stent

     

Select            
Trial Studied trt Control trt patientstagsROB Trial result

antithrombotics

not classified
DECLARE-LONG II , 2011      -
EXCELLENT, 2011      NCT6-month dual antiplatelet therapy12 months dual antiplateletnegative
PRODIGY, 2011      NCT24 months of dual antiplatelet treatment6 months dual antiplateletnegative
WOEST    NCTtriple therapydual antiplatelet therapy -
RESET    NCTEndeavor stent and three months of DAPTstandard 12-month DAPT and other DESnegative
DES-LATE, 2010    NCTprolonged dual antiplatelet therapy12 months dual antiplateletRisk of bias negative
ISAR-SAFE, 2009      NCT12 months dual antiplatelet6 months dual antiplateletLow risk of bias -
CILON-T, 2010     triple antiplateletdual antiplatelet therapyExploratory negative
cilostazol
Kunishima, 1997     cilostazolaspirinnegative
Sekiya, 1998     cilostazol + aspirinaspirinnegative
Kozuma, 2001     cilostazol + aspirinticlopidine + aspirinnegative
Ochiai, 1999     cilostazol + aspirinticlopidine + aspirinnegative
Park, 1999     cilostazol + aspirinticlopidine + aspirinnegative
Yoon, 1999     cilostazol + aspirinticlopidine + aspirinnegative
Kamishirado, 2002     cilostazol + aspirinticlopidine + aspirinnegative
clopidogrel
REAL-LATE, ZEST-LATE, 2010      NCTclopidogrel+aspirinaspirinnegative
GRAVITAS, 2011      NCThigh-dose clopidogrelnormal-dose clopidogrelRisk of bias negative
Müller, 2000     clopidogrel + aspirinticlopidine + aspirinnegative
CLASSICS, 2000     clopidogrel + aspirinticlopidine + aspirinnegative
TOPPS, 2001     clopidogrel + aspirinticlopidine + aspirinnegative
Piamsomboon, 2001   clopidogrel + aspirinticlopidine + aspirinnegative
ticlopidine
STARS (vs aspirin), 1998     ticlopidine + aspirinaspirinsuggesting
Hall, 1996     ticlopidine + aspirinaspirinnegative
FANTASTIC, 1998     ticlopidine + aspirincoumadin + aspirinnegative
ISAR, 1996     ticlopidine + aspirincoumadin + aspirinsuggesting
Foussas, 2000   ticlopidine + aspirincoumadin + aspirinsuggesting
MATTIS, 1998     ticlopidine + aspirincoumadin + aspirinnegative
STARS (vs coumadin+asp), 1998     ticlopidine + aspirincoumadin + aspirinsuggesting

dual antiplatelet therapy

not classified
OPTIMIZE, 2013      NCT3 months DAPT 12 months DAPTRisk of bias -
EXCELLENT, 2011      NCT6-month dual antiplatelet therapy12 months dual antiplateletnegative
PRODIGY, 2011      NCT24 months of dual antiplatelet treatment6 months dual antiplateletnegative
RESET    NCTEndeavor stent and three months of DAPTstandard 12-month DAPT and other DESnegative
DES-LATE, 2010    NCTprolonged dual antiplatelet therapy12 months dual antiplateletRisk of bias negative
ISAR-SAFE, 2009      NCT12 months dual antiplatelet6 months dual antiplateletLow risk of bias -
clopidogrel
REAL-LATE, ZEST-LATE, 2010      NCTclopidogrel+aspirinaspirinnegative
GRAVITAS, 2011      NCThigh-dose clopidogrelnormal-dose clopidogrelRisk of bias negative