patients at high risk for cardiovascular events  

     

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Trial Studied trt Control trt patientstagsNCTROB Result

angiotensin-Converting Enzyme Inhibitors

enalapril
CAMELOT (enalapril), 2004enalaprilplaceboLow risk of bias negative
perindopril
EUROPA, 2003perindoprilplaceboLow risk of bias suggesting
quinapril
QUIET, 2001quinaprilplaceboLow risk of bias negative
ramipril
HOPE, 2000ramiprilplaceboLow risk of bias suggesting
ONTARGET (association vs ramipril), 2008telmisartan + ramiprilramiprilNCT00153101Low risk of bias negative
ONTARGET (association vs telmisartan), 2008telmisartan + ramipriltelmisartanNCT00153101Low risk of bias suggesting
trandolapril
PEACE, 2004trandolaprilplaceboNCT00000558Low risk of bias suggesting

angiotensin-receptor blockers

not classified
Ruilope, 2010LCZ696placeboLow risk of bias -
VALUE, 2004valsartanamlodipineNCT00129233Low risk of bias suggesting
candesartan
SCOPE, 2003candesartanplaceboLow risk of bias negative
losartan
RENAAL, 2001losartanplaceboLow risk of bias -
LIFE, 2002losartanatenololLow risk of bias suggesting
ramipril
ONTARGET (association vs ramipril), 2008telmisartan + ramiprilramiprilNCT00153101Low risk of bias negative
ONTARGET (association vs telmisartan), 2008telmisartan + ramipriltelmisartanNCT00153101Low risk of bias suggesting
telmisartan
TRANSCEND, 2008telmisartanplaceboNCT00153101Low risk of bias suggesting
PROPHESS, 2008telmisartanplaceboNCT00153062Low risk of bias negative
ONTARGET (telmisartan alone), 2008telmisartanramiprilNCT00153101Low risk of bias suggesting

inhibition of the renin-angiotensin system (ACEI or ARB)

enalapril
CAMELOT (enalapril), 2004enalaprilplaceboLow risk of bias negative
perindopril
EUROPA, 2003perindoprilplaceboLow risk of bias suggesting
quinapril
QUIET, 2001quinaprilplaceboLow risk of bias negative
ramipril
HOPE, 2000ramiprilplaceboLow risk of bias suggesting
ONTARGET (association vs ramipril), 2008telmisartan + ramiprilramiprilNCT00153101Low risk of bias negative
ONTARGET (association vs telmisartan), 2008telmisartan + ramipriltelmisartanNCT00153101Low risk of bias suggesting
telmisartan
TRANSCEND, 2008telmisartanplaceboNCT00153101Low risk of bias suggesting
ONTARGET (telmisartan alone), 2008telmisartanramiprilNCT00153101Low risk of bias suggesting
trandolapril
PEACE, 2004trandolaprilplaceboNCT00000558Low risk of bias suggesting