peripheral vascular diseases

     

Select            
Trial Studied trt Control trt patientstagsROB Trial result

anticoagulant

not classified
Kretschmer, 1992   phenprocoumoncontrôle -
warfarin
Johnson, 2002   warfarincontrôle -
Sarac, 1998   warfarincontrôle -

antioxydants

not classified
POPADAD (antioxydant), 2008   combinationplaceboLow risk of bias negative
vitamin e
Livingstone, 1958   placebo -
Hamilton, 1953   placebo -

antiplatelets drug

aspirin
Schoop, 1983   aspirinplaceboLow risk of bias -
Hess, 1985   aspirinplacebo -
Munich A, 1975   aspirinplaceboLow risk of bias -
Munich B, 1975   aspirinplaceboLow risk of bias -
CLIPS, 2007     aspirinplaceboLow risk of bias suggesting
clopidogrel
CAPRIE (PAD subgroup), 1996   clopidogrelaspirinLow risk of bias suggesting
dipyridamol
Hess (2), 1985   aspirin + dipyridamolplaceboLow risk of bias -
Schoop (2), 1983   aspirin + dipyridamolplaceboLow risk of bias -
VA study, 1986   aspirin + dipyridamolplaceboLow risk of bias -
ketanserine
PACK, 1996   ketanserineplaceboLow risk of bias -
Walden, 1991   ketanserineplaceboLow risk of bias -
Thulesius, 1987   ketanserineplaceboLow risk of bias -
picotamide
ADEP, 1993   picotamideplaceboLow risk of bias -
Neirotti, 1994   picotamideplaceboLow risk of bias -
Coto, 1989   picotamideplaceboLow risk of bias -
suloctidil
Adriaensen, 1976   suloctidilplaceboLow risk of bias -
Verhaeghe, 1981   suloctidilplaceboLow risk of bias -
Jones, 1982   suloctidilplaceboLow risk of bias -
Holm, 1984   suloctidilplaceboLow risk of bias -
ticagrelor
EUCLID, 2016        NCTticagrelorclopidogrelLow risk of bias -
ticlopidine
EMATAP, 1993   ticlopidineplaceboLow risk of bias -
Katsumara, 1982   ticlopidineplaceboLow risk of bias -
Aukland, 1982   ticlopidineplaceboLow risk of bias -
Stiegler, 1984   ticlopidineplaceboLow risk of bias -
Ellis, 1986   ticlopidineplaceboLow risk of bias -
Cloarec, 1986   ticlopidineplaceboLow risk of bias -
Arcan, 1988   ticlopidineplaceboLow risk of bias -
Balsano, 1989   ticlopidineplaceboLow risk of bias -
STIMS, 1990   ticlopidineplaceboLow risk of bias -
Hurlow, 1980   ticlopidineplaceboLow risk of bias -
Krause, 1980   ticlopidineplaceboLow risk of bias -
various
CRAMPS, 2000   cloricromeneplaceboLow risk of bias -

antithrombotics

not classified
Goldman, 1984   contrôle -
Clyne, 1987   contrôle -
Donaldson, 1985   contrôle -
Green, 1982   contrôle -
Kohler , 1984   contrôle -
McCollum, 1991   contrôle -
Kretschmer, 1992   phenprocoumoncontrôle -
Calabro, 1993   LMWHplacebo -
Mannarino, 1991   LMWHplacebo -
De Smit, 1987   phenprocoumonplacebo -
Edmondson, 1994   HBPM -
acenocoumarol
APIC, 1989   acenocoumarolplacebo -
aspirin
Lassila R, 1991   aspirincontrôle -
CLIPS, 2007     aspirinplaceboLow risk of bias suggesting
BOA, 2000   aspirin -
ticlopidine
Becquemin, 1997   ticlopidinecontrôle -
UFH
Antonicelli, 1999   HNFplacebo -
Tesi, 1989   HNFplacebo -
warfarin
Johnson, 2002   warfarincontrôle -
Sarac, 1998   warfarincontrôle -

cell-based therapies

not classified
RAVE (Rajagopalan), 2003     AdVEGF121placeboLow risk of bias -
DELTA (Grossman), 2007     Del-1placeboLow risk of bias -
Kusumanto, 2006     phVEGF165placeboLow risk of bias -
TRAFFIC (Lederman), 2002     rFGF-2placeboLow risk of bias -
Makinen, 2002     VEGF geneplaceboLow risk of bias -

cholesterol lowering intervention

atorvastatin
Mohler III, 2003   atorvastatinplaceboPeripheral Arterial DiseaseExploratory -
bezafibrate
LEADER trial, 2000   bezafibrateplaceboPeripheral Arterial DiseaseLow risk of bias -
niacin
CLAS, 1987   colestipol-niacinplaceboPeripheral Arterial DiseaseExploratory -
probucol
PQRST, 1994   probucolplaceboPeripheral Arterial DiseaseExploratory -
simvastatin
HPS (sub group), 2002   simvastatinplaceboPeripheral Arterial DiseaseLow risk of bias -
Mondillo, 2003   simvastatinplaceboPeripheral Arterial DiseaseExploratory -
Aronow , 2003   simvastatinplaceboPeripheral Arterial DiseaseExploratory -

Exercise Therapy

Exercise Therapy
Gelin, 2001   Exercise TherapyControl -
Mannarino E, 1991   Exercise TherapyControl -
Dahllof AG, 1974   Exercise TherapyControl -
Hiatt WR, 1990   Exercise TherapyControl -
Hiatt WR, 1994   Exercise TherapyControl -
Larsen OA, 1966   Exercise TherapyControl -
Tisi PV, 1997   Exercise TherapyControl -
Holm J, 1973   Exercise TherapyControl -
Fowler, 2002   Exercise TherapyControl -
Gardner, 2001   Exercise TherapyControl -

vasodilators therapy

not classified
Barnes RW, 1977   sympathectomiecontrôle -
Satiani B, 1982   sympathectomiecontrôle -
buflomedil
LIMB, 2008   buflomedilplaceboLow risk of bias suggesting
Diamantopoulos, 2001   buflomédilplacebo -
cilostazol
Beebe, 1999   cilostazolplacebo -
Dawson, 1998   cilostazolplacebo -
Money, 1998   cilostazolplacebo -
Strandness, 2002   cilostazolplacebo -
Dawson (cilostazol), 2000   cilostazolplacebo -
Elam, 1998     cilostazolplaceboLow risk of bias -
Otsuka 21-95-201   cilostazolplaceboLow risk of bias -
ginko biloba
Bauer, 1984   ginko bilobaplacebo -
Peters, 1998   ginko bilobaplacebo -
naftidrofuryl
Meehan, 1982   naftidrofuryl IVcontrol -
NIQOL germany, 1999   Naftidrofurylplacebo -
Clyne, 1980   naftidrofurylplacebo -
NIQOL belgium, 2001   naftidrofurylplacebo -
NCIS, 2001   naftidrofurylplacebo -
Testart, 1994   naftidrofuryl IVplacebo -
D'Hooge D, 2001   naftidrofuryl IVplacebo -
Negus, 1987   naftidrofuryl IVprostacyclin -
pentoxifylline
Dawson (pentoxifylline), 2000   pentoxifyllineplacebo -
APIC, 1989   pentoxifyllineplacebo -
Donaldson, 1984   pentoxifyllineplacebo -
Porter, 1982   pentoxifyllineplacebo -
Belcaro, 2002   pentoxifyllineplacebo -