post myocardial infarction

     

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Trial Studied trt Control trt patientstagsNCTROB Result

anti inflammatory drugs

not classified
CANTOS, 2017canakinumab placeboNCT01327846 -

antiarrythmic drugs

not classified
BASIS, 1990class I drugscontrol -
CAST I, 1991placeboNCT00000526 -
Julian, 1982d,l sotalolplacebo -
amiodarone
BASIS, 1990early amiodaronecontrolsuggesting
Navarro-Lopez, 1993early amiodaronecontrolnegative
CAMIAT , 1991early amiodaroneplacebonegative
Ceremuzynski, 1992early amiodaroneplacebonegative
Hockings, 1987early amiodaroneplacebonegative
Azimilide
ALIVE, 2004azimilideplacebo -
dofetilide
DIAMOND MI, 1997dofetilideplacebo -
moricizine
CAST II (early treatment), 1992moricizineplacebo -
CAST II (late treatment), 1992moricizineplacebo -

anticoagulant

not classified
Sixty Plus reinfarction Study, 1980any anticoagulantplacebo -
German-Austrian Study Group (oac vs pbo), 1980phenprocoumonplacebonegative
EPSIM, 1982any anticoagulantaspirinnegative
German-Austrian Study Group (oac vs asp), 1980phenprocoumonaspirinnegative
coumadin
ASPECT-2 (coumadin+ASA vs ASA), 2002coumadincontrol (on top of aspirin)negative
ASPECT, 1994coumadinplacebosuggesting
ASPECT-2 (coumadin alone), 2002coumadinaspirinsuggesting
warfarin
APRICOT-2, 2002warfarincontrol (on top of aspirin)suggesting
Zibaeenezhad, 2004warfarincontrol (on top of aspirin)negative
WARIS, 1999warfarincontrol (on top of aspirin) -
CHAMP, 2002warfarincontrol (on top of aspirin)negative
CARS (warafrin 3mg), 1997warfarincontrol (on top of aspirin)suggesting
LoWASA, 2004warfarincontrol (on top of aspirin)Risk of bias suggesting
CARS (warfarin 1mg), 1997warfarincontrol (on top of aspirin)negative
WARIS II (warfarin+ASA), 2002warfarincontrol (on top of aspirin)suggesting
Williams, 1997warfarinplacebo (on top of aspirin)suggesting
WARIS II (warfarin alone), 2002warfarinaspirinsuggesting

antioxydants

not classified
ARISE, 2007succinobucolplaceboNCT00066898Low risk of bias -

antiplatelets drug

aspirin
CDPA, 1976aspirinplacebonegative
Cardiff I, 1974aspirinplacebonegative
Cardiff II, 1979aspirinplacebonegative
Vogel, 1979aspirinplacebosuggesting
AMIS, 1980aspirinplaceboNCT00000491suggesting
GAMIS, 1980aspirinplacebonegative
PARIS, 1980aspirinplacebonegative
JAMIS, 1999aspirinplacebosuggesting
clopidogrel
CAPRIE, 1996clopidogrelaspirin -
dipyridamol
PARIS, 1980dipyridamol + aspirinplacebonegative
PARIS-II, 1986dipyridamol + aspirinplacebonegative
PARIS, 1980dipyridamol + aspirinaspirinnegative
ticagrelor
PEGASUS 60mg, 2015ticagrelorplacebo (on top aspirin)secondary preventionNCT01225562Low risk of bias suggesting
PEGASUS 90mg, 2015ticagrelorplacebo (on top aspirin)secondary preventionNCT01225562suggesting
vorapaxar
TRA-2P TIMI 50, 2012vorapaxarplacebo (on top aspirin)secondary preventionNCT00526474Low risk of bias suggesting

antithrombotics

dabigatran
REDEEM, 2009dabigatranplaceboNCT00621855negative

calcium channel blockers

diltiazem
MDPIT, 1988diltiazemplacebonegative
nifedipine
MI study group, 1979nifedipine -
SPRINT I, 1988nifedipineplacebonegative
SPRINT II, 1993nifedipineplacebonegative
verapamil
DAVIT I, 1984verapamilplacebo -
DAVIT II, 1990verapamilplacebonegative
CRIS, 1996verapamilplacebonegative
Danish study, 1984verapamilplacebonegative

cholesterol lowering intervention

atorvastatin
TNT, 2005atorvastatin high doseatorvastatinsecondary preventionNCT00327691Low risk of bias conclusive
Vascular basis, 2005atorvastatin high doselovastatinsecondary preventionExploratory negative
REVERSAL, 2004atorvastatin high dosepravastatinsecondary preventionExploratory negative
SAGE, 2007atorvastatin high dosepravastatinsecondary preventionExploratory suggesting
IDEAL, 2005atorvastatin high dosesimvastatinsecondary preventionNCT00159835Risk of bias suggesting
bezafibrate
BECAIT, 1996bezafibrateplacebosecondary preventionExploratory suggesting
BIP, 2000bezafibrateplacebosecondary preventionLow risk of bias negative
diet
Tuttle, 2008low fat dietmediterranean-style dietRisk of bias -
ezetimibe
IMPROVE-IT, 2014ezetimibecontrol early initiation NCT00202878suggesting
gemfibrozil
VA-HIT, 1999gemfibrozilplaceboNCT00283335Low risk of bias suggesting
niacin
Carlson (Stockholm), 1977clofibtate+niacinplacebosecondary preventionRisk of bias suggesting
pravastatin
PACT, 2004pravastatinplacebosecondary preventionLow risk of bias negative
LIPID, 1998pravastatinplacebosecondary preventionLow risk of bias conclusive
CARE, 1996pravastatinplacebosecondary preventionLow risk of bias conclusive
simvastatin
4S, 1994simvastatinplacebosecondary preventionLow risk of bias conclusive

omega-3 fatty acids

not classified
OMEGA, 2009omega-3 Fatty acidscontrolNCT00251134Risk of bias negative

secondary prevention

aspirin
CDPA, 1976aspirinplacebonegative
Cardiff I, 1974aspirinplacebonegative
Cardiff II, 1979aspirinplacebonegative
Vogel, 1979aspirinplacebosuggesting
AMIS, 1980aspirinplaceboNCT00000491suggesting
GAMIS, 1980aspirinplacebonegative
PARIS, 1980aspirinplacebonegative
JAMIS, 1999aspirinplacebosuggesting
clopidogrel
CAPRIE, 1996clopidogrelaspirin -
dipyridamol
PARIS, 1980dipyridamol + aspirinplacebonegative
PARIS-II, 1986dipyridamol + aspirinplacebonegative
PARIS, 1980dipyridamol + aspirinaspirinnegative