post stroke

     

Select            
Trial Studied trt Control trt patientstagsROB Trial result

anti hypertensive agents

telmisartan
PROFESS, 2008   telmisartanplacebo -

anticoagulant

not classified
Baker, 1964   anticoagulantno anticoagulantnegative
Bradshaw, 1975   anticoagulantno anticoagulantnegative
LHSPS, 1999   anticoagulantno anticoagulantnegative
VA Study, 1961   anticoagulantno anticoagulantnegative
Wallace, 1964   anticoagulantno anticoagulantsuggesting
McDevitt, 1959     anticoagulantplacebonegative
dicoumarol
Howard, 1963   dicoumarolplacebonegative
Nat-Coop, 1962   dicoumarolplacebosuggesting
phenindione
Enger, 1965   phenindioneplacebonegative
Thygesen, 1964   phenindioneplacebonegative
rivaroxaban
NAVIGATE ESUS, 2018      NCTrivaroxabanaspirin -
warfarin
SWAT, 1998   warfarinaspirinnegative

antiplatelets drug

aspirin
Canadian study (CCSG), 1978   aspirinplaceboLow risk of bias negative
Swedish study , 1987   aspirinplacebonegative
UK-TIA low dose , 1988   aspirinplacebonegative
UK-TIA high dose , 1988   aspirinplacebosuggesting
SALT , 1991   aspirinplacebonegative
Reuther , 1976   aspirinplacebonegative
AITA, 1975   aspirinplacebonegative
DCS, 1980   aspirinplacebonegative
AICLA, 1981   aspirinplacebonegative
Lindblad , 1991   aspirinplacebosuggesting
Danish low-dose, 1986   aspirinplacebonegative
ESPS 2 , 1996   aspirinplacebosuggesting

cholesterol lowering intervention

atorvastatin
SPARCL, 2006      NCTatorvastatinplacebopost stroke cerebral vascular disease Low risk of bias suggesting
simvastatin
HPS (post troke sub group), 2004     simvastatinplacebopost stroke cerebral vascular disease Low risk of bias suggesting

foramen ovale closure

not classified
CLOSURE I, 2010      NCTStarflexmedical treatmentRisk of bias negative

prevention

folic acid
VITATOPS, 2010    NCTfolic acid, vit B12 and vit B6placeboLow risk of bias suggesting
VISP (Toole), 2004   high dose - folic acid, vit B12 and vit B6low dose - folic acid, vit B12 and vit B6Low risk of bias negative