CABG surgery  

     

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Trial Studied trt Control trt patientstagsNCTROB Result

antiplatelets drug

not classified
VA Co-op CABG, 1988variousplaceboLow risk of bias negative
Guiteras, 1989variousplaceboLow risk of bias negative
aspirin
McEnany, 1982aspirinplaceboLow risk of bias negative
Lorenz, 1984aspirinplaceboLow risk of bias negative
GESIC (aspirin), 1990aspirinplaceboLow risk of bias negative
Sydney, 1991aspirinplaceboLow risk of bias -
Hockings, 1993aspirinplaceboLow risk of bias -
cangrelor
Bridge ongoing cangrelor placeboNCT00767507Low risk of bias ongoing
clopidogrel
CASCADE, 2009clopidogrel+aspirinaspirinNCT00228423Low risk of bias -
dipyridamol
Pantely, 1979aspirin + dipyridamolcontrolnegative
Brussels, 1987aspirin + dipyridamolcontrolnegative
Czech, 1986aspirin + dipyridamolcontrol -
Des Moines, 1980aspirin + dipyridamolcontrol -
Toronto dipyridamole, 1987dipyridamolcontrol -
Brooks, 1985aspirin + dipyridamolplaceboLow risk of bias negative
Mayo-A, 1984aspirin + dipyridamolplaceboLow risk of bias negative
Wadsworth, 1985aspirin + dipyridamolplaceboLow risk of bias negative
Basel, 1989aspirin + dipyridamolplaceboLow risk of bias negative
Leeds-B, 1985aspirin + dipyridamolplaceboLow risk of bias -
Thaulow, 1987aspirin + dipyridamolplaceboLow risk of bias -
GESIC (aspirin+dipyridamol), 1990aspirin + dipyridamolplaceboLow risk of bias negative
Ekestrom, 1990dipyridamolplaceboLow risk of bias -
sulfinpyrazone
Baur, 1982sulfinpyrazoneplaceboLow risk of bias -
sulotroban
German sulotroban, 1989sulotrobancontrol -
ticlopidine
Zurich, 1982ticlopidinecontrol -
Knudsen-B, 1983ticlopidinecontrol -
Romeo, 1983ticlopidinecontrol -
Kohn, 1990ticlopidinecontrol -
Liège-I, 1984ticlopidineplaceboLow risk of bias negative
Liège-II, 1987ticlopidineplaceboLow risk of bias negative

cholesterol lowering intervention

not classified
Song, 2008NCT00611143negative
atorvastatin
Chello et al., 2006preoperative atorvastatinplaceboLow risk of bias negative
Patti et al., 2006preoperative atorvastatinplaceboLow risk of bias suggesting
simvastatin
Christenson, 1999preoperative simvastatinno treatmentnegative

off-pump CABG

not classified
BBS (Moller), 2010off-pumpon-pumpNCT00120991Risk of bias suggesting
DOORS, 2009off-pumpon-pumpNCT00123981Risk of bias negative
PRAGUE 4 (Widimsky), 2004off-pumpon-pumpRisk of bias negative
BHACAS I (Ascione), 1999off-pumpon-pumpRisk of bias suggesting
BHACAS II (Angelini), 2002off-pumpon-pumpRisk of bias suggesting
OCTOPUS (van Dijk), 2002off-pumpon-pumpRisk of bias negative
SMART (Staton), 2003off-pumpon-pumpRisk of bias negative
Al-Ruzzeh b, 2006off-pumpon-pumpRisk of bias negative
Gu, 1998off-pumpon-pumpExploratory negative
Diegeler, 2000off-pumpon-pumpExploratory negative
Gulielmos, 1999off-pumpon-pumpExploratory negative
Matata, 2000off-pumpon-pumpExploratory negative
Covino, 2001off-pumpon-pumpExploratory negative
Penttila, 2001off-pumpon-pumpExploratory negative
Caputo, 2002off-pumpon-pumpExploratory negative
Zamvar, 2002off-pumpon-pumpExploratory negative
Carrier, 2003off-pumpon-pumpExploratory negative
Raja b, 2003off-pumpon-pumpExploratory suggesting
Alwan, 2004off-pumpon-pumpExploratory negative
Gerola, 2001off-pumpon-pumpExploratory negative
Khan, 2004off-pumpon-pumpExploratory suggesting
Legare, 2004off-pumpon-pumpNCT00216957Exploratory negative
Lingaas, 2003off-pumpon-pumpExploratory negative
Motallebzadeh, 2004off-pumpon-pumpExploratory negative
Selvanayagam, 2004off-pumpon-pumpExploratory negative
Ascionee, 2005off-pumpon-pumpExploratory negative
Kobayashi, 2005off-pumpon-pumpExploratory negative
Ascione, 2006off-pumpon-pumpExploratory negative
Michaux, 2006off-pumpon-pumpExploratory negative
Motallebzadeh b, 2006off-pumpon-pumpExploratory negative
Niranjan, 2006off-pumpon-pumpExploratory negative
Paparella, 2006off-pumpon-pumpExploratory negative
Tatoulis, 2006off-pumpon-pumpExploratory negative
Jares, 2006off-pumpon-pumpExploratory negative
Kunes, 2007off-pumpon-pumpExploratory negative
Ozkara, 2007off-pumpon-pumpExploratory negative
ROOBY (Shroyer), 2009off-pumpon-pumpNCT00032630Risk of bias suggesting
Baker, 2001off-pumpon-pumpExploratory negative
Lee, 2003off-pumpon-pumpExploratory negative
Vedin, 2006off-pumpon-pumpExploratory negative
Czerny, 2000off-pumpon-pumpExploratory negative
Czerny b, 2001off-pumpon-pumpExploratory negative
Dorman, 2004off-pumpon-pumpExploratory -
Gasz, 2004off-pumpon-pumpExploratory negative
Guler, 2001off-pumpon-pumpExploratory negative
Muneretto, 2003off-pumpon-pumpExploratory suggesting
Parolari, 2003off-pumpon-pumpExploratory negative
Parolari b, 2003off-pumpon-pumpExploratory -
Puskas, 2004off-pumpon-pumpExploratory negative
Sahlman, 2003off-pumpon-pumpExploratory negative
Syed, 2004off-pumpon-pumpExploratory -
Tang, 2002off-pumpon-pumpExploratory negative
Velisaris, 2003off-pumpon-pumpExploratory negative
Vural, 1995off-pumpon-pumpExploratory negative
Wan, 2004off-pumpon-pumpExploratory -
Wandschneider, 2000off-pumpon-pumpExploratory negative
PROMISS (Uva), 2010off-pumpon-pumpRisk of bias negative
OCTOPUS II ongoing off-pumpon-pump ongoing
Ontario ongoing off-pumpon-pumpNCT00259493Low risk of bias ongoing
GOPCABE ongoing off-pumpon-pumpNCT00719667 ongoing

preconditioning

not classified
Cheung, 2006remote ischemic preconditioningcontrol -
Gunaydin, 2000remote ischemic preconditioningcontrol -
Hausenloy, 2007remote ischemic preconditioningcontrolNCT00397163 -
Ali, 2007remote ischemic preconditioningno RIPC -
Meybohm ongoing remote ischemic preconditioningsham procedureNCT00882622Low risk of bias ongoing
Seoul ongoing remote ischemic preconditioningsham procedureNCT00889811Low risk of bias ongoing

radial graft

not classified
CARRPO, 2009artery graftssaphenous vein graftsNCT00159991Exploratory negative
RAS ongoing artery graftssaphenous vein graftsNCT00475488 ongoing
RAPS (Desai), 2004radial artery graftssaphenous vein graftsNCT00187356Exploratory suggesting
RSVP, 2008radial artery graftssaphenous vein graftsNCT00139399Risk of bias suggesting
Gaudino (radial A), 2005radial artery graftssaphenous vein graftsRisk of bias suggesting
VA CABG, 2010radial artery graftssaphenous vein graftsNCT00054847Exploratory negative
Gaudino (RITA), 2005right internal thoracic artery graftssaphenous vein graftsExploratory suggesting

vein grafts pretreatment

not classified
PREVENT IV, 2005edifoligide pretreatmentplaceboNCT00042081Low risk of bias negative