post myocardial infarction  

     

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Trial Studied trt Control trt patientstagsNCTROB Result

anti inflammatory drugs

not classified
CANTOS, 2017canakinumab placeboNCT01327846Low risk of bias -

antiarrythmic drugs

not classified
BASIS, 1990class I drugscontrol -
CAST I, 1991placeboNCT00000526Low risk of bias -
Julian, 1982d,l sotalolplaceboLow risk of bias -
amiodarone
BASIS, 1990early amiodaronecontrolsuggesting
Navarro-Lopez, 1993early amiodaronecontrolnegative
CAMIAT , 1991early amiodaroneplaceboLow risk of bias negative
Ceremuzynski, 1992early amiodaroneplaceboLow risk of bias negative
Hockings, 1987early amiodaroneplaceboLow risk of bias negative
Azimilide
ALIVE, 2004azimilideplaceboLow risk of bias -
dofetilide
DIAMOND MI, 1997dofetilideplaceboLow risk of bias -
moricizine
CAST II (early treatment), 1992moricizineplaceboLow risk of bias -
CAST II (late treatment), 1992moricizineplaceboLow risk of bias -

anticoagulant

not classified
Sixty Plus reinfarction Study, 1980any anticoagulantplaceboLow risk of bias -
German-Austrian Study Group (oac vs pbo), 1980phenprocoumonplaceboLow risk of bias negative
EPSIM, 1982any anticoagulantaspirinnegative
German-Austrian Study Group (oac vs asp), 1980phenprocoumonaspirinLow risk of bias negative
coumadin
ASPECT-2 (coumadin+ASA vs ASA), 2002coumadincontrol (on top of aspirin)negative
ASPECT, 1994coumadinplaceboLow risk of bias suggesting
ASPECT-2 (coumadin alone), 2002coumadinaspirinsuggesting
warfarin
APRICOT-2, 2002warfarincontrol (on top of aspirin)suggesting
Zibaeenezhad, 2004warfarincontrol (on top of aspirin)negative
WARIS, 1999warfarincontrol (on top of aspirin)Low risk of bias -
CHAMP, 2002warfarincontrol (on top of aspirin)negative
CARS (warafrin 3mg), 1997warfarincontrol (on top of aspirin)Low risk of bias suggesting
LoWASA, 2004warfarincontrol (on top of aspirin)Risk of bias suggesting
CARS (warfarin 1mg), 1997warfarincontrol (on top of aspirin)Low risk of bias negative
WARIS II (warfarin+ASA), 2002warfarincontrol (on top of aspirin)suggesting
Williams, 1997warfarinplacebo (on top of aspirin)Low risk of bias suggesting
WARIS II (warfarin alone), 2002warfarinaspirinsuggesting

antioxydants

not classified
ARISE, 2007succinobucolplaceboNCT00066898Low risk of bias -

antiplatelets drug

aspirin
CDPA, 1976aspirinplaceboLow risk of bias negative
Cardiff I, 1974aspirinplaceboLow risk of bias negative
Cardiff II, 1979aspirinplaceboLow risk of bias negative
Vogel, 1979aspirinplaceboLow risk of bias suggesting
AMIS, 1980aspirinplaceboNCT00000491Low risk of bias suggesting
GAMIS, 1980aspirinplaceboLow risk of bias negative
PARIS, 1980aspirinplaceboLow risk of bias negative
JAMIS, 1999aspirinplacebosuggesting
clopidogrel
CAPRIE, 1996clopidogrelaspirinLow risk of bias -
dipyridamol
PARIS, 1980dipyridamol + aspirinplaceboLow risk of bias negative
PARIS-II, 1986dipyridamol + aspirinplaceboLow risk of bias negative
PARIS, 1980dipyridamol + aspirinaspirinLow risk of bias negative
ticagrelor
PEGASUS 60mg, 2015ticagrelorplacebo (on top aspirin)secondary preventionNCT01225562Low risk of bias suggesting
PEGASUS 90mg, 2015ticagrelorplacebo (on top aspirin)secondary preventionNCT01225562Low risk of bias suggesting
vorapaxar
TRA-2P TIMI 50, 2012vorapaxarplacebo (on top aspirin)secondary preventionNCT00526474Low risk of bias suggesting

antithrombotics

dabigatran
REDEEM, 2009dabigatranplaceboNCT00621855Low risk of bias negative

calcium channel blockers

diltiazem
MDPIT, 1988diltiazemplaceboLow risk of bias negative
nifedipine
MI study group, 1979nifedipine -
SPRINT I, 1988nifedipineplaceboLow risk of bias negative
SPRINT II, 1993nifedipineplaceboLow risk of bias negative
verapamil
DAVIT I, 1984verapamilplaceboLow risk of bias -
DAVIT II, 1990verapamilplaceboLow risk of bias negative
CRIS, 1996verapamilplaceboLow risk of bias negative
Danish study, 1984verapamilplaceboLow risk of bias negative

cholesterol lowering intervention

atorvastatin
TNT, 2005atorvastatin high doseatorvastatinsecondary preventionNCT00327691Low risk of bias conclusive
Vascular basis, 2005atorvastatin high doselovastatinsecondary preventionExploratory negative
REVERSAL, 2004atorvastatin high dosepravastatinsecondary preventionExploratory negative
SAGE, 2007atorvastatin high dosepravastatinsecondary preventionExploratory suggesting
IDEAL, 2005atorvastatin high dosesimvastatinsecondary preventionNCT00159835Risk of bias suggesting
bezafibrate
BECAIT, 1996bezafibrateplacebosecondary preventionExploratory suggesting
BIP, 2000bezafibrateplacebosecondary preventionLow risk of bias negative
diet
Tuttle, 2008low fat dietmediterranean-style dietRisk of bias -
ezetimibe
IMPROVE-IT, 2014ezetimibecontrol early initiation NCT00202878Low risk of bias suggesting
gemfibrozil
VA-HIT, 1999gemfibrozilplaceboNCT00283335Low risk of bias suggesting
niacin
Carlson (Stockholm), 1977clofibtate+niacinplacebosecondary preventionRisk of bias suggesting
pravastatin
PACT, 2004pravastatinplacebosecondary preventionLow risk of bias negative
LIPID, 1998pravastatinplacebosecondary preventionLow risk of bias conclusive
CARE, 1996pravastatinplacebosecondary preventionLow risk of bias conclusive
simvastatin
4S, 1994simvastatinplacebosecondary preventionLow risk of bias conclusive

omega-3 fatty acids

not classified
OMEGA, 2009omega-3 Fatty acidscontrolNCT00251134Risk of bias negative

secondary prevention

aspirin
CDPA, 1976aspirinplaceboLow risk of bias negative
Cardiff I, 1974aspirinplaceboLow risk of bias negative
Cardiff II, 1979aspirinplaceboLow risk of bias negative
Vogel, 1979aspirinplaceboLow risk of bias suggesting
AMIS, 1980aspirinplaceboNCT00000491Low risk of bias suggesting
GAMIS, 1980aspirinplaceboLow risk of bias negative
PARIS, 1980aspirinplaceboLow risk of bias negative
JAMIS, 1999aspirinplacebosuggesting
clopidogrel
CAPRIE, 1996clopidogrelaspirinLow risk of bias -
dipyridamol
PARIS, 1980dipyridamol + aspirinplaceboLow risk of bias negative
PARIS-II, 1986dipyridamol + aspirinplaceboLow risk of bias negative
PARIS, 1980dipyridamol + aspirinaspirinLow risk of bias negative