percutaneous coronary intervention

     

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Trial Studied trt Control trt patientstagsNCTROB Result

anti inflammatory drugs

pexelizumab
APEX-AMI, 2007pexelizumabplaceboNCT00091637Low risk of bias negative

anti-anginal drugs

nicorandil
Nishimura, 2009nicorandilcontrolRisk of bias -

anticoagulant

not classified
BriegerenoxaparinUFH -
bivalirudin
REPLACE-2, 2003bivalirudinheparin + GP2b3a inhibitors -
HORIZONS-AMI (Stone), 2008bivalirudinheparin + GP2b3a inhibitorsNCT00433966Risk of bias suggesting
ACUITY (Stone) (bivalirudin alone), 2006bivalirudinheparin + GP2b3a inhibitorsNCT00093158Risk of bias -
Kleiman, 2002bivalirudin + eptifibatideheparin + GP2b3a inhibitorsExploratory -
ISAR-REACT 3, 2008bivalirudinUFHNCT00262054Low risk of bias -
REPLACE-1, 2004bivalirudinUFHExploratory negative
BAT (Bittl), 1995bivalirudinUFHLow risk of bias suggesting
ARMYDA BIVALVEbivalirudinUFH -
NAPLES (Tavano), 2009bivalirudinUFH plus tirofibanRisk of bias suggesting
dalteparin
Natarajan (without antiGp2b3a), 2003dalteparinUFH -
Natarajan (+ antiGp2b3a), 2003dalteparinUFH + anti Gp2b3a -
enoxaparin
STEEPLE, 2006enoxaparinUFHNCT00077844Risk of bias -
Rabah, 1999enoxaparinUFHExploratory negative
CRUISE, 2003enoxaparinUFHExploratory negative
Galeote, 2001enoxaparinUFHnegative
Dudek, 2000enoxaparinUFHnegative
Dudek b (enox alone), 2000enoxaparinUFH -
Drozd, 2001enoxaparinUFHnegative
ATOLL, 2010enoxaparinUFHRisk of bias -
Dubek b (+abciximal), 2001enoxaparin+abciximabUFH -
fondaparinux
SWITCH III ongoing fondaparinuxunfractionated heparin or bivalirudinNCT00464087 ongoing
reviparin
REDUCE, 1996reviparinUFHLow risk of bias suggesting

antiplatelets drug

not classified
DECLARE-LONG II , 2011 -
OPTIMIZE, 20133 months DAPT 12 months DAPTNCT01113372 -
EXCELLENT, 20116-month dual antiplatelet therapy12 months dual antiplateletNCT00698607negative
PRODIGY, 201124 months of dual antiplatelet treatment6 months dual antiplateletNCT00611286negative
WOESTtriple therapydual antiplatelet therapyNCT00769938 -
RESETEndeavor stent and three months of DAPTstandard 12-month DAPT and other DESNCT01145079negative
ARTIC (extended dual antiplatelet) ongoing 18 months dual antiplatelet12 months dual antiplateletNCT00827411 ongoing
DES-LATE, 2010prolonged dual antiplatelet therapy12 months dual antiplateletNCT00484926Risk of bias negative
DAPT ongoing prolonged dual antiplatelet therapy12 months dual antiplateletNCT00977938 ongoing
OPTIMIZED ongoing prolonged dual antiplatelet therapy12 months dual antiplatelet ongoing
ITALIC ongoing 6 months DAPT24 months DAPTNCT01476020 ongoing
ISAR-SAFE, 200912 months dual antiplatelet6 months dual antiplateletNCT00661206Low risk of bias -
ARTIC adjusted ongoing Monitoring Adjusted Antiplatelet TreatmentCommon Antiplatelet Treatment ongoing
CILON-T, 2010triple antiplateletdual antiplatelet therapyExploratory negative
cilostazol
Kunishima, 1997cilostazolaspirinnegative
Sekiya, 1998cilostazol + aspirinaspirinnegative
Kozuma, 2001cilostazol + aspirinticlopidine + aspirinnegative
Ochiai, 1999cilostazol + aspirinticlopidine + aspirinnegative
Park, 1999cilostazol + aspirinticlopidine + aspirinnegative
Yoon, 1999cilostazol + aspirinticlopidine + aspirinnegative
Kamishirado, 2002cilostazol + aspirinticlopidine + aspirinnegative
clopidogrel
REAL-LATE, ZEST-LATE, 2010clopidogrel+aspirinaspirinNCT00484926negative
GRAVITAS, 2011high-dose clopidogrelnormal-dose clopidogrelNCT00645918Risk of bias negative
Müller, 2000clopidogrel + aspirinticlopidine + aspirinnegative
CLASSICS, 2000clopidogrel + aspirinticlopidine + aspirinnegative
TOPPS, 2001clopidogrel + aspirinticlopidine + aspirinnegative
Piamsomboon, 2001clopidogrel + aspirinticlopidine + aspirinnegative
ticlopidine
STARS (vs aspirin), 1998ticlopidine + aspirinaspirinsuggesting
Hall, 1996ticlopidine + aspirinaspirinnegative
FANTASTIC, 1998ticlopidine + aspirincoumadin + aspirinnegative
ISAR, 1996ticlopidine + aspirincoumadin + aspirinsuggesting
Foussas, 2000ticlopidine + aspirincoumadin + aspirinsuggesting
MATTIS, 1998ticlopidine + aspirincoumadin + aspirinnegative
STARS (vs coumadin+asp), 1998ticlopidine + aspirincoumadin + aspirinsuggesting

antithrombotics

not classified
EPIC (without infusion), 1991 -
IMPACT (12h), 1993 -
IMPACT-II (0.75µg), 1994 -
EXCELLENT, 20116-month dual antiplatelet therapy12 months dual antiplateletNCT00698607negative
Finci, 1989placebonegative
Oriol, 1995placebonegative
TRA-PCI, 2009SCH 530348placeboNCT00132912Exploratory -
BriegerenoxaparinUFH -
ARTIC (extended dual antiplatelet) ongoing 18 months dual antiplatelet12 months dual antiplateletNCT00827411 ongoing
DES-LATE, 2010prolonged dual antiplatelet therapy12 months dual antiplateletNCT00484926Risk of bias negative
DAPT ongoing prolonged dual antiplatelet therapy12 months dual antiplateletNCT00977938 ongoing
OPTIMIZED ongoing prolonged dual antiplatelet therapy12 months dual antiplatelet ongoing
ISAR-SAFE, 200912 months dual antiplatelet6 months dual antiplateletNCT00661206Low risk of bias -
ARTIC adjusted ongoing Monitoring Adjusted Antiplatelet TreatmentCommon Antiplatelet Treatment ongoing
CILON-T, 2010triple antiplateletdual antiplatelet therapyExploratory negative
abciximab
RAPPORT, 1998Abciximabplacebo -
ADMIRAL, 2001Abciximabplacebo -
CADILLAC, 2002Abciximabplacebo -
EPIC (with infusion), 1994Abciximabplacebo -
EPILOG, 1997Abciximabplacebo -
EPISTENT, 1998Abciximabplacebo -
CAPTURE, 1997Abciximabplacebo -
ERASER, 1999Abciximabplacebo -
Petronio, 2002Abciximabplacebo -
Simoons, 1994Abciximabplacebo -
Kini, 2001Abciximabplacebo -
Tamburino, 2002Abciximabplacebo -
ISAR-2, 2000Abciximabplacebo -
aspirin
Taylor (Perth), 1991aspirinplacebonegative
M-HEART II (aspirin), 1995aspirinplacebonegative
bivalirudin
REPLACE-2, 2003bivalirudinheparin + GP2b3a inhibitors -
HORIZONS-AMI (Stone), 2008bivalirudinheparin + GP2b3a inhibitorsNCT00433966Risk of bias suggesting
ACUITY (Stone) (bivalirudin alone), 2006bivalirudinheparin + GP2b3a inhibitorsNCT00093158Risk of bias -
Kleiman, 2002bivalirudin + eptifibatideheparin + GP2b3a inhibitorsExploratory -
ISAR-REACT 3, 2008bivalirudinUFHNCT00262054Low risk of bias -
REPLACE-1, 2004bivalirudinUFHExploratory negative
BAT (Bittl), 1995bivalirudinUFHLow risk of bias suggesting
ARMYDA BIVALVEbivalirudinUFH -
NAPLES (Tavano), 2009bivalirudinUFH plus tirofibanRisk of bias suggesting
BRAVE-4 ongoing Prasugrel and BivalirudinClopidogrel and HeparinNCT00976092 ongoing
cangrelor
CHAMPION PHOENIX, 2013cangrelorclopidogrelNCT01156571Low risk of bias suggesting
CHAMPION-PCI, 2009cangrelor up frontclopidogrel up frontNCT00305162Low risk of bias negative
CHAMPION-PLATFORM, 2009cangrelor up frontdelayed clopidogrelNCT00385138negative
cilostazol
Kunishima, 1997cilostazolaspirinnegative
Sekiya, 1998cilostazol + aspirinaspirinnegative
Kozuma, 2001cilostazol + aspirinticlopidine + aspirinnegative
Ochiai, 1999cilostazol + aspirinticlopidine + aspirinnegative
Park, 1999cilostazol + aspirinticlopidine + aspirinnegative
Yoon, 1999cilostazol + aspirinticlopidine + aspirinnegative
Kamishirado, 2002cilostazol + aspirinticlopidine + aspirinnegative
clopidogrel
GRAVITAS, 2011high-dose clopidogrelnormal-dose clopidogrelNCT00645918Risk of bias negative
Müller, 2000clopidogrel + aspirinticlopidine + aspirinnegative
CLASSICS, 2000clopidogrel + aspirinticlopidine + aspirinnegative
TOPPS, 2001clopidogrel + aspirinticlopidine + aspirinnegative
Piamsomboon, 2001clopidogrel + aspirinticlopidine + aspirinnegative
dalteparin
Natarajan (without antiGp2b3a), 2003dalteparinUFH -
Natarajan (+ antiGp2b3a), 2003dalteparinUFH + anti Gp2b3a -
dipyridamol
Schwartz (Toronto), 1988aspirin + dipyridamolplacebosuggesting
White (aspirin+dipiridamol), 1991aspirin + dipyridamolplacebonegative
Nye (Dunedin), 1990aspirin + dipyridamolplacebonegative
Mayo-PTCA, 1989aspirin + dipyridamolplacebonegative
elinogrel
INNOVATE PCIelinogrelclopidogrelNCT00751231 -
enoxaparin
STEEPLE, 2006enoxaparinUFHNCT00077844Risk of bias -
Rabah, 1999enoxaparinUFHExploratory negative
CRUISE, 2003enoxaparinUFHExploratory negative
Galeote, 2001enoxaparinUFHnegative
Dudek, 2000enoxaparinUFHnegative
Dudek b (enox alone), 2000enoxaparinUFH -
Drozd, 2001enoxaparinUFHnegative
ATOLL, 2010enoxaparinUFHRisk of bias -
Dubek b (+abciximal), 2001enoxaparin+abciximabUFH -
STREAM ongoing enoxaparinunfractionated heparinNCT00882635 ongoing
eptifibatide
IMPACT (4h), 1995Eptifibatideplacebo -
IMPACT-II (0.5µg), 1997Eptifibatideplacebo -
ESPRIT, 2000Eptifibatideplacebo -
Harrington, 1995Eptifibatideplacebo -
fondaparinux
SWITCH III ongoing fondaparinuxunfractionated heparin or bivalirudinNCT00464087 ongoing
prasugrel
TRITOM TIMI 38 (PCI subgroup), 2009prasugrelclopidogrel -
JUMBO-TIMI 26, 2005prasugrelclopidogrelExploratory negative
TRIGGER-PCI ongoing prasugrelClopidogrelNCT00910299 ongoing
reviparin
REDUCE, 1996reviparinUFHLow risk of bias suggesting
sulotroban
M-HEART II (sulotroban), 1995sulotrobanplacebo -
ticlopidine
TACT, 1990ticlopidineplacebonegative
White (ticlopidine), 1991ticlopidineplacebo -
STARS (vs aspirin), 1998ticlopidine + aspirinaspirinsuggesting
Hall, 1996ticlopidine + aspirinaspirinnegative
FANTASTIC, 1998ticlopidine + aspirincoumadin + aspirinnegative
ISAR, 1996ticlopidine + aspirincoumadin + aspirinsuggesting
Foussas, 2000ticlopidine + aspirincoumadin + aspirinsuggesting
MATTIS, 1998ticlopidine + aspirincoumadin + aspirinnegative
STARS (vs coumadin+asp), 1998ticlopidine + aspirincoumadin + aspirinsuggesting
tirofiban
RESTORE, 1997Tirofibanplacebo -
Kereiakis, 1996Tirofibanplacebo -

bioresorbable vascular scaffold

not classified
ABSORB III, 2015NCT01751906 -
LEADERS FREENCT01623180 -
EVOLVE II ongoing NCT01665053 ongoing
DESSOLVE-II ongoing NCT01294748 ongoing
REMEDEE ongoing NCT00967902 ongoing
HARMONEE ongoing NCT02073565 ongoing
EXCELLA II ongoing NCT00792753 ongoing
TROFI II ongoing NCT01986803 ongoing
BIOFLOW-Vbiodegradable polymer sirolimus-eluting stent durable polymer everolimus-eluting stentNCT02389946 -
ABSORB II(Absorb, Abbott Vascular,everolimus-eluting metallic stent NCT01425281 -

pre treatment for PCI

cangrelor
CHAMPION-PCI, 2009cangrelor up frontclopidogrel up frontNCT00305162Low risk of bias negative

proton-pump inhibitors

not classified
COGENT, 2009omeprazoleplaceboNCT00557921Low risk of bias suggesting
OCLA, 2008omeprazoleplaceboNCT00349661Exploratory -
PACA, 2009pantoprazoleomeprazole -

radial access

not classified
Grinfeld, 1996radialfemoral -
Mann , 1996radialfemoral -
ACCESS , 1997radialfemoralnegative
BRAFE , 1997radialfemoralnegative
Cooper , 1999radialfemoralnegative
Mann , 1998radialfemoralnegative
Monsegu , 2000radialfemoral -
CARAFE , 2001radialfemoral -
Gorge and Kirstein, 2001radialfemoralnegative
Moriyama , 2002radialfemoral -
TEMPURA , 2003radialfemoralnegative
OCTOPLUS , 2004radialfemoralsuggesting
Tian , 2003radialfemoral -
Reddy , 2004radialfemoral -
RADIAL AMI , 2005radialfemoralnegative
Achenbach , 2005radialfemoralnegative
OUTCLAS , 2005radialfemoralnegative
FARMI , 2007radialfemoralnegative
Lange and von Boetticher, 2006radialfemoral -
RADIAMI , 2007radialfemoralnegative
Bodi, 2008radialfemoralsuggesting
Li , 2007radialfemoral -
Vazquez-Rodriguez, 2004radialfemoralnegative

restenosis prevention

amlodipine
Jorgensen (NICOLE), 2001amlodipineplacebosuggesting
diltiazem
Corcos, 1985diltiazemcontrolnegative
O’Keefe, 1991diltiazemplacebonegative
Unverdorben, 1996diltiazemplacebosuggesting
nifedipine
Whitworth, 1986nifedipineplacebonegative
nisoldipine
Dens (CAPARES), 2000nisoldipineplacebosuggesting
rosiglitazone
PROVIDENCE ongoing rosiglitazoneplaceboNCT00116792Exploratory ongoing
verapamil
Hoberg, 1994verapamilplacebonegative

statins

not classified
Briguori, 2004various statinsplacebosuggesting
atorvastatin
NAPLES II (Briguori), 2009atorvastatincontrolsuggesting
ESTATE ongoing AtorvastatincontrolNCT00979940 ongoing
ARMYDA, 2004atorvastatinplacebosuggesting
ARMYDA-RECAPTURE, 2009atorvastatin reloadplaceboLow risk of bias suggesting
GAIN, 2001atorvastatinusual carenegative
fluvastatin
FLARE, 1999fluvastatinplacebonegative
LIPS, 2002fluvastatinplacebonegative
pravastatin
PREDICT, 1997pravastatinplacebonegative

thrombectomy

not classified
DIPLOMATE, 2004Angioguardconventional PCInegative
Wang, 2003Angioguardconventional PCI -
AiMI, 2006AngioJetconventional PCInegative
Florence, 2004AngioJetconventional PCInegative
JETSTENT, 2010AnjioJetconventional PCIExploratory negative
TAPAS, 2008Exportconventional PCIISRCTN16716833suggesting
Noel, 2005Exportconventional PCInegative
EXPIRA, 2005Exportconventional PCInegative
Export (Chevalier), 2008Exportconventional PCIsuggesting
Lipiecki, 2009Exportconventional PCI -
UpFlow MI, 2007FilterWireconventional PCInegative
PROMISE, 2005FilterWireconventional PCI -
DEDICATION, 2008FilterWiregconventional PCInegative
Tahk, 2008GuardWireconventional PCIsuggesting
MICADO, 2007GuardWireconventional PCInegative
Ochala, 2007GuardWireconventional PCInegative
EMERALD, 2005GuardWireconventional PCInegative
ASPARAGUS, 2008Guardwireconventional PCInegative
Nanasato, 2004Guardwireconventional PCI -
DEAR-MI, 2006Prontoconventional PCINCT00257153suggesting
Kaltoft, 2006Rescueconventional PCInegative
Dudek, 2004Rescueconventional PCIsuggesting
NONSTOP, 2004Rescueconventional PCI -
PREMIAR, 2007SpideRXconventional PCInegative
TROPHIthrombectomyconventional PCI -
MUSTELLAthrombectomyconventional PCI -
Ciszewski, 2011thrombectomyconventional PCI -
Liistro, 2009thrombectomyconventional PCI -
INFUSE AMI, 2013thrombectomyconventional PCI -
Chao, 2008thrombectomyconventional PCI -
VAMPIRE, 2004TVACconventional PCIsuggesting
X AMINE ST, 2005X-sizerconventional PCIsuggesting
Napodano, 2003X-sizerconventional PCIsuggesting
Beran, 2002X-sizerconventional PCIsuggesting
TASTE (Fröbert), 2013thrombectomyPCI onlyNCT01093404 -
TOTAL, 2015thrombectomyPCI onlyaaaNCT01149044negative
divers
De Luca, 2006Diverconventional PCIsuggesting
REMEDIA, 2005Diverconventional PCIsuggesting
PIHRATE, 2004Diverconventional PCInegative
Sardella, 2005Diverconventional PCI -