patients at high risk for cardiovascular events

     

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Trial Studied trt Control trt patientstagsNCTROB Result

angiotensin-Converting Enzyme Inhibitors

enalapril
CAMELOT (enalapril), 2004enalaprilplacebonegative
perindopril
EUROPA, 2003perindoprilplacebosuggesting
quinapril
QUIET, 2001quinaprilplacebonegative
ramipril
HOPE, 2000ramiprilplacebosuggesting
ONTARGET (association vs ramipril), 2008telmisartan + ramiprilramiprilNCT00153101negative
ONTARGET (association vs telmisartan), 2008telmisartan + ramipriltelmisartanNCT00153101suggesting
trandolapril
PEACE, 2004trandolaprilplaceboNCT00000558suggesting

angiotensin-receptor blockers

not classified
Ruilope, 2010LCZ696placeboExploratory -
VALUE, 2004valsartanamlodipineNCT00129233Low risk of bias suggesting
candesartan
SCOPE, 2003candesartanplaceboLow risk of bias negative
losartan
RENAAL, 2001losartanplaceboLow risk of bias -
LIFE, 2002losartanatenololLow risk of bias suggesting
ramipril
ONTARGET (association vs ramipril), 2008telmisartan + ramiprilramiprilNCT00153101negative
ONTARGET (association vs telmisartan), 2008telmisartan + ramipriltelmisartanNCT00153101suggesting
telmisartan
TRANSCEND, 2008telmisartanplaceboNCT00153101Low risk of bias suggesting
PROPHESS, 2008telmisartanplaceboNCT00153062Low risk of bias negative
ONTARGET (telmisartan alone), 2008telmisartanramiprilNCT00153101Low risk of bias suggesting

inhibition of the renin-angiotensin system (ACEI or ARB)

enalapril
CAMELOT (enalapril), 2004enalaprilplacebonegative
perindopril
EUROPA, 2003perindoprilplacebosuggesting
quinapril
QUIET, 2001quinaprilplacebonegative
ramipril
HOPE, 2000ramiprilplacebosuggesting
ONTARGET (association vs ramipril), 2008telmisartan + ramiprilramiprilNCT00153101negative
ONTARGET (association vs telmisartan), 2008telmisartan + ramipriltelmisartanNCT00153101suggesting
telmisartan
TRANSCEND, 2008telmisartanplaceboNCT00153101Low risk of bias suggesting
ONTARGET (telmisartan alone), 2008telmisartanramiprilNCT00153101Low risk of bias suggesting
trandolapril
PEACE, 2004trandolaprilplaceboNCT00000558suggesting