patients at high risk for cardiovascular events

     

Select            
Trial Studied trt Control trt patientstagsROB Trial resultCardiovascular deathAll cause death

angiotensin-Converting Enzyme Inhibitors

enalapril
CAMELOT (enalapril), 2004     enalaprilplaceboLow risk of bias negative143%30%
perindopril
EUROPA, 2003     perindoprilplaceboLow risk of bias suggesting -14%-11%
quinapril
QUIET, 2001     quinaprilplaceboLow risk of bias negative-8%-1%
ramipril
HOPE, 2000     ramiprilplaceboLow risk of bias suggesting -25%-15%
ONTARGET (association vs ramipril), 2008    NCTtelmisartan + ramiprilramiprilLow risk of bias negative 4%6%
ONTARGET (association vs telmisartan), 2008    NCTtelmisartan + ramipriltelmisartanLow risk of bias suggesting 4%8%
trandolapril
PEACE, 2004      NCTtrandolaprilplaceboLow risk of bias suggesting-5%-11%

angiotensin-receptor blockers

not classified
Ruilope, 2010   LCZ696placeboLow risk of bias -
VALUE, 2004      NCTvalsartanamlodipineLow risk of bias suggesting -1%2%
candesartan
SCOPE, 2003   candesartanplaceboLow risk of bias negative-5%-3%
losartan
RENAAL, 2001     losartanplaceboLow risk of bias -
LIFE, 2002     losartanatenololLow risk of bias suggesting -13%-11%
ramipril
ONTARGET (association vs ramipril), 2008    NCTtelmisartan + ramiprilramiprilLow risk of bias negative 4%6%
ONTARGET (association vs telmisartan), 2008    NCTtelmisartan + ramipriltelmisartanLow risk of bias suggesting 4%8%
telmisartan
TRANSCEND, 2008    NCTtelmisartanplaceboLow risk of bias suggesting2%5%
PROPHESS, 2008      NCTtelmisartanplaceboLow risk of bias negative-15%2%
ONTARGET (telmisartan alone), 2008      NCTtelmisartanramiprilLow risk of bias suggesting 0%-2%

inhibition of the renin-angiotensin system (ACEI or ARB)

enalapril
CAMELOT (enalapril), 2004     enalaprilplaceboLow risk of bias negative143%30%
perindopril
EUROPA, 2003     perindoprilplaceboLow risk of bias suggesting -14%-11%
quinapril
QUIET, 2001     quinaprilplaceboLow risk of bias negative-8%-1%
ramipril
HOPE, 2000     ramiprilplaceboLow risk of bias suggesting -25%-15%
ONTARGET (association vs ramipril), 2008    NCTtelmisartan + ramiprilramiprilLow risk of bias negative 4%6%
ONTARGET (association vs telmisartan), 2008    NCTtelmisartan + ramipriltelmisartanLow risk of bias suggesting 4%8%
telmisartan
TRANSCEND, 2008    NCTtelmisartanplaceboLow risk of bias suggesting2%5%
ONTARGET (telmisartan alone), 2008      NCTtelmisartanramiprilLow risk of bias suggesting 0%-2%
trandolapril
PEACE, 2004      NCTtrandolaprilplaceboLow risk of bias suggesting-5%-11%