patients at high risk for cardiovascular events

     

Select            
Trial Studied trt Control trt patientstagsROB Trial result

angiotensin-Converting Enzyme Inhibitors

enalapril
CAMELOT (enalapril), 2004     enalaprilplaceboLow risk of bias negative
perindopril
EUROPA, 2003     perindoprilplaceboLow risk of bias suggesting
quinapril
QUIET, 2001     quinaprilplaceboLow risk of bias negative
ramipril
HOPE, 2000     ramiprilplaceboLow risk of bias suggesting
ONTARGET (association vs ramipril), 2008    NCTtelmisartan + ramiprilramiprilLow risk of bias negative
ONTARGET (association vs telmisartan), 2008    NCTtelmisartan + ramipriltelmisartanLow risk of bias suggesting
trandolapril
PEACE, 2004      NCTtrandolaprilplaceboLow risk of bias suggesting

angiotensin-receptor blockers

not classified
Ruilope, 2010   LCZ696placeboLow risk of bias -
VALUE, 2004      NCTvalsartanamlodipineLow risk of bias suggesting
candesartan
SCOPE, 2003   candesartanplaceboLow risk of bias negative
losartan
RENAAL, 2001     losartanplaceboLow risk of bias -
LIFE, 2002     losartanatenololLow risk of bias suggesting
ramipril
ONTARGET (association vs ramipril), 2008    NCTtelmisartan + ramiprilramiprilLow risk of bias negative
ONTARGET (association vs telmisartan), 2008    NCTtelmisartan + ramipriltelmisartanLow risk of bias suggesting
telmisartan
TRANSCEND, 2008    NCTtelmisartanplaceboLow risk of bias suggesting
PROPHESS, 2008      NCTtelmisartanplaceboLow risk of bias negative
ONTARGET (telmisartan alone), 2008      NCTtelmisartanramiprilLow risk of bias suggesting

inhibition of the renin-angiotensin system (ACEI or ARB)

enalapril
CAMELOT (enalapril), 2004     enalaprilplaceboLow risk of bias negative
perindopril
EUROPA, 2003     perindoprilplaceboLow risk of bias suggesting
quinapril
QUIET, 2001     quinaprilplaceboLow risk of bias negative
ramipril
HOPE, 2000     ramiprilplaceboLow risk of bias suggesting
ONTARGET (association vs ramipril), 2008    NCTtelmisartan + ramiprilramiprilLow risk of bias negative
ONTARGET (association vs telmisartan), 2008    NCTtelmisartan + ramipriltelmisartanLow risk of bias suggesting
telmisartan
TRANSCEND, 2008    NCTtelmisartanplaceboLow risk of bias suggesting
ONTARGET (telmisartan alone), 2008      NCTtelmisartanramiprilLow risk of bias suggesting
trandolapril
PEACE, 2004      NCTtrandolaprilplaceboLow risk of bias suggesting