pulmonary embolism

     

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Trial Studied trt Control trt patientstagsNCTROB Result

antithrombotics

not classified
BARRIT, 1960anticoagulantno anticoagulantsuggesting
CASSIOPEA, 2012idrabiotaparinuxwarfarinNCT00345618negative
OTPE (Aujesky), 2011outpatient treatmentinpatient treatmentNCT00425542Risk of bias negative
Otero, 2010outpatient treatmentinpatient treatmentNCT00214929Risk of bias negative
apixaban
AMPLIFY-EXT 2.5mg, 2012apixaban 2.5mgdiscontinuationNCT00633893suggesting
AMPLIFY-EXT 5mg, 2012apixaban 5mgdiscontinuationNCT00633893suggesting
AMPLIFY, 2013apixaban (without LMWH)LMWH/VKA DOAC without heparin NCT00643201Low risk of bias suggesting
Certoparin
Certoparin-Study Group sub group, 1998Certoparinunfractionated heparinExploratory negative
dalteparin
Kuijer, 1995Dalteparinunfractionated heparinnegative
Meyer, 1995Dalteparinunfractionated heparinnegative
enoxaparin
PREPIC, 1998Enoxaparinunfractionated heparinRisk of bias negative
Merli sub group, 2001Enoxaparinunfractionated heparinExploratory negative
fondaparinux
MATISSE PE, 2003fondaparinuxheparinRisk of bias negative
idraparinux
VanGogh PE, 2007idraparinux (without heparin)heparin/VKANCT00062803Risk of bias negative
nadroparin
European multicentre study, 1991Nadroparinunfractionated heparinRisk of bias negative
Prandoni sub-group, 1992Nadroparinunfractionated heparinExploratory negative
Thery, 1992Nadroparinunfractionated heparinExploratory negative
reviparin
COLOMBUS sub group, 1997Reviparinunfractionated heparinExploratory negative
rivaroxaban
Einstein-PE Evaluation, 2012rivaroxaban (without LMWH)LMWH/VKANCT00439777Risk of bias -
tinzaparin
ACTSG (Hull) sub-group, 1992Tinzaparinunfractionated heparinExploratory negative
THESEE, 1997Tinzaparinunfractionated heparinRisk of bias negative
Campbell, 1998Tinzaparinunfractionated heparinnegative

fibrinolysis

not classified
MOPETT, 2012half-dose t-PAno fibrinolysis -
candesartan
Tebbe, 2009desmoteplasealteplaseExploratory -
rt-PA
PAIMS 2, 1992rt-PAno fibrinolysisExploratory negative
Goldhaber, 1993rt-PAno fibrinolysisExploratory negative
PIOPED, 1990rt-PAplaceboExploratory negative
Levine, 1990rt-PAplaceboLow risk of bias negative
Konstantinides, 2002rt-PAplaceboLow risk of bias negative
streptokinase
Tibbutt, 1974streptokinaseno fibrinolysisExploratory negative
Ly, 1978streptokinaseno fibrinolysisExploratory negative
Jerjes-Sanchez, 1995streptokinaseno fibrinolysisExploratory -
tenecteplase
PEITHO ongoing tenecteplaseplaceboNCT00639743 ongoing
urokinase
Marini, 1988urokinaseno fibrinolysisExploratory -
UPET, 1973urokinaseplaceboLow risk of bias negative