post stroke

     

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Trial Studied trt Control trt patientstagsNCTROB Result

anti hypertensive agents

telmisartan
PROFESS, 2008telmisartanplacebo -

anticoagulant

not classified
Baker, 1964anticoagulantno anticoagulantnegative
Bradshaw, 1975anticoagulantno anticoagulantnegative
LHSPS, 1999anticoagulantno anticoagulantnegative
VA Study, 1961anticoagulantno anticoagulantnegative
Wallace, 1964anticoagulantno anticoagulantsuggesting
McDevitt, 1959anticoagulantplacebonegative
dicoumarol
Howard, 1963dicoumarolplacebonegative
Nat-Coop, 1962dicoumarolplacebosuggesting
phenindione
Enger, 1965phenindioneplacebonegative
Thygesen, 1964phenindioneplacebonegative
warfarin
SWAT, 1998warfarinaspirinnegative

antiplatelets drug

aspirin
Canadian study (CCSG), 1978aspirinplacebonegative
Swedish study , 1987aspirinplacebonegative
UK-TIA low dose , 1988aspirinplacebonegative
UK-TIA high dose , 1988aspirinplacebosuggesting
SALT , 1991aspirinplacebonegative
Reuther , 1976aspirinplacebonegative
AITA, 1975aspirinplacebonegative
DCS, 1980aspirinplacebonegative
AICLA, 1981aspirinplacebonegative
Lindblad , 1991aspirinplacebosuggesting
Danish low-dose, 1986aspirinplacebonegative
ESPS 2 , 1996aspirinplacebosuggesting

cholesterol lowering intervention

atorvastatin
SPARCL, 2006atorvastatinplacebopost stroke cerebral vascular disease NCT00147602Low risk of bias suggesting
simvastatin
HPS (post troke sub group), 2004simvastatinplacebopost stroke cerebral vascular disease Exploratory suggesting

foramen ovale closure

not classified
CLOSE ongoing Device for PFO closuremedical treatmentNCT00562289Risk of bias ongoing
CryptoCard ongoing Device for PFO closuremedical treatmentNCT01018355 ongoing
REDUCE ongoing GORE HELEXmedical treatmentNCT00738894 ongoing
CLOSURE I, 2010Starflexmedical treatmentNCT00201461Risk of bias negative

prevention

folic acid
VITATOPS, 2010folic acid, vit B12 and vit B6placeboNCT00097669ÐX&Low risk of bias suggesting
VISP (Toole), 2004high dose - folic acid, vit B12 and vit B6low dose - folic acid, vit B12 and vit B6Low risk of bias negative