prevention of sudden death

     

Select            
Trial Studied trt Control trt patientstagsROB Trial resultAll cause deathhospitalisation for heart failure

ICD

not classified
MADIT, 1996     ICDno ICD -

resynchronization (CRT) - defibrillators (ICD)

not classified
RethinQ, 2007      NCTCombined CRT + ICDno CRTExploratory negative150%
CARE-HF, 2005     CRTno CRTsuggesting-33%-47%
COMPANION (CRT vs MT), 2004     CRTno CRTRisk of bias negative-16%
MIRACLE, 2002     CRTno CRTsuggesting-26%-48%
MUSTIC-SR, 2001       CRTno CRTnegative+Infini%-67%
MUSTIC AF, 2002     CRTno CRTnegative+Infini%-64%
Garrigue, 2002     CRTno CRT -
PATH-CHF, 2002     CRTno CRT -
RD-CHF, 2003   CRTno CRTnegative-50%-86%
AMIOVIRT, 2003     Combined CRT + ICDno CRT no ICD -
COMPANION (CRT+ICD vs MT), 2004     Combined CRT + ICDno CRT no ICDsuggesting-30%
CAT, 2002     ICDno ICD -
DEFINITE, 2004       ICDno ICD -
MADIT-II, 2002     ICDno ICDsuggesting-29%
SCD-HeFT (ICD vs placebo), 2005      NCTICDno ICD -
MADIT, 1996     ICDno ICD -
CABG-patch, 1997      NCTICDno ICD -
DINAMIT, 2004     ICDno ICDnegative10%
MUSIT, 1999     ICDno ICD -
SCD-HeFT (ICD vs amiodarone), 2005      NCTICDno ICD -
AVID, 1997      NCTICDno ICD -
CASH, 2000     ICDno ICD -
CIDS, 2000     ICDno ICD -
Dutch trial, 1995     ICDno ICDnegative-61%
COMPANION (CRT+ICD vs CRT), 2004     Combined CRT + ICDCRTnegative-17%
CONTAK-CD , 2003     Combined CRT + ICDICD alone -
MIRACLE-ICD-I, 2003     Combined CRT + ICDICD aloneLow risk of bias negative-22%6%
MIRACLE-ICD-II, 2004     Combined CRT + ICDICD aloneLow risk of bias negative19%