CABG surgery

     

Select            
Trial Studied trt Control trt patientstagsROB Trial result

antiplatelets drug

not classified
VA Co-op CABG, 1988   variousplaceboLow risk of bias negative
Guiteras, 1989     variousplaceboLow risk of bias negative
aspirin
McEnany, 1982   aspirinplaceboLow risk of bias negative
Lorenz, 1984   aspirinplaceboLow risk of bias negative
GESIC (aspirin), 1990   aspirinplaceboLow risk of bias negative
Sydney, 1991   aspirinplaceboLow risk of bias -
Hockings, 1993   aspirinplaceboLow risk of bias -
clopidogrel
CASCADE, 2009      NCTclopidogrel+aspirinaspirinLow risk of bias -
dipyridamol
Pantely, 1979   aspirin + dipyridamolcontrolnegative
Brussels, 1987   aspirin + dipyridamolcontrolnegative
Czech, 1986   aspirin + dipyridamolcontrol -
Des Moines, 1980   aspirin + dipyridamolcontrol -
Toronto dipyridamole, 1987   dipyridamolcontrol -
Brooks, 1985     aspirin + dipyridamolplaceboLow risk of bias negative
Mayo-A, 1984   aspirin + dipyridamolplaceboLow risk of bias negative
Wadsworth, 1985   aspirin + dipyridamolplaceboLow risk of bias negative
Basel, 1989   aspirin + dipyridamolplaceboLow risk of bias negative
Leeds-B, 1985   aspirin + dipyridamolplaceboLow risk of bias -
Thaulow, 1987   aspirin + dipyridamolplaceboLow risk of bias -
GESIC (aspirin+dipyridamol), 1990   aspirin + dipyridamolplaceboLow risk of bias negative
Ekestrom, 1990   dipyridamolplaceboLow risk of bias -
sulfinpyrazone
Baur, 1982     sulfinpyrazoneplaceboLow risk of bias -
sulotroban
German sulotroban, 1989   sulotrobancontrol -
ticlopidine
Zurich, 1982   ticlopidinecontrol -
Knudsen-B, 1983   ticlopidinecontrol -
Romeo, 1983   ticlopidinecontrol -
Kohn, 1990   ticlopidinecontrol -
Liège-I, 1984   ticlopidineplaceboLow risk of bias negative
Liège-II, 1987   ticlopidineplaceboLow risk of bias negative

cholesterol lowering intervention

not classified
Song, 2008      NCTnegative
atorvastatin
Chello et al., 2006     preoperative atorvastatinplaceboLow risk of bias negative
Patti et al., 2006     preoperative atorvastatinplaceboLow risk of bias suggesting
simvastatin
Christenson, 1999     preoperative simvastatinno treatmentnegative

off-pump CABG

not classified
BBS (Moller), 2010          NCToff-pumpon-pumpRisk of bias suggesting
DOORS, 2009    NCToff-pumpon-pumpRisk of bias negative
PRAGUE 4 (Widimsky), 2004     off-pumpon-pumpRisk of bias negative
BHACAS I (Ascione), 1999           off-pumpon-pumpRisk of bias suggesting
BHACAS II (Angelini), 2002       off-pumpon-pumpRisk of bias suggesting
OCTOPUS (van Dijk), 2002               off-pumpon-pumpRisk of bias negative
SMART (Staton), 2003           off-pumpon-pumpRisk of bias negative
Al-Ruzzeh b, 2006     off-pumpon-pumpRisk of bias negative
Gu, 1998     off-pumpon-pumpExploratory negative
Diegeler, 2000       off-pumpon-pumpExploratory negative
Gulielmos, 1999   off-pumpon-pumpExploratory negative
Matata, 2000     off-pumpon-pumpExploratory negative
Covino, 2001   off-pumpon-pumpExploratory negative
Penttila, 2001     off-pumpon-pumpExploratory negative
Caputo, 2002   off-pumpon-pumpExploratory negative
Zamvar, 2002     off-pumpon-pumpExploratory negative
Carrier, 2003     off-pumpon-pumpExploratory negative
Raja b, 2003   off-pumpon-pumpExploratory suggesting
Alwan, 2004     off-pumpon-pumpExploratory negative
Gerola, 2001       off-pumpon-pumpExploratory negative
Khan, 2004     off-pumpon-pumpExploratory suggesting
Legare, 2004          NCToff-pumpon-pumpExploratory negative
Lingaas, 2003               off-pumpon-pumpExploratory negative
Motallebzadeh, 2004     off-pumpon-pumpExploratory negative
Selvanayagam, 2004         off-pumpon-pumpExploratory negative
Ascionee, 2005     off-pumpon-pumpExploratory negative
Kobayashi, 2005     off-pumpon-pumpExploratory negative
Ascione, 2006     off-pumpon-pumpExploratory negative
Michaux, 2006     off-pumpon-pumpExploratory negative
Motallebzadeh b, 2006       off-pumpon-pumpExploratory negative
Niranjan, 2006     off-pumpon-pumpExploratory negative
Paparella, 2006     off-pumpon-pumpExploratory negative
Tatoulis, 2006         off-pumpon-pumpExploratory negative
Jares, 2006     off-pumpon-pumpExploratory negative
Kunes, 2007     off-pumpon-pumpExploratory negative
Ozkara, 2007     off-pumpon-pumpExploratory negative
ROOBY (Shroyer), 2009    NCToff-pumpon-pumpRisk of bias suggesting
Baker, 2001   off-pumpon-pumpExploratory negative
Lee, 2003   off-pumpon-pumpExploratory negative
Vedin, 2006   off-pumpon-pumpExploratory negative
Czerny, 2000   off-pumpon-pumpExploratory negative
Czerny b, 2001   off-pumpon-pumpExploratory negative
Dorman, 2004   off-pumpon-pumpExploratory -
Gasz, 2004   off-pumpon-pumpExploratory negative
Guler, 2001   off-pumpon-pumpExploratory negative
Muneretto, 2003   off-pumpon-pumpExploratory suggesting
Parolari, 2003   off-pumpon-pumpExploratory negative
Parolari b, 2003   off-pumpon-pumpExploratory -
Puskas, 2004   off-pumpon-pumpExploratory negative
Sahlman, 2003   off-pumpon-pumpExploratory negative
Syed, 2004   off-pumpon-pumpExploratory -
Tang, 2002   off-pumpon-pumpExploratory negative
Velisaris, 2003   off-pumpon-pumpExploratory negative
Vural, 1995   off-pumpon-pumpExploratory negative
Wan, 2004   off-pumpon-pumpExploratory -
Wandschneider, 2000   off-pumpon-pumpExploratory negative
PROMISS (Uva), 2010   off-pumpon-pumpRisk of bias negative

preconditioning

not classified
Cheung, 2006     remote ischemic preconditioningcontrol -
Gunaydin, 2000     remote ischemic preconditioningcontrol -
Hausenloy, 2007      NCTremote ischemic preconditioningcontrol -
Ali, 2007     remote ischemic preconditioningno RIPC -

radial graft

not classified
CARRPO, 2009      NCTartery graftssaphenous vein graftsExploratory negative
RAPS (Desai), 2004          NCTradial artery graftssaphenous vein graftsExploratory suggesting
RSVP, 2008      NCTradial artery graftssaphenous vein graftsRisk of bias suggesting
Gaudino (radial A), 2005     radial artery graftssaphenous vein graftsRisk of bias suggesting
VA CABG, 2010    NCTradial artery graftssaphenous vein graftsExploratory negative
Gaudino (RITA), 2005     right internal thoracic artery graftssaphenous vein graftsExploratory suggesting

vein grafts pretreatment

not classified
PREVENT IV, 2005    NCTedifoligide pretreatmentplaceboLow risk of bias negative