-A , 1976HydroxychloroquineplaceboExploratory negative
Danish-B , 1976HydroxychloroquineplaceboExploratory suggesting
Carter IA, 1971hydroxychloroquineplaceboLow risk of bias -
Carter IB, 1971hydroxychloroquineplaceboExploratory -
Carter II, 1974hydroxychloroquineplaceboLow risk of bias -
New York, 1977hydroxychloroquineplaceboExploratory -
Vermont, 1975hydroxychloroquineplaceboLow risk of bias -
Wood , 1973RA233placeboExploratory negative
Athens, 1981spplaceboLow risk of bias -
aspirin
Clagett, 1975aspirincontrolRisk of bias -
Zekert VI, 1982aspirincontrolRisk of bias -
Pasteyer, 1977Aspirinno treatmentExploratory negative
Rocha, 1986Aspirinno treatmentExploratory suggesting
Stockholm-I, 1975AspirinplaceboExploratory negative
Harris-I, 1977AspirinplaceboLow risk of bias suggesting
McKenna-I, 1980AspirinplaceboExploratory suggesting
Sautter, 1983AspirinplaceboExploratory suggesting
McBride, 1983AspirinplaceboExploratory negative
Zekert-I , 1974AspirinplaceboExploratory suggesting
Powers , 1976AspirinplaceboExploratory suggesting
Erfurt-B , 1979AspirinplaceboExploratory negative
PEP hip-fracture, 2000aspirinplaceboLow risk of bias suggesting
MRC, 1972aspirinplaceboLow risk of bias negative
Loew DVT, 1974aspirinplaceboLow risk of bias -
Erfurt-A, 1979aspirinplaceboLow risk of bias -
Zekert V, 1980aspirinplaceboLow risk of bias -
Vinazzer I, 1980aspirinplaceboLow risk of bias -
Vinazzer II, 1977aspirinplaceboLow risk of bias -
PEP elective arthroplasty, 2000aspirinplaceboLow risk of bias -
dipyridamol
Chicago, 1982aspirin + dipyridamolcontrolExploratory negative
Parodi I, 1973dipyridamol + aspirincontrolExploratory suggesting
Parodi II, 1973dipyridamol + aspirincontrolRisk of bias -
Zekert-III, 1977dipyridamol + aspirincontrolRisk of bias -
Australian I, 1975dipyridamol + aspirincontrolRisk of bias -
Australian II, 1976dipyridamol + aspirincontrolRisk of bias -
Toulouse I, 1979dipyridamol + aspirincontrolRisk of bias -
Harjola DVT, 1982dipyridamol + aspirincontrolRisk of bias -
Weiss, 1977dipyridamol + aspirincontrolExploratory -
Lyon-I, 1975aspirin + dipyridamolno treatmentExploratory suggesting
Morris-B , 1977aspirin + dipyridamolno treatmentExploratory negative
Morris-A , 1977dipyridamolno treatmentExploratory negative
Hamburg, 1976aspirin + dipyridamolplaceboExploratory negative
Encke-II , 1976aspirin + dipyridamolplaceboExploratory negative
Frankfurt, 1981aspirin + dipyridamolplaceboExploratory negative
Encke IA, 1976dipyridamol + aspirinplaceboExploratory -
Encke IB, 1976dipyridamol + aspirinplaceboExploratory -
suloctidil
Turpie, 1985SuloctidilplaceboLow risk of bias -
ticlopidine
McKenna-II, 1983TiclopidineplaceboExploratory negative
Lyon-IITiclopidineplaceboExploratory negative
GardeckiTiclopidineplaceboExploratory negative
Lasierra, 1982ticlopidineplaceboExploratory -
Walker, 1974ticlopidineplaceboExploratory -
McKenna-II , 1983ticlopidineplacebonegative
UFH
Morris, 1974UFHno treatmentsuggesting
Welin-Berger, 1982UFHno treatmentnegative
Bergqvist , 1979UFHno treatmentsuggesting
VTCSG, 1975UFHno treatmentnegative
Mannucci , 1976UFHno treatmentsuggesting
Dechavanne, 1974UFHno treatmentsuggesting
Dechavanne, 1975UFHno treatmentsuggesting
Bergqvist, 1979UFHno treatmentsuggesting
Galasko , 1976UFHno treatmentsuggesting
Gallus , 1973UFHno treatmentsuggesting
Morris , 1977UFHno treatmentnegative
Williams , 1978UFHplacebonegative
Abraham-Inpijn , 1975UFHplacebonegative
Hampson, 1974UFHplacebonegative
Moskovitz, 1978UFHplacebosuggesting
Lahnborg, 1980UFHplacebosuggesting
Xabregas , 1977UFHplacebonegative
Moskovitz, 1978UFHplacebonegative
Svend-Hansen, 1981UFHplacebosuggesting

antithrombotics

not classified
Veth, 1985spcontrolRisk of bias -
Cohen (L8405), 2007compression stocking groupcontrol (on top fondaparinux)Risk of bias negative
SAVE-HIP1, 2012semuloparinenoxaparinNCT00697099suggesting
SAVE-KNEE, 2012semuloparinenoxaparinNCT00718224negative
SAVE-HIP 2, 2012semuloparinenoxaparinNCT00721760negative
EXCLAIM, 2010Extended-duration prophylaxiserrorNCT00077753Low risk of bias suggesting
Borsgtrom, 1965no treatment -
Mocris-C , 1977Flurbiprofenno treatmentExploratory negative
Massachusetts-I , 1981Hydroxychloroquineno treatmentExploratory negative
LIFENOX, 2011enoxaparinplaceboNCT00622648Low risk of bias negative
Denver-I errorplacebonegative
Denver-Il , 1980errorplaceboExploratory negative
Toulouse-Il errorplacebonegative
Den Ottolander , 1982errorplacebonegative
GRAND , 1987errorplacebonegative
Jones , 1987errorplacebonegative
Valle , 1988fluxumplacebonegative
Massachusetts-II, 1976HydroxychloroquineplaceboExploratory suggesting
Cooke, 1977HydroxychloroquineplaceboExploratory negative
Hume-A, 1977HydroxychloroquineplaceboExploratory negative
Stockholm-II, 1981HydroxychloroquineplaceboExploratory negative
Danish-A , 1976HydroxychloroquineplaceboExploratory negative
Danish-B , 1976HydroxychloroquineplaceboExploratory suggesting
Carter IA, 1971hydroxychloroquineplaceboLow risk of bias -
Carter IB, 1971hydroxychloroquineplaceboExploratory -
Carter II, 1974hydroxychloroquineplaceboLow risk of bias -
New York, 1977hydroxychloroquineplaceboExploratory -
Vermont, 1975hydroxychloroquineplaceboLow risk of bias -
Dahan, 1986Pharmukaplacebosuggesting
Wood , 1973RA233placeboExploratory negative
MARINER ongoing rivaroxabanplaceboNCT02111564 ongoing
Athens, 1981spplaceboLow risk of bias -
Marlovits, 2007extended-duration thromboprophylaxisstandard-duration thromboprophylaxisRisk of bias suggesting
DRIVE, 2008SR123781AenoxaparinNCT00338897Exploratory -
PENTHIFRA–PLUS (Eriksson), 2003extended prophylaxisstandard prophylaxisLow risk of bias -
Lausen, 1998extended prophylaxisstandard prophylaxisnegative
ENOXACAN II (Bergqvist), 2002extended prophylaxisstandard prophylaxissuggesting
FAME (Rasmussen), 2006extended prophylaxisstandard prophylaxissuggesting
Harenberg, 1990LMWHUFHnegative
Harenberg, 1996LMWHUFHnegative
Limmer, 1994antixarinunfractionated heparin -
Chiapuzzo , 1988fluxumUnfractionated heparinnegative
Pini , 1989fluxumUnfractionated heparinnegative
Catania, 1988parnaparinunfractionated heparinnegative
Salcuni, 1988parnaparinunfractionated heparinnegative
Verardi, 1989parnaparinunfractionated heparinnegative
Garcea, 1992parnaparinunfractionated heparin -
ToÈrngren, 1984SSHAunfractionated heparinnegative
acenocoumarol
Hamulyak, 1994AcenocoumarolNadroparinnegative
Samama, 2001AcenocoumarolReviparinnegative
van Geloven, 1977Acenocoumarolunfractionated heparin -
apixaban
ADOPT, 2011apixabanenoxaparinNCT00457002suggesting
CV185-027 ongoing apixabanplaceboNCT00320255 ongoing
ADVANCE 3, 2010apixabanenoxaparinNCT00423319Low risk of bias suggesting
ADVANCE 2, 2010apixabanenoxaparin (europe regimen)NCT00452530Low risk of bias suggesting
APROPOS 2.5mg, 2007apixabanenoxaparin (US regimen)NCT00097357Exploratory negative
ardeparin
Levine, 1996ardeparinplacebosuggesting
Heit, 2000out of hospital Ardeparinstandard prophylaxisnegative
Godwin, 1993ardeparinunfractionated heparin -
aspirin
Clagett, 1975aspirincontrolRisk of bias -
Zekert VI, 1982aspirincontrolRisk of bias -
Pasteyer, 1977Aspirinno treatmentExploratory negative
Rocha, 1986Aspirinno treatmentExploratory suggesting
PEP hip-fracture, 2000aspirinplaceboLow risk of bias suggesting
Stockholm-I, 1975AspirinplaceboExploratory negative
Harris-I, 1977AspirinplaceboLow risk of bias suggesting
McKenna-I, 1980AspirinplaceboExploratory suggesting
Sautter, 1983AspirinplaceboExploratory suggesting
McBride, 1983AspirinplaceboExploratory negative
Zekert-I , 1974AspirinplaceboExploratory suggesting
Powers , 1976AspirinplaceboExploratory suggesting
Erfurt-B , 1979AspirinplaceboExploratory negative
MRC, 1972aspirinplaceboLow risk of bias negative
Loew DVT, 1974aspirinplaceboLow risk of bias -
Erfurt-A, 1979aspirinplaceboLow risk of bias -
Zekert V, 1980aspirinplaceboLow risk of bias -
Vinazzer I, 1980aspirinplaceboLow risk of bias -
Vinazzer II, 1977aspirinplaceboLow risk of bias -
PEP elective arthroplasty, 2000aspirinplaceboLow risk of bias -
betrixaban
APEX, 2016betrixabanenoxaparinNCT01583218suggesting
candesartan
Ericksson, 1997desirudinenoxaparin -
REVASC, 1997desirudinUFH -
Eriksson, 1996desirudinUFH -
Certoparin
Kock, 1995certoparincontrolRisk of bias negative
CERTIFY, 2010certoparinUFH -
Schmitz-Huebner, 1984certoparinunfractionated heparinnegative
Sasahara, 1986certoparinunfractionated heparinsuggesting
Voigt, 1986certoparinunfractionated heparinnegative
Welzel, 1988certoparinunfractionated heparinsuggesting
Kakkar, 1989certoparinunfractionated heparinnegative
Adolf, 1989certoparinunfractionated heparinnegative
Heilmann, 1989certoparinunfractionated heparinnegative
Baumgartner, 1989certoparinunfractionated heparinnegative
Hoffmann and Largiade, 1990certoparinunfractionated heparinnegative
Koppenhagen, 1990certoparinunfractionated heparin -
Schielke, 1991certoparinunfractionated heparin -
Koppenhagen, 1992certoparinunfractionated heparin -
Hoffmann and Largiader, 1992certoparinunfractionated heparin -
Heilmann, 1997certoparinunfractionated heparin -
Haas, 1999certoparinunfractionated heparin -
Haas , 1987certoparine + DHEUnfractionated heparinnegative
Lassen, 1988certoparine + DHEUnfractionated heparinsuggesting
Lassen, 1989certoparine + DHEUnfractionated heparinnegative
dabigatran
RE-NOVATE (150mg), 2007dabigatran 150mgenoxaparinNCT00168818Low risk of bias negative
RE-NOVATE (220mg), 2007dabigatran 220mgenoxaparinNCT00168818Low risk of bias negative
RE-NOVATE 2dabigatran 220mgenoxaparinNCT00657150Low risk of bias negative
RE-MODEL (150mg), 2007dabigatran 150mgenoxaparin (europe regimen)Low risk of bias negative
RE-MODEL (220mg), 2007dabigatran 220mgenoxaparin (europe regimen)Low risk of bias negative
RE-MOBILIZE (150mg), 2008dabigatran 150mgenoxaparin (US regimen)Low risk of bias negative
RE-MOBILIZE (220mg), 2008dabigatran 220mgenoxaparin (US regimen)Low risk of bias negative
dalteparin
Jorgensen, 1989dalteparinplacebosuggesting
Torholm, 1991dalteparinplacebosuggesting
Leizorovicz, 2004dalteparinplacebosuggesting
Ockelford , 1989dalteparinplacebosuggesting
Lapidus, 2007dalteparinplaceboLow risk of bias negative
Lapidus, 2007dalteparinplaceboLow risk of bias negative
D-KAf (Selby), 2007dalteparinplaceboNCT00187408negative
Eriksson , 1988dalteparinDextransuggesting
Matzsch , 1988dalteparinDextrannegative
Matzsch , 1991dalteparinDextransuggesting
Dahl, 1997out of hospital Dalteparinstandard prophylaxissuggesting
Lassen, 1998out of hospital Dalteparinstandard prophylaxisnegative
Hull, 2000out of hospital Dalteparinstandard prophylaxissuggesting
PROTECT, 2011dalteparinUFHNCT00182143Low risk of bias suggesting